Abstract：
BACKGROUND:Adaptive protein evolution is common in several Drosophila species investigated. Some studies point to very weak selection operating on amino-acid mutations, with average selection intensities on the order of Nes approximately in D. melanogaster and D. simulans. Species with lower effective population sizes should undergo less adaptation since they generate fewer mutations and selection is ineffective on a greater proportion of beneficial mutations. RESULTS:Here I study patterns of polymorphism and divergence at 91 X-linked loci in D. miranda, a species with a roughly 5-fold smaller effective population size than D. melanogaster. Surprisingly, I find a similar fraction of amino-acid mutations being driven to fixation by positive selection in D. miranda and D. melanogaster. Genes with higher rates of amino-acid evolution show lower levels of neutral diversity, a pattern predicted by recurrent adaptive protein evolution. I fit a hitchhiking model to patterns of polymorphism in D. miranda and D. melanogaster and estimate an order of magnitude higher selection coefficients for beneficial mutations in D. miranda. CONCLUSION:This analysis suggests that effective population size may not be a major determinant in rates of protein adaptation. Instead, adaptation may not be mutation-limited, or the distribution of fitness effects for beneficial mutations might differ vastly between different species or populations. Alternative explanation such as biases in estimating the fraction of beneficial mutations or slightly deleterious mutation models are also discussed.
journal_name
BMC Evol Bioljournal_title
BMC evolutionary biologyauthors
Bachtrog Ddoi
10.1186/1471-2148-8-334subject
Has Abstractpub_date
2008-12-18 00:00:00pages
334issn
1471-2148pii
1471-2148-8-334journal_volume
8pub_type
杂志文章abstract：BACKGROUND:Previous phylogenetic analyses of African elephants have included limited numbers of forest elephant samples. A large-scale assessment of mitochondrial DNA diversity in forest elephant populations here reveals a more complex evolutionary history in African elephants as a whole than two-taxon models assume. ...
journal_title：BMC evolutionary biology
pub_type： 杂志文章
doi：10.1186/1471-2148-7-244
更新日期：2007-12-19 00:00:00
abstract：BACKGROUND:The ability of an immune system to remember pathogens improves the chance of the host to survive a second exposure to the same pathogen. This immunological memory has evolved in response to the pathogen environment of the hosts. In vertebrates, the memory of previous infection is physiologically accomplished...
journal_title：BMC evolutionary biology
pub_type： 杂志文章
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更新日期：2010-12-08 00:00:00
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journal_title：BMC evolutionary biology
pub_type： 杂志文章
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更新日期：2009-08-11 00:00:00
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journal_title：BMC evolutionary biology
pub_type： 杂志文章
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更新日期：2020-10-19 00:00:00
abstract：BACKGROUND:Humans and insect herbivores are competing for the same food crops and have been for thousands of years. Despite considerable advances in crop pest management, losses due to insects remain considerable. The global homogenisation of agriculture has supported the range expansion of numerous insect pests and ha...
journal_title：BMC evolutionary biology
pub_type： 杂志文章
doi：10.1186/1471-2148-13-228
更新日期：2013-10-18 00:00:00
abstract：BACKGROUND:Arthropods are infected by a wide diversity of maternally transmitted microbes. Some of these manipulate host reproduction to facilitate population invasion and persistence. Such parasites transmit vertically on an ecological timescale, but rare horizontal transmission events have permitted colonisation of n...
journal_title：BMC evolutionary biology
pub_type： 杂志文章
doi：10.1186/1471-2148-7-238
更新日期：2007-11-29 00:00:00
abstract：BACKGROUND:Computer-assisted analyses have shown that all bacterial genomes contain a small percentage of open reading frames with a frameshift or in-frame stop codon We report here a comparative analysis of these interrupted coding sequences (ICDSs) in six isolates of M. tuberculosis, two of M. bovis and one of M. afr...
journal_title：BMC evolutionary biology
pub_type： 杂志文章
doi：10.1186/1471-2148-8-78
更新日期：2008-03-06 00:00:00
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journal_title：BMC evolutionary biology
pub_type： 杂志文章
doi：10.1186/1471-2148-13-77
更新日期：2013-04-03 00:00:00
abstract：BACKGROUND:Numerous biological functions of long intergenic non-coding RNAs (lincRNAs) have been identified. However, the contribution of lincRNAs to the domestication process has remained elusive. Following domestication from their wild ancestors, animals display substantial changes in many phenotypic traits. Therefor...
journal_title：BMC evolutionary biology
pub_type： 杂志文章
doi：10.1186/s12862-017-1036-6
更新日期：2017-08-15 00:00:00
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journal_title：BMC evolutionary biology
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更新日期：2011-01-26 00:00:00
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journal_title：BMC evolutionary biology
pub_type： 杂志文章
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更新日期：2010-10-07 00:00:00
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journal_title：BMC evolutionary biology
pub_type： 杂志文章
doi：10.1186/s12862-014-0197-9
更新日期：2014-09-25 00:00:00
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journal_title：BMC evolutionary biology
pub_type： 杂志文章
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更新日期：2011-09-14 00:00:00
abstract：BACKGROUND:Chimpanzees (Pan troglodytes) can be divided into four subspecies. Substantial phylogenetic evidence suggests that these subspecies can be grouped into two distinct lineages: a western African group that includes P. t. verus and P. t. ellioti and a central/eastern African group that includes P. t. troglodyte...
journal_title：BMC evolutionary biology
pub_type： 杂志文章
doi：10.1186/s12862-014-0276-y
更新日期：2015-01-21 00:00:00
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journal_title：BMC evolutionary biology
pub_type： 杂志文章
doi：10.1186/1471-2148-13-273
更新日期：2013-12-17 00:00:00
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pub_type： 杂志文章
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更新日期：2007-06-26 00:00:00
abstract：BACKGROUND:The Visayan Tarictic Hornbill (Penelopides panini) and the Walden's Hornbill (Aceros waldeni) are two threatened hornbill species endemic to the western islands of the Visayas that constitute - between Luzon and Mindanao - the central island group of the Philippine archipelago. In order to evaluate their gen...
journal_title：BMC evolutionary biology
pub_type： 杂志文章
doi：10.1186/1471-2148-12-203
更新日期：2012-10-12 00:00:00
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journal_title：BMC evolutionary biology
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doi：10.1186/s12862-014-0200-5
更新日期：2014-09-23 00:00:00
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journal_title：BMC evolutionary biology
pub_type： 杂志文章
doi：10.1186/s12862-019-1418-z
更新日期：2019-04-25 00:00:00
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pub_type： 杂志文章
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更新日期：2008-02-26 00:00:00
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更新日期：2017-05-04 00:00:00
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更新日期：2015-11-19 00:00:00
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journal_title：BMC evolutionary biology
pub_type： 杂志文章
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更新日期：2011-07-28 00:00:00
abstract：BACKGROUND:The flat periwinkles, Littorina fabalis and L. obtusata, are two sister species widely distributed throughout the Northern Atlantic shores with high potential to inform us about the process of ecological speciation in the intertidal. However, whether gene flow has occurred during their divergence is still a ...
journal_title：BMC evolutionary biology
pub_type： 杂志文章
doi：10.1186/s12862-019-1561-6
更新日期：2020-02-10 00:00:00
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journal_title：BMC evolutionary biology
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更新日期：2018-08-30 00:00:00
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journal_title：BMC evolutionary biology
pub_type： 杂志文章
doi：10.1186/s12862-019-1545-6
更新日期：2019-12-05 00:00:00
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journal_title：BMC evolutionary biology
pub_type： 杂志文章
doi：10.1186/1471-2148-9-207
更新日期：2009-08-20 00:00:00
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journal_title：BMC evolutionary biology
pub_type： 杂志文章
doi：10.1186/1471-2148-11-325
更新日期：2011-11-06 00:00:00
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journal_title：BMC evolutionary biology
pub_type： 杂志文章
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更新日期：2008-02-08 00:00:00
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journal_title：BMC evolutionary biology
pub_type： 杂志文章
doi：10.1186/1471-2148-11-247
更新日期：2011-08-31 00:00:00
