Occam's razor and the unraveling of atrial fibrillation.

Abstract:

:The search for a mechanism to explain atrial fibrillation (AF) has lasted for over a century and continues. Significant progress in understanding this arrhythmia accelerated with the era of operative treatment of this arrhythmia and intensified with the advent of catheter ablation. Through considerable trial and some error, effective "curative" therapies have evolved for paroxysmal AF and are evolving for persistent AF. It is becoming clear that no single mechanism suffices to explain AF in all its forms and multiple mechanisms are playing a role in the most complicated cases.

authors

Klein GJ,O'Neill MD,Hocini M,Jaïs P,Haïssaguerre M,Clementy J

doi

10.1111/j.1540-8167.2006.00738.x

subject

Has Abstract

pub_date

2007-04-01 00:00:00

pages

451-4

issue

4

eissn

1045-3873

issn

1540-8167

pii

JCE738

journal_volume

18

pub_type

历史文章,杂志文章
  • Major complications and mortality within 30 days of an electrophysiological procedure at an academic medical center: implications for developing national standards.

    abstract:BACKGROUND:Despite growing attention to performance and quality measures, national standards for reporting of outcomes after all electrophysiology (EP) procedures have not yet been developed. We sought to characterize the incidence and timing of adverse events up to 30 days after EP procedures at a tertiary academic me...

    journal_title:Journal of cardiovascular electrophysiology

    pub_type: 杂志文章

    doi:10.1111/jce.12639

    authors: Hussain SK,Eddy MM,Moorman L,Malhotra R,Darby AE,Bilchick K,Mason P,Mangrum MJ,Dimarco JP,Ferguson JD

    更新日期:2015-05-01 00:00:00

  • Long-term effects of biatrial synchronous pacing to prevent drug-refractory atrial tachyarrhythmia: a nine-year experience.

    abstract:INTRODUCTION:Results of previous studies suggest that atrial resynchronization by multisite atrial pacing may contribute to prevention of recurrences in patients with drug-refractory atrial tachyarrhythmias and significant intra-atrial conduction delay. METHODS AND RESULTS:To verify this hypothesis, a prospective nonc...

    journal_title:Journal of cardiovascular electrophysiology

    pub_type: 杂志文章

    doi:10.1111/j.1540-8167.2000.tb01752.x

    authors: D'Allonnes GR,Pavin D,Leclercq C,Ecke JE,Jauvert G,Mabo P,Daubert JC

    更新日期:2000-10-01 00:00:00

  • Time-domain T-wave alternans is strongly associated with a history of ventricular fibrillation in patients with Brugada syndrome.

    abstract:AIMS:T-wave alternans (TWA) is an indicator of vulnerability to ventricular arrhythmias and is useful for predicting sudden cardiac death (SCD) in patients with various structural heart diseases. We evaluated whether high levels of time-domain TWA on ambulatory ECG (AECG) are associated with a history of ventricular fi...

    journal_title:Journal of cardiovascular electrophysiology

    pub_type: 杂志文章

    doi:10.1111/jce.12441

    authors: Uchimura-Makita Y,Nakano Y,Tokuyama T,Fujiwara M,Watanabe Y,Sairaku A,Kawazoe H,Matsumura H,Oda N,Ikanaga H,Motoda C,Kajihara K,Oda N,Verrier RL,Kihara Y

    更新日期:2014-09-01 00:00:00

  • Role of virtual electrodes in arrhythmogenesis: pinwheel experiment revisited.

    abstract:INTRODUCTION:Recent experimental evidence demonstrates that a point stimulus generates a nonuniform distribution of transmembrane potential (virtual electrode pattern) consisting of large adjacent areas of depolarization and hyperpolarization. This simulation study focuses on the role of virtual electrodes in reentry i...

    journal_title:Journal of cardiovascular electrophysiology

    pub_type: 杂志文章

    doi:10.1111/j.1540-8167.2000.tb01796.x

    authors: Lindblom AE,Roth BJ,Trayanova NA

    更新日期:2000-03-01 00:00:00

  • Long-term follow-up of right atrial ablation in patients with atrial fibrillation:.

    abstract:INTRODUCTION:The aim of this study was to evaluate the efficacy and the impact on quality of life of a new ablative approach to the right atrium in patients with atrial fibrillation (AF). METHODS AND RESULTS:Seventy-four symptomatic patients with paroxysmal (n = 49) or permanent (n = 25) refractory AF underwent radiof...

    journal_title:Journal of cardiovascular electrophysiology

    pub_type: 临床试验,杂志文章

    doi:10.1046/j.1540-8167.2004.03264.x

    authors: Calò L,Lamberti F,Loricchio ML,Castro A,Shpun S,Boggi A,Pandozi C,Santini M

    更新日期:2004-01-01 00:00:00

  • Radiofrequency catheter ablation of an atriofascicular pathway during atrial fibrillation: a case report.

    abstract:INTRODUCTION:A male patient with an atriofascicular pathway underwent catheter ablation of the atriofascicular pathway during atrial fibrillation. METHODS AND RESULTS:The patient had preexcited atrial fibrillation both clinically and repeatedly during electrophysiologic study. A preexcited tachycardia with a 1:1 AV re...

    journal_title:Journal of cardiovascular electrophysiology

    pub_type: 杂志文章

    doi:10.1111/j.1540-8167.1994.tb01123.x

    authors: Miller JM,Harper GR,Rothman SA,Hsia HH

    更新日期:1994-10-01 00:00:00

  • Complex fractionated atrial electrograms related to left atrial wall thickness.

    abstract:INTRODUCTION:The mechanism of complex fractionated atrial electrogram (CFAE) in patients with atrial fibrillation (AF) remains controversial. This study investigated the relationship between CFAE and left atrial (LA) wall thickness. METHODS AND RESULTS:LA muscular wall thickness (excluding fat) was measured by cardiac...

    journal_title:Journal of cardiovascular electrophysiology

    pub_type: 杂志文章

    doi:10.1111/jce.12473

    authors: Wi J,Lee HJ,Uhm JS,Kim JY,Pak HN,Lee M,Kim YJ,Joung B

    更新日期:2014-11-01 00:00:00

  • Potentiating effect of acetylcholine on stimulation by isoproterenol of L-type Ca2+ current and arrhythmogenic triggered activity in guinea pig ventricular myocytes.

    abstract:INTRODUCTION:The objective of this study was to determine whether the effect of isoproterenol (Iso) to increase L-type Ca2+ current [I(Ca(L))] and action potential duration (APD) was potentiated in ventricular myocytes following termination of an exposure of these cells to acetylcholine (ACh), and whether this potentia...

    journal_title:Journal of cardiovascular electrophysiology

    pub_type: 杂志文章

    doi:10.1111/j.1540-8167.1998.tb00959.x

    authors: Song Y,Shryock JC,Belardinelli L

    更新日期:1998-07-01 00:00:00

  • Idiopathic left ventricular tachycardia with left and right bundle branch block configurations.

    abstract:INTRODUCTION:Idiopathic left ventricular tachycardia typically has a right bundle branch block configuration. The purpose of this case report is to demonstrate that idiopathic ventricular tachycardia arising in or near the left posterior fascicle also may have a left bundle branch block configuration. METHODS AND RESU...

    journal_title:Journal of cardiovascular electrophysiology

    pub_type: 杂志文章

    doi:10.1111/j.1540-8167.1997.tb00810.x

    authors: Zivin A,Goyal R,Daoud E,Man KC,Strickberger SA,Morady F

    更新日期:1997-04-01 00:00:00

  • Time course of esophageal lesions after catheter ablation with cryothermal and radiofrequency ablation: implication for atrio-esophageal fistula formation after catheter ablation for atrial fibrillation.

    abstract:BACKGROUND:Atrio-esophageal fistulas have been described as a consequence of radiofrequency (RF) ablation for the treatment of atrial fibrillation (AF). However, whether cryoablation can avoid this potential fatal complication remains unclear. METHODS AND RESULTS:We studied the effects of direct application of RF and ...

    journal_title:Journal of cardiovascular electrophysiology

    pub_type: 杂志文章

    doi:10.1111/j.1540-8167.2007.00790.x

    authors: Ripley KL,Gage AA,Olsen DB,Van Vleet JF,Lau CP,Tse HF

    更新日期:2007-06-01 00:00:00

  • Efficacy of Intentional Permanent Atrial Pacing in the Long-Term Management of Congenital Long QT Syndrome.

    abstract:BACKGROUND:Unfortunately, some patients with long QT syndrome (LQTS) experience breakthrough cardiac events (BCEs) despite maximal therapy. Small studies have shown that refractory LQTS cases may benefit from intentional permanent atrial pacing (IPAP). As such, we sought to determine the genotype-specific utilization a...

    journal_title:Journal of cardiovascular electrophysiology

    pub_type: 杂志文章

    doi:10.1111/jce.14920

    authors: Kowlgi GN,Giudicessi JR,Barake W,Bos JM,Ackerman MJ

    更新日期:2021-01-29 00:00:00

  • Alpha 1-adrenergic blockade and sudden cardiac death.

    abstract:INTRODUCTION:The primary goal of the present study was to test whether selective pharmacologic blockade of alpha 1 receptors, and specifically of the subtype alpha 1a, could prevent ventricular fibrillation (VF) during acute myocardial ischemia. BACKGROUND:The development of new autonomic interventions is of clinical ...

    journal_title:Journal of cardiovascular electrophysiology

    pub_type: 杂志文章

    doi:10.1111/j.1540-8167.1994.tb01116.x

    authors: Vanoli E,Hull SS Jr,Foreman RD,Ferrari A,Schwartz PJ

    更新日期:1994-01-01 00:00:00

  • First human chronic experience with cardiac contractility modulation by nonexcitatory electrical currents for treating systolic heart failure: mid-term safety and efficacy results from a multicenter study.

    abstract:INTRODUCTION:Conventional electrical therapies for heart failure (HF) encompass defibrillation and ventricular resynchronization for patients at high risk for lethal arrhythmias and/or with inhomogeneous ventricular contraction. Cardiac contractility modulation (CCM) by means of nonexcitatory electrical currents delive...

    journal_title:Journal of cardiovascular electrophysiology

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1046/j.1540-8167.2004.03580.x

    authors: Pappone C,Augello G,Rosanio S,Vicedomini G,Santinelli V,Romano M,Agricola E,Maggi F,Buchmayr G,Moretti G,Mika Y,Ben-Haim SA,Wolzt M,Stix G,Schmidinger H

    更新日期:2004-04-01 00:00:00

  • Relationship between atrial scar on cardiac magnetic resonance and pulmonary vein reconnection after catheter ablation for paroxysmal atrial fibrillation.

    abstract:INTRODUCTION:Pulmonary vein (PV) reconnection is frequent in patients showing atrial fibrillation (AF) recurrence after PV isolation (PVI). Its detection with cardiac magnetic resonance (CMR) may help predict outcome and guide redo procedures. We assessed the relationship between scar on CMR and PV reconnection after c...

    journal_title:Journal of cardiovascular electrophysiology

    pub_type: 杂志文章

    doi:10.1111/jce.13908

    authors: Jefairi NA,Camaioni C,Sridi S,Cheniti G,Takigawa M,Nivet H,Denis A,Derval N,Mathilde Merle,Laurent F,Montaudon M,Sacher F,Hocini M,Haissaguerre M,Jais P,Cochet H

    更新日期:2019-05-01 00:00:00

  • K2p 3.1 protein is expressed as a transmural gradient across the rat left ventricular free wall.

    abstract:INTRODUCTION:K2p 3.1, also known as TASK-1, is a twin-pore acid-sensitive repolarizing K+ channel, responsible for a background potassium current that significantly contributes to setting the resting membrane potential of cardiac myocytes. Inhibition of IK2p3.1 alters cardiac repolarization and is proarrhythmogenic. In...

    journal_title:Journal of cardiovascular electrophysiology

    pub_type: 杂志文章

    doi:10.1111/jce.13805

    authors: Jones SA,Walton RD,Morton M,Lancaster MK

    更新日期:2019-03-01 00:00:00

  • Signal transduction in ischemic preconditioning: the role of kinases and mitochondrial K(ATP) channels.

    abstract::Ischemic preconditioning is a phenomenon whereby exposure of the myocardium to a brief episode of ischemia and reperfusion markedly reduces tissue necrosis induced by a subsequent prolonged ischemia. Therefore, it is hoped that elucidation of the mechanism of preconditioning will yield therapeutic strategies capable o...

    journal_title:Journal of cardiovascular electrophysiology

    pub_type: 杂志文章,评审

    doi:10.1111/j.1540-8167.1999.tb00251.x

    authors: Baines CP,Cohen MV,Downey JM

    更新日期:1999-05-01 00:00:00

  • Dizziness during atrial antitachycardia pacing: What is the cause.

    abstract::A 74-year-old with a history of sinus node dysfunction and intermittent AV block s/p permanent pacemaker implant 6 years prior, complains of one episode of dizziness. ...

    journal_title:Journal of cardiovascular electrophysiology

    pub_type: 杂志文章

    doi:10.1111/jce.14728

    authors: Gianni C,Canby RC,Della Rocca DG,Natale A,Al-Ahmad A

    更新日期:2020-11-01 00:00:00

  • A quantitative measurement of spatial order in ventricular fibrillation.

    abstract:INTRODUCTION:The degree of organization in ventricular fibrillation (VF) is not known. As an objective measurement of spatial order, spatial correlation functions and their characteristic lengths were estimated from epicardial electrograms of pigs in VF. METHODS AND RESULTS:VF was induced by premature stimulation in f...

    journal_title:Journal of cardiovascular electrophysiology

    pub_type: 杂志文章

    doi:10.1111/j.1540-8167.1993.tb01242.x

    authors: Bayly PV,Johnson EE,Wolf PD,Greenside HS,Smith WM,Ideker RE

    更新日期:1993-10-01 00:00:00

  • QRS characteristics fail to reliably identify ventricular tachycardias that require epicardial ablation in ischemic heart disease.

    abstract:OBJECTIVES:We tested proposed algorithms for idiopathic and nonischemic tachycardias for their ability to identify epicardial LV-VT origins. BACKGROUND:Several ECG features have been reported to identify epicardial origins for left ventricular tachycardias (LV-VTs) in the absence of myocardial infarction. Only limited...

    journal_title:Journal of cardiovascular electrophysiology

    pub_type: 杂志文章

    doi:10.1111/j.1540-8167.2011.02179.x

    authors: Martinek M,Stevenson WG,Inada K,Tokuda M,Tedrow UB

    更新日期:2012-02-01 00:00:00

  • The mechanism of pause-induced torsade de pointes in long QT syndrome.

    abstract:INTRODUCTION:Torsade de pointes (TdP), is often preceded by a short-long cycle length sequence. However, the causal relationship between the pause associated with a short-long cycle length sequence and TdP is not completely understood. This study tests the hypothesis that a pause enhances both dispersion of repolarizat...

    journal_title:Journal of cardiovascular electrophysiology

    pub_type: 杂志文章

    doi:10.1111/j.1540-8167.2005.40677.x

    authors: Liu J,Laurita KR

    更新日期:2005-09-01 00:00:00

  • Localization of arrhythmogenic triggers of atrial fibrillation.

    abstract:INTRODUCTION:Mapping procedures to identify triggers of atrial fibrillation from pulmonary veins (PVs) are not well established. We sought to determine the value of multipolar recordings from the coronary sinus (CS) and crista terminalis (CT) for identifying the origin of paced and atrial premature depolarizations (APD...

    journal_title:Journal of cardiovascular electrophysiology

    pub_type: 临床试验,杂志文章

    doi:10.1046/j.1540-8167.2000.01300.x

    authors: Ashar MS,Pennington J,Callans DJ,Marchlinski FE

    更新日期:2000-12-01 00:00:00

  • Risk stratification in asymptomatic patients with Brugada syndrome: Utility of multiple risk factor combination rather than programmed electrical stimulation.

    abstract:BACKGROUND:The prognostic value of programmed electrical stimulation (PES) in Brugada syndrome (BrS) remains controversial. Asymptomatic BrS patients generally have a better prognosis than those with symptoms. The purpose of this study was to evaluate the value of nonaggressive PES with up to two extra stimuli and pred...

    journal_title:Journal of cardiovascular electrophysiology

    pub_type: 杂志文章

    doi:10.1111/jce.14848

    authors: Shinohara T,Takagi M,Kamakura T,Sekiguchi Y,Yokoyama Y,Aihara N,Hiraoka M,Aonuma K,Japan Idiopathic Ventricular Fibrillation Study (J-IVFS) Investigators.

    更新日期:2020-12-25 00:00:00

  • Safety and efficacy of catheter ablation for atrial fibrillation in abdominal solid organ (renal and hepatic) transplant recipients: A single-center pilot experience.

    abstract:BACKGROUND:Atrial fibrillation (AF) is common in abdominal solid organ transplant recipients and a cause of morbidity and mortality in this population. However, the outcomes of catheter ablation (CA) in transplant recipients with AF remain unclear. This study aimed to elucidate the outcomes of CA in renal and hepatic t...

    journal_title:Journal of cardiovascular electrophysiology

    pub_type: 杂志文章

    doi:10.1111/jce.14775

    authors: Su X,Zhao X,Long DY,Sang CH,Yu RH,Tang RB,Bai R,Liu N,Jiang CX,Li SN,Guo XY,Wang W,Hu R,Du X,Dong JZ,Ma CS

    更新日期:2020-12-01 00:00:00

  • A regular wide QRS complex tachycardia: What is the mechanism?

    abstract::A 14-year-old girl with a history of recurrent palpitations and documented wide QRS complex tachycardia was referred for electrophysiologic study and catheter ablation. ...

    journal_title:Journal of cardiovascular electrophysiology

    pub_type:

    doi:10.1111/jce.13905

    authors: Arias MA,Puchol A,Pachón M,Martín-Sierra C

    更新日期:2019-07-01 00:00:00

  • Correlation of spontaneous and induced premature atrial complexes initiating atrial fibrillation in humans: electrophysiologic parameters for guiding therapy.

    abstract:INTRODUCTION:The low frequency of spontaneous premature atrial contractions (PACs) may be an impediment to mapping and ablation of atrial fibrillation (AF). It has been shown that PACs following external or internal cardioversion of AF can initiate AF. If this method could reproducibly induce PACs from the same locatio...

    journal_title:Journal of cardiovascular electrophysiology

    pub_type: 杂志文章

    doi:10.1046/j.1540-8167.2001.01347.x

    authors: Sra J,Zaidi ST,Krum D,Georgakopoulos N,Ahmad A,Akhtar M

    更新日期:2001-12-01 00:00:00

  • Leadless multisite pacing: A feasibility study using wireless power transfer based on Langendorff rodent heart models.

    abstract:INTRODUCTION:Fifteen to thirty percent of patients with impaired cardiac function have ventricular dyssynchrony and warrant cardiac resynchronization therapy (CRT). While leadless pacemakers eliminate lead-related complications, their current form factor is limited to single-chamber pacing. In this study, we demonstrat...

    journal_title:Journal of cardiovascular electrophysiology

    pub_type: 杂志文章

    doi:10.1111/jce.13738

    authors: Lyu H,John M,Burkland D,Greet B,Xi Y,Sampaio LC,Taylor DA,Babakhani A,Razavi M

    更新日期:2018-11-01 00:00:00

  • Incidence of asymptomatic cerebral microthromboembolism after atrial fibrillation ablation guided by complex fractionated atrial electrogram.

    abstract:BACKGROUND:The incidence of cerebral thromboembolism after pulmonary vein isolation (PVI) ranges from 2% to 14%. This study investigated the incidence of cerebral thromboembolism after complex fractionated atrial electrogram (CFAE) ablation with or without PVI. METHODS:One hundred consecutive atrial fibrillation (AF) ...

    journal_title:Journal of cardiovascular electrophysiology

    pub_type: 杂志文章

    doi:10.1111/j.1540-8167.2011.02259.x

    authors: Ichiki H,Oketani N,Ishida S,Iriki Y,Okui H,Maenosono R,Ninomiya Y,Matsushita T,Miyata M,Hamasaki S,Tei C

    更新日期:2012-06-01 00:00:00

  • Narrow irregular QRS tachycardia with AV dissociation: what is the mechanism?

    abstract::A 39-year-old woman with no structural heart disease and frequent episodes of sudden onset palpitations was referred for the electrophysiological study. During the study, a slightly irregular narrow QRS tachycardia with AV dissociation was repeatedly induced and spontaneously terminated. Apparently, irregular cycles a...

    journal_title:Journal of cardiovascular electrophysiology

    pub_type: 杂志文章

    doi:10.1111/jce.12026

    authors: Castillo Castillo J,Peñafiel Verdú P,Martínez Sánchez J,García Alberola A

    更新日期:2013-03-01 00:00:00

  • Relationship between complex fractionated atrial electrograms during atrial fibrillation and the critical site of atrial tachycardia that develops after catheter ablation for atrial fibrillation.

    abstract:INTRODUCTION:Complex fractionated atrial electrograms (CFAEs) are a substrate modification target in patients with atrial fibrillation (AF). However, whether CFAEs can be also arrhythmogenic grounds of atrial tachycardia (AT) presenting after AF ablation remains to be determined. We investigated the relationship betwee...

    journal_title:Journal of cardiovascular electrophysiology

    pub_type: 临床试验,杂志文章

    doi:10.1111/jce.12300

    authors: Ban JE,Chen YL,Park HC,Lee HS,Lee DI,Choi JI,Lim HE,Park SW,Kim YH

    更新日期:2014-02-01 00:00:00

  • Reduction in atrial defibrillation threshold by a single linear ablation lesion.

    abstract:INTRODUCTION:This study investigated a hybrid approach to reduce the atrial defibrillation threshold (ADFT) by determining the effect of a single linear radiofrequency ablation (RFA) lesion on both the ADFT and activation patterns during atrial fibrillation (AF). METHODS AND RESULTS:In 18 open chest sheep (45 to 57 kg...

    journal_title:Journal of cardiovascular electrophysiology

    pub_type: 杂志文章

    doi:10.1046/j.1540-8167.2001.00463.x

    authors: White JB,Fotuhi PC,Pedoto RW,Chattipakorn N,Rogers JM,Ideker RE

    更新日期:2001-04-01 00:00:00