Mild intellectual disability associated with a progeny of father-daughter incest: genetic and environmental considerations.

Abstract:

:We report the case of a 34-year-old female resulting from a father-daughter sexual abuse and presenting a phenotype of mild intellectual disability with minor dysmorphic features. Karyotyping showed a normal 46, XX constitution. Array-based comparative genomic hybridization (array-CGH) revealed a heterozygote 320kb 6p22.3 microdeletion in the proband, encompassing only one known gene, and therefore unlikely to be the cause of the phenotype. However, the role of other genetic factors, such as a recessive condition, could not be ruled out as a putative cause for the phenotype. On the other hand, the role played by a heavily detrimental familial situation on the development and outcome, and possibly leading or contributing to a mild intellectual disability, should be taken into account.

journal_name

J Child Sex Abus

authors

Ansermet F,Lespinasse J,Gimelli S,Béna F,Paoloni-Giacobino A

doi

10.1080/10538711003788991

subject

Has Abstract

pub_date

2010-05-01 00:00:00

pages

337-44

issue

3

eissn

1053-8712

issn

1547-0679

pii

922541599

journal_volume

19

pub_type

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