Photodynamic therapy using pheophorbide a and Nd:YAG laser.

Abstract:

:The authors describe a new photodynamic therapy (PDT) method for malignant brain tumors. Pheophorbide a (Ph-a), the photosensitizer, has low toxicity, causes no skin sensitization and is activated with an acoustic Q switched neodymium yttrium-argon-garnet (Nd:YAG) laser which achieves deep tissue penetration. The Ph-a distribution in Fisher 344 (F344) rats bearing rat T9 glioma at 24 hours after intravenous injection was very low in the normal brain tissue, but significantly higher in the T9 glioma giving a tumor to normal brain tissue concentration ratio of 7.5:1. The in vitro survival rate of T9 glioma cells pretreated with Ph-a was 68.8 +/- 5.4% after laser irradiation for 20 minutes, significantly lower than in the control groups. This indicates that Ph-a was activated with the acoustic Q switched Nd:YAG laser causing the photodynamic effect. The survival rate after Ph-a pretreatment and laser irradiation in a waterbath at 44.0 degrees C was further reduced to 15.8 +/- 3.3%. In vivo PDT studies using T9 glioma cells inoculated into the dorsal region of F344 rats showed tumor eradication in four of six rats. The combination of PDT and laser hyperthermia produced tumor eradication in all six rats. The combination of PDT and hyperthermia is a promising method for tumor treatment.

authors

Fujishima I,Sakai T,Tanaka T,Ryu H,Uemura K,Fujishima Y,Horiuchi K,Daikuzono N,Sekiguchi Y

doi

10.2176/nmc.31.257

subject

Has Abstract

pub_date

1991-05-01 00:00:00

pages

257-63

issue

5

eissn

0470-8105

issn

1349-8029

pii

JST.Journalarchive/nmc1959/31.257

journal_volume

31

pub_type

杂志文章
  • Clinical Features and Surgical Treatment of Superficial Peroneal Nerve Entrapment Neuropathy.

    abstract::Superficial peroneal nerve (S-PN) entrapment neuropathy (S-PNEN) is comparatively rare and may be an elusive clinical entity. There is yet no established surgical procedure to treat idiopathic S-PNEN. We report our surgical treatment and clinical outcomes. We surgically treated 5 patients (6 sites) with S-PNEN. The 2 ...

    journal_title:Neurologia medico-chirurgica

    pub_type: 杂志文章

    doi:10.2176/nmc.oa.2018-0039

    authors: Matsumoto J,Isu T,Kim K,Iwamoto N,Yamazaki K,Isobe M

    更新日期:2018-07-15 00:00:00

  • Treatment of spontaneous intracranial hypotension secondary to C-2 meningeal cyst by surgical packing--case report.

    abstract::A 41-year-old man presented with progressive worsening of postural headache. Computed tomography (CT) showed bilateral subdural hematomas without prior history of trauma. The diagnosis was spontaneous intracranial hypotension (SIH). Conservative treatment with oral steroids failed to prevent gradual deterioration of t...

    journal_title:Neurologia medico-chirurgica

    pub_type: 杂志文章

    doi:10.2176/nmc.44.326

    authors: Inamasu J,Nakamura Y,Orii M,Saito R,Kuroshima Y,Mayanagi K,Ichikizaki K,Doi H

    更新日期:2004-06-01 00:00:00

  • Photophobia as the visual manifestation of chiasmal compression by unruptured anterior communicating artery aneurysm. Case report.

    abstract::A 37-year-old woman presented with photophobia without visual loss associated with chiasmal compression by an unruptured anterior communicating artery (AcomA) aneurysm. She had suffered progressive photophobia for one year. Neuroimaging indicated an AcomA aneurysm attached to the chiasm. Photophobia was resolved follo...

    journal_title:Neurologia medico-chirurgica

    pub_type: 杂志文章

    doi:10.2176/nmc.49.159

    authors: Hagihara N,Abe T,Yoshioka F,Watanabe M,Tabuchi K

    更新日期:2009-04-01 00:00:00

  • Endoscopic endonasal pituitary and skull base surgery.

    abstract::Here we describe the procedures of endoscopic pituitary and skull base surgery in our institute. We also review the literature to reveal recent advances in this field. Endonasal approach via the sphenoid ostium was carried out for pituitary lesions without the nasal speculum. Postoperative nasal packing was basically ...

    journal_title:Neurologia medico-chirurgica

    pub_type: 杂志文章,评审

    doi:10.2176/nmc.50.756

    authors: Saeki N,Horiguchi K,Murai H,Hasegawa Y,Hanazawa T,Okamoto Y

    更新日期:2010-01-01 00:00:00

  • Analysis of Puncture Site-related Complications in Japanese Registry of Neuroendovascular Therapy (JR-NET)3.

    abstract::A subgroup analysis of puncture site-related complications listed in the Japanese Registry of NeuroEndovascular Therapy 3, based on retrospective studies, was performed. Puncture site-related complications occurred in 315 (0.73%, average age: 65.2) of 36,708 patients out of all 43,303 registered cases. Carotid artery ...

    journal_title:Neurologia medico-chirurgica

    pub_type: 杂志文章

    doi:10.2176/nmc.oa.2019-0243

    authors: Sato M,Matsumaru Y,Sakai N,JR-NET study group affiliations.

    更新日期:2020-05-15 00:00:00

  • Association of paranasal sinus osteoma and intracranial mucocele--two case reports.

    abstract::Two young adult males presented with paranasal sinus osteoma associated with mucocele. A 20-year-old man presented with headache and seizure, and another 20-year-old man presented with headache, frontal deformity, and visual disturbances. Both patients underwent surgery and satisfactory results were obtained. Isolated...

    journal_title:Neurologia medico-chirurgica

    pub_type: 杂志文章,评审

    doi:10.2176/nmc.44.201

    authors: Akay KM,Ongürü O,Sirin S,Celasun B,Gönül E,Timurkaynak E

    更新日期:2004-04-01 00:00:00

  • Cystic lesion at the foramen magnum disseminated from a pituitary adenoma--case report.

    abstract::A 38-year-old male presented with a cystic lesion at the foramen magnum due to intracranial dissemination from a pituitary adenoma. The primary tumor had required reoperation for regrowth twice. The tumor at the foramen magnum was removed surgically. Two smaller solid tumors were located in the left parietal convexity...

    journal_title:Neurologia medico-chirurgica

    pub_type: 杂志文章

    doi:10.2176/nmc.39.606

    authors: Shimizu K,Takamiya Y,Furuhata S,Naritaka H,Kameya T

    更新日期:1999-08-01 00:00:00

  • Intracranial hemorrhage associated with nontraumatic disseminated intravascular coagulation--report of four cases.

    abstract::The authors report four cases of intracranial hemorrhage associated with nontraumatic disseminated intravascular coagulation (DIC). Two cases demonstrated a sudden onset of intracerebral hemorrhage. The other two showed chronic subdural hematoma initially, followed by acute multiple intracranial hemorrhages or general...

    journal_title:Neurologia medico-chirurgica

    pub_type: 杂志文章

    doi:10.2176/nmc.30.610

    authors: Kawakami Y,Ueki K,Chikama M,Shimamura Y,Naito T

    更新日期:1990-08-01 00:00:00

  • Primary germinoma in the medulla oblongata - case report - .

    abstract::A 27-year-old woman presented with a case of primary medulla oblongata germinoma manifesting as sleep apnea, aspiration pneumonia, and left hemiparesis. Magnetic resonance (MR) imaging revealed a dorsal mass in the medulla oblongata with heterogeneous enhancement by gadolinium (Gd). Emergent biopsy and foramen magnum ...

    journal_title:Neurologia medico-chirurgica

    pub_type: 杂志文章

    doi:10.2176/nmc.51.326

    authors: Yasuhara T,Ichikawa T,Miyoshi Y,Kurozumi K,Maruo T,Yanai H,Date I

    更新日期:2011-01-01 00:00:00

  • [Spinal epidural cavernous hemangioma. Case report].

    abstract::Spinal epidural cavernous hemangiomas are very rare; only 18 cases have been reported in the literature. The authors describe the case of a 38-year-old male whose first symptom was numbness of the foot, which, after 2 years, spread to the abdomen. On admission, he had no weakness but exhibited hyper-reflex of the lowe...

    journal_title:Neurologia medico-chirurgica

    pub_type: 杂志文章,评审

    doi:10.2176/nmc.29.538

    authors: Kurose K,Kishi H,Sadatoh T

    更新日期:1989-06-01 00:00:00

  • A Ruptured Basilar Tip Aneurysm Showing Repeated Perianeurysmal Edema after Endovascular Coil Embolization: Case Report.

    abstract::The authors present an extremely rare case of a 48-year-old female who developed repeated perianeurysmal edema at 2, 9, and 16 weeks after endovascular coil embolization for the ruptured intracranial aneurysm. Interestingly, the mechanism for this edema could be different at each time point in this case; acute thrombo...

    journal_title:Neurologia medico-chirurgica

    pub_type: 杂志文章,评审

    doi:10.2176/nmc.cr.2013-0217

    authors: Takeshita T,Horie N,Fukuda Y,So G,Hayashi K,Morikawa M,Suyama K,Nagata I

    更新日期:2015-01-01 00:00:00

  • Survival probability, delayed mortality, and relationship between short-term outcome and long-term survival after aneurysmal subarachnoid hemorrhage.

    abstract::The long-term survival probability, causes of delayed mortality, and relationship between short-term outcome and long-term survival after aneurysmal subarachnoid hemorrhage were retrospectively studied in 106 patients followed up for longer than 5 years. The Kaplan-Meier cumulative survival probabilities at 1 month, 6...

    journal_title:Neurologia medico-chirurgica

    pub_type: 杂志文章

    doi:10.2176/nmc.37.18

    authors: Mori T,Mori K,Kurisaka M,Morimoto M

    更新日期:1997-01-01 00:00:00

  • Magnetic resonance angiography visualization of four vessel (bilateral carotid and vertebral artery) occlusion--two case reports.

    abstract::A 44-year-old female with transient vertigo and a 51-year-old female with headache and numbness of the hand presented with four vessel occlusion of the cerebral arteries (bilateral internal carotid arteries and bilateral vertebral arteries). This is an extremely rare entity, and the clinicoradiological features are no...

    journal_title:Neurologia medico-chirurgica

    pub_type: 杂志文章

    doi:10.2176/nmc.38.28

    authors: Okada Y,Shima T,Nishida M,Kagawa R

    更新日期:1998-01-01 00:00:00

  • Fluorine-18-fluorodeoxyglucose positron emission tomography may predict the outcome in patients with asymptomatic mild stenosis of internal carotid artery--case report.

    abstract::A 47-year-old male presented with asymptomatic mild (45%) internal carotid artery (ICA) stenosis associated with familial hypercholesterolemia. Fluorine-18-fluorodeoxyglucose ([(18)F]FDG) positron emission tomography (PET) showed that the carotid plaque had high uptake of [(18)F]FDG on the initial scan. He was treated...

    journal_title:Neurologia medico-chirurgica

    pub_type: 杂志文章

    doi:10.2176/nmc.51.720

    authors: Motegi H,Kuroda S,Nakayama N,Hirata K,Shiga T,Tamaki N

    更新日期:2011-01-01 00:00:00

  • Ring-enhanced primary intracranial malignant lymphoma--report of two cases.

    abstract::Two nonimmunosuppressed patients with primary intracranial malignant lymphoma demonstrated ring-enhanced lesion on postcontrast CT scans. One patient underwent total removal of the tumor and the other patient biopsy, both followed by whole brain irradiation. Histological examination revealed the tumors contained diffu...

    journal_title:Neurologia medico-chirurgica

    pub_type: 杂志文章,评审

    doi:10.2176/nmc.31.214

    authors: Tan EC,Wakabayashi S,Kanai H,Nagai H

    更新日期:1991-04-01 00:00:00

  • Thermal Annuloplasty Using Percutaneous Endoscopic Discectomy for Elite Athletes with Discogenic Low Back Pain.

    abstract::The purpose of this study was to assess the usefulness of radiofrequency thermal annuloplasty (TA) using percutaneous endoscopic discectomy/TA (PED/TA) in elite athletes with discogenic low back pain. Twelve patients (11 men, 1 woman; mean age 27.9 years) underwent PED/TA under local anesthesia. Clinical data for thes...

    journal_title:Neurologia medico-chirurgica

    pub_type: 杂志文章

    doi:10.2176/nmc.oa.2018-0256

    authors: Manabe H,Yamashita K,Tezuka F,Takata Y,Sakai T,Maeda T,Sairyo K

    更新日期:2019-02-15 00:00:00

  • AVDO2 and EEG as indicators for treatment of post-traumatic brain swelling--experimental study.

    abstract::A cat model of compression ischemia using epidural balloon inflation investigated: 1) the relationship between postischemic cerebral blood flow (CBF) and metabolism and brain swelling, 2) the use of arteriovenous oxygen difference (AVDO2) and electroencephalographic (EEG) frequency band analysis for monitoring CBF and...

    journal_title:Neurologia medico-chirurgica

    pub_type: 杂志文章

    doi:10.2176/nmc.31.568

    authors: Yabuki A,Mishina H,Miyazaki M,Maeda M,Sato K,Ishii S

    更新日期:1991-09-01 00:00:00

  • Two-staged resection of a left frontal astrocytoma involving the operculum and insula using intraoperative neurophysiological monitoring--case report.

    abstract::A 29-year-old right-handed male with a 12-year education presented with a 2-month history of generalized epileptic activity. Neuroradiological imaging demonstrated a large lesion in the left frontal lobe involving the insulooperculum and in the temporal tip. Neurological and neuropsychological examination revealed no ...

    journal_title:Neurologia medico-chirurgica

    pub_type: 杂志文章

    doi:10.2176/nmc.38.503

    authors: Kumabe T,Nakasato N,Suzuki K,Sato K,Sonoda Y,Kawagishi J,Yoshimoto T

    更新日期:1998-08-01 00:00:00

  • Migration of a subduroperitoneal shunt catheter into the subdural space--case report.

    abstract::An 82-year-old male with intractable bilateral chronic subdural hematomas was treated by emplacement of bilateral subduroperitoneal shunts on the left in 1990 and on the right in 1991. Chronic subdural hematoma recurred in 1992 due to an unusual migration of a shunt catheter into the subdural space. This migration was...

    journal_title:Neurologia medico-chirurgica

    pub_type: 杂志文章

    doi:10.2176/nmc.35.251

    authors: Sunada I,Akano Y,Inoue T,Tamura K,Fu Y,Yamamoto S,Baba T

    更新日期:1995-04-01 00:00:00

  • Spontaneous subperiosteal hematoma of the orbit--case report.

    abstract::A 62-year-old female was admitted with complaints of sudden proptosis of the left eye and severe left orbital pain without history of trauma or previous illness. Computed tomography and magnetic resonance imaging demonstrated a biconvex extraconal hematoma in the upper part of the left orbit. Surgical exploration of t...

    journal_title:Neurologia medico-chirurgica

    pub_type: 杂志文章

    doi:10.2176/nmc.34.27

    authors: Matsumoto S,Yamamoto T,Ban S,Motozaki T,Sato S,Shingu T,Yoshida S,Tsuiki H

    更新日期:1994-01-01 00:00:00

  • Diaphragma sellae meningioma associated only with signs of hypopituitarism--case report.

    abstract::A rare diaphragma sellae meningioma presenting only with signs of hypopituitarism occurred in a 54-year-old male. Preoperative magnetic resonance (MR) imaging clearly demonstrated a small lesion in the supradiaphragmatic area immediately beneath the optic chiasm, displacing the pituitary stalk laterally. Intraoperativ...

    journal_title:Neurologia medico-chirurgica

    pub_type: 杂志文章

    doi:10.2176/nmc.32.765

    authors: Okuno S,Hisanaga M,Tsunoda S,Sakaki T

    更新日期:1992-09-01 00:00:00

  • Spinal cord edema preceding syringomyelia associated with Chiari I malformation--case report.

    abstract::A 38-year-old woman with Chiari I malformation presented with spinal cord edema preceding syringomyelia manifesting as a 5-month history of nuchal pain and numbness of the upper extremities. Magnetic resonance imaging showed spinal cord edema, a poorly defined syrinx at the C-2 to T-2 levels, and distorted cerebellar ...

    journal_title:Neurologia medico-chirurgica

    pub_type: 杂志文章

    doi:10.2176/nmc.42.410

    authors: Itoh Y,Kuwahara N,Sasajima T,Mizoi K,Hatazawa J

    更新日期:2002-09-01 00:00:00

  • Traumatic carotid-cavernous fistula identified by three-dimensional digital subtraction angiography--technical note.

    abstract::Conventional digital subtraction angiography (DSA) identified a right carotid-cavernous fistula (CCF). Three-dimensional DSA (3D-DSA) was used to evaluate the CCF before treatment. The 3D-DSA images showed the anatomical relationship of the parent artery and the veins, which was difficult to understand on conventional...

    journal_title:Neurologia medico-chirurgica

    pub_type: 杂志文章

    doi:10.2176/nmc.43.369

    authors: Ishida F,Kojima T,Kawaguchi K,Hoshino T,Murao K,Taki W

    更新日期:2003-07-01 00:00:00

  • Preoperative regional cerebral blood flow and postoperative clinical improvement in patients with Parkinson's disease undergoing subthalamic nucleus deep brain stimulation.

    abstract::Preoperative regional cerebral blood flow (rCBF) was measured in 92 patients with Parkinson's disease (PD) by iodine-123 N-isopropyl-p-iodoamphetamine single-photon emission computed tomography. Quantitative mapping of rCBF was performed using the stereotactic extraction estimation method. The clinical features of the...

    journal_title:Neurologia medico-chirurgica

    pub_type: 杂志文章

    doi:10.2176/nmc.52.865

    authors: Nagai T,Kajita Y,Maesawa S,Nakatsubo D,Yoshida K,Kato K,Wakabayashi T

    更新日期:2012-01-01 00:00:00

  • Subependymoma in the lateral ventricle manifesting as intraventricular hemorrhage.

    abstract::A 32-year-old man presented with subependymoma in the lateral ventricle causing intraventricular hemorrhage and manifesting as severe headache and disturbance of consciousness. Computed tomography on admission showed a massive intraventricular hemorrhage and acute obstructive hydrocephalus. Cerebral angiography reveal...

    journal_title:Neurologia medico-chirurgica

    pub_type: 杂志文章

    doi:10.2176/nmc.50.1020

    authors: Akamatsu Y,Utsunomiya A,Suzuki S,Endo T,Suzuki I,Nishimura S,Ezura M,Suzuki H,Uenohara H,Tominaga T

    更新日期:2010-01-01 00:00:00

  • Aneurysm of the distal anterior inferior cerebellar artery--case report.

    abstract::A 38-year-old female presented with vertigo, right hearing disturbance, and slight headache which were treated medically. However, she suddenly developed severe headache with vomiting and vertigo. Computed tomography revealed subarachnoid hemorrhage, and right vertebral angiography disclosed a rare aneurysm at the dis...

    journal_title:Neurologia medico-chirurgica

    pub_type: 杂志文章

    doi:10.2176/nmc.35.587

    authors: Yokoyama S,Kadota K,Asakura T,Kawazoe K

    更新日期:1995-08-01 00:00:00

  • Endovascular coiling as the first treatment strategy for ruptured pericallosal artery aneurysms: results, complications, and follow up.

    abstract::We apply endovascular coiling as the first treatment option for ruptured pericallosal artery aneurysms. We conducted a retrospective analysis of the clinical and radiological outcomes of this treatment strategy and morphological factors associated with the success of endovascular coiling, to assess the safety and feas...

    journal_title:Neurologia medico-chirurgica

    pub_type: 杂志文章

    doi:10.2176/nmc.53.409

    authors: Yamazaki T,Sonobe M,Kato N,Kasuya H,Ikeda G,Nakamura K,Ito Y,Tsuruta W,Nakai Y,Matsumura A

    更新日期:2013-01-01 00:00:00

  • Sponge-induced granuloma ("gauzoma") as a complication of posterior lumbar surgery.

    abstract::A 45-year-old woman presented with complaints of low back pain and sciatica on the left persisting for 2 years. She had undergone left hemilaminectomy and discectomy for L4-5 intervertebral disc herniation at another medical center. Spinal computed tomography and magnetic resonance (MR) imaging revealed a mass lesion ...

    journal_title:Neurologia medico-chirurgica

    pub_type: 杂志文章

    doi:10.2176/nmc.45.209

    authors: Turgut M,Akyüz O,Ozsunar Y,Kacar F

    更新日期:2005-04-01 00:00:00

  • Quantitative kinetic analysis of blood vessels in the outer membranes of chronic subdural hematomas.

    abstract::Dynamic biologic modeling was used to calculate the transfer rate constant for gadolinium-diethylenetriaminepenta-acetic acid (Gd-DTPA) and capillary permeability in the outer membrane of chronic subdural hematomas and effusions. Following intravenous Gd-DTPA injection, Gd concentrations in the subdural fluid and in t...

    journal_title:Neurologia medico-chirurgica

    pub_type: 杂志文章

    doi:10.2176/nmc.38.697

    authors: Mori K,Adachi K,Cho K,Ishimaru S,Maeda M

    更新日期:1998-11-01 00:00:00

  • Petrous bone meningioma originating from the jugular foramen--case report.

    abstract::A 49-year-old female presented with a rare meningioma in the petrous bone. High resolution computed tomography and magnetic resonance imaging demonstrated that the tumor had developed in the jugular foramen and extended into the infralabyrinthine area of the petrous bone and intracranially into the cerebellopontine an...

    journal_title:Neurologia medico-chirurgica

    pub_type: 杂志文章

    doi:10.2176/nmc.37.472

    authors: Ohta S,Yokoyama T,Uemura K,Nishizawa S,Yamamoto S,Hoshino T

    更新日期:1997-06-01 00:00:00