Babesia bovis: analysis of and preliminary vaccination studies with a defined infected erythrocyte membrane binding antigen.

Abstract:

:Murine monoclonal antibodies (MAB) were produced against the 'beta' fraction of Babesia bovis. A MAB, W11C5, selected on the criterion of its staining of erythrocytes infected with B. bovis, was purified. The antigen identified by MAB W11C5 was extracted from B. bovis infected erythrocytes by affinity chromatography and used in a vaccination trial to test its vaccine efficacy against homologous B. bovis infection in splenectomized calves. The vaccinated group showed significantly different parasitaemias from the control group and it was concluded that the B. bovis antigen 11C5 induced a protective immune response when used as a vaccine. This antigen should be synthesized using recombinant DNA techniques to determine its efficacy and suitability as a commercial vaccine against B. bovis infection.

journal_name

Int J Parasitol

authors

Goodger BV,Waltisbuhl DJ,Wright IG,White M

doi

10.1016/0020-7519(92)90156-f

keywords:

subject

Has Abstract

pub_date

1992-07-01 00:00:00

pages

533-5

issue

4

eissn

0020-7519

issn

1879-0135

pii

0020-7519(92)90156-F

journal_volume

22

pub_type

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