Abstract:
PURPOSE:The health care system in the United States is inherently hierarchical. Patients are "nested" within physicians who in turn are "nested" within practices. Much of the research data gathered in practice-based research networks (PBRNs) also have similar patterns of nesting (clustering). When research data are nested, statistical approaches to the data must account for the multilevel nature of the data or risk errors in interpretation. We illustrate the concept of multilevel structure and provide examples with implications for practice-based research. METHODS:We present a selection of multilevel (hierarchical) models and contrast them with traditional linear regression models, using an example of a simulated observational study to illustrate increasingly complex statistical approaches, as well as to explore the consequences of ignoring clustering in data. Additionally, we discuss other types of outcome data and designs, and the effects of clustering on sample size and power. RESULTS:Multilevel models demonstrate that the effects of physician-level activities may differ from clinic to clinic as well as between rural and urban settings; this variability would be undetected in traditional linear regression approaches. Study conclusions differed when the data were analyzed with multilevel methods compared with traditional linear regression methods. Clustered data also affected sample size; as the intraclass correlation increased and the patients per cluster increased, the required number of patients increased dramatically. CONCLUSIONS:Recognizing and accounting for multilevel structure when analyzing data from PBRN studies can lead to more accurate conclusions, as well as offer opportunities to explore contextual effects and differences across sites. Accommodating multilevel structure in planning research studies can result in more appropriate estimation of required sample size.
journal_name
Ann Fam Medjournal_title
Annals of family medicineauthors
Dickinson LM,Basu Adoi
10.1370/afm.340keywords:
subject
Has Abstractpub_date
2005-05-01 00:00:00pages
S52-60eissn
1544-1709issn
1544-1717pii
3/suppl_1/s52journal_volume
3 Suppl 1pub_type
杂志文章abstract:BACKGROUND:We undertook a study to understand how women who are victims of intimate partner violence (IPV) want physicians to manage these abusive relationships in the primary care office. METHODS:Thirty-two mothers in IPV shelters or support groups in southwestern Ohio were interviewed to explore their abuse experien...
journal_title:Annals of family medicine
pub_type: 杂志文章
doi:10.1370/afm.74
更新日期:2004-05-01 00:00:00
abstract:BACKGROUND:We wanted to determine the frequency of self-reported receipt of screening mammography and Papanicolaou (Pap) tests in older women and investigate important predictors of utilization, based on 2 national longitudinal surveys. METHODS:This cohort study includes participants from 4 waves (1994-2000) of the He...
journal_title:Annals of family medicine
pub_type: 杂志文章
doi:10.1370/afm.54
更新日期:2003-11-01 00:00:00
abstract:PURPOSE:Conducting studies in national practice-based research networks presents logistic and methodologic challenges. Pediatric Research in Office Settings (PROS) has learned valuable lessons in implementing new strategies and adapting to challenges. We describe practical challenges and results of novel applied strate...
journal_title:Annals of family medicine
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1370/afm.1809
更新日期:2015-09-01 00:00:00
abstract:PURPOSE:Practice transformation in primary care is a movement toward data-driven redesign of care, patient-centered care delivery, and practitioner activation. A critical requirement for achieving practice transformation is availability of tools to engage practices. METHODS:A total of 48 practices with 109 practice si...
journal_title:Annals of family medicine
pub_type: 杂志文章
doi:10.1370/afm.2382
更新日期:2019-08-12 00:00:00
abstract:PURPOSE:Results of case management designed for patients with dementia and their caregivers in community-based primary health care (CBPHC) were inconsistent. Our objective was to identify the relationships between key outcomes of case management and barriers to implementation. METHODS:We conducted a systematic mixed s...
journal_title:Annals of family medicine
pub_type: 杂志文章,评审
doi:10.1370/afm.1677
更新日期:2014-09-01 00:00:00
abstract::This narrative presents my personal reflections as a medical anthropology researcher, and my journey as a chronic patient suffering for 30 years from ulcerative colitis. My surgeon promised me "a new life" after recommending a total colectomy 20 years ago. Indeed, a new life did begin following surgery, but I find I m...
journal_title:Annals of family medicine
pub_type: 杂志文章
doi:10.1370/afm.2181
更新日期:2018-03-01 00:00:00
abstract:PURPOSE:Hot tea and coffee have been found to have antimicrobial properties. The purpose of this study was to determine whether the consumption of tea, coffee, or both is associated with less frequent nasal carriage of methicillin-resistant Staphylococcus aureus (MRSA). METHODS:We performed a secondary analysis of dat...
journal_title:Annals of family medicine
pub_type: 杂志文章
doi:10.1370/afm.1262
更新日期:2011-07-01 00:00:00
abstract::We sought to describe the proportion of patients in contact with a primary care physician, as well as the total number of primary care contacts over a 2-year period, using the 2002-2017 Medical Expenditure Panel Survey. The rate of any contact with a primary care physician for patients in the population decreased by 2...
journal_title:Annals of family medicine
pub_type: 杂志文章
doi:10.1370/afm.2631
更新日期:2021-01-01 00:00:00
abstract:PURPOSE:Knowledge about the ways patients perceive their vulnerability to disease is important for communication with patients about risk and preventive health measures. This interview study aimed to explore how patients with a diagnosis of heterozygous familial hypercholesterolemia understand and perceive their vulner...
journal_title:Annals of family medicine
pub_type: 杂志文章
doi:10.1370/afm.529
更新日期:2006-05-01 00:00:00
abstract:BACKGROUND:Notions about the most common errors in medicine currently rest on conjecture and weak epidemiologic evidence. We sought to determine whether cascade analysis is of value in clarifying the epidemiology and causes of errors and whether physician reports are sensitive to the impact of errors on patients. METH...
journal_title:Annals of family medicine
pub_type: 杂志文章,多中心研究
doi:10.1370/afm.126
更新日期:2004-07-01 00:00:00
abstract:PURPOSE:Although screening for unipolar depression is controversial, it is potentially an efficient way to find undetected cases and improve diagnostic acumen. Using a reference standard, we aimed to validate the 2- and 9-question Patient Health Questionnaires (PHQ-2 and PHQ-9) in primary care settings. The PHQ-2 compr...
journal_title:Annals of family medicine
pub_type: 杂志文章
doi:10.1370/afm.1139
更新日期:2010-07-01 00:00:00
abstract:PURPOSE:In 2004, we undertook a consultation with Canadian primary health care experts to define the attributes that should be evaluated in predominant and proposed models of primary health care in the Canadian context. METHOD:Twenty persons considered to be experts in primary health care or recommended by at least 2 ...
journal_title:Annals of family medicine
pub_type: 杂志文章
doi:10.1370/afm.682
更新日期:2007-07-01 00:00:00
abstract:PURPOSE:We aimed to advance the internal and external validity of research by sharing our empirical experience and recommendations for systematically reporting contextual factors. METHODS:Fourteen teams conducting research on primary care practice transformation retrospectively considered contextual factors important ...
journal_title:Annals of family medicine
pub_type: 杂志文章
doi:10.1370/afm.1549
更新日期:2013-05-01 00:00:00
abstract:PURPOSE:Avoidable hospitalizations due to adverse drug events and high-risk prescribing are common in older people. Primary care physicians prescribe most on-going medicines. Deprescribing has long been essential to best prescribing practice. We sought to explore the views of primary care physicians on the barriers and...
journal_title:Annals of family medicine
pub_type: 杂志文章
doi:10.1370/afm.2094
更新日期:2017-07-01 00:00:00
abstract:PURPOSE:In this study, we compared the rate of depression diagnoses in adults with and without diabetes mellitus, while carefully controlling for number of primary care visits. METHODS:We matched adults with incident diabetes (n = 2,932) or prevalent diabetes (n = 14,144) to nondiabetic control patients based on (1) a...
journal_title:Annals of family medicine
pub_type: 杂志文章
doi:10.1370/afm.964
更新日期:2009-07-01 00:00:00
abstract:PURPOSE:A randomized controlled trial found that patients with diabetes had lower HbA1c levels after 6 months of peer health coaching than patients who did not receive coaching. This paper explores whether the peer coaches in that trial, all low-income patients with diabetes, mastered and utilized an evidence-based hea...
journal_title:Annals of family medicine
pub_type: 杂志文章,随机对照试验
doi:10.1370/afm.1756
更新日期:2015-08-01 00:00:00
abstract:PURPOSE:In screening for type 2 diabetes, guidelines recommend targeting high-risk individuals. Our objectives were to assess the yield of opportunistic targeted screening for type 2 diabetes in primary care and to assess the diagnostic value of various risk factors. METHODS:In 11 family practices (total practice popu...
journal_title:Annals of family medicine
pub_type: 杂志文章
doi:10.1370/afm.997
更新日期:2009-09-01 00:00:00
abstract:PURPOSE:This review summarizes the evidence regarding the efficacy of adjuvant steroids for pain reduction in acute pharyngitis. METHODS:We searched for randomized controlled trials, using MEDLINE, EMBASE, and the Cochrane Database of Systematic Reviews, published between 1966 and December 2008. Two reviewers assessed...
journal_title:Annals of family medicine
pub_type: 杂志文章,评审
doi:10.1370/afm.1038
更新日期:2010-01-01 00:00:00
abstract:PURPOSE:Because recognition and management of patients with somatoform disorders are difficult, we wanted to determine the specificity, sensitivity, and the test-retest reliability of the 15-symptom Patient Health Questionnaire (PHQ-15) for detection of somatoform disorders in a high-risk primary care population. METH...
journal_title:Annals of family medicine
pub_type: 杂志文章
doi:10.1370/afm.985
更新日期:2009-05-01 00:00:00
abstract::Two voices tell the story of an evolving doctor-patient relationship. Seizures are the first indication of squamous cell lung cancer metastatic to the brain. Both doctor and patient describe the course of the illness, treatment, and remarkable recovery, each from his own perspective. The patient describes how the canc...
journal_title:Annals of family medicine
pub_type: 杂志文章
doi:10.1370/afm.9
更新日期:2003-05-01 00:00:00
abstract:PURPOSE:There is a shortage of rural primary care personnel with expertise in team care for patients with common mental disorders. Building the workforce for this population is a national priority. We investigated the feasibility of regular systematic case reviews through telepsychiatric consultation, within collaborat...
journal_title:Annals of family medicine
pub_type: 杂志文章
doi:10.1370/afm.2561
更新日期:2020-09-01 00:00:00
abstract:PURPOSE:We undertook a study to identify distinct functional trajectories in the year before hospice, to determine how patients with these trajectories differ according to demographic characteristics and hospice diagnosis, and to evaluate the association between these trajectories and subsequent outcomes. METHODS:From...
journal_title:Annals of family medicine
pub_type: 杂志文章
doi:10.1370/afm.1720
更新日期:2015-01-01 00:00:00
abstract:PURPOSE:Traditionally first-void urine specimens are used to test for Chlamydia trachomatis. In contrast, midstream urine specimens are traditionally recommended for microscopy and culture of presumptive bacterial urinary tract infections. The ability to test for both C trachomatis and urinary tract infection on a sing...
journal_title:Annals of family medicine
pub_type: 杂志文章
doi:10.1370/afm.1323
更新日期:2012-01-01 00:00:00
abstract:BACKGROUND:The 5As (ask, advise, assess, assist, arrange) are recommended as a strategy for brief physical activity counseling in primary care. There is no reference standard for measurement, however, and patient participation is not well understood. This study's objectives were to (1) develop a coding scheme to measur...
journal_title:Annals of family medicine
pub_type: 杂志文章
doi:10.1370/afm.1299
更新日期:2011-09-01 00:00:00
abstract:PURPOSE:Automated office blood pressure monitoring during 30 minutes (OBP30) may reduce overtreatment of patients with white-coat hypertension in primary health care. OBP30 results approximate those of ambulatory blood pressure monitoring, but OBP30 is much more convenient. In this study, we compared OBP30 with routine...
journal_title:Annals of family medicine
pub_type: 杂志文章
doi:10.1370/afm.2041
更新日期:2017-03-01 00:00:00
abstract:PURPOSE:Previous studies suggest that the highest-risk patients value accessible, coordinated primary care that they perceive to be of high technical quality. We have limited understanding, however, of how low-income, chronically ill patients and the staff who care for them experience each individual step in the primar...
journal_title:Annals of family medicine
pub_type: 杂志文章,多中心研究
doi:10.1370/afm.1808
更新日期:2015-07-01 00:00:00
abstract:PURPOSE:We wanted to obtain perspectives of mothers and daughters on facilitators of and barriers to with adolescent girls' timely access to risk-appropriate reproductive care. METHODS:We conducted 5 separate focus groups with Latina and black mothers and their adolescent daughters. All participants resided in impover...
journal_title:Annals of family medicine
pub_type: 杂志文章,多中心研究
doi:10.1370/afm.601
更新日期:2006-11-01 00:00:00
abstract::Hatpins is a first-person narrative that delves into a physician's experience of a patient death during the early years of residency. The essay reflects on the conflicted physician-patient relationships that can develop even over the short tenure of residency. While residency seeks to create medically prepared and com...
journal_title:Annals of family medicine
pub_type: 杂志文章
doi:10.1370/afm.2135
更新日期:2017-11-01 00:00:00
abstract:PURPOSE:This study was conducted to document current immunization practices by family physicians. METHODS:In 2008 the American Academy of Family Physicians (AAFP) conducted a survey among a random sample of 2,000 of its members who reported spending 80% or more of their time in direct patient care. The survey consiste...
journal_title:Annals of family medicine
pub_type: 杂志文章
doi:10.1370/afm.1185
更新日期:2010-11-01 00:00:00
abstract:PURPOSE:We wanted to identify characteristics of adults who do not have a usual source of care and then stratify the analysis by those who prefer vs those who do not prefer to have a usual source of care. METHODS:We analyzed data from a nationally representative sample of 9,011 adults to identify characteristics of th...
journal_title:Annals of family medicine
pub_type: 杂志文章
doi:10.1370/afm.557
更新日期:2006-07-01 00:00:00