Abstract：
:The majority of patients diagnosed with adenocarcinoma of the pancreas have advanced disease at presentation, with only 20% surviving beyond one year. Even among the 10% to 15% of patients who present with localized disease, only 20% will be alive 5 years post surgical resection. Systemic therapy for pancreatic adenocarcinoma to date has failed to provide more than a very modest survival benefit for patients with advanced disease. However, the past decade has seen significant advances in the understanding of the molecular pathogenesis of pancreatic cancer, culminating in the sequencing of the pancreatic cancer genome. New generations of therapeutic agents targeting key oncogenic cellular signaling pathways are currently under evaluation in advanced pancreatic adenocarcinoma. Although thus far only erlotinib has been shown to improve survival when compared to gemcitabine monotherapy, the authors anticipate that further developments in biomarker analysis and pharmacogenomics, along with the identification of new drugs will help maximize the benefit of novel therapeutics by directing effective use in the future. Herein the authors review the evidence to date for the use of novel cytotoxic and molecularly targeted agents in pancreatic adenocarcinoma, and discuss key areas for future therapeutic development.
journal_name
Minerva Chirjournal_title
Minerva chirurgicaauthors
Lowery M,O'Reilly EMsubject
Has Abstractpub_date
2009-10-01 00:00:00pages
501-19issue
5eissn
0026-4733issn
1827-1626pii
R06095174journal_volume
64pub_type
杂志文章,评审abstract：:The authors report a case of gastric leiomyoblastoma, a rare benign neoplasm that can sometimes undergo a malignant course. The main clinical an pathological issues are reviewed, in order to offer guidance as to the best suited surgical approach. ...
journal_title：Minerva chirurgica
pub_type： 杂志文章,评审
doi：
更新日期：1992-11-01 00:00:00
abstract：:Hemangiopericytoma is a rare and solitary solid tumor originating from pericytes, which are contractile pericapillary cells, first identified and described by Zimmermann in 1923. This neoplasm occurs most commonly in the lower extremities and retroperitoneum. The Authors describe the case of a patient affected with a ...
journal_title：Minerva chirurgica
pub_type： 杂志文章
doi：
更新日期：1993-06-30 00:00:00
abstract：:Abdomen and pelvic radiation therapy, as a complement to medical and surgery therapy in malignancies, may determine acute and chronic intestinal injuries. The acute intestinal effects of ionizing radiation are the necrosis of crypt epithelial cells and the cessation of the intestinal epithelium; late radiation injury ...
journal_title：Minerva chirurgica
pub_type： 杂志文章
doi：
更新日期：1996-03-01 00:00:00
abstract：:Thirty-four patients who underwent carotid-subclavian bypass (64.7%), aorto-carotid bypass (17.6%), endarterectomy of subclavian artery (5.8%) or endarterectomy of innominate artery for "subclavian" or "innominate steal" syndromes, had a follow-up studies 3-8 years since surgery. All patients demonstrated originally a...
journal_title：Minerva chirurgica
pub_type： 杂志文章
doi：
更新日期：1980-08-15 00:00:00
abstract：:Pancreatoblastoma is a very rare tumor of the pancreas, affecting children in the first decade of life. Ultrasound and CT scan may be useful but pre-operative diagnosis is often quite difficult. High level of seric alpha-fetoprotein could be suggestive of pancreatoblastoma. The definitive diagnosis is however made by ...
journal_title：Minerva chirurgica
pub_type： 杂志文章
doi：
更新日期：1996-09-01 00:00:00
abstract：:A small contribution is made to the work of widening the knowledge of the main principles followed in the emergency management of injuries to the face and jaws. The topic is rendered easily comprehensible by the nonspecialist through the use of many pictures. A short compendium of emergency therapies and personal expe...
journal_title：Minerva chirurgica
pub_type： 杂志文章
doi：
更新日期：1980-10-15 00:00:00
abstract：:Cholecystolithotomy and cholecystojejunostomy has been carried out on 11 patients with severe hypertension from cirrhosis. The indications were frequently recurring attacks of biliary cholic or acute cholecystitis at onset. There was 1 postoperative death from cardiac infarction and only minor in-hospital morbidity. N...
journal_title：Minerva chirurgica
pub_type： 临床试验,杂志文章
doi：
更新日期：1995-03-01 00:00:00
abstract：:A rare case of gastric schwannoma is reported. A 36-year-old woman whose endoscopy showed a mucosa tumor, biopsy findings were suggestive for leiomyoma. Diagnosis was made only with postoperative histology that revealed the benign schwannoma. Immunohistochemical staining showed positivity for S-100 protein and the neu...
journal_title：Minerva chirurgica
pub_type： 杂志文章
doi：
更新日期：1997-07-01 00:00:00
abstract：AIM:The aim of this study was to assess retrospectively at 5 years the clinical outcome of bone regeneration in patients who underwent maxillary sinus lift with different equine-derived, enzyme-deantigenated equine bone grafts, and simultaneous placement of acid-etched surface implants. METHODS:Eighteen patients (10 m...
journal_title：Minerva chirurgica
pub_type： 杂志文章
doi：
更新日期：2008-04-01 00:00:00
abstract：:Twenty autotransplantations and five allotransplantations were performed in female pigs; exocrine secretion was suppressed by injecting an acrylic glue into the ductal system; pancreatic segment was transplanted extraperitoneally in the iliac fussa. We describe an original technique most suitable to the morfologic car...
journal_title：Minerva chirurgica
pub_type： 杂志文章
doi：
更新日期：1980-05-31 00:00:00
abstract：:This article addresses emergent endoluminal technologies currently available for the treatment of gastroesophageal reflux disease (GERD) and compares it to the laparoscopic Nissen fundoplication. To date the mainstay of GERD therapy has been achieved with either open or laparoscopic fundoplication or life-long medical...
journal_title：Minerva chirurgica
pub_type： 杂志文章,评审
doi：
更新日期：2004-10-01 00:00:00
abstract：:Obesity is the leading public health concern in the industrialized world with the advent of the very obese or "super obese" increasing exponentially. Bariatric surgery remains the only effective and enduring treatment for morbid obesity and can be safely accomplished in experienced centers. Surgery in the very obese m...
journal_title：Minerva chirurgica
pub_type： 杂志文章
doi：
更新日期：2010-12-01 00:00:00
abstract：AIMS AND BACKGROUND:Helicobacter pylori is known to be the pathogenic agent of atrophic gastritis and above all ulcer disease. It is also thought to play a role, together with other factors, in the development of stomach cancer and is currently the focus of numerous studies. In industrialised countries, infection is re...
journal_title：Minerva chirurgica
pub_type： 杂志文章
doi：
更新日期：1999-06-01 00:00:00
abstract：:This report describes 51 vascular patients with peripheral vascular disease treated intraoperatively by means of the autotransfusion apparatus with a minimum of 750 cc of reinfused blood. An early decrease of Hct, Hb, RBC, fibrinogen and Plt count was observed without any significant coagulation disorder. ...
journal_title：Minerva chirurgica
pub_type： 杂志文章
doi：
更新日期：1990-11-01 00:00:00
abstract：:The key concepts regarding nutrition of elderly patients prior to surgery are outlined. The main metabolic changes that occur during surgical stress, paying special attention to the characteristics of elderly patients, are described. Lastly, the caloric-energy intake required by postoperative geriatric patients is eva...
journal_title：Minerva chirurgica
pub_type： 杂志文章,评审
doi：
更新日期：1999-01-01 00:00:00
abstract：:This paper presents guidelines for the safe outpatient practice of aesthetic surgery. These guidelines have been prepared by the Lombard Association of Plastic Surgery for Outpatients (ALChiPlA), an association confined to board certified plastic surgeons and holders of official authorizations issued by the Lombard AS...
journal_title：Minerva chirurgica
pub_type： 杂志文章,实务指引
doi：
更新日期：2010-04-01 00:00:00
abstract：INTRODUCTION:Over recent years, minimally invasive hepatic resections have increasingly been reported in the literature. Even though hepatic surgery is still considered a challenge for surgeons due to its technical difficulties and high morbidity, the development and spread of robotic surgery has highlighted a new inte...
journal_title：Minerva chirurgica
pub_type： 杂志文章,评审
doi：
更新日期：2016-12-01 00:00:00
abstract：:Operations and follow-up examinations were conducted on 106 patients with ulcerative colitis, 33 with colitis Crohn, and 163 with diverticulitis, at the University Clinics of Cologne and Munich. Overall mortality rates were 24.5% (n = 26), 6.1% (n = 2) and 16% (n = 26), respectively. In the surgical treatment of ulcer...
journal_title：Minerva chirurgica
pub_type： 杂志文章
doi：
更新日期：1978-06-15 00:00:00
abstract：:The literature concerning accidents and complications of transcutaneous splenoportography is examined and compared with personal experience. The technique used is discussed and some of its advantages with respect to selective arteriography of the coeliac tripod are stressed. It is concluded transcutaneous that splenop...
journal_title：Minerva chirurgica
pub_type： 杂志文章
doi：
更新日期：1975-09-30 00:00:00
abstract：:A 54 year-old man, without any remarkable medical history, was examined for recurrent episodes of colicky abdominal pain, over a period of nine months, with positive faecal occult blood test. Three months earlier he had undergone an extensive evaluation for a single episode of melaena, including upper gastrointestinal...
journal_title：Minerva chirurgica
pub_type： 杂志文章
doi：
更新日期：2006-12-01 00:00:00
abstract：BACKGROUND:The conservative surgery is considered currently the treatment of choice for the carcinoma of the breast in the initial stage. METHODS:From 1993 to the 2000, 46 patients (median age 52 years) affected by intraductal carcinoma of the breast, have been submitted to surgical intervention. In 10 cases (21,7%) a...
journal_title：Minerva chirurgica
pub_type： 杂志文章,评审
doi：
更新日期：2003-08-01 00:00:00
abstract：:The Authors report a case of benign mucocele which was brought to their attention for emergency treatment. Following a review of the literature, they examine the clinical, anatomopathological, pathogenetic and therapeutic problems related to this rare disease. In conclusion, it is important to assess the benign nature...
journal_title：Minerva chirurgica
pub_type： 杂志文章
doi：
更新日期：1990-10-31 00:00:00
abstract：:The bacterial infections constitute a serious problem for the surgeon: the choice of antibiotic drugs is really important and, as often as possible, should be guided by antibiotic sensitivity tests. In this study we used sulbactam-ampicillin (Unasyn) who is an antibiotic combination between sulbactam, inhibitor of bet...
journal_title：Minerva chirurgica
pub_type： 临床试验,杂志文章
doi：
更新日期：1992-10-31 00:00:00
abstract：:Hepatitis C is one of the leading indications for liver transplantation. Recipients can expect at least a short-term survival equivalent to other indications for liver transplantation. However, the rates of cirrhosis and decompensation development is substantially faster than those rates seen in non-transplant setting...
journal_title：Minerva chirurgica
pub_type： 杂志文章,评审
doi：
更新日期：2003-08-01 00:00:00
abstract：:A series of 100 patients suffering from deep venous thrombosis with prior episodes of pulmonary embolism or ilio-caval floating thrombi, submitted to surgery for the prevention of new embolic episodes, is analysed. Indications are discussed together with the various prevention techniques adopted over the past 5 years....
journal_title：Minerva chirurgica
pub_type： 杂志文章
doi：
更新日期：1991-10-15 00:00:00
abstract：BACKGROUND:Surgeon's position during open cholecystectomy operation has been standardized since more than 100 years, being traditionally fixed at the right side of the patient. Only a few French authors adopted the "left location" just for the time requested for the common bile duct exploration. METHODS:In this paper ...
journal_title：Minerva chirurgica
pub_type： 杂志文章
doi：
更新日期：1998-07-01 00:00:00
abstract：BACKGROUND:There is an increasing preference for early laparoscopic cholecystectomy (ELC) as compared to delayed LC (DLC) in the management of acute cholecystitis (AC). Conversion to open cholecystectomy (LOC) remains an important outcome. We aim to compare ELC and DLC outcomes and identify LOC predictors. METHODS:Ret...
journal_title：Minerva chirurgica
pub_type： 杂志文章
doi：10.23736/S0026-4733.17.07412-0
更新日期：2017-12-01 00:00:00
abstract：:Small cell carcinoma of the esophagus is a rare tumor. It was described for the first time in 1952 by McKeown and 200 cases have been reported till now. Because of its similarity with small cell carcinoma of the lung, the treatment of this tumor is controversial. In our Institute we treated three patients with small c...
journal_title：Minerva chirurgica
pub_type： 杂志文章
doi：
更新日期：2003-08-01 00:00:00
abstract：:Late thrombosis of inserted prosthetic grafts for arterial reconstructive surgery is one of the most frequent late complication. Its incidence is influenced by many factors: hemodynamic conditions, quality of run-in and run-off, technical aspects of the primary repair. Progressive arteriosclerosis in femoral vessels w...
journal_title：Minerva chirurgica
pub_type： 杂志文章
doi：
更新日期：1989-03-31 00:00:00
abstract：:A case of distal volvulus of the stomach as a cause of acute intestinal obstruction in a paraesophageal hernia is presented. The patient, an old woman aged 82, had been suffering from abdominal pain and vomiting for about 48 hours. She successfully underwent emergency operation for the reduction of hernia and plasty o...
journal_title：Minerva chirurgica
pub_type： 杂志文章
doi：
更新日期：1989-10-31 00:00:00
