Babesia bovis: analysis of and preliminary vaccination studies with a defined infected erythrocyte membrane binding antigen.


:Murine monoclonal antibodies (MAB) were produced against the 'beta' fraction of Babesia bovis. A MAB, W11C5, selected on the criterion of its staining of erythrocytes infected with B. bovis, was purified. The antigen identified by MAB W11C5 was extracted from B. bovis infected erythrocytes by affinity chromatography and used in a vaccination trial to test its vaccine efficacy against homologous B. bovis infection in splenectomized calves. The vaccinated group showed significantly different parasitaemias from the control group and it was concluded that the B. bovis antigen 11C5 induced a protective immune response when used as a vaccine. This antigen should be synthesized using recombinant DNA techniques to determine its efficacy and suitability as a commercial vaccine against B. bovis infection.


Int J Parasitol


Goodger BV,Waltisbuhl DJ,Wright IG,White M





Has Abstract


1992-07-01 00:00:00














  • Haemolysin A and listeriolysin--two vaccine delivery tools for the induction of cell-mediated immunity.

    abstract::Haemolysin A of Escherichia coli and listeriolysin of Listeria monocytogenes represent important bacterial virulence factors. While such cytolysins are usually the reason for morbidity and even mortality, vaccine researchers have turned haemolysin A and listeriolysin into tools for vaccine delivery. Both cytolysins ha...

    journal_title:International journal for parasitology

    pub_type: 杂志文章,评审


    authors: Dietrich G,Viret JF,Gentschev I

    更新日期:2003-05-01 00:00:00

  • Adoptive transfer of protection to Taenia taeniaeformis infection in rats with immune spleen cells.

    abstract::The effector mechanism of the protection against re-infection with eggs of Taenia taeniaeformis was evaluated in rats by analysing protection dynamics against an ongoing primary infection. Immune spleen cells were prepared from F344 donor rats 10 days after oral inoculation with 200 eggs and used for adoptive transfer...

    journal_title:International journal for parasitology

    pub_type: 杂志文章


    authors: Asano K,Ito A,Ikeda K,Okamoto K

    更新日期:1994-05-01 00:00:00

  • Hc-daf-2 encodes an insulin-like receptor kinase in the barber's pole worm, Haemonchus contortus, and restores partial dauer regulation.

    abstract::Infective L3s (iL3s) of parasitic nematodes share common behavioural, morphological and developmental characteristics with the developmentally arrested (dauer) larvae of the free-living nematode Caenorhabditis elegans. It is proposed that similar molecular mechanisms regulate entry into or exit from the dauer stage in...

    journal_title:International journal for parasitology

    pub_type: 杂志文章


    authors: Li F,Lok JB,Gasser RB,Korhonen PK,Sandeman MR,Shi D,Zhou R,Li X,Zhou Y,Zhao J,Hu M

    更新日期:2014-06-01 00:00:00

  • Desiccation survival of the infective larvae of the insect parasitic nematode, Heterorhabditis zealandica poinar.

    abstract::Desiccation survival of the insect parasitic nematode Heterorhabditis zealandica upon exposure to various relative humidities on membrane filters and agar plates was determined. Survival was poor once water had been lost from the substrate. A screening experiment indicates that survival would not be improved by adjust...

    journal_title:International journal for parasitology

    pub_type: 杂志文章


    authors: Surrey MR,Wharton DA

    更新日期:1995-06-01 00:00:00

  • Production-based control of parasitic nematodes of cattle.

    abstract::Nematode parasite control in cattle is the goal of the parasitologist and the cattle producer. However, the language used to express the impact of that control has been a source of confusion between the two groups. Veterinary parasitologists speak in terms of reduction in worms or worm eggs, and cattle producers in te...

    journal_title:International journal for parasitology

    pub_type: 杂志文章,评审


    authors: Rew RS

    更新日期:1999-01-01 00:00:00

  • RIOK-2 protein is essential for egg hatching in a common parasitic nematode.

    abstract::The atypical protein kinase RIOK-2 is a non-ribosomal factor essential for ribosome maturation in yeast and human cells; however, little is known about its physiological role in pathogens. Our earlier work examined the expression profile of a RIOK-2 gene (Ss-riok-2) in Strongyloides stercoralis - a prevalent nematode ...

    journal_title:International journal for parasitology

    pub_type: 杂志文章


    authors: Zhou H,Zhou T,Zhang B,Lei W,Yuan W,Shan J,Zhang Y,Gupta N,Hu M

    更新日期:2020-07-01 00:00:00

  • Experimental and modelling investigations of Opisthorchis viverrini miracidia transmission over time and across temperatures: implications for control.

    abstract::Transmissibility is a significant factor in parasite fitness. The rate and magnitude of parasite transmission affect prevalence and infection intensity in individual hosts and are influenced by environmental factors. In this context, the objectives of this study were: (i) to experimentally assess Opisthorchis viverrin...

    journal_title:International journal for parasitology

    pub_type: 杂志文章


    authors: Echaubard P,León T,Suwanatrai K,Chaiyos J,Kim CS,Mallory FF,Kaewkes S,Spear RC,Sripa B

    更新日期:2017-04-01 00:00:00

  • Treatment of multiple resistant field strain of Ostertagia spp. in Cashmere and Angora goats.

    abstract::A multiple resistant field strain of gastro-intestinal nematodes was detected in Cashmere and Angora goats imported from New Zealand. Different treatments with three types of broad spectrum anthelmintics (albendazole, levamisole/tetramisole and ivermectin) at various dose rates are described. Satisfactory effect in An...

    journal_title:International journal for parasitology

    pub_type: 杂志文章


    authors: Várady M,Praslicka J,Corba J

    更新日期:1994-05-01 00:00:00

  • A molecular systematic framework for equine strongyles based on ribosomal DNA sequence data.

    abstract::In this study, molecular data sets were used to address the controversies relating to the systematics of strongyloid nematodes of equids utilising morphological data sets. DNA sequences of the first and second internal transcribed spacers (ITS-1 and ITS-2) of ribosomal DNA were determined for 30 species of equine stro...

    journal_title:International journal for parasitology

    pub_type: 杂志文章


    authors: Hung GC,Chilton NB,Beveridge I,Gasser RB

    更新日期:2000-01-01 00:00:00

  • Genetic epidemiology of lymphatic filariasis in American Samoa after mass drug administration.

    abstract::Over 892 million people in 48 countries are at risk of infection by nematodes that cause lymphatic filariasis. As part of the Global Programme to Eliminate Lymphatic Filariasis, mass drug administration is distributed to communities until surveillance indicates infection rates are below target prevalence thresholds. I...

    journal_title:International journal for parasitology

    pub_type: 杂志文章


    authors: Hedtke SM,Zendejas-Heredia PA,Graves PM,Sheridan S,Sheel M,Fuimaono SD,Lau CL,Grant WN

    更新日期:2020-11-07 00:00:00

  • Leishmania MAP kinases--familiar proteins in an unusual context.

    abstract::Mitogen-activated protein kinases are well-known mediators of signal transduction of higher eukaryotes regulating important processes like proliferation, differentiation, stress response and apoptosis. In Leishmania, the typical three-tiered module of MAP kinase signal transduction pathways is present. However, typica...

    journal_title:International journal for parasitology

    pub_type: 杂志文章


    authors: Wiese M

    更新日期:2007-08-01 00:00:00

  • Aggregation and species coexistence of ectoparasites of marine fishes.

    abstract::Interspecific interaction may lead to species exclusion but there are several ways in which species can coexist. One way is by reducing the overall intensity of competition via aggregated utilisation of fragmented resources. Known as the 'aggregation model of coexistence', this system assumes saturation and an equilib...

    journal_title:International journal for parasitology

    pub_type: 杂志文章


    authors: Morand S,Poulin R,Rohde K,Hayward C

    更新日期:1999-05-01 00:00:00

  • Actions of glutamate and ivermectin on the pharyngeal muscle of Ascaridia galli: a comparative study with Caenorhabditis elegans.

    abstract::The actions of glutamate and ivermectin were examined in the pharynx of Ascaridia galli and the results compared with those on the pharynx of Caenorhabditis elegans. In both preparations glutamate elicits a depolarization and inhibition of pharyngeal pumping, but the response of the pharynx of A. galli was much less t...

    journal_title:International journal for parasitology

    pub_type: 杂志文章


    authors: Holden-Dye L,Walker RJ

    更新日期:2006-04-01 00:00:00

  • Evaluation of the specificity of five oligoprobes for identification of cyathostomin species from horses.

    abstract::Here, we report evaluation of five oligoprobes designed from intergenic spacer (IGS) region sequences for identification of cyathostomin species. Oligoprobes were designed for identification of Cylicocyclus ashworthi, Cylicocyclus nassatus, Cylicostephanus longibursatus, Cylicostephanus goldi and a fifth probe designe...

    journal_title:International journal for parasitology

    pub_type: 杂志文章


    authors: Hodgkinson JE,Love S,Lichtenfels JR,Palfreman S,Ramsey YH,Matthews JB

    更新日期:2001-02-01 00:00:00

  • Cryptosporidium molnari n. sp. (Apicomplexa: Cryptosporidiidae) infecting two marine fish species, Sparus aurata L. and Dicentrarchus labrax L.

    abstract::Cryptosporidium molnari n. sp. is described from two teleost fish, the gilthead sea bream (Sparus aurata L.) and the European sea bass (Dicentrarchus labrax L.). The parasite was found mainly in the stomach epithelium and seldom in the intestine. Oocysts were almost spherical, with four naked sporozoites and a promine...

    journal_title:International journal for parasitology

    pub_type: 杂志文章


    authors: Alvarez-Pellitero P,Sitjà-Bobadilla A

    更新日期:2002-07-01 00:00:00

  • Molecular analysis of T and B cell repertoires in mice immunized with Opisthorchis viverrini antigens.

    abstract::B10 mice were immunized with an Opisthorchis viverrini somatic extract and then their responses were analyzed. The antigenic fractions of the extract were separated by SDS-polyacrylamide gel electrophoresis, electroblotted to nitrocellulose membranes and solubilized for use in lymphocyte culture. Antibody specificity ...

    journal_title:International journal for parasitology

    pub_type: 杂志文章


    authors: Wongratanacheewin S,Good MF,Sithithaworn P,Haswell-Elkins MR

    更新日期:1991-10-01 00:00:00

  • Use of long synthetic peptides to study the antigenicity and immunogenicity of the Plasmodium vivax circumsporozoite protein.

    abstract::Three long synthetic peptides corresponding to amino (N), repeat (R) and carboxyl (C) regions of the Plasmodium vivax circumsporozoite (CS) protein were synthesised and used to assess their potential as vaccine candidates. Antigenicity studies were carried out using human blood samples from residents of a malaria-ende...

    journal_title:International journal for parasitology

    pub_type: 杂志文章


    authors: Herrera S,Bonelo A,Perlaza BL,Valencia AZ,Cifuentes C,Hurtado S,Quintero G,López JA,Corradin G,Arévalo-Herrera M

    更新日期:2004-12-01 00:00:00

  • Development of a pharmacodynamic model of murine malaria and antimalarial treatment with dihydroartemisinin.

    abstract::Antimalarial treatment strategies based on in vitro studies are limited by the paucity of pharmacodynamic information for dosage regimen design. We postulated that a murine model could be used for pre-clinical stages of drug development, especially in dose-response studies and evaluation of combination therapies. Swis...

    journal_title:International journal for parasitology

    pub_type: 杂志文章


    authors: Gibbons PL,Batty KT,Barrett PH,Davis TM,Ilett KF

    更新日期:2007-12-01 00:00:00

  • Platyhelminth FMRFamide-related peptides.

    abstract::Platyhelminths are the most primitive metazoan phylum to possess a true central nervous system, comprising a brain and longitudinal nerve cords connected by commissures. Additional to the presence of classical neurotransmitters, the nervous systems of all major groups of flatworms examined have widespread and abundant...

    journal_title:International journal for parasitology

    pub_type: 杂志文章,评审


    authors: Shaw C,Maule AG,Halton DW

    更新日期:1996-04-01 00:00:00

  • Inflammatory responses in the intestinal mucosa of gerbils and hamsters experimentally infected with the adult stage of Taenia solium.

    abstract::The inflammatory response in gerbils and hamsters harbouring experimental infections with Taenia solium adult parasites as well as worm burden and duration of infections were examined. For this purpose, non-suppressed or immunosuppressed rodents were infected with eight cysticerci and necropsied at different times up ...

    journal_title:International journal for parasitology

    pub_type: 杂志文章


    authors: Avila G,Aguilar L,Benitez S,Yepez-Mulia L,Lavenat I,Flisser A

    更新日期:2002-09-01 00:00:00

  • Influence of hydrogen peroxide on acid-fast staining of Cryptosporidium parvum oocysts.

    abstract::Infections by the protozoan parasite Cryptosporidium parvum are routinely diagnosed by modified Ziehl-Neelsen (acid-fast) staining of faecal preparations despite the counterstaining and ghost-like appearance of some oocysts. Quantitative studies demonstrated that only a small percentage of oocysts excreted by naturall...

    journal_title:International journal for parasitology

    pub_type: 杂志文章


    authors: Entrala E,Rueda-Rubio M,Janssen D,Mascaró C

    更新日期:1995-12-01 00:00:00

  • The effect of anti-sandfly saliva antibodies on Phlebotomus argentipes and Leishmania donovani.

    abstract::A study was undertaken to find the effect of repeated bites of the sandfly, Phlebotomus argentipes, on its host as well as on the vector itself. The study also aimed to find the effect of the immune serum on the parasite, Leishmania donovani, naturally transmitted by the vector. The hamster which was exposed to sandfl...

    journal_title:International journal for parasitology

    pub_type: 杂志文章


    authors: Ghosh KN,Mukhopadhyay J

    更新日期:1998-02-01 00:00:00

  • Host genes, parasites and parasitic infections.

    abstract::Resistance to infection of mammalian hosts by parasites is under genetic control at many different levels: between species, between races, breeds and lines of single species and between individuals. These genetic effects have been described in many host-parasite systems. Here we review the interaction between three el...

    journal_title:International journal for parasitology

    pub_type: 杂志文章,评审


    authors: Gray GD,Gill HS

    更新日期:1993-07-01 00:00:00

  • Development of forward genetics in Toxoplasma gondii.

    abstract::The development of forward genetics as a functional system in Toxoplasma gondii spanned more than three decades from the mid-1970s until now. The initial demonstration of experimental genetics relied on chemically induced drug-resistant mutants that were crossed by co-infecting cats, collecting oocysts, sporulating an...

    journal_title:International journal for parasitology

    pub_type: 历史文章,杂志文章,评审


    authors: Sibley LD

    更新日期:2009-07-01 00:00:00

  • Organisation and sequence determination of glutamine-dependent carbamoyl phosphate synthetase II in Toxoplasma gondii.

    abstract::Carbamoyl phosphate synthetase II encodes the first enzymic step of de novo pyrimidine biosynthesis. Carbamoyl phosphate synthetase II is essential for Toxoplasma gondii replication and virulence. In this study, we characterised the primary structure of a 28kb gene encoding Toxoplasma gondii carbamoyl phosphate synthe...

    journal_title:International journal for parasitology

    pub_type: 杂志文章


    authors: Fox BA,Bzik DJ

    更新日期:2003-01-01 00:00:00

  • Molecular basis of hyperlipidemia in golden hamsters during experimental infection with Ancylostoma ceylanicum (Nematoda:Strongylidae).

    abstract::An infection of golden hamsters with Ancylostoma ceylanicum, a hookworm parasite, induced profound hyperlipidemia, particularly hypertriglyceridemia, and the effect was directly related to the degree of infection. A significant increase was also noticed in serum cholesterol and phospholipid levels. The appearance of l...

    journal_title:International journal for parasitology

    pub_type: 杂志文章


    authors: Mukerjee S,Chander R,Tekwani BL,Gupta S,Katiyar JC,Shukla OP,Kapoor NK

    更新日期:1990-04-01 00:00:00

  • Serodiagnosis of amoebiasis using a recombinant protein fragment of the 29 kDa surface antigen of Entamoeba histolytica.

    abstract::To develop an improved serodiagnostic test for amoebiasis, we performed a detailed analysis of the immunodominant epitopes of the 29 kDa surface antigen and evaluated its sensitivity and specificity. Enzyme-linked immunosorbent assay (ELISA) based on the fragment containing the immunodominant epitope was evaluated fur...

    journal_title:International journal for parasitology

    pub_type: 杂志文章


    authors: Lee J,Park SJ,Yong TS

    更新日期:2000-12-01 00:00:00

  • RNA-Seq analysis during the life cycle of Cryptosporidium parvum reveals significant differential gene expression between proliferating stages in the intestine and infectious sporozoites.

    abstract::Cryptosporidium parvum is a major cause of diarrhoea in humans and animals. There are no vaccines and few drugs available to control C. parvum. In this study, we used RNA-Seq to compare gene expression in sporozoites and intracellular stages of C. parvum to identify genes likely to be important for successful completi...

    journal_title:International journal for parasitology

    pub_type: 杂志文章


    authors: Lippuner C,Ramakrishnan C,Basso WU,Schmid MW,Okoniewski M,Smith NC,Hässig M,Deplazes P,Hehl AB

    更新日期:2018-05-01 00:00:00

  • Molecular characterisation of MEK1/2- and MKK3/6-like mitogen-activated protein kinase kinases (MAPKK) from the fox tapeworm Echinococcus multilocularis.

    abstract::Mitogen-activated protein kinase kinases (MAPKKs) are essential components of evolutionary conserved signalling modules that regulate a variety of fundamental cellular processes in response to environmental stimuli. To date, no MAPKK ortholog has been characterised in free-living or parasitic flatworm species. Here, w...

    journal_title:International journal for parasitology

    pub_type: 杂志文章


    authors: Gelmedin V,Spiliotis M,Brehm K

    更新日期:2010-04-01 00:00:00

  • Ultrastructural differentiation of Toxoplasma gondii schizonts (types B to E) and gamonts in the intestines of cats fed bradyzoites.

    abstract::The ultrastructural characterisitics of four types of Toxoplasma gondii schizonts (types B, C, D and E) and their merozoites, microgamonts and macrogamonts were compared in cats killed at days 1, 2, 4 and 6 after feeding tissues cysts from the brains of mice. Schizonts, merozoites and gamonts contained most of the ult...

    journal_title:International journal for parasitology

    pub_type: 杂志文章


    authors: Speer CA,Dubey JP

    更新日期:2005-02-01 00:00:00