Abstract:
PURPOSE:Coating endosseous dental implants with growth factors such as bone morphogenetic proteins (BMPs) may be one way to accelerate and/or enhance the quality of osseointegration. The purpose of this study was to investigate in the murine muscle pouch model whether sintered porous-surfaced titanium alloy implants coated with BMPs would lead to heterotopic bone formation around and within the implant surface geometry. MATERIALS:Porous-surfaced dental implants were coated with partially purified native human BMPs, with or without a carrier of Poloxamer 407 (BASF Corp., Parsippany, NJ), placed in gelatin capsules and implanted into the hindquarter muscles of mice. Mice were euthanized after 28 days. Sections of retrieved specimens were subsequently prepared for morphometric analysis of bone formation using backscatter electron microscopic images. RESULTS:Human BMPs, either with or without the carrier of Poloxamer 407, led to bone formation within and outside of the sintered porous implant surface. When the sintered implant surface region was subdivided into inner and outer halves, similar levels of bone ingrowth and contact were seen in the 2 halves. Evidence of bone formation to the depth of the solid implant core (i.e., the deepest level possible) also was seen. DISCUSSION AND CONCLUSIONS:Sintered porous-surfaced dental implants can be used as substrate for partially purified BMPs in the murine muscle pouch model. With the addition of these osteoinductive factors, the porous implant surface supported bone formation within the surface porosity provided, in some instances, all the way to the solid implant core. The addition of growth factors to a sintered porous surface may be an efficient method for altering locally the healing sequence and quality of bone associated with osseointegration of bone-interfacing implants.
journal_name
Implant Dentjournal_title
Implant dentistryauthors
Simon Z,Deporter DA,Pilliar RM,Clokie CMdoi
10.1097/01.id.0000226754.71828.6bsubject
Has Abstractpub_date
2006-09-01 00:00:00pages
265-74issue
3eissn
1056-6163issn
1538-2982pii
00008505-200609000-00011journal_volume
15pub_type
杂志文章abstract:OBJECTIVES:The aim of this study was to determine the influence of different frontal bone defect localizations on primary stability values of 2 different implant designs. MATERIALS AND METHODS:Eight cow rib segments were prepared before implant installation, as 2 segments with coronal, 2 with middle, and 2 with apical...
journal_title:Implant dentistry
pub_type: 杂志文章
doi:10.1097/ID.0000000000000536
更新日期:2017-02-01 00:00:00
abstract:PURPOSE:Autogenous bone has been used with success as implants in intrabony defects, because of its biological advantages and osteogenic potential. The objective of this study was to evaluate histological and histometrically the bony repair in intrabony defects after dental extractions in rats with graft of a combinati...
journal_title:Implant dentistry
pub_type: 杂志文章
doi:10.1097/ID.0b013e31815705a5
更新日期:2007-12-01 00:00:00
abstract:PURPOSE:To study implant primary stability and bone healing using resonance frequency analysis in different anatomical locations 4 months after placement. MATERIAL AND METHODS:Fifty-six partially edentulous patients restored by dental implants were included. Overall, 214 implants were placed without bone or soft tissu...
journal_title:Implant dentistry
pub_type: 杂志文章
doi:10.1097/ID.0000000000000019
更新日期:2014-02-01 00:00:00
abstract::The accuracy of determining marginal bone height changes around osseointegrated implants depends on the validity of comparing serial films and the reliability of the measurements. X-ray beam orientation changes can alter the validity of serial films. A human dry mandible containing a Brånemark implant was irradiated +...
journal_title:Implant dentistry
pub_type: 杂志文章
doi:
更新日期:1992-04-01 00:00:00
abstract:PURPOSE:The association of doxycycline (DOX) and autogenous bone on repair of critical-size defects was evaluated. MATERIALS AND METHODS:Fifty albino rats were divided into 5 groups (n = 10). A 5-mm diameter defect was treated with: control (CO)-blood clot; DOX in Natrosol (NAT)-10% gel; NAT-gel; particulate autogenou...
journal_title:Implant dentistry
pub_type: 杂志文章
doi:10.1097/ID.0000000000000783
更新日期:2018-08-01 00:00:00
abstract:PURPOSE:To present a vertical ridge augmentation with a composite synthetic bone graft by the mixed bone-filling materials and autogenous bone chips retrieved from the implant osteotomy site for a case for esthetic implant prosthesis on the atrophied alveolar bone. MATERIALS:Nonresorbable and resorbable hydroxyapatite...
journal_title:Implant dentistry
pub_type: 杂志文章
doi:10.1097/ID.0b013e3181fce1a9
更新日期:2010-12-01 00:00:00
abstract::Functional stability and the preservation of remaining alveolar bone are primary, and often elusive, goals when restoring the partially edentulous arch. The incorporation of dental implants for the partial support of removable prostheses offers a practical adjunct in the fulfillment of these objectives. Planning for c...
journal_title:Implant dentistry
pub_type: 杂志文章
doi:10.1097/00008505-199901000-00009
更新日期:1999-01-01 00:00:00
abstract::Advantages of telescopic prostheses are in maintenance, repair, alteration, conversion, and offsetting problems of parallelism. A cemented telescopic implant prosthesis can be retrieved by incorporating a window or recess in the copings during the wax-up and using a flat-ended instrument for disengagement of the prost...
journal_title:Implant dentistry
pub_type: 杂志文章
doi:
更新日期:1996-07-01 00:00:00
abstract:PURPOSE:The objective of this study was to compare the reliability and results of 2 flap techniques, flapless (FL) and full-thickness (FT) flap, during implant placement. MATERIALS AND METHODS:Online and hand searches of the literature published were conducted to identify studies examining different flap techniques on...
journal_title:Implant dentistry
pub_type: 杂志文章,评审
doi:10.1097/ID.0000000000000460
更新日期:2016-12-01 00:00:00
abstract:PURPOSE:To evaluate, in vitro, the leakage observed in internal hexagon and Morse taper implant-abutment connections. MATERIALS:Ten specimens with internal hexagon and 10 with Cone Morse connection were used. The inner parts of 5 implants, per group, were inoculated with Pseudomonas aeruginosa (PS) suspension and 5 im...
journal_title:Implant dentistry
pub_type: 杂志文章
doi:10.1097/ID.0b013e31825cd472
更新日期:2012-08-01 00:00:00
abstract:OBJECTIVE:A recent study demonstrated that UV treatment of titanium implants (photofunctionalization) enabled a higher level of osseointegration by establishing a 98.2% bone-implant contact (BIC) as opposed to a 53.0% BIC around untreated implants. This study examined whether, and how, the BIC increase affects the peri...
journal_title:Implant dentistry
pub_type: 杂志文章
doi:10.1097/ID.0b013e31827b9415
更新日期:2013-02-01 00:00:00
abstract:INTRODUCTION:The aim of this study was to assess the correlation between the fractal analysis of gingival changes and systemic nitro-oxidative stress in a short-term low-dose ibuprofen (IBU) treatment at experimental peri-implantitis (PI). MATERIALS AND METHODS:Six adult male mixed-breed dogs with PI were randomly tre...
journal_title:Implant dentistry
pub_type: 杂志文章
doi:10.1097/ID.0000000000000065
更新日期:2014-06-01 00:00:00
abstract:PURPOSE:This study investigated the bone integration ability of a biphasic calcium phosphate bioceramic implanted in dental alveolus of rats. MATERIALS AND METHODS:A total of 21 male rats were submitted to upper right incisor extraction and implanted with a synthetic bioceramic (Straumann Bone Ceramic). The animals we...
journal_title:Implant dentistry
pub_type: 杂志文章
doi:10.1097/ID.0000000000000172
更新日期:2014-12-01 00:00:00
abstract::Successful implant dentistry is based on adequate training, proper selection of patients, careful surgery, preplanned restorations, and postoperative and supportive care. Although implant therapy is highly successful and predictable, it is not without possible early and/or late complications. The aim of this article i...
journal_title:Implant dentistry
pub_type: 杂志文章
doi:10.1097/01.id.0000127518.60701.a1
更新日期:2004-06-01 00:00:00
abstract::The purpose of this study was to test whether a handheld magnifier could be used as an accurate instrument to examine the periapical radiographs and measure the marginal bone levels around dental implants system. A radiologic evaluation of marginal bone loss around 11 Astra Tech (Astra Tech AB, Mölndal, Sweden) oral i...
journal_title:Implant dentistry
pub_type: 杂志文章
doi:10.1097/01.id.0000188464.76640.c7
更新日期:2005-12-01 00:00:00
abstract:PURPOSE:To evaluate the influence of Morse taper implant index on microleakage. MATERIALS AND METHODS:Thirty implants and abutments were divided into 3 groups (n = 10): CM1 (universal post and implant without index), CM2 (universal post and implant with index), and CM3 (abutment and implant with index). To evaluate th...
journal_title:Implant dentistry
pub_type: 杂志文章
doi:10.1097/ID.0000000000000284
更新日期:2015-10-01 00:00:00
abstract:PURPOSE:To describe an unusual case of mandibular fracture after osseointegrated dental implant removal placed after inferior alveolar nerve transposition. REPORT OF CASE:The patient underwent inferior nerve transposition for implant placement due to lack of interarch space. Two months after metal-ceramic crowns insta...
journal_title:Implant dentistry
pub_type: 杂志文章
doi:10.1097/ID.0000000000000609
更新日期:2017-08-01 00:00:00
abstract:PURPOSE:The purpose of this study was to analyze the biomechanical behavior of implants with varying number, inclination, and size, using 3-dimensional finite element (FE) analysis. MATERIAL AND METHODS:A total of 10 FE models were constructed to simulate 5 implant placement configurations: 4 and 5 axial implants, 4 i...
journal_title:Implant dentistry
pub_type: 杂志文章
doi:10.1097/ID.0000000000000158
更新日期:2014-12-01 00:00:00
abstract::Papillon-Lefevre syndrome (PLS) is an autosomal recessive disorder. Main features of PLS are hyperkeratosis of palms and soles concomitant with premature loss of primary and permanent dentition due to progressive periodontitis. Dental management of patients with PLS is usually challenging because of early excessive lo...
journal_title:Implant dentistry
pub_type: 杂志文章
doi:10.1097/ID.0b013e3181ed0798
更新日期:2010-10-01 00:00:00
abstract::Placement of endosseous implants and inferior alveolar nerve transposition is a treatment option for patients with an edentulous posterior mandible with inadequate bone height superior to the inferior alveolar canal. Complications associated with these procedures include infection, prolonged neurosensory disturbances,...
journal_title:Implant dentistry
pub_type: 杂志文章
doi:10.1097/01.id.0000078232.90185.82
更新日期:2003-01-01 00:00:00
abstract:PURPOSE:The purpose of this study was to compare the bone regenerative capability of using unsintered hydroxyapatite/poly-L-lactic acid (uHA/PLLA) mesh and titanium mesh. MATERIALS AND METHODS:Adult male white rabbits (n = 24) were divided into 2 groups. After incising along the mandible, 3 × 5 mm bone defects were ma...
journal_title:Implant dentistry
pub_type: 杂志文章
doi:10.1097/ID.0b013e31828336be
更新日期:2013-06-01 00:00:00
abstract::A calcified alloplast was evaluated as a gap-filling material around implants placed immediately into fresh extraction sockets. Periodontal measurements and computed tomography scans were obtained to evaluate the clinical effectiveness of the alloplast when compared with demineralized freeze-dried bone. To determine w...
journal_title:Implant dentistry
pub_type: 临床试验,杂志文章
doi:10.1097/00008505-200107000-00016
更新日期:2001-01-01 00:00:00
abstract:PURPOSE:This study compared the load transfer characteristics of a complete-arch restoration supported by 4 implants, with external and internal implant-abutment connections. Three loading positions were applied to the prostheses. MATERIALS AND METHODS:Epoxy resin models were used to simulate bone. Two types of implan...
journal_title:Implant dentistry
pub_type: 杂志文章
doi:10.1097/ID.0000000000000063
更新日期:2014-04-01 00:00:00
abstract:OBJECTIVES:The purpose of this study was to evaluate the peri-implant bone tissue level on postextractive resorbable calcium phosphate coated single implants placed in premaxillary sites grafted with autologous bone, anorganic bovine bone (ABB), platelet-rich plasma (PRP), and keratinized epithelial connective graft ov...
journal_title:Implant dentistry
pub_type: 杂志文章
doi:10.1097/ID.0000000000000790
更新日期:2018-08-01 00:00:00
abstract::Currently, the preparation of surgical templates is a multistage process that engages the restorative dentist, dental laboratory, and external computed tomography center. This new method for production of templates and guides, as well as data transfer protocol, significantly simplifies commonly used methods and remove...
journal_title:Implant dentistry
pub_type: 杂志文章
doi:10.1097/ID.0b013e31820fb47f
更新日期:2011-04-01 00:00:00
abstract::In 1980 the Veterans Administration Cooperative Studies Program No. 147 initiated a multicenter, multidisciplinary clinical study to evaluate the use of alternative alloys for porcelain-fused-to-metal restorations. An investigation of interexaminer agreement was conducted after seven years utilizing three measures of ...
journal_title:Implant dentistry
pub_type: 杂志文章
doi:10.1097/00008505-199312000-00004
更新日期:1993-01-01 00:00:00
abstract:PURPOSE:The aim of this work was to compare histologically bone biopsies obtained during dental implant placement in atrophic jaws reconstructed with fresh-frozen bone (FFB) or autologous bone blocks. MATERIALS AND METHODS:Twenty partially or totally edentulous patients were treated either with iliac crest FFB grafts ...
journal_title:Implant dentistry
pub_type: 杂志文章
doi:10.1097/ID.0000000000000451
更新日期:2016-12-01 00:00:00
abstract::Surgical placement of dental implants requires an osteotomy. There is suspicion that osseous drilling may generate detrimental heat in the site that may cause localized bone necrosis and, subsequently, failure of the dental implant to osseointegrate. Cooling aqueous irrigation has been advocated to prevent such overhe...
journal_title:Implant dentistry
pub_type: 杂志文章
doi:10.1097/ID.0b013e3181dc9852
更新日期:2010-06-01 00:00:00
abstract::The influence of tissue biotype in natural dentition is already well demonstrated in the literature, with numerous articles showing that thicker tissue is a preferred biotype for optimal surgical and prosthetic outcomes. In this same line of thought, current studies are directed to explore whether mucosal thickness wo...
journal_title:Implant dentistry
pub_type: 杂志文章,评审
doi:10.1097/ID.0b013e3182181d3d
更新日期:2011-06-01 00:00:00
abstract:PURPOSE:The main objective of this study, involving 11 patients, is to share our experience on an integrated treatment modality, namely, the use of cellular therapy simultaneously with surgical reconstruction. Published works show that the implantation of monocytes in ischemic tissue enhances healing by providing neo-a...
journal_title:Implant dentistry
pub_type: 杂志文章
doi:10.1097/ID.0000000000000813
更新日期:2018-10-01 00:00:00