Expression of vascular endothelial growth factor and angiogenesis in the diabetic frozen shoulder.

Abstract:

:The purpose of this study was to investigate neovascularization and the expression of vascular endothelial growth factor (VEGF) in patients with diabetic frozen shoulders. Eleven patients with diabetic frozen shoulders underwent arthroscopic lysis of adhesions, and we observed the reported findings. VEGF expression was determined by immunohistochemistry and Western blot analysis, and the density of vessels was evaluated based on CD34 immunoreactivity by use of samples of the synovial tissue. For the control group, we took 5 samples of synovium from patients undergoing shoulder arthroscopy. The arthroscopic findings showed hyperemia of the synovial tissue in all cases of diabetic frozen shoulder. This synovium showed stronger immunostaining to VEGF (P = .010) and CD34 (P = .011) than the control synovial tissue. Western blot analysis also showed a stronger VEGF intensity than in the control group. We postulate that VEGF is synthesized and secreted in the synovium of diabetic frozen shoulders and VEGF may have some role in the pathogenesis and neovascularization of frozen shoulders in diabetic patients.

journal_name

J Shoulder Elbow Surg

authors

Ryu JD,Kirpalani PA,Kim JM,Nam KH,Han CW,Han SH

doi

10.1016/j.jse.2006.01.002

subject

Has Abstract

pub_date

2006-11-01 00:00:00

pages

679-85

issue

6

eissn

1058-2746

issn

1532-6500

pii

S1058-2746(06)00072-3

journal_volume

15

pub_type

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