当前位置： SCI文献检索 > JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS期刊下所有文献 > The nitric oxide donor molsidomine improves survival and reduces hepatocyte apoptosis in cholestasis and endotoxemia.

The nitric oxide donor molsidomine improves survival and reduces hepatocyte apoptosis in cholestasis and endotoxemia.

Abstract：

BACKGROUND:Cholestasis and endotoxemia have been demonstrated to cause hepatocyte apoptosis through caspase-mediated pathways. In vitro nitric oxide (NO) donors reduce hepatocyte apoptosis and caspase activation in several models. The nitric oxide donor molsidomine improves survival in an in vivo model of endotoxemia. We tested the effect of molsidomine on survival and hepatocyte apoptosis in a model of obstructive jaundice and endotoxemia. STUDY DESIGN:Sprague-Dawley rats underwent common bile duct ligation on day 1. On day 3, animals were given either 100 mg/kg of molsidomine or an equivalent volume of saline, and 30 minutes later they were given endotoxin 3 mg/kg or 10 mg/kg intravenously. Animals were sacrificed 4 or 16 hours after endotoxin injection. Serum samples were analyzed for alanine aminotransferase and frozen liver samples were analyzed for caspase 3 activity. Paraffin-embedded liver sections were assayed for apoptosis using the terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate nick-end labeling assay. Survival was measured in a separate experiment in which animals underwent the same protocol, but were given three different doses of endotoxin and were observed for 72 hours before sacrifice. RESULTS:At endotoxin 3 mg/kg, the 72-hour survival in saline-treated animals was 92%, which decreased to 45% at 10 mg/kg and to 29% at 15 mg/kg. All of the molsidomine-treated animals survived all endotoxin doses. Alanine aminotransferase was reduced in molsidomine-treated animals compared with those treated with saline. Apoptosis was attenuated in molsidomine-treated animals. Caspase 3 activity was decreased in molsidomine-treated animals compared with those given saline. CONCLUSIONS:Molsidomine attenuates caspase activation and hepatocyte apoptosis and improves survival after cholestatic endotoxic injury.

journal_name

J Am Coll Surg

journal_title

Journal of the American College of Surgeons

authors

Brown KM,Brems JJ,Moazzam FN,Hartman GG,Gamelli RL,Ding JW

doi

10.1016/S1072-7515(03)00386-7

keywords:

subject

Has Abstract

pub_date

2003-08-01 00:00:00

pages

261-9

issue

2

eissn

1072-7515

issn

1879-1190

pii

S1072-7515(03)00386-7

journal_volume

197

pub_type

杂志文章

相关文献

JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS文献大全
  • Safety, accuracy, and diagnostic yield of needle localization biopsy of the breast performed using local anesthesia.

    abstract：BACKGROUND:In changing our technique to performing needle localization breast biopsies (NLBB) using local anesthesia in an outpatient setting, we investigated whether or not our complication rates with local anesthesia were acceptable when compared with complications from a cohort of biopsies of the breast performed fo...

    journal_title：Journal of the American College of Surgeons

    pub_type： 杂志文章

    doi：

    authors： Kaelin CM,Smith TJ,Homer MJ,Taback B,Azurin D,Schmid CH,Weld L

    更新日期：1994-09-01 00:00:00

  • Risk factors for wound complication in pilonidal sinus procedures.

    abstract：BACKGROUND:Pilonidal disease is a common condition among young people. Complicated pilonidal surgical wounds are associated with considerable morbidity, including chronic sacral wound, loss of work time, and lifestyle limitation. The aim of our study is to report our experience with Karydakis procedure and explore the ...

    journal_title：Journal of the American College of Surgeons

    pub_type： 杂志文章

    doi：10.1016/j.jamcollsurg.2007.04.034

    authors： Al-Khayat H,Al-Khayat H,Sadeq A,Groof A,Haider HH,Hayati H,Shamsah A,Zarka ZA,Al-Hajj H,Al-Momen A

    更新日期：2007-09-01 00:00:00

  • Enhanced Recovery After Surgery Protocols Are Valuable in Pancreas Surgery Patients.

    abstract：BACKGROUND:There is increasing interest in implementing comprehensive perioperative protocols, including preoperative optimization and education, perioperative goal-directed fluid management, and postoperative fast tracking, to enhance recovery after surgery. Data on the outcomes of these protocols in pancreatic surger...

    journal_title：Journal of the American College of Surgeons

    pub_type： 杂志文章

    doi：10.1016/j.jamcollsurg.2015.12.036

    authors： Morgan KA,Lancaster WP,Walters ML,Owczarski SM,Clark CA,McSwain JR,Adams DB

    更新日期：2016-04-01 00:00:00

  • Safety and immunogenicity observations pooled from eight clinical trials of recombinant human thrombin.

    abstract：BACKGROUND:We evaluated safety and immunogenicity observations pooled from 8 clinical trials of recombinant human thrombin (rThrombin), an active topical hemostatic agent. STUDY DESIGN:Recombinant thrombin was applied with an absorbable gelatin sponge or spray applicator during a surgical procedure (day 1). Adverse ev...

    journal_title：Journal of the American College of Surgeons

    pub_type： 杂志文章,meta分析

    doi：10.1016/j.jamcollsurg.2009.09.042

    authors： Ballard JL,Weaver FA,Singla NK,Chapman WC,Alexander WA

    更新日期：2010-02-01 00:00:00

  • The longitudinal study of surgical residents, 1993 to 1994.

    abstract：BACKGROUND:The American College of Surgeons (ACS) has collected comprehensive data about surgical residents for the past 12 years and has published an annual report, the Longitudinal Study of Surgical Residents. In 1994, the ACS and the American Medical Association (AMA) agreed to collaborate in collecting data about s...

    journal_title：Journal of the American College of Surgeons

    pub_type： 杂志文章

    doi：

    authors： Kwakwa F,Jonasson O

    更新日期：1996-11-01 00:00:00

  • Impact of New Vascular Fellowship Programs on Vascular Surgery Operative Volume of Residents in Associated General Surgery Programs.

    abstract：BACKGROUND:General surgery (GS) resident vascular surgery (VS) operations have declined significantly in the last 15 years. We hypothesized that initiation of VS fellowship programs (VSFPs) contributes to that decline. This study examined the effect of establishing new VSFPs on VS case volumes of residents in associate...

    journal_title：Journal of the American College of Surgeons

    pub_type： 杂志文章

    doi：10.1016/j.jamcollsurg.2018.12.010

    authors： Shannon AH,Robinson WP 3rd,Hanks JB,Potts JR 3rd

    更新日期：2019-04-01 00:00:00

  • Surgical treatment of early-stage breast cancer in the Department of Defense Healthcare System.

    abstract：BACKGROUND:The choice between breast-conserving surgery and modified radical mastectomy in the treatment of women with early stage breast cancer in the Department of Defense Healthcare System may be influenced by demographic factors. STUDY DESIGN:The Department of Defense Automated Central Tumor Registry (ACTUR) was q...

    journal_title：Journal of the American College of Surgeons

    pub_type： 杂志文章

    doi：10.1016/s1072-7515(00)00803-6

    authors： Kelemen JJ 3rd,Poulton T,Swartz MT,Jatoi I

    更新日期：2001-03-01 00:00:00

  • A novel technique for natural orifice endoscopic full-thickness colon wall resection: an experimental pilot study.

    abstract：BACKGROUND:Natural orifice endoscopic full-thickness colon resection attempts to overcome the need for invasive surgery in selected colorectal indications. Because basic technical requirements have not been met so far, the aim of this study was to develop a novel technique for endolumenal colon-wedge resection addressi...

    journal_title：Journal of the American College of Surgeons

    pub_type： 杂志文章

    doi：10.1016/j.jamcollsurg.2011.05.015

    authors： Rieder E,Martinec DV,Dunst CM,Swanström LL

    更新日期：2011-09-01 00:00:00

  • Management of pancreatic pseudocysts.

    abstract：BACKGROUND:Operative internal drainage has been standard treatment for chronic unresolved pancreatic pseudocysts (PPs). Recently, percutaneous external drainage (PED) has become the primary mode of treatment at many medical centers. STUDY DESIGN:A retrospective chart review was performed of 96 patients with PPs who we...

    journal_title：Journal of the American College of Surgeons

    pub_type： 杂志文章

    doi：10.1016/s1072-7515(98)00088-x

    authors： Spivak H,Galloway JR,Amerson JR,Fink AS,Branum GD,Redvanly RD,Richardson WS,Mauren SJ,Waring JP,Hunter JG

    更新日期：1998-05-01 00:00:00

  • Objective comparison of complications resulting from laparoscopic bariatric procedures.

    abstract：BACKGROUND:Several surgical treatment options for morbid obesity exist. Currently, there are no studies that objectively compare complication rates after laparoscopic bariatric operations performed at a single institution. We objectively classify and compare complications resulting from laparoscopic adjustable gastric ...

    journal_title：Journal of the American College of Surgeons

    pub_type： 杂志文章

    doi：10.1016/j.jamcollsurg.2005.10.003

    authors： Parikh MS,Laker S,Weiner M,Hajiseyedjavadi O,Ren CJ

    更新日期：2006-02-01 00:00:00

  • Report of a Simplified Frailty Score Predictive of Short-Term Postoperative Morbidity and Mortality.

    abstract：BACKGROUND:Frailty is an objective method of quantifying a patient's fitness for surgery. Its clinical use is limited by the time needed to complete, as well as a lack of evidence-based interventions to improve outcomes in identified frail patients. The purpose of this study was to critically analyze the components of ...

    journal_title：Journal of the American College of Surgeons

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.jamcollsurg.2015.01.053

    authors： Revenig LM,Canter DJ,Kim S,Liu Y,Sweeney JF,Sarmiento JM,Kooby DA,Maithel SK,Hill LL,Master VA,Ogan K

    更新日期：2015-05-01 00:00:00

  • Emergency laparoscopic management of perforated sigmoid diverticulitis: a promising alternative to more radical procedures.

    abstract：BACKGROUND:Classic emergency surgical management of complicated perforated sigmoid diverticulitis is based on the principle of a two-stage operation, with colon resection and temporary stoma (Hartmann's procedure). But the later second-stage operation can be technically difficult and can be associated with a significan...

    journal_title：Journal of the American College of Surgeons

    pub_type： 杂志文章

    doi：10.1016/j.jamcollsurg.2007.11.018

    authors： Bretagnol F,Pautrat K,Mor C,Benchellal Z,Huten N,de Calan L

    更新日期：2008-04-01 00:00:00

  • Advanced donor age alone does not affect patient or graft survival after liver transplantation.

    abstract：BACKGROUND:Individuals greater than 60 years old donate an important portion of the organs available for orthotopic liver transplantation (OLT), but use of donors in this age group remains controversial. We hypothesized that proper selection of donors older than age 60 would not disadvantage recipients in terms of pati...

    journal_title：Journal of the American College of Surgeons

    pub_type： 杂志文章

    doi：10.1016/j.jamcollsurg.2008.08.009

    authors： Anderson CD,Vachharajani N,Doyle M,Lowell JA,Wellen JR,Shenoy S,Lisker-Melman M,Korenblat K,Crippin J,Chapman WC

    更新日期：2008-12-01 00:00:00

  • Pathologic response to induction chemotherapy in locally advanced carcinoma of the breast: a determinant of outcome.

    abstract：BACKGROUND:The prognosis for patients with locally advanced carcinoma of the breast remains poor. This study examines the pathologic evidence of response of the mammary tumor and axillary nodes after preoperative chemotherapy. We sought to determine if there was a relationship between the histologic response and clinic...

    journal_title：Journal of the American College of Surgeons

    pub_type： 杂志文章

    doi：

    authors： Sataloff DM,Mason BA,Prestipino AJ,Seinige UL,Lieber CP,Baloch Z

    更新日期：1995-03-01 00:00:00

  • Improved long-term survival of dialysis patients after near-total parathyroidectomy.

    abstract：BACKGROUND:Severe secondary hyperparathyroidism, which is associated with life-threatening complications, can develop in dialysis-dependent end-stage renal disease patients. The aim of this study was to compare short- and long-term mortality in dialysis patients who underwent near-total parathyroidectomy (NTPTX) and ma...

    journal_title：Journal of the American College of Surgeons

    pub_type： 杂志文章

    doi：10.1016/j.jamcollsurg.2011.12.046

    authors： Sharma J,Raggi P,Kutner N,Bailey J,Zhang R,Huang Y,Herzog CA,Weber C

    更新日期：2012-04-01 00:00:00

  • GATA-3 expression as a predictor of hormone response in breast cancer.

    abstract：BACKGROUND:Expression of estrogen receptor-alpha (ERalpha) as determined by immunohistochemistry of tumor tissue is currently the most clinically useful test to predict hormone responsiveness of breast cancer. Thirty percent of ERalpha-positive breast cancers do not respond to hormonal therapy. GATA-3 is a transcriptio...

    journal_title：Journal of the American College of Surgeons

    pub_type： 杂志文章

    doi：10.1016/j.jamcollsurg.2004.12.025

    authors： Parikh P,Palazzo JP,Rose LJ,Daskalakis C,Weigel RJ

    更新日期：2005-05-01 00:00:00

  • Angiotensin Inhibition Is Associated with Preservation of T-Cell and Monocyte Function and Decreases Multiple Organ Failure in Obese Trauma Patients.

    abstract：BACKGROUND:Obese patients are more prone to post-injury multiple organ failure (MOF). Obesity pathophysiology includes an adipose-tissue-derived, renin-angiotensin-aldosterone system affecting inflammatory responses via leukocyte angiotensin receptors. We hypothesized that obese patients receiving pre-injury angiotensi...

    journal_title：Journal of the American College of Surgeons

    pub_type： 杂志文章

    doi：10.1016/j.jamcollsurg.2015.03.051

    authors： Winfield RD,Southard RE,Turnbull IR,Bochicchio K,Reese S,Freeman BD,Bochicchio GV

    更新日期：2015-08-01 00:00:00

  • Imaging or Fiber Probe-Based Approach? Assessing Different Methods to Detect Near Infrared Autofluorescence for Intraoperative Parathyroid Identification.

    abstract：BACKGROUND:Near infrared autofluorescence (NIRAF) can guide intraoperative parathyroid gland (PG) identification. NIRAF detection devices typically rely on imaging and fiber probe-based approaches. Imaging modalities provide NIRAF pictures on adjacent display monitors, and fiber probe-based systems measure tissue NIRAF...

    journal_title：Journal of the American College of Surgeons

    pub_type： 杂志文章

    doi：10.1016/j.jamcollsurg.2019.09.003

    authors： Thomas G,Squires MH,Metcalf T,Mahadevan-Jansen A,Phay JE

    更新日期：2019-12-01 00:00:00

  • Atypical variants of classic achalasia are common and currently under-recognized: a study of prevalence and clinical features.

    abstract：BACKGROUND:Advances in esophageal manometry have facilitated identification of variants of achalasia, suggesting they are more common than previously thought. This study assesses the frequency and clinical characteristics of patients with motility abnormalities similar to, but not meeting criteria for, classic achalasi...

    journal_title：Journal of the American College of Surgeons

    pub_type： 杂志文章

    doi：10.1016/j.jamcollsurg.2011.02.008

    authors： Galey KM,Wilshire CL,Niebisch S,Jones CE,Raymond DP,Litle VR,Watson TJ,Peters JH

    更新日期：2011-07-01 00:00:00

  • Caval inflow to the graft: a successful way to overcome diffuse portal system thrombosis in liver transplantation.

    abstract：:Portal vein thrombosis was considered to be a major contraindication to liver transplantation before the introduction of vessel grafts from the recipient's area of confluence of the splenic and superior mesenteric veins, behind the neck of the pancreas, to the graft's portal vein. Refinement in surgical technique has ...

    journal_title：Journal of the American College of Surgeons

    pub_type： 杂志文章

    doi：10.1016/s1072-7515(99)00299-9

    authors： Azoulay D,Hargreaves GM,Castaing D,Bismuth H

    更新日期：2000-04-01 00:00:00

  • Primary fascial closure with mesh reinforcement is superior to bridged mesh repair for abdominal wall reconstruction.

    abstract：BACKGROUND:Many surgeons believe that primary fascial closure with mesh reinforcement should be the goal of abdominal wall reconstruction (AWR), yet others have reported acceptable outcomes when mesh is used to bridge the fascial edges. It has not been clearly shown how the outcomes for these techniques differ. We hypo...

    journal_title：Journal of the American College of Surgeons

    pub_type： 杂志文章

    doi：10.1016/j.jamcollsurg.2013.08.015

    authors： Booth JH,Garvey PB,Baumann DP,Selber JC,Nguyen AT,Clemens MW,Liu J,Butler CE

    更新日期：2013-12-01 00:00:00

  • Antithrombotic therapy and endovascular stents are effective treatment for blunt carotid injuries: results from longterm followup.

    abstract：BACKGROUND:Significant confusion exists about management of blunt carotid injuries (BCI). Currently, three common treatments are being used without significant longterm followup data to demonstrate efficacy. Although heparin has been shown to reduce in-hospital stroke rates, antiplatelet therapy (aspirin and clopidogre...

    journal_title：Journal of the American College of Surgeons

    pub_type： 杂志文章

    doi：10.1016/j.jamcollsurg.2006.12.041

    authors： Edwards NM,Fabian TC,Claridge JA,Timmons SD,Fischer PE,Croce MA

    更新日期：2007-05-01 00:00:00

  • Comparative study of laparoscopy-assisted distal gastrectomy and open distal gastrectomy.

    abstract：BACKGROUND:Most studies comparing surgical results of laparoscopic procedures for gastric cancer with open gastrectomies have been conducted based on limited experience. We aimed to compare laparoscopy-assisted distal gastrectomy (LADG) and conventional open distal gastrectomy (ODG) after a protracted learning experien...

    journal_title：Journal of the American College of Surgeons

    pub_type： 杂志文章

    doi：10.1016/j.jamcollsurg.2006.02.028

    authors： Lee SI,Choi YS,Park DJ,Kim HH,Yang HK,Kim MC

    更新日期：2006-06-01 00:00:00

  • Minimally Invasive Repairs of Pectus Excavatum: Surgical Outcomes, Quality of Life, and Predictors of Reoperation.

    abstract：BACKGROUND:We sought to examine our institutional experience (1998 to 2014) with minimally invasive repairs of pectus excavatum (MIRPE). STUDY DESIGN:We conducted a retrospective review and a mailed survey (quality of life assessment). Associations with reoperation due to bar migration and recurrence after bar removal...

    journal_title：Journal of the American College of Surgeons

    pub_type： 杂志文章

    doi：10.1016/j.jamcollsurg.2015.11.020

    authors： Gibreel W,Zendejas B,Joyce D,Moir CR,Zarroug AE

    更新日期：2016-03-01 00:00:00

  • Thyroid and parathyroid operations in veterans affairs and selected university medical centers: results of the patient safety in surgery study.

    abstract：BACKGROUND:There is increasing interest in surgical outcomes. The Patient Safety in Surgery (PSS) Study database was examined about thyroid and parathyroid procedures to determine risk factors for adverse outcomes and outcomes rates. Relative outcomes performance for the Veterans Affairs (VA) and private-sector populat...

    journal_title：Journal of the American College of Surgeons

    pub_type： 杂志文章

    doi：10.1016/j.jamcollsurg.2007.02.073

    authors： Hall BL,Hirbe M,Yan Y,Khuri SF,Henderson WG,Hamilton BH

    更新日期：2007-06-01 00:00:00

  • How slow is too slow? Correlation of operative time to complications: an analysis from the Tennessee Surgical Quality Collaborative.

    abstract：BACKGROUND:The Tennessee Surgical Quality Collaborative analyzes NSQIP data from 21 participating hospitals. The Tennessee Surgical Quality Collaborative has reduced surgical complications, but causative factors are unclear. We sought to correlate surgical duration with complications to reveal mitigating strategies. S...

    journal_title：Journal of the American College of Surgeons

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.jamcollsurg.2014.12.040

    authors： Daley BJ,Cecil W,Clarke PC,Cofer JB,Guillamondegui OD

    更新日期：2015-04-01 00:00:00

  • Natural orifice translumenal endoscopic surgery used for perforated viscus repair is feasible using lower peritoneal pressures than laparoscopy in a porcine model.

    abstract：BACKGROUND:Procedure-related complications contribute to 1-year mortality in patients with perforated ulcers. Natural orifice translumenal endoscopic surgery (NOTES) might offer a new repair approach. STUDY DESIGN:Swine were randomized to laparoscopic or NOTES repair. Laparoscopic gastrotomy creation (1 cm) was follow...

    journal_title：Journal of the American College of Surgeons

    pub_type： 杂志文章

    doi：10.1016/j.jamcollsurg.2009.11.014

    authors： Moran EA,Gostout CJ,McConico AL,Bingener J

    更新日期：2010-04-01 00:00:00

  • Comparing Preoperative Targets to Failure-to-Rescue for Surgical Mortality Improvement.

    abstract：BACKGROUND:Failure-to-rescue (FTR or death after postoperative complication) is thought to explain surgical mortality excesses across hospitals, and FTR is an emerging performance measure and target for quality improvement. We compared the FTR population to preoperatively identifiable subpopulations for their potential...

    journal_title：Journal of the American College of Surgeons

    pub_type： 杂志文章

    doi：10.1016/j.jamcollsurg.2015.02.036

    authors： Hyder JA,Wakeam E,Adler JT,DeBord Smith A,Lipsitz SR,Nguyen LL

    更新日期：2015-06-01 00:00:00

  • The utility of sestamibi scanning in the operative management of patients with primary hyperparathyroidism.

    abstract：BACKGROUND:The role of imaging studies before parathyroidectomy has been extensively debated and recent advances in unilateral parathyroidectomy intensify this controversy. The purpose of this study was to review the parathyroidectomy experience of a single surgeon, looking at the role of sestamibi scans and a standard...

    journal_title：Journal of the American College of Surgeons

    pub_type： 杂志文章

    doi：10.1016/s1072-7515(00)00258-1

    authors： Dillavou ED,Jenoff JS,Intenzo CM,Cohn HE

    更新日期：2000-05-01 00:00:00

  • Laparoscopic appendectomy during pregnancy: between personal experiences and scientific evidence.

    abstract：BACKGROUND:Although laparoscopic appendectomy is a safe and effective procedure for management of acute appendicitis, data about the feasibility and safety during pregnancy are limited. We aimed to study our experience in this field and to review the scientific evidence available. STUDY DESIGN:All patients undergoing ...

    journal_title：Journal of the American College of Surgeons

    pub_type： 杂志文章

    doi：10.1016/j.jamcollsurg.2007.01.068

    authors： Moreno-Sanz C,Pascual-Pedreño A,Picazo-Yeste JS,Seoane-Gonzalez JB

    更新日期：2007-07-01 00:00:00