Identification of protein fragments as pattern features in MALDI-MS analyses of serum.

abstract：:The Lewis x (Le(x)) structure (Galβ1-4(Fucα1-3)GlcNAc-R) is a carbohydrate epitope comprising the stage-specific embryonic antigen-1 (SSEA-1) and CD15, and it is synthesized by α1,3-fucosyltransferase 9 (Fut9). Fut9 is expressed specifically in the stomach, kidney, brain, and in leukocytes, suggesting a specific funct...

journal_title：Journal of proteome research

authors： Noro E,Togayachi A,Sato T,Tomioka A,Fujita M,Sukegawa M,Suzuki N,Kaji H,Narimatsu H

更新日期：2015-09-04 00:00:00

abstract：:Selenite has been a touted cancer chemopreventative agent but generates conflicting outcomes. Multiple mechanisms of selenite cytotoxicity in cancer cells are thought to be induced by metabolites of selenite. We observed that intracellular metabolism of selenite generates endogenous selenium nanoparticles (SeNPs) in c...

journal_title：Journal of proteome research

authors： Bao P,Chen Z,Tai RZ,Shen HM,Martin FL,Zhu YG

更新日期：2015-02-06 00:00:00

abstract：:Metabolically engineered Escherichia coli has previously been used to degrade cis-1,2-dichloroethylene (cis-DCE). The strains express the six genes of an evolved toluene ortho-monooxygenase from Burkholderia cepacia G4 (TOM-Green, which formed a reactive epoxide) with either (1) gamma-glutamylcysteine synthetase (GSHI...

journal_title：Journal of proteome research

authors： Lee J,Cao L,Ow SY,Barrios-Llerena ME,Chen W,Wood TK,Wright PC

更新日期：2006-06-01 00:00:00

abstract：:N-Glycans are an important source of milk oligosaccharides. In addition to free oligosaccharides found in milk, N-glycans can also be utilized by gut microbes. A potential for milk N-glycans to act as gut microbe regulators in suckling animals has attracted considerable attention; however, sow milk N-glycans and their...

journal_title：Journal of proteome research

authors： Mu C,Cai Z,Bian G,Du Y,Ma S,Su Y,Liu L,Voglmeir J,Huang R,Zhu W

更新日期：2019-03-01 00:00:00

abstract：:We have investigated the transcriptome and proteome of the venom of a cryptic Australian elapid snake Drysdalia coronoides. To probe into the transcriptome, we constructed a partial cDNA library from the venom gland of D. coronoides. The proteome of the venom of D. coronoides was explored by tryptic digestion of the c...

journal_title：Journal of proteome research

authors： Chatrath ST,Chapeaurouge A,Lin Q,Lim TK,Dunstan N,Mirtschin P,Kumar PP,Kini RM

更新日期：2011-02-04 00:00:00

abstract：:We have investigated the molecular mechanisms regulating the necrosis and apoptosis that occur on treatment of mouse mammary tumor FM3A cells with 5-fluoro-2'-deoxyuridine (FUdR), a potent anticancer agent, using the original clone F28-7 and its variant F28-7-A cells. Previously, we reported an interesting observation...

journal_title：Journal of proteome research

authors： Sato A,Satake A,Hiramoto A,Wataya Y,Kim HS

更新日期：2010-05-07 00:00:00

abstract：:The development of the nematode Caenorhabditis elegans is a highly dynamic process. Although various studies have assessed global transcriptome changes, information on the dynamics of the proteome during ontogenesis is not available. We metabolically labeled C. elegans by using ¹⁵N ammonium chloride as a precursor in ...

journal_title：Journal of proteome research

authors： Geillinger KE,Kuhlmann K,Eisenacher M,Meyer HE,Daniel H,Spanier B

更新日期：2012-09-07 00:00:00

abstract：:Proteomics methods are being increasingly used to study archaeological and palaeontological bone, assisting in species identification and phylogenetic studies as well as improving our understanding of bone diagenesis. More recently, there are developing interests in the study of post-translational modifications, some ...

journal_title：Journal of proteome research

authors： Procopio N,Buckley M

更新日期：2017-02-03 00:00:00

abstract：:The endothelium plays a critical role in orchestrating the inflammatory response seen during sepsis. Many of the inflammatory effects of Gram-negative sepsis are elicited by lipopolysaccharide (LPS), a glycolipid component of bacterial cell walls. Lipid-rich microdomains have been shown to concentrate components of th...

journal_title：Journal of proteome research

authors： Karsan A,Blonder J,Law J,Yaquian E,Lucas DA,Conrads TP,Veenstra T

更新日期：2005-03-01 00:00:00

abstract：:To gain insights into how TGF-beta regulates epithelial-mesenchymal transition (EMT), we assessed the time course of proteins and mRNAs during EMT by multiplex iTRAQ labeling and 2D-LC-MS/MS, and by hybridization, respectively. Temporal iTRAQ analysis identified 66 proteins as differentially expressed during EMT, incl...

journal_title：Journal of proteome research

authors： Keshamouni VG,Jagtap P,Michailidis G,Strahler JR,Kuick R,Reka AK,Papoulias P,Krishnapuram R,Srirangam A,Standiford TJ,Andrews PC,Omenn GS

更新日期：2009-01-01 00:00:00

abstract：:Secondary to the increased survival following chemotherapy, brain metastases have recently become a significant clinical problem for breast cancer patients. The aim of this study was to characterize those functional phenotypes that might enhance brain metastasis in breast cancer cells. We first analyzed by two-dimensi...

journal_title：Journal of proteome research

authors： Martín B,Aragüés R,Sanz R,Oliva B,Boluda S,Martínez A,Sierra A

更新日期：2008-03-01 00:00:00

abstract：:As work on systematic searches for developmentally-regulated proteins is limited, whole brains of CL57B/6J mice were taken from day 16 of gestation, at postnatal days 7 and 54-58. Proteins were extracted, and analyzed by a gel-based proteomic method (ion trap HCT). Antioxidant, cytoskeleton, chaperone, several metabol...

journal_title：Journal of proteome research

authors： Myung JK,Shim KS,Li L,Höger H,Lubec G

更新日期：2009-03-01 00:00:00

abstract：:FDA oversight of medical devices, including in vitro diagnostic devices (IVDs or laboratory tests), in the United States was a direct result of the passage of the Medical Device Amendments of 1976. This law introduced a series of general controls for medical devices including registration and listing, requirements for...

journal_title：Journal of proteome research

authors： Hackett JL,Gutman SI

更新日期：2005-07-01 00:00:00

abstract：:Seasonal nitrogen (N) cycling in temperate deciduous trees involves the accumulation of bark storage proteins (BSPs) in phloem parenchyma and xylem ray cells. BSPs are anabolized using recycled N during autumn leaf senescence and later become a source of N during spring shoot growth as they are catabolized. Little is ...

journal_title：Journal of proteome research

authors： Islam N,Li G,Garrett WM,Lin R,Sriram G,Cooper B,Coleman GD

更新日期：2015-02-06 00:00:00

abstract：:Repeat administration of psychostimulants, such as methamphetamine, produces a progressive increase in locomotor activity (behavioral sensitization) in rodents that is believed to represent the underlying neurochemical changes driving psychoses. Alterations to the prefrontal cortex (PFC) are suggested to mediate the e...

journal_title：Journal of proteome research

authors： Wearne TA,Mirzaei M,Franklin JL,Goodchild AK,Haynes PA,Cornish JL

更新日期：2015-01-02 00:00:00

abstract：:Many neurodegenerative diseases, such as Parkinson's disease, can be directly correlated with the deregulation in neuronal signaling. Hence, it is indispensable for therapy development to understand the participating signaling processes. Because the activity of the involved protein kinases is of major interest for the...

journal_title：Journal of proteome research

authors： Höfener M,Pachl F,Take T,Fischer von Mollard G,Kuster B,Sewald N

更新日期：2014-08-01 00:00:00

abstract：:Nicotinamide adenine dinucleotide (NAD) is a coenzyme found in all living cells and mediates multiple cellular signaling pathways. In the present study, a 35% decrease of cellular NAD level is achieved by stable expression of the N-terminal truncated CD38, a NAD hydrolase. CD38-expressing (CD38(+)) cells have the lowe...

journal_title：Journal of proteome research

authors： Hu Y,Wang H,Wang Q,Deng H

更新日期：2014-02-07 00:00:00

abstract：:Glioblastoma multiforme (GBM) is the most aggressive malignant primary brain tumor, with a dismal mean survival even with the current standard of care. Although in vitro cell systems can provide mechanistic insight into the regulatory networks governing GBM cell proliferation and migration, clinical samples provide a ...

journal_title：Journal of proteome research

authors： Johnson H,White FM

更新日期：2014-11-07 00:00:00

abstract：:Ozonated autohemotherapy (O3-AHT) is a medical approach during which blood obtained from the patient is ozonated and injected back into the body. Despite an increasing number of evidence that O3-AHT is safe, this type of therapy remains controversial. To extend knowledge about the changes in blood evoked by O3-AHT, LC...

journal_title：Journal of proteome research

authors： Ciborowski M,Lipska A,Godzien J,Ferrarini A,Korsak J,Radziwon P,Tomasiak M,Barbas C

更新日期：2012-12-07 00:00:00

abstract：:Knowledge of protein subcellular localization assists in the elucidation of protein function and understanding of different biological mechanisms that occur at discrete subcellular niches. Organelle-centric proteomics enables localization of thousands of proteins simultaneously. Although such techniques have successfu...

journal_title：Journal of proteome research

authors： Groen AJ,Sancho-Andrés G,Breckels LM,Gatto L,Aniento F,Lilley KS

更新日期：2014-02-07 00:00:00

abstract：:Hepatocellular carcinoma is one of the most fatal cancers worldwide. In this study, a reversed-phase-strong cation exchange-reversed-phase three-dimensional liquid chromatography strategy was established and coupled with mass spectrometry to investigate the differential proteome expression of HCC and normal liver tiss...

journal_title：Journal of proteome research

authors： Xu B,Wang F,Song C,Sun Z,Cheng K,Tan Y,Wang H,Zou H

更新日期：2014-08-01 00:00:00

abstract：:To estimate the potential of the state-of-the-art proteomics technologies on full coverage of the encoding gene products, the Chinese Human Chromosome Proteome Consortium (CCPC) applied a multiomics strategy to systematically analyze the transciptome, translatome, and proteome of the same cultured hepatoma cells with ...

journal_title：Journal of proteome research

authors： Chang C,Li L,Zhang C,Wu S,Guo K,Zi J,Chen Z,Jiang J,Ma J,Yu Q,Fan F,Qin P,Han M,Su N,Chen T,Wang K,Zhai L,Zhang T,Ying W,Xu Z,Zhang Y,Liu Y,Liu X,Zhong F,Shen H,Wang Q,Hou G,Zhao H,Li G,Liu S,G

更新日期：2014-01-03 00:00:00

abstract：:NO-mediated S-nitrosation of cysteine residues has been recognized as a fundamental post-translational modification. S-Nitrosation of endothelial cell (EC) proteins can alter function and affect vascular homeostasis. Trace amounts of S-nitrosoproteins in endothelial cells (ECs) in vivo coupled with lability of the S-n...

journal_title：Journal of proteome research

authors： Huang B,Liao CL,Lin YP,Chen SC,Wang DL

更新日期：2009-10-01 00:00:00

abstract：:Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder caused by a mutation in the Huntingtin gene, where excessive (≥ 36) CAG repeats encode for glutamine expansion in the huntingtin protein. Research using mouse models and human pathological material has indicated dysfunctions in a myriad of s...

journal_title：Journal of proteome research

authors： McQuade LR,Balachandran A,Scott HA,Khaira S,Baker MS,Schmidt U

更新日期：2014-12-05 00:00:00

abstract：:Sperm proteomes have emerged for several species; however, the extent of species similarity is unknown. Sheep are an important agricultural species for which a comprehensive sperm proteome has not been produced. In addition, potential proteomic factors from seminal plasma that may contribute to improved fertility afte...

journal_title：Journal of proteome research

authors： Pini T,Leahy T,Soleilhavoup C,Tsikis G,Labas V,Combes-Soia L,Harichaux G,Rickard JP,Druart X,de Graaf SP

更新日期：2016-10-07 00:00:00

abstract：:Prostate cancer (PCa) is the second leading cause of cancer-related mortality in men. The prevalent diagnosis method is based on the serum prostate-specific antigen (PSA) screening test, which suffers from low specificity, overdiagnosis, and overtreatment. In this work, untargeted metabolomic profiling of age-matched ...

journal_title：Journal of proteome research

authors： Zang X,Jones CM,Long TQ,Monge ME,Zhou M,Walker LD,Mezencev R,Gray A,McDonald JF,Fernández FM

更新日期：2014-07-03 00:00:00

abstract：:Autosomal dominant polycystic liver disease (PCLD) is characterized by multiple liver cysts and is caused by mutations in PRKCSH (hepatocystin). Mechanisms of cystogenesis are unknown, but previous studies have shown that hepatocystin is secreted in vitro. The goal of this study was to determine the fate of hepatocyst...

journal_title：Journal of proteome research

authors： Waanders E,Lameris AL,Op den Camp HJ,Pluk W,Gloerich J,Strijk SP,Drenth JP

更新日期：2008-06-01 00:00:00

abstract：:Mycobacterium tuberculosis, the causative agent of tuberculosis, accounts for 1.5 million human deaths annually worldwide. Despite efforts to eradicate tuberculosis, it still remains a deadly disease. The two best characterized strains of M. tuberculosis, virulent H37Rv and avirulent H37Ra, provide a unique platform t...

journal_title：Journal of proteome research

authors： Verma R,Pinto SM,Patil AH,Advani J,Subba P,Kumar M,Sharma J,Dey G,Ravikumar R,Buggi S,Satishchandra P,Sharma K,Suar M,Tripathy SP,Chauhan DS,Gowda H,Pandey A,Gandotra S,Prasad TS

更新日期：2017-04-07 00:00:00

abstract：:Inspired by the availability of de novo transcriptome of horse gram (Macrotyloma uniflorum) and recent developments in systems biology studies, the first ever global protein-protein interactome (PPI) map was constructed for this highly drought-tolerant legume. Large-scale studies of PPIs and the constructed database w...

journal_title：Journal of proteome research

authors： Bhardwaj J,Gangwar I,Panzade G,Shankar R,Yadav SK

更新日期：2016-06-03 00:00:00

abstract：:Skeletal muscle has emerged as an important secretory organ that produces so-called myokines, regulating energy metabolism via autocrine, paracrine, and endocrine actions; however, the nature and extent of the muscle secretome has not been fully elucidated. Mass spectrometry (MS)-based proteomics, in principle, allows...

journal_title：Journal of proteome research

authors： Deshmukh AS,Cox J,Jensen LJ,Meissner F,Mann M

更新日期：2015-11-06 00:00:00