Abstract:
BACKGROUND:A Y chromosomal role in prostate cancer has previously been suggested by both cytogenetic findings and patterns of Y chromosomal gene expression. We took advantage of the well established and stable phylogeny of the non-recombining segment of the Y chromosome to investigate the association between Y chromosomal DNA variation and prostate cancer risk. METHODS:We examined the distribution of 116 Y lineages in 930 prostate cancer cases and 1208 controls from four ethnic groups from a cohort study in Hawaii and California. RESULTS:One lineage, found only among the Japanese group in our study, was associated with a statistically significant predisposition to prostate cancer (odds ratio (OR) = 1.63; 95% confidence interval (CI) 1.07 to 2.47), and, in particular, to high severity disease in younger individuals (OR = 3.89; 95% CI 1.34 to 11.31). CONCLUSIONS:This finding suggests that a Y chromosomal factor contributes significantly to the development of prostate cancer in Japanese men.
journal_name
J Med Genetjournal_title
Journal of medical geneticsauthors
Paracchini S,Pearce CL,Kolonel LN,Altshuler D,Henderson BE,Tyler-Smith Cdoi
10.1136/jmg.40.11.815keywords:
subject
Has Abstractpub_date
2003-11-01 00:00:00pages
815-9issue
11eissn
0022-2593issn
1468-6244journal_volume
40pub_type
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