Abstract：
:Murine monoclonal antibodies (MAB) were produced against the 'beta' fraction of Babesia bovis. A MAB, W11C5, selected on the criterion of its staining of erythrocytes infected with B. bovis, was purified. The antigen identified by MAB W11C5 was extracted from B. bovis infected erythrocytes by affinity chromatography and used in a vaccination trial to test its vaccine efficacy against homologous B. bovis infection in splenectomized calves. The vaccinated group showed significantly different parasitaemias from the control group and it was concluded that the B. bovis antigen 11C5 induced a protective immune response when used as a vaccine. This antigen should be synthesized using recombinant DNA techniques to determine its efficacy and suitability as a commercial vaccine against B. bovis infection.
journal_name
Int J Parasitoljournal_title
International journal for parasitologyauthors
Goodger BV,Waltisbuhl DJ,Wright IG,White Mdoi
10.1016/0020-7519(92)90156-fkeywords:
subject
Has Abstractpub_date
1992-07-01 00:00:00pages
533-5issue
4eissn
0020-7519issn
1879-0135pii
0020-7519(92)90156-Fjournal_volume
22pub_type
杂志文章abstract：:The feasibility of identifying parasite DNA and specific mRNAs from wild-caught Anopheles dirus mosquitoes was assessed using dried mosquito salivary glands preserved on filter paper. We were able to detect Plasmodium falciparum, Plasmodium vivax, Plasmodium malariae and Plasmodium knowlesi DNA by conventional PCR and...
journal_title：International journal for parasitology
pub_type： 杂志文章
doi：10.1016/j.ijpara.2009.08.005
更新日期：2009-12-01 00:00:00
abstract：:Among schistosomatids, Trichobilharzia regenti, displays an unusual migration through the peripheral and central nervous system prior to residence in the nasal cavity of the definitive avian host. Migration causes tissue degradation and neuromotor dysfunction both in birds and experimentally infected mice. Although sc...
journal_title：International journal for parasitology
pub_type： 杂志文章
doi：10.1016/j.ijpara.2005.02.018
更新日期：2005-07-01 00:00:00
abstract：:Transmission of Pseudodiplorchis americanus is restricted to the brief period when its host, a desert toad, enters water to spawn. The parasite accumulates its entire annual reproductive output within an elongated uterus during the 10-11-month period of host hibernation. Embryos of P. americanus, at all stages of deve...
journal_title：International journal for parasitology
pub_type： 杂志文章
doi：10.1016/s0020-7519(97)00068-4
更新日期：1997-09-01 00:00:00
abstract：:Coccidiosis of the domestic fowl is a worldwide disease caused by seven species of protozoan parasites of the genus Eimeria. The genome of the model species, Eimeria tenella, presents a complexity of 55-60MB distributed in 14 chromosomes. Relatively few studies have been undertaken to unravel the complexity of the tra...
journal_title：International journal for parasitology
pub_type： 杂志文章
doi：10.1016/j.ijpara.2011.10.008
更新日期：2012-01-01 00:00:00
abstract：:The potential role of the 5 surface proteins of Toxoplasma gondii tachyzoites in host cell invasion was investigated using an in vitro neutralization assay. Supporting earlier findings, TG05.54, a monoclonal antibody recognizing the major surface protein SAG 1, was shown to cause a consistent and significant blockade ...
journal_title：International journal for parasitology
pub_type： 杂志文章
doi：10.1016/0020-7519(95)00103-4
更新日期：1996-02-01 00:00:00
abstract：:The survival of exsheathed infective juveniles (IJs) of 4 Steinernema species, S. glaseri (NC), S. feltiae (UK76), S. carpocapsae (All) and S. riobravis (Biosys355), was assessed following fast and slow drying on glass slides and 1% (w/v) agarose, respectively. Freshly harvested and aged (75-day-old) IJs were desiccat...
journal_title：International journal for parasitology
pub_type： 杂志文章
doi：10.1016/s0020-7519(96)00154-3
更新日期：1997-01-01 00:00:00
abstract：:A Petri dish bioassay was used to study chemoattraction of the cercariae of Echinostoma trivolvis and E. caproni in the presence of various bench chemicals prepared as 5 mM solutions in agar. The design compared the attraction of cercariae migrating toward the plugs impregnated with chemicals compared to unimpregnated...
journal_title：International journal for parasitology
pub_type： 杂志文章
doi：10.1016/s0020-7519(96)00199-3
更新日期：1997-03-01 00:00:00
abstract：:The isolation of biological clones of Trypanosoma cruzi by microscopically dispensing individual organisms or by serial dilution is laborious and time consuming. The inability to resolve mixed T. cruzi infections, from vectors and hosts, and to isolate clones of slow growing genotypes by efficient plating on solid med...
journal_title：International journal for parasitology
pub_type： 杂志文章
doi：10.1016/j.ijpara.2006.08.002
更新日期：2007-01-01 00:00:00
abstract：:Caenorhabditis elegans represents an excellent model in which to dissect the biosynthesis and assembly of the nematode cuticle. A sequenced genome, straightforward transgenesis, available mutants and practical genome-wide RNAi approaches provide an invaluable toolkit in the characterization of cuticle components. We h...
journal_title：International journal for parasitology
pub_type： 杂志文章
doi：10.1016/j.ijpara.2006.01.004
更新日期：2006-05-31 00:00:00
abstract：:In the present study, the relationship between progression of Mesocestoides vogae infection in the liver of mice, the accumulation rate of collagen types I and III, gene expression of fibrogenic factors and cytokines was examined within 6weeks p.i. Due to asexual multiplication, the total number of larvae in the liver...
journal_title：International journal for parasitology
pub_type： 杂志文章
doi：10.1016/j.ijpara.2009.06.008
更新日期：2010-02-01 00:00:00
abstract：:Babesia parasites infect a diverse range of vertebrate hosts, from penguins to pigs. Recently, the emergence of zoonotic Babesia infection has been increasing, and the list of species reported to infect humans continues to grow. Babesiosis represents a burgeoning veterinary and medical threat, and the need for novel t...
journal_title：International journal for parasitology
pub_type： 杂志文章,评审
doi：10.1016/j.ijpara.2018.09.005
更新日期：2019-02-01 00:00:00
abstract：:Echinococcus spp. are the etiological agents of hydatid disease in man and other intermediate hosts. Many questions regarding the factors which determine susceptibility/resistance to hydatid disease, and the factors which influence the viability and fertility of hydatid cysts, remain to be answered. Recent research in...
journal_title：International journal for parasitology
pub_type： 杂志文章,评审
doi：10.1016/0020-7519(90)90194-r
更新日期：1990-07-01 00:00:00
abstract：:Analysis of 10 stocks of Blastocystis hominis isolated from human stools revealed two discrete groups of organisms. Proteins of the two groups were immunologically distinct and hybridization with random probes generated from the DNA of one stock showed that the DNA content of the two groups was different. Further stud...
journal_title：International journal for parasitology
pub_type： 杂志文章
doi：10.1016/0020-7519(92)90079-z
更新日期：1992-02-01 00:00:00
abstract：:A detergent extract of adult Haemonchus contortus enriched in the integral membrane protein H11, previously shown to give protective immunity against the parasite, was fractionated by lectin and ion-exchange chromatography. The fractions were evaluated for their ability to immunize Clun Forest and Dorset Horn sheep ag...
journal_title：International journal for parasitology
pub_type： 杂志文章
doi：10.1016/0020-7519(93)90150-w
更新日期：1993-04-01 00:00:00
abstract：:Resistance to Schistosoma mansoni infection has been correlated with IgE responses to the adult worm. Molecular targets of this response are gaining interest as markers of immunity and as indicators of allergenic properties. Few protein families contain IgE antigens (allergens) and one of the most highly represented a...
journal_title：International journal for parasitology
pub_type： 杂志文章
doi：10.1016/j.ijpara.2014.02.004
更新日期：2014-05-01 00:00:00
abstract：:A set of 65 Trypanosoma cruzi stocks from dogs, opossums, insect vectors and humans was isolated in a geographically restricted endemic area for Chagas' disease in Argentina and was analysed by multilocus enzyme electrophoresis for 15 loci. The results show that at least five multilocus genotypes (clonets) circulate i...
journal_title：International journal for parasitology
pub_type： 杂志文章
doi：10.1016/s0020-7519(03)00139-5
更新日期：2003-09-15 00:00:00
abstract：:The various stages of the malaria parasites in the vertebrate host and in the mosquito vector offer numerous candidates for vaccine and drug development. However, the biological complexity of the parasites and the interaction with the immune system of the host continue to frustrate all such efforts thus far. While mos...
journal_title：International journal for parasitology
pub_type： 杂志文章,评审
doi：10.1016/s0020-7519(02)00184-4
更新日期：2002-12-04 00:00:00
abstract：:The hindgut, as a part of the tick excretory system, plays an important physiological role in maintaining homoeostases and waste elimination. Immunoreactive projections from the synganglion to the hindgut were found using antibodies against four different neuropeptides: FGLamide related allatostatin, myoinhibitory pep...
journal_title：International journal for parasitology
pub_type： 杂志文章
doi：10.1016/j.ijpara.2014.06.007
更新日期：2014-10-01 00:00:00
abstract：:In an attempt to determine whether in vitro oviposition of adult S. mansoni reflects the fecundity status of worms in vivo, Mongolian gerbils and ICR, BALB/c and SCID mice were infected with about 100 cercariae and examined on an individual basis, 5-12 weeks later, for worm burden, counts of eggs in liver and small in...
journal_title：International journal for parasitology
pub_type： 杂志文章
doi：10.1016/s0020-7519(96)00191-9
更新日期：1997-04-01 00:00:00
abstract：:Parasitic nematode species have extremely high levels of genetic diversity, presenting a number of experimental challenges for genomic and genetic work. Consequently, there is a need to develop inbred laboratory strains with reduced levels of polymorphism. The most efficient approach to inbred line development is sing...
journal_title：International journal for parasitology
pub_type： 杂志文章
doi：10.1016/j.ijpara.2017.08.010
更新日期：2018-02-01 00:00:00
abstract：:The eggs of Echinococcus multilocularis, the infectious stage, are spread into the environment through wild and domestic carnivore faeces. The spatial location of the faeces containing infective E. multilocularis eggs is a key parameter for studying areas of exposure and understanding the transmission processes to the...
journal_title：International journal for parasitology
pub_type： 杂志文章
doi：10.1016/j.ijpara.2020.07.008
更新日期：2020-12-01 00:00:00
abstract：:Phospholipase A2 (PLA2) enzymes play a central role in the initiation, propagation and resolution of inflammation. Here, we describe de novo expression of group IVC PLA2 (PLA2g4c) within the intestinal epithelium of Trichinella spiralis parasitised mice. This mouse mast cell protease-1 sensitive, calcium-independent P...
journal_title：International journal for parasitology
pub_type： 杂志文章
doi：10.1016/j.ijpara.2007.10.002
更新日期：2008-02-01 00:00:00
abstract：:Like any obligate intracellular pathogen, the parasite Toxoplasma gondii has lost its capacity for living independently of another organism. Toxoplasma lacks many genes that encode for entire metabolic pathways and has, in return, expanded genes that promote nutrient scavenging to meet its basic metabolic requirements...
journal_title：International journal for parasitology
pub_type： 杂志文章
doi：10.1016/j.ijpara.2013.09.003
更新日期：2014-02-01 00:00:00
abstract：:The intracellular stages of apicomplexan parasites are known to extensively modify their host cells to ensure their own survival. Recently, considerable progress has been made in understanding the molecular details of these parasite-dependent effects for Plasmodium-, Toxoplasma- and Theileria-infected cells. We have b...
journal_title：International journal for parasitology
pub_type： 杂志文章,评审
doi：10.1016/j.ijpara.2008.09.013
更新日期：2009-01-01 00:00:00
abstract：:Complete mitochondrial genomes and nuclear rRNA operons of eight geographically distinct isolates of the Asian fish tapeworm Schyzocotyle acheilognathi (syn. Bothriocephalus acheilognathi), representing the parasite's global diversity spanning four continents, were fully characterised using an Illumina sequencing plat...
journal_title：International journal for parasitology
pub_type： 杂志文章
doi：10.1016/j.ijpara.2016.03.009
更新日期：2016-08-01 00:00:00
abstract：:Standard enzyme cytochemical and indirect immunocytochemical techniques have been used in conjunction with light and confocal scanning laser microscopy (CSLM) to visualize cholinergic, serotoninergic and peptidergic nerve elements in whole-mount preparations of the amphibian urinary-bladder fluke, Gorgoderina vitellil...
journal_title：International journal for parasitology
pub_type： 杂志文章
doi：10.1016/0020-7519(91)90122-n
更新日期：1991-02-01 00:00:00
abstract：:Studies were conducted on 41 cross-bred (Bos taurus x Bos indicus) calves which were less than 1 year old. Three types of salivary gland antigens (SG Ag) viz. SG Ag-I (whole), SG Ag-II (supernatant) and SG Ag-III (sediment), prepared from the ixodid tick, Hyalomma anatolicum anatolicum, were used for immunizing these ...
journal_title：International journal for parasitology
pub_type： 杂志文章
doi：10.1016/0020-7519(90)90037-n
更新日期：1990-11-01 00:00:00
abstract：:The cattle tick, Rhipicephalus (Boophilus) microplus, is a haematophagous arthropod responsible for considerable losses in the livestock industry. Immunological control with vaccines is a promising alternative to replace chemical acaricides. Due to their importance in parasite physiology, cysteine endopeptidases are p...
journal_title：International journal for parasitology
pub_type： 杂志文章
doi：10.1016/j.ijpara.2012.04.013
更新日期：2012-06-01 00:00:00
abstract：:Control of Haemonchus contortus at present is largely by the use of anthelmintics, assisted in some regions by management programs. Widespread development of resistance, particularly in South Africa and Australia, and concerns associated with the manufacture and use of chemicals have led to increasing interest in vacc...
journal_title：International journal for parasitology
pub_type： 杂志文章,评审
doi：10.1016/0020-7519(95)00065-a
更新日期：1995-11-01 00:00:00
abstract：:Contortin was the first intestinal antigen of the sheep parasite Haemonchus contortus which induced significant levels of protection when used to vaccinate lambs. This antigen is present in the intestine of L4 and adult worms as a helical polymeric structure attached to the luminal surface of the intestinal cells. How...
journal_title：International journal for parasitology
pub_type： 杂志文章
doi：10.1016/j.ijpara.2008.05.002
更新日期：2008-11-01 00:00:00
