当前位置： SCI文献检索 > Genome Medicine期刊下所有文献 > PPAR action in insulin resistance unraveled by metabolomics: potential clinical implications.

PPAR action in insulin resistance unraveled by metabolomics: potential clinical implications.

Abstract：

:Metabolomic analysis will provide the next large set of clues to further our understanding of human health and disease. A recent study has elucidated the significant differences in the metabolomes of adipocytes, serum and an adipocyte cell line after activation of two nuclear receptors, peroxisome proliferator activated receptor β/δ (PPARβ/δ) and PPARγ. These findings hold great promise for explaining fundamental differences in the mechanisms of PPAR agonists and for identifying targets for the treatment of diabetes.See related research article: http://genomebiology.com/2011/12/8/R75.

journal_name

Genome Med

journal_title

Genome medicine

authors

Patterson AD,Peters JM

doi

10.1186/gm270

subject

Has Abstract

pub_date

2011-08-23 00:00:00

pages

54

issue

8

issn

1756-994X

pii

gm270

journal_volume

3

pub_type

杂志文章

相关文献

Genome Medicine文献大全
  • Best practices for bioinformatic characterization of neoantigens for clinical utility.

    abstract：:Neoantigens are newly formed peptides created from somatic mutations that are capable of inducing tumor-specific T cell recognition. Recently, researchers and clinicians have leveraged next generation sequencing technologies to identify neoantigens and to create personalized immunotherapies for cancer treatment. To cr...

    journal_title：Genome medicine

    pub_type： 杂志文章,评审

    doi：10.1186/s13073-019-0666-2

    authors： Richters MM,Xia H,Campbell KM,Gillanders WE,Griffith OL,Griffith M

    更新日期：2019-08-28 00:00:00

  • Sharing knowledge: a new frontier for public-private partnerships in medicine.

    abstract：:To help overcome the bottlenecks that limit the development of diagnostic and therapeutic products, academic and industrial researchers, patient organizations and charities, and regulatory and funding institutions should redefine the basis for sharing the knowledge collected in large-scale clinical and experimental st...

    journal_title：Genome medicine

    pub_type： 杂志文章

    doi：10.1186/gm29

    authors： Auffray C

    更新日期：2009-03-04 00:00:00

  • Epigenomics and transcriptomics of systemic sclerosis CD4+ T cells reveal long-range dysregulation of key inflammatory pathways mediated by disease-associated susceptibility loci.

    abstract：BACKGROUND:Systemic sclerosis (SSc) is a genetically complex autoimmune disease mediated by the interplay between genetic and epigenetic factors in a multitude of immune cells, with CD4+ T lymphocytes as one of the principle drivers of pathogenesis. METHODS:DNA samples exacted from CD4+ T cells of 48 SSc patients and ...

    journal_title：Genome medicine

    pub_type： 杂志文章

    doi：10.1186/s13073-020-00779-6

    authors： Li T,Ortiz-Fernández L,Andrés-León E,Ciudad L,Javierre BM,López-Isac E,Guillén-Del-Castillo A,Simeón-Aznar CP,Ballestar E,Martin J

    更新日期：2020-09-25 00:00:00

  • An epigenome-wide association study of sex-specific chronological ageing.

    abstract：BACKGROUND:Advanced age is associated with cognitive and physical decline and is a major risk factor for a multitude of disorders. There is also a gap in life expectancy between males and females. DNA methylation differences have been shown to be associated with both age and sex. Here, we investigate age-by-sex differe...

    journal_title：Genome medicine

    pub_type： 杂志文章

    doi：10.1186/s13073-019-0693-z

    authors： McCartney DL,Zhang F,Hillary RF,Zhang Q,Stevenson AJ,Walker RM,Bermingham ML,Boutin T,Morris SW,Campbell A,Murray AD,Whalley HC,Porteous DJ,Hayward C,Evans KL,Chandra T,Deary IJ,McIntosh AM,Yang J,Visscher PM,McRa

    更新日期：2019-12-31 00:00:00

  • Mining the literature: new methods to exploit keyword profiles.

    abstract：UNLABELLED:Bibliographic records in the PubMed database of biomedical literature are annotated with Medical Subject Headings (MeSH) by curators, which summarize the content of the articles. Two recent publications explain how to generate profiles of MeSH terms for a set of bibliographic records and to use them to defin...

    journal_title：Genome medicine

    pub_type： 杂志文章

    doi：10.1186/gm382

    authors： Andrade-Navarro MA

    更新日期：2012-10-30 00:00:00

  • An ethics safe harbor for international genomics research?

    abstract：BACKGROUND:Genomics research is becoming increasingly globally connected and collaborative, contesting traditional ethical and legal boundaries between global and local research practice. As well, global data-driven genomics research holds great promise for health discoveries. Yet, paradoxically, current research ethic...

    journal_title：Genome medicine

    pub_type： 杂志文章

    doi：10.1186/gm503

    authors： Dove ES,Knoppers BM,Zawati MH

    更新日期：2013-11-22 00:00:00

  • Phylogenetically informative mutations in genes implicated in antibiotic resistance in Mycobacterium tuberculosis complex.

    abstract：BACKGROUND:A comprehensive understanding of the pre-existing genetic variation in genes associated with antibiotic resistance in the Mycobacterium tuberculosis complex (MTBC) is needed to accurately interpret whole-genome sequencing data for genotypic drug susceptibility testing (DST). METHODS:We investigated mutation...

    journal_title：Genome medicine

    pub_type： 杂志文章

    doi：10.1186/s13073-020-00726-5

    authors： Merker M,Kohl TA,Barilar I,Andres S,Fowler PW,Chryssanthou E,Ängeby K,Jureen P,Moradigaravand D,Parkhill J,Peacock SJ,Schön T,Maurer FP,Walker T,Köser C,Niemann S

    更新日期：2020-03-06 00:00:00

  • Integrating informatics tools and portable sequencing technology for rapid detection of resistance to anti-tuberculous drugs.

    abstract：BACKGROUND:Mycobacterium tuberculosis resistance to anti-tuberculosis drugs is a major threat to global public health. Whole genome sequencing (WGS) is rapidly gaining traction as a diagnostic tool for clinical tuberculosis settings. To support this informatically, previous work led to the development of the widely use...

    journal_title：Genome medicine

    pub_type： 杂志文章

    doi：10.1186/s13073-019-0650-x

    authors： Phelan JE,O'Sullivan DM,Machado D,Ramos J,Oppong YEA,Campino S,O'Grady J,McNerney R,Hibberd ML,Viveiros M,Huggett JF,Clark TG

    更新日期：2019-06-24 00:00:00

  • Integrative analysis of DNA methylation and gene expression reveals hepatocellular carcinoma-specific diagnostic biomarkers.

    abstract：BACKGROUND:Hepatocellular carcinoma (HCC) is the one of the most common cancers and lethal diseases in the world. DNA methylation alteration is frequently observed in HCC and may play important roles in carcinogenesis and diagnosis. METHODS:Using the TCGA HCC dataset, we classified HCC patients into different methylat...

    journal_title：Genome medicine

    pub_type： 杂志文章

    doi：10.1186/s13073-018-0548-z

    authors： Cheng J,Wei D,Ji Y,Chen L,Yang L,Li G,Wu L,Hou T,Xie L,Ding G,Li H,Li Y

    更新日期：2018-05-30 00:00:00

  • Imiquimod has strain-dependent effects in mice and does not uniquely model human psoriasis.

    abstract：BACKGROUND:Imiquimod (IMQ) produces a cutaneous phenotype in mice frequently studied as an acute model of human psoriasis. Whether this phenotype depends on strain or sex has never been systematically investigated on a large scale. Such effects, however, could lead to conflicts among studies, while further impacting st...

    journal_title：Genome medicine

    pub_type： 杂志文章

    doi：10.1186/s13073-017-0415-3

    authors： Swindell WR,Michaels KA,Sutter AJ,Diaconu D,Fritz Y,Xing X,Sarkar MK,Liang Y,Tsoi A,Gudjonsson JE,Ward NL

    更新日期：2017-03-09 00:00:00

  • Survey of European clinical geneticists on awareness, experiences and attitudes towards direct-to-consumer genetic testing.

    abstract：BACKGROUND:The advent of direct-to-consumer (DTC) genetic testing (GT) has sparked a number of debates regarding the scientific validity of tests, their broad health and ethical implications for society as well as their legal status. To date, relatively few empirical studies have been published regarding this phenomeno...

    journal_title：Genome medicine

    pub_type： 杂志文章

    doi：10.1186/gm449

    authors： Howard HC,Borry P

    更新日期：2013-05-22 00:00:00

  • Genomic variants associated with primary biliary cirrhosis.

    abstract：:Primary biliary cirrhosis (PBC) is an autoimmune hepatobiliary disease characterized by immune-mediated injury of small and medium-sized bile ducts, eventually leading to liver cirrhosis. Several studies have addressed PBC immunopathology, and the data support an immune activation leading to autoantibodies and autorea...

    journal_title：Genome medicine

    pub_type： 杂志文章

    doi：10.1186/gm126

    authors： Selmi C,Torok NJ,Affronti A,Gershwin ME

    更新日期：2010-01-26 00:00:00

  • The futility of genomic counseling: essential role of electronic health records.

    abstract：:Technological advances over the past several years have dramatically reduced the cost of whole-genome sequencing. At the same time, understanding of the functional significance of genetic variation has advanced considerably. The routine generation of whole-genome sequence data for individual patients will soon be suff...

    journal_title：Genome medicine

    pub_type： 社论

    doi：10.1186/gm48

    authors： Belmont J,McGuire AL

    更新日期：2009-05-08 00:00:00

  • Therapy-induced stress response is associated with downregulation of pre-mRNA splicing in cancer cells.

    abstract：BACKGROUND:Abnormal pre-mRNA splicing regulation is common in cancer, but the effects of chemotherapy on this process remain unclear. METHODS:To evaluate the effect of chemotherapy on slicing regulation, we performed meta-analyses of previously published transcriptomic, proteomic, phosphoproteomic, and secretome datas...

    journal_title：Genome medicine

    pub_type： 杂志文章

    doi：10.1186/s13073-018-0557-y

    authors： Anufrieva KS,Shender VО,Arapidi GP,Pavlyukov MS,Shakhparonov MI,Shnaider PV,Butenko IO,Lagarkova MA,Govorun VM

    更新日期：2018-06-27 00:00:00

  • Enabling multiplexed testing of pooled donor cells through whole-genome sequencing.

    abstract：:We describe a method that enables the multiplex screening of a pool of many different donor cell lines. Our method accurately predicts each donor proportion from the pool without requiring the use of unique DNA barcodes as markers of donor identity. Instead, we take advantage of common single nucleotide polymorphisms,...

    journal_title：Genome medicine

    pub_type： 杂志文章

    doi：10.1186/s13073-018-0541-6

    authors： Chan Y,Chan YK,Goodman DB,Guo X,Chavez A,Lim ET,Church GM

    更新日期：2018-04-19 00:00:00

  • Systems and genome-wide approaches unite to provide a route to personalized medicine.

    abstract：:A report on the Keystone Symposium 'Complex Traits: Genomics and Computational approaches', Breckenridge, Colorado, USA, 20-25 February 2012. ...

    journal_title：Genome medicine

    pub_type： 杂志文章

    doi：10.1186/gm328

    authors： Stranger BE,Björkegren J,Dolan ME,Ritchie MD

    更新日期：2012-03-30 00:00:00

  • CRISPR-SONIC: targeted somatic oncogene knock-in enables rapid in vivo cancer modeling.

    abstract：:CRISPR/Cas9 has revolutionized cancer mouse models. Although loss-of-function genetics by CRISPR/Cas9 is well-established, generating gain-of-function alleles in somatic cancer models is still challenging because of the low efficiency of gene knock-in. Here we developed CRISPR-based Somatic Oncogene kNock-In for Cance...

    journal_title：Genome medicine

    pub_type： 杂志文章

    doi：10.1186/s13073-019-0627-9

    authors： Mou H,Ozata DM,Smith JL,Sheel A,Kwan SY,Hough S,Kucukural A,Kennedy Z,Cao Y,Xue W

    更新日期：2019-04-16 00:00:00

  • Stem cell banking: between traceability and identifiability.

    abstract：:Stem cell banks are increasingly seen as an essential resource of biological materials for both basic and translational research. Stem cell banks support transnational access to quality-controlled and ethically sourced stem cell lines from different origins and of varying grades. According to the Organisation for Econ...

    journal_title：Genome medicine

    pub_type： 杂志文章

    doi：10.1186/gm194

    authors： Knoppers BM,Isasi R

    更新日期：2010-10-05 00:00:00

  • Genetic and epigenetic insights into fetal alcohol spectrum disorders.

    abstract：:The magnitude of the detrimental effects following in utero alcohol exposure, including fetal alcohol syndrome and other fetal alcohol spectrum disorders (FASD), is globally underestimated. The effects include irreversible cognitive and behavioral disabilities as a result of abnormal brain development, pre- and postna...

    journal_title：Genome medicine

    pub_type： 杂志文章

    doi：10.1186/gm148

    authors： Ramsay M

    更新日期：2010-04-28 00:00:00

  • Host genetic variation and its microbiome interactions within the Human Microbiome Project.

    abstract：BACKGROUND:Despite the increasing recognition that microbial communities within the human body are linked to health, we have an incomplete understanding of the environmental and molecular interactions that shape the composition of these communities. Although host genetic factors play a role in these interactions, these...

    journal_title：Genome medicine

    pub_type： 杂志文章

    doi：10.1186/s13073-018-0515-8

    authors： Kolde R,Franzosa EA,Rahnavard G,Hall AB,Vlamakis H,Stevens C,Daly MJ,Xavier RJ,Huttenhower C

    更新日期：2018-01-29 00:00:00

  • Defining functional signatures of dysbiosis in periodontitis progression.

    abstract：:Periodontitis is a common inflammatory disease that leads to tooth loss and has been linked to cardiovascular disease and diabetes mellitus. The periodontal microbiome is highly diverse, and metatranscriptomic studies have indicated that the genes that are expressed by the microbiota are more relevant than the microbi...

    journal_title：Genome medicine

    pub_type： 杂志文章

    doi：10.1186/s13073-015-0165-z

    authors： Wang GP

    更新日期：2015-04-27 00:00:00

  • An integrated in silico immuno-genetic analytical platform provides insights into COVID-19 serological and vaccine targets.

    abstract：:During COVID-19, diagnostic serological tools and vaccines have been developed. To inform control activities in a post-vaccine surveillance setting, we have developed an online "immuno-analytics" resource that combines epitope, sequence, protein and SARS-CoV-2 mutation analysis. SARS-CoV-2 spike and nucleocapsid prote...

    journal_title：Genome medicine

    pub_type： 杂志文章

    doi：10.1186/s13073-020-00822-6

    authors： Ward D,Higgins M,Phelan JE,Hibberd ML,Campino S,Clark TG

    更新日期：2021-01-07 00:00:00

  • Pan-cancer identification of clinically relevant genomic subtypes using outcome-weighted integrative clustering.

    abstract：BACKGROUND:Comprehensive molecular profiling has revealed somatic variations in cancer at genomic, epigenomic, transcriptomic, and proteomic levels. The accumulating data has shown clearly that molecular phenotypes of cancer are complex and influenced by a multitude of factors. Conventional unsupervised clustering appl...

    journal_title：Genome medicine

    pub_type： 杂志文章

    doi：10.1186/s13073-020-00804-8

    authors： Arora A,Olshen AB,Seshan VE,Shen R

    更新日期：2020-12-03 00:00:00

  • A comparison of epigenetic mitotic-like clocks for cancer risk prediction.

    abstract：BACKGROUND:DNA methylation changes that accrue in the stem cell pool of an adult tissue in line with the cumulative number of cell divisions may contribute to the observed variation in cancer risk among tissues and individuals. Thus, the construction of epigenetic "mitotic" clocks that can measure the lifetime number o...

    journal_title：Genome medicine

    pub_type： 杂志文章

    doi：10.1186/s13073-020-00752-3

    authors： Teschendorff AE

    更新日期：2020-06-24 00:00:00

  • The balance of expression of PTPN22 splice forms is significantly different in rheumatoid arthritis patients compared with controls.

    abstract：BACKGROUND:The R620W variant in protein tyrosine phosphatase non-receptor 22 (PTPN22) is associated with rheumatoid arthritis (RA). The PTPN22 gene has alternatively spliced transcripts and at least two of the splice forms have been confirmed to encode different PTPN22 (LYP) proteins, but detailed information regarding...

    journal_title：Genome medicine

    pub_type： 杂志文章

    doi：10.1186/gm301

    authors： Ronninger M,Guo Y,Shchetynsky K,Hill A,Khademi M,Olsson T,Reddy PS,Seddighzadeh M,Clark JD,Lin LL,O'Toole M,Padyukov L

    更新日期：2012-01-20 00:00:00

  • Polygenic risk scores: from research tools to clinical instruments.

    abstract：:Genome-wide association studies have shown unequivocally that common complex disorders have a polygenic genetic architecture and have enabled researchers to identify genetic variants associated with diseases. These variants can be combined into a polygenic risk score that captures part of an individual's susceptibilit...

    journal_title：Genome medicine

    pub_type： 杂志文章,评审

    doi：10.1186/s13073-020-00742-5

    authors： Lewis CM,Vassos E

    更新日期：2020-05-18 00:00:00

  • Bridging the gap between systems biology and medicine.

    abstract：:Systems biology has matured considerably as a discipline over the last decade, yet some of the key challenges separating current research efforts in systems biology and clinically useful results are only now becoming apparent. As these gaps are better defined, the new discipline of systems medicine is emerging as a tr...

    journal_title：Genome medicine

    pub_type： 杂志文章

    doi：10.1186/gm88

    authors： Clermont G,Auffray C,Moreau Y,Rocke DM,Dalevi D,Dubhashi D,Marshall DR,Raasch P,Dehne F,Provero P,Tegner J,Aronow BJ,Langston MA,Benson M

    更新日期：2009-09-29 00:00:00

  • Network strategies to understand the aging process and help age-related drug design.

    abstract：:Recent studies have demonstrated that network approaches are highly appropriate tools for understanding the extreme complexity of the aging process. Moreover, the generality of the network concept helps to define and study the aging of technological and social networks and ecosystems, which may generate novel concepts...

    journal_title：Genome medicine

    pub_type： 杂志文章

    doi：10.1186/gm90

    authors： Simkó GI,Gyurkó D,Veres DV,Nánási T,Csermely P

    更新日期：2009-09-28 00:00:00

  • Mode and dynamics of vanA-type vancomycin resistance dissemination in Dutch hospitals.

    abstract：BACKGROUND:Enterococcus faecium is a commensal of the gastrointestinal tract of animals and humans but also a causative agent of hospital-acquired infections. Resistance against glycopeptides and to vancomycin has motivated the inclusion of E. faecium in the WHO global priority list. Vancomycin resistance can be confer...

    journal_title：Genome medicine

    pub_type： 杂志文章

    doi：10.1186/s13073-020-00825-3

    authors： Arredondo-Alonso S,Top J,Corander J,Willems RJL,Schürch AC

    更新日期：2021-01-20 00:00:00

  • Biomarker discovery in human cerebrospinal fluid: the need for integrative metabolome and proteome databases.

    abstract：:The number of metabolites identified in human cerebrospinal fluid (CSF) has steadily increased over the past 5 years, and in this issue of Genome Medicine David Wishart and colleagues provide a comprehensive update that brings the number of metabolites listed in the CSF metabolome database to 476 compounds. There is n...

    journal_title：Genome medicine

    pub_type： 杂志文章

    doi：10.1186/gm338

    authors： Schwarz E,Torrey EF,Guest PC,Bahn S

    更新日期：2012-04-30 00:00:00