The antioxidant effect of melatonin in lung injury after aortic occlusion-reperfusion.

Abstract:

:Acute aortic occlusion with subsequent ischemia-reperfusion of the lower extremities is well known to predispose to lung injury. Melatonin (MEL), a pineal hormone, is a free radical scavenger and an antioxidant. The purpose of this study was to assess the putative protective role of MEL in lung ischemia-reperfusion injury induced by aortic occlusion-reperfusion. Thirty-two rats were randomly allocated to four groups as follows: SHAM (Sham Laparotomy), SHAM+MEL, Aortic Ischemia Reperfusion (AIR) and AIR+MEL. Twenty mg/kg live weight MEL was given intraperitoneally 1 h prior to the experiment. An atraumatic microvascular clamp was placed across the infrarenal abdominal aorta (IAA) just after its origin from the aorta for 30 min. The microvascular clamp on IAA was removed and reperfused for 12 h. Lung tissues were assessed for malondialdehyde (MDA) level and myeloperoxidase (MPO) activity. MDA level and MPO activity, indicating the extent of lipid peroxidation and neutrophil infiltration of lung, respectively, significantly increased in AIR group when compared to SHAM and SHAM+MEL groups (P<0.05). Treating rat with MEL significantly decreased MDA levels as well as MPO activity in AIR+MEL group when compared to AIR group (P<0.05). In this study, exogenously administered MEL reduced lung injury after aortic occlusion reperfusion.

authors

Okutan H,Savas C,Delibas N

doi

10.1016/j.icvts.2004.05.005

subject

Has Abstract

pub_date

2004-09-01 00:00:00

pages

519-22

issue

3

eissn

1569-9293

issn

1569-9285

pii

3/3/519

journal_volume

3

pub_type

杂志文章
  • A minimally invasive approach for open surgical thoracoabdominal aortic replacement: experimental concept for a novel surgical procedure.

    abstract:Objectives:We aimed to develop a simple, reliable, and timesaving technique for the therapy of thoracoabdominal aortic (TAA) aneurysms that are not suitable for endovascular repair. Methods:In this pilot study, we sought to combine the advantages of classic open vascular procedure with the use of endoscopic surgical t...

    journal_title:Interactive cardiovascular and thoracic surgery

    pub_type: 杂志文章

    doi:10.1093/icvts/ivw379

    authors: Andrási TB,Kékesi V,Merkely B,Grossmann M,Danner BC,Schöndube FA

    更新日期:2017-04-01 00:00:00

  • Starting out in minimally invasive aortic valve replacement in the UK.

    abstract:OBJECTIVES:Here we aim to describe in detail the logical procedure and philosophical approach to establish a minimally access aortic valve replacement programme in the current era. METHODS:A real example of a National Health Service Trust in the United Kingdom has been described in a step-wise manner. RESULTS:The out...

    journal_title:Interactive cardiovascular and thoracic surgery

    pub_type: 杂志文章,评审

    doi:10.1093/icvts/ivv279

    authors: Vohra HA,Vaja R,Iakovakis I,Bapat V,Szostek J,Young C

    更新日期:2016-01-01 00:00:00

  • A meta-analysis of adjusted risk estimates for survival from observational studies of complete versus incomplete revascularization in patients with multivessel disease undergoing coronary artery bypass grafting.

    abstract::To determine whether coronary artery bypass grafting (CABG) with complete revascularization improves survival in patients with multivessel disease (MVD) over CABG with incomplete revascularization, we performed a meta-analysis of adjusted (but not unadjusted) risk estimates from observational studies. Databases includ...

    journal_title:Interactive cardiovascular and thoracic surgery

    pub_type: 杂志文章,meta分析,评审

    doi:10.1093/icvts/ivu012

    authors: Takagi H,Watanabe T,Mizuno Y,Kawai N,Umemoto T,ALICE (All-Literature Investigation of Cardiovascular Evidence) Group.

    更新日期:2014-05-01 00:00:00

  • Improvements in left ventricular twist mechanics following myectomy for hypertrophic cardiomyopathy with mid-ventricular obstruction.

    abstract::We aimed to evaluate left ventricle twist mechanics in mid-ventricular obstructive and apical type of hypertrophic cardiomyopathy and changes induced by myectomy. We studied 3 consecutive patients by cardiac magnetic resonance preoperatively and 6 weeks after myectomy. We calculated the apical and basal rotations at t...

    journal_title:Interactive cardiovascular and thoracic surgery

    pub_type: 杂志文章

    doi:10.1093/icvts/ivx054

    authors: Adhyapak SM,Menon PG,Rao Parachuri V

    更新日期:2017-07-01 00:00:00

  • The complications of repeat median sternotomy in paediatrics: six-months follow-up of consecutive cases.

    abstract::Repeat median sternotomy in paediatrics though associated with increased perioperative risks, yet the incidence of injury to the underlying structures during sternal re-entry is poorly quantified. We reviewed 108 patients undergoing repeat sternotomies (group-I) and a control group of 516 patients undergoing first tim...

    journal_title:Interactive cardiovascular and thoracic surgery

    pub_type: 杂志文章,收录出版

    doi:10.1510/icvts.2005.107755

    authors: Elahi MM,Kirke R,Lee D,Dhannapuneni RR,Hickey MS

    更新日期:2005-08-01 00:00:00

  • Systemic levels of endothelin correlate with systemic inflammation and not with myocardial injury or left ventricular ejection fraction in patients undergoing percutaneous coronary intervention and on-pump coronary artery bypass grafting.

    abstract::Endothelin (ET-1) is a potent vasoconstrictor. We compared patterns of ET-1 in percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG) and correlated it with markers of inflammation. Patients with multivessel disease were enrolled in a prospective randomized study of PCI vs. on-pump CABG. Pr...

    journal_title:Interactive cardiovascular and thoracic surgery

    pub_type: 杂志文章,随机对照试验

    doi:10.1510/icvts.2011.278192

    authors: Cuculi F,Lim CC,van Gaal W,Testa L,Westaby S,Arnold JR,Neubauer S,Banning AP

    更新日期:2011-12-01 00:00:00

  • Ministernotomy for repair of congenital cardiac disease.

    abstract::We report our experience with repair of a variety of congenital heart defects utilizing a ministernotomy incision. A ministernotomy was used in 79 patients with a variety of congenital heart diseases from November 2004 to August 2007. Patients included 36 males and 43 females with ages ranging from 1 month to 122 mont...

    journal_title:Interactive cardiovascular and thoracic surgery

    pub_type: 杂志文章

    doi:10.1510/icvts.2009.209593

    authors: Sebastian VA,Guleserian KJ,Leonard SR,Forbess JM

    更新日期:2009-11-01 00:00:00

  • The use of ultrasound in the management of a life-threatening malignant laryngotracheal obstruction.

    abstract::Ultrasound is becoming a valuable diagnostic tool in the armamentarium of thoracic surgeons. We report its use to follow stent placement in the laryngotracheal position for management of life-threatening neoplastic obstruction. For this purpose, a 15-MHz linear probe was placed in the midline at the level of the crico...

    journal_title:Interactive cardiovascular and thoracic surgery

    pub_type: 杂志文章

    doi:10.1093/icvts/ivx298

    authors: Fiorelli A,Messina G,Raucci A,Santini M

    更新日期:2018-02-01 00:00:00

  • Perforation of the right atrium and the ascending aorta following percutaneous transcatheter atrial septal defect closure.

    abstract::Transcatheter closure of secundum atrial septal defect has become an alternative to surgery. We present a patient with hemodynamic collapse secondary to cardiac perforation occurring 36 h after the placement of an Amplatzer Septal Occluder and discuss complications of this kind of device. ...

    journal_title:Interactive cardiovascular and thoracic surgery

    pub_type: 杂志文章

    doi:10.1510/icvts.2004.100669

    authors: Vojácek J,Mates M,Popelová J,Pavel P

    更新日期:2005-06-01 00:00:00

  • Surgery for mediastinal neurogenic tumours: a 25-year single-centre retrospective study.

    abstract:OBJECTIVES:Mediastinal neurogenic tumours are uncommon and often benign neoplasms mostly located in the posterior mediastinum and usually diagnosed incidentally. We reviewed our results after surgical resection. We compared patient characteristics and tumour nature between children and adults. Differences between thora...

    journal_title:Interactive cardiovascular and thoracic surgery

    pub_type: 杂志文章

    doi:10.1093/icvts/ivab002

    authors: Lacquet M,Moons J,Ceulemans LJ,De Leyn P,Van Raemdonck D

    更新日期:2021-02-01 00:00:00

  • Balancing the benefits and risks of blood transfusions in patients undergoing cardiac surgery: a propensity-matched analysis.

    abstract:OBJECTIVES:Prior studies have found that cardiac surgery patients receiving blood transfusions are at risk for increased mortality and morbidity following surgery. It is not clear whether this increased risk occurs across all haematocrit (HCT) levels. The goal of this study was to compare operative mortality in propens...

    journal_title:Interactive cardiovascular and thoracic surgery

    pub_type: 杂志文章

    doi:10.1093/icvts/ivt124

    authors: Shaw RE,Johnson CK,Ferrari G,Zapolanski A,Brizzio M,Rioux N,Edara S,Sperling J,Grau JB

    更新日期:2013-07-01 00:00:00

  • Is microwave ablation an alternative to stereotactic ablative body radiotherapy in patients with inoperable early-stage primary lung cancer?

    abstract::A best evidence topic was written according to a structured protocol. The question addressed was: in patients with inoperable early-stage primary lung cancer does microwave ablation (MWA) or stereotactic ablative body radiotherapy (SBRT) achieve improved outcomes in terms of local control, recurrence, survival and com...

    journal_title:Interactive cardiovascular and thoracic surgery

    pub_type: 杂志文章,评审

    doi:10.1093/icvts/ivz123

    authors: Watson RA,Tol I,Gunawardana S,Tsakok MT

    更新日期:2019-10-01 00:00:00

  • On-X mitral valve replacement: a single-centre experience in 318 patients.

    abstract:OBJECTIVES:If mitral valve repair is not feasible, mitral valve replacement remains the only option. Based on our overall experience with the On-X mitral valve, the aim of this study was to investigate early and late outcomes after mitral valve replacement using this latest generation prosthesis. METHODS:From 1998 to ...

    journal_title:Interactive cardiovascular and thoracic surgery

    pub_type: 杂志文章

    doi:10.1093/icvts/ivy184

    authors: Murana G,Alfonsi J,Savini C,Mariani C,Coppola G,Lo Coco V,Pilato E,Pacini D,Di Bartolomeo R

    更新日期:2018-12-01 00:00:00

  • Reduction of aberrant aortic haemodynamics following aortic root replacement with a mechanical valved conduit.

    abstract:OBJECTIVES:Previous work suggests that aortic root and valve prostheses alter blood flow patterns in the ascending aorta, creating aberrant haemodynamics compared with those of healthy volunteers. Various valve designs have been proposed to better restore physiological haemodynamics. In this study, magnetic resonance i...

    journal_title:Interactive cardiovascular and thoracic surgery

    pub_type: 杂志文章

    doi:10.1093/icvts/ivw173

    authors: Keller EJ,Malaisrie SC,Kruse J,McCarthy PM,Carr JC,Markl M,Barker AJ,Collins JD

    更新日期:2016-09-01 00:00:00

  • Endothelin-1 may play an important role in the Fontan circulation.

    abstract:OBJECTIVES:Our goal was to evaluate whether endothlin-1 (ET-1) plays an important role in the Fontan circulation. METHODS:Thirteen patients with single-ventricle physiology (Glenn circulation, n = 7; Fontan circulation, n = 6) were evaluated using lung histopathological and immunohistochemical studies and then compare...

    journal_title:Interactive cardiovascular and thoracic surgery

    pub_type: 杂志文章

    doi:10.1093/icvts/ivx378

    authors: Aoki M,Hirono K,Higuma T,Suzuki Y,Nakayama K,Ichida F,Origasa H,Nishida N,Imura J,Emoto N,Yoshimura N

    更新日期:2018-03-01 00:00:00

  • Acute DeBakey Type I aortic dissection without intimal tear in the arch: is total arch replacement the right choice?

    abstract:OBJECTIVES:Surgical management of acute DeBakey Type I aortic dissection without intimal tear in the aortic arch is controversial. This study compared short- and long-term outcomes of total arch replacement (TAR) versus limited ascending aorta/hemiarch replacement (no-TAR) in a consecutive series of patients. METHODS:...

    journal_title:Interactive cardiovascular and thoracic surgery

    pub_type: 杂志文章

    doi:10.1093/icvts/ivx229

    authors: Colli A,Carrozzini M,Francescato A,Galuppo M,Comisso M,Toto F,Gregori D,Gerosa G

    更新日期:2018-01-01 00:00:00

  • Fistula formation between the arterial blood supply of pulmonary sequestration and the oesophagus accompanied by an intermittent haematemesis.

    abstract::This study aimed to report the case of a patient diagnosed with pulmonary sequestration accompanied by an intermittent haematemesis as the initial and life-threatening symptom. Emergent surgical intervention finally confirmed a rare direct fistula formation between the arterial blood supply of pulmonary sequestration ...

    journal_title:Interactive cardiovascular and thoracic surgery

    pub_type: 杂志文章

    doi:10.1093/icvts/ivy247

    authors: Wang WP,Ma J,Lu Q,Li XF

    更新日期:2019-03-01 00:00:00

  • Serum carbohydrate antigen 12-5 level enhances the prognostic value in primary adenosquamous carcinoma of the lung: a two-institutional experience.

    abstract:OBJECTIVES:Primary adenosquamous carcinoma (ASC) of the lung is rare. The current study was a retrospective two-institutional analysis of surgical therapy with respect to the clinicopathological characteristics and prognostic factors associated with ASC of the lung. METHODS:The clinical records of patients with pathol...

    journal_title:Interactive cardiovascular and thoracic surgery

    pub_type: 杂志文章,多中心研究

    doi:10.1093/icvts/ivv369

    authors: Lian S,Huang Y,Yang H,Zhao H

    更新日期:2016-04-01 00:00:00

  • Acute regional neuronal injury following hypothermic circulatory arrest in a porcine model.

    abstract:OBJECTIVES:Although deep hypothermic circulatory arrest (HCA) is routinely used to interrupt normal perfusion of the brain and prevent subsequent cerebral ischemic injury during cardiac surgery, it is associated with various forms of neurologic disturbances. Neurologic sequelae after prolonged HCA include motor, memory...

    journal_title:Interactive cardiovascular and thoracic surgery

    pub_type: 杂志文章

    doi:10.1510/icvts.2005.112813

    authors: Ananiadou OG,Drossos GE,Bibou KN,Palatianos GM,Johnson EO

    更新日期:2005-12-01 00:00:00

  • Effects of a 3D segmental prosthetic system for tricuspid valve annulus remodelling on the right coronary artery: a human cadaveric coronary angiography study.

    abstract:OBJECTIVES:A prosthetic system to repair secondary tricuspid valve regurgitation was developed. The conceptual engineering of the current device is based on 3D segmental remodelling of the tricuspid valve annulus in lieu of reductive annuloplasty. This study was designed to investigate the operational safety of the cur...

    journal_title:Interactive cardiovascular and thoracic surgery

    pub_type: 杂志文章

    doi:10.1093/icvts/ivx102

    authors: Riki-Marishani M,Gholoobi A,Sazegar G,Aazami MH,Hedjazi A,Sajjadian M,Ebrahimi M,Aghaii-Zade Torabi A

    更新日期:2017-09-01 00:00:00

  • Huge thymoma: role of preoperative WHO histological classification.

    abstract::A 57-year-old woman was admitted to our hospital with complaints of recent onset of dyspnea on exertion. A chest computed tomography revealed a large mediastinal mass which extrinsically compressed the heart and mediastinal structures, occupying one half of the hemithorax. A needle biopsy was performed to find a thymo...

    journal_title:Interactive cardiovascular and thoracic surgery

    pub_type: 杂志文章

    doi:10.1510/icvts.2008.177162

    authors: Takeda S,Koma M,Maeda H

    更新日期:2008-12-01 00:00:00

  • The number of wires for sternal closure has a significant influence on sternal complications in high-risk patients.

    abstract:OBJECTIVES:Sternal dehiscence and mediastinitis are rare but serious complications following cardiac surgery. The aim of this study was to investigate the influence of the number of sternal wires used for chest closure on sternal complications. METHODS:From May 2003 to April 2007, 4714 adult patients received cardiac ...

    journal_title:Interactive cardiovascular and thoracic surgery

    pub_type: 杂志文章

    doi:10.1093/icvts/ivs293

    authors: Kamiya H,Al-maisary SS,Akhyari P,Ruhparwar A,Kallenbach K,Lichtenberg A,Karck M

    更新日期:2012-10-01 00:00:00

  • Increased mRNA expression of decorin in the prolapsing posterior leaflet of the mitral valve.

    abstract::To improve our understanding of myxomatous degeneration of the valvar tissue as seen in mitral valve prolapse, we have compared the biosynthetic phenotype of the connective tissue cells in myxomatous segments (n=4) resected during surgery with that of homologous segments of normal valves (n=4) harvested in age-matched...

    journal_title:Interactive cardiovascular and thoracic surgery

    pub_type: 杂志文章

    doi:10.1016/S1569-9293(03)00107-5

    authors: Radermecker MA,Limet R,Lapiere CM,Nusgens B

    更新日期:2003-09-01 00:00:00

  • Failure of Marfan anatomic criteria to predict risk of aortic dissection in Turner syndrome: necessity of specific adjusted risk thresholds.

    abstract::Patients with Turner syndrome are prompt to develop spontaneous acute aortic dissection following insidious aortic dilatation, with abnormal cardiovascular anatomy and consequently require specific guidelines for regular surveillance since they represent a subset of high-risk young patients. We report a rare and uncom...

    journal_title:Interactive cardiovascular and thoracic surgery

    pub_type: 杂志文章

    doi:10.1093/icvts/ivr172

    authors: Maureira JP,Vanhuyse F,Lekehal M,Hubert T,Vigouroux C,Mattei MF,Grandmougin D,Villemot JP

    更新日期:2012-05-01 00:00:00

  • Elevated anti-cholesterol antibody levels in the sera of non-small cell lung cancer patients.

    abstract::There have been no published data yet on the serum level of antibodies against cholesterol (anti-cholesterol antibodies) in oncological patients. We decided to examine these levels in the sera of non-small cell lung cancer (NSCLC) patients. Measurements were performed by ELISA technique in the sera of 44 NSCLC patient...

    journal_title:Interactive cardiovascular and thoracic surgery

    pub_type: 杂志文章

    doi:10.1510/icvts.2006.129171

    authors: Egri G,Orosz I

    更新日期:2006-10-01 00:00:00

  • Fast-track approach in abdominal aortic surgery: left subcostal incision with blended anesthesia.

    abstract:OBJECTIVES:The introduction of fast-tracking multidisciplinary programs allows good results in postoperative outcome in many surgical specialties. We evaluated a multimodal clinical program (based on mininvasive surgery, epidural anesthesia and early mobilization and feeding) in abdominal aortic surgery. METHODS:Betwe...

    journal_title:Interactive cardiovascular and thoracic surgery

    pub_type: 杂志文章

    doi:10.1510/icvts.2006.137562

    authors: Brustia P,Renghi A,Fassiola A,Gramaglia L,Della Corte F,Cassatella R,Cumino A

    更新日期:2007-02-01 00:00:00

  • Outcome and survival analysis of intestinal ischaemia following cardiac surgery.

    abstract:OBJECTIVES:Intestinal ischaemia is an uncommon (<1%) but serious complication of cardiac surgery with a mortality rate exceeding 50%. Diagnosis of this potentially lethal condition can be difficult and requires a high index of suspicion. The purpose of this study was to analyse the outcomes and prognostic factors in pa...

    journal_title:Interactive cardiovascular and thoracic surgery

    pub_type: 杂志文章

    doi:10.1093/icvts/ivs181

    authors: Pang PY,Sin YK,Lim CH,Su JW,Chua YL

    更新日期:2012-08-01 00:00:00

  • Fibrovascular polyp of the esophagus: diagnostic dilemma.

    abstract::A 51-year-old female patient was admitted to our department. She had symptoms of dysphagia, regurgitation of a fleshy mass into the mouth, and attacks of dyspnea. Every effort was made for diagnosis. At cervical exploration, upper esophageal polyp was discovered incidentally, and removed. We present this case because ...

    journal_title:Interactive cardiovascular and thoracic surgery

    pub_type: 杂志文章

    doi:10.1016/j.icvts.2003.11.013

    authors: Ozcelik C,Onat S,Dursun M,Arslan A

    更新日期:2004-06-01 00:00:00

  • Mid-term outcomes of congenital mitral valve surgery: Shone's syndrome is a risk factor for death and reintervention.

    abstract:OBJECTIVES:To study the recent trends and outcomes of congenital mitral valve surgery in children. METHODS:From 2008 to 2014, 84 procedures in 66 consecutive patients (41 procedures in 31 patients with mitral stenosis and 43 procedures in 35 patients with mitral regurgitation) were retrospectively evaluated. The mean ...

    journal_title:Interactive cardiovascular and thoracic surgery

    pub_type: 杂志文章

    doi:10.1093/icvts/ivx211

    authors: Sughimoto K,Konstantinov IE,d'Udekem Y,Brink J,Zannino D,Brizard CP

    更新日期:2017-11-01 00:00:00

  • Outcome reporting for surgical treatment of degenerative mitral valve disease: a systematic review and critical appraisal.

    abstract:OBJECTIVES:Standardized outcome reporting is of critical importance for performance monitoring, improvement of existing techniques and introduction of novel technologies. Whether outcome reporting for surgical treatment of degenerative mitral valve disease complies with the guidelines has not been assessed to date. ME...

    journal_title:Interactive cardiovascular and thoracic surgery

    pub_type: 杂志文章

    doi:10.1093/icvts/ivx370

    authors: Tomšic A,Arabkhani B,Schoones JW,van Brakel TJ,Takkenberg JJM,Palmen M,Klautz RJM

    更新日期:2018-04-01 00:00:00