当前位置： SCI文献检索 > European Journal of Medical Genetics期刊下所有文献 > Similar prevalence of founder BRCA1 and BRCA2 mutations among Ashkenazi and non-Ashkenazi men with breast cancer: evidence from 261 cases in Israel, 1976-1999.

Similar prevalence of founder BRCA1 and BRCA2 mutations among Ashkenazi and non-Ashkenazi men with breast cancer: evidence from 261 cases in Israel, 1976-1999.

Abstract：

:To evaluate the potential contribution of mutations in the BRCA1 and BRCA2 genes to male breast cancer (MBC), we expanded a previous study to screen a total of 261 Israeli men diagnosed with breast carcinoma. A total of 21 BRCA2 6174delT and 8 BRCA1 185delAG mutations were found. Similar frequencies of BRCA1 and BRCA2 mutation carriers were found among Ashkenazi (12.8%) and non-Ashkenazi Jews (9.1%). The combined prevalence of BRCA1/BRCA2 founder mutations among Ashkenazi Jewish men is slightly higher than for women, due to a higher frequency of BRCA2 mutations.

journal_name

Eur J Med Genet

journal_title

European journal of medical genetics

authors

Chodick G,Struewing JP,Ron E,Rutter JL,Iscovich J

doi

10.1016/j.ejmg.2007.11.001

subject

Has Abstract

pub_date

2008-03-01 00:00:00

pages

141-7

issue

2

eissn

1769-7212

issn

1878-0849

pii

S1769-7212(07)00118-8

journal_volume

51

pub_type

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