Bone tissue engineering: recent advances and promising therapeutic agents.


:Bone regeneration can be accomplished with growth factors, cells and delivery systems. This review is a summary of these components that may be used for tissue regeneration. Support for the potential therapeutic applications of transcription factors in bone tissue engineering will also be discussed.


Expert Opin Biol Ther


Jadlowiec JA,Celil AB,Hollinger JO





Has Abstract


2003-06-01 00:00:00












  • The role of quantitative PCR for the immune monitoring of cancer patients.

    abstract::Human tumour immunology is at a standstill whereas implemented cancer vaccines have shown effectiveness in inducing immune responses detectable in circulating lymphocytes. In most circumstances, however, such immune responses are not sufficient to induce cancer regression. This paradoxical observation could be explain...

    journal_title:Expert opinion on biological therapy

    pub_type: 杂志文章,评审


    authors: Panelli MC,Wang E,Monsurro V,Marincola FM

    更新日期:2002-06-01 00:00:00

  • Becaplermin: recombinant platelet derived growth factor, a new treatment for healing diabetic foot ulcers.

    abstract::Chronic or non-healing lower extremity ulcerations in diabetics are a significant cause of morbidity and mortality, and account for a large proportion of the financial burden related to the care of diabetics. Lower extremity ulcerations develop primarily as a consequence of neuropathy and the goal in addressing any wo...

    journal_title:Expert opinion on biological therapy

    pub_type: 杂志文章,评审


    authors: Nagai MK,Embil JM

    更新日期:2002-02-01 00:00:00

  • Meningococcal tetravalent conjugate vaccine.

    abstract:BACKGROUND:Neisseria meningitidis is a leading cause of meningitis and sepsis worldwide. Since 1981, a tetravalent meningococcal polysaccharide vaccine has been available in the US but it has been limited to high-risk patients and outbreak settings. In 2005, a tetravalent polysaccharide meningococcal conjugate vaccine ...

    journal_title:Expert opinion on biological therapy

    pub_type: 杂志文章,评审


    authors: Smith MJ

    更新日期:2008-12-01 00:00:00

  • Preclinical models of multiple myeloma: a critical appraisal.

    abstract:INTRODUCTION:Preclinical models, by definition, are an approximation of reality, and their use in developing anticancer drugs is eagerly explored. Positive clinical correlations have been identified with different test systems, in addition to limitations and a need to improve preclinical model systems. Predicting wheth...

    journal_title:Expert opinion on biological therapy

    pub_type: 杂志文章,评审


    authors: Schüler J,Ewerth D,Waldschmidt J,Wäsch R,Engelhardt M

    更新日期:2013-06-01 00:00:00

  • Inhibiting the TGF-beta signalling pathway as a means of cancer immunotherapy.

    abstract::Cancers have developed numerous mechanisms for escaping the immune response, either by successfully evading a fully functional immune system or by actively suppressing the immune system so that they are no longer recognised or effectively eliminated. Current evidence supports active cancer cell-mediated immunosuppress...

    journal_title:Expert opinion on biological therapy

    pub_type: 杂志文章,评审


    authors: Kirkbride KC,Blobe GC

    更新日期:2003-04-01 00:00:00

  • Dendritic cell-based vaccines and therapies for cancer.

    abstract::Dendritic cells (DCs) are the most potent professional antigen-presenting cells (APCs), and are capable of stimulating naive T cells and driving primary immune responses. Due to this unique property, DCs represent both vectors and targets for immunological intervention in numerous diseases and are optimal candidates f...

    journal_title:Expert opinion on biological therapy

    pub_type: 杂志文章,评审


    authors: Tatsumi T,Storkus WJ

    更新日期:2002-12-01 00:00:00

  • A review of current progress in gene and stem cell therapy for erectile dysfunction.

    abstract:BACKGROUND:Current gene-based strategies for treatment of erectile dysfunction (ED) are based on the nitric oxide (NO)/cGMP system; although growth factors, calcium sensitization, and potassium channel expression have been studied. Initial investigations of stem-cell-based therapy have attracted attention. Results of t...

    journal_title:Expert opinion on biological therapy

    pub_type: 杂志文章,评审


    authors: Gur S,Kadowitz PJ,Hellstrom WJ

    更新日期:2008-10-01 00:00:00

  • The immunological challenges of malaria vaccine development.

    abstract::Malaria remains an important public health problem throughout the tropical world causing immense human suffering and impeding economic development. Despite extensive research for > 100 years, options for preventing malaria remain limited to vector control and chemoprophylaxis. The complexity of the organism and its li...

    journal_title:Expert opinion on biological therapy

    pub_type: 杂志文章,评审


    authors: Wipasa J,Riley EM

    更新日期:2007-12-01 00:00:00

  • Efficacy and safety of HLA-B7/beta-2 microglobulin plasmid DNA/lipid complex (Allovectin-7) in patients with metastatic melanoma.

    abstract::Human leukocyte antigen (HLA)-B7/beta-2 microglobulin plasmid DNA/lipid complex, otherwise known as Allovectin-7 (Vical, Inc., San Diego, CA, USA), has been developed as a non-viral gene delivery product. After multiple laboratory and human trials, it appears that the concept of gene transfer has established itself as...

    journal_title:Expert opinion on biological therapy

    pub_type: 杂志文章,评审


    authors: Bergen M,Chen R,Gonzalez R

    更新日期:2003-04-01 00:00:00

  • Hepatocyte growth factor gene therapy for islet transplantation.

    abstract::Recent clinical studies have documented that human islet transplantation has the potential to replace pancreatic endocrine function in patients with type 1 diabetes. These studies have also highlighted an enormous shortage of human islets that impedes the use of islet transplantation in clinical practice on a larger s...

    journal_title:Expert opinion on biological therapy

    pub_type: 杂志文章,评审


    authors: Rao P,Cozar-Castellano I,Roccisana J,Vasavada RC,Garcia-Ocaña A

    更新日期:2004-04-01 00:00:00

  • Nasal drug delivery.

    abstract::The Nasal Drug Delivery Conference was held at the Institute of Directors in London, England. The meeting was organised by the Management Forum Ltd and chaired by P Seeney (PA Consulting, UK) and Professor F Merkus (Leiden University, The Netherlands; Innoscience Technology, Belgium). The conference covered a wide ran...

    journal_title:Expert opinion on biological therapy



    authors: Suman JD

    更新日期:2003-06-01 00:00:00

  • Recent developments in transposon-mediated gene therapy.

    abstract:INTRODUCTION:The continuous improvement of gene transfer technologies has broad implications for stem cell biology, gene discovery, and gene therapy. Although viral vectors are efficient gene delivery vehicles, their safety, immunogenicity and manufacturing challenges hamper clinical progress. In contrast, non-viral ge...

    journal_title:Expert opinion on biological therapy

    pub_type: 杂志文章,评审


    authors: Di Matteo M,Belay E,Chuah MK,Vandendriessche T

    更新日期:2012-07-01 00:00:00

  • Peginterferon α in the treatment of chronic hepatitis B.

    abstract:INTRODUCTION:Hepatitis B virus (HBV) infection is a global health problem. Peginterferon α (PEG-IFN), which includes PEG-IFN α-2a (Pegasys) and PEG-IFN α-2b (Peg-Intron), can be used to treat patients with chronic hepatitis B (CHB) infection. A finite duration of PEG-IFN therapy may lead to long-term viral suppression....

    journal_title:Expert opinion on biological therapy

    pub_type: 杂志文章,评审


    authors: Tseng TC,Kao JH,Chen DS

    更新日期:2014-07-01 00:00:00

  • Interleukin-2 receptor blockade with humanized monoclonal antibody for solid organ transplantation.

    abstract:IMPORTANCE OF THE FIELD:Induction therapy has reduced the incidence of acute rejection compared with historical standards. The potency of currently available induction immunosuppression is not without risk and should be carefully considered. Induction with daclizumab, an IL-2 receptor antagonist, has been used safely a...

    journal_title:Expert opinion on biological therapy

    pub_type: 杂志文章,评审


    authors: Campara M,Tzvetanov IG,Oberholzer J

    更新日期:2010-06-01 00:00:00

  • Nivolumab for the treatment of bladder cancer.

    abstract:INTRODUCTION:The checkpoint inhibitor nivolumab has recently demonstrated effectiveness against metatstatic urothelial carcinoma. Nivolumab is a fully human monoclonal antibody blocking PD-1 and thereby enhancing antitumour immune mechanisms. Areas covered: In this review, the authors describe the treatment of metastat...

    journal_title:Expert opinion on biological therapy

    pub_type: 杂志文章


    authors: Hakenberg OW

    更新日期:2017-10-01 00:00:00

  • Immunome-derived vaccines.

    abstract::Immune response to a subset of antigens and epitopes derived from an infectious pathogen may be sufficient for competent protection; immune recognition of every potential epitope derived from the pathogen's genome does not appear to be required. The pneumococcal and hepatitis vaccines, both of which are subunit vaccin...

    journal_title:Expert opinion on biological therapy

    pub_type: 社论


    authors: De Groot AS

    更新日期:2004-06-01 00:00:00

  • The future of immunotherapy for sarcoma.

    abstract:INTRODUCTION:The use of immunotherapeutic challenges for sarcoma has a long history. Despite the existence of objective responses, immunotherapy has been overshadowed by the results of chemotherapy, especially for osteosarcoma. However, the prognosis for non-responders to chemotherapy is still poor and immunotherapy is...

    journal_title:Expert opinion on biological therapy

    pub_type: 杂志文章,评审


    authors: Tsukahara T,Emori M,Murata K,Mizushima E,Shibayama Y,Kubo T,Kanaseki T,Hirohashi Y,Yamashita T,Sato N,Torigoe T

    更新日期:2016-08-01 00:00:00

  • Engineered adenovirus serotypes for overcoming anti-vector immunity.

    abstract::Adenovirus (Ad)-based gene transfer has been successfully utilised in gene therapy and vaccine applications. To date, an increasing number of human clinical trials utilise recombinant Ad-based vectors as a gene transfer platform. In particular, progress has been made recently in utilising Ad-based vectors as a vaccine...

    journal_title:Expert opinion on biological therapy

    pub_type: 杂志文章,评审


    authors: Dharmapuri S,Peruzzi D,Aurisicchio L

    更新日期:2009-10-01 00:00:00

  • Adjuvant treatment of breast cancer: impact of monoclonal antibody therapy directed against the HER2 receptor.

    abstract::The use of chemotherapy and endocrine therapies as adjuncts to the treatment of early-stage breast cancer has yielded small but significant improvements in disease-free and overall survival. Increased understanding of the role of growth factor receptors enabled the rational development of agents that are capable of mo...

    journal_title:Expert opinion on biological therapy

    pub_type: 杂志文章,评审


    authors: Simonds HM,Miles D

    更新日期:2007-04-01 00:00:00

  • Atoh1 gene therapy in the cochlea for hair cell regeneration.

    abstract:INTRODUCTION:The sensory epithelium of the cochlea is a complex structure containing hair cells, supporting cells and auditory nerve endings, all of which degenerate after hearing loss in mammals. Biological approaches are being considered to preserve and restore the sensory epithelium after hearing loss. Of particular...

    journal_title:Expert opinion on biological therapy

    pub_type: 杂志文章,评审


    authors: Richardson RT,Atkinson PJ

    更新日期:2015-03-01 00:00:00

  • Drug delivery to the retina: challenges and opportunities.

    abstract::Retinal drug delivery is a challenging area in the field of ophthalmic drug delivery. An ideal drug delivery system for the retina and vitreous humor has not yet been found, despite extensive research. Drug delivery to retinal tissue and vitreous via systemic administration is constrained due to the presence of a bloo...

    journal_title:Expert opinion on biological therapy

    pub_type: 杂志文章,评审


    authors: Duvvuri S,Majumdar S,Mitra AK

    更新日期:2003-02-01 00:00:00

  • Dendritic cell vaccine strategies for renal cell carcinoma.

    abstract::Dendritic cell (DC) vaccines are an important experimental immunotherapy for renal cell carcinomas. DC vaccines have proven safe, but only minimal clinical efficacy has been observed to date. DC vaccine strategies reflect the continually evolving understanding of DC biology. The use of mature DCs is particularly impor...

    journal_title:Expert opinion on biological therapy

    pub_type: 杂志文章,评审


    authors: Schendel DJ

    更新日期:2007-02-01 00:00:00

  • Oncolytic vaccinia virus for the treatment of cancer.

    abstract:INTRODUCTION:Gene therapy offers promising approaches for the development of anticancer agents with new modes of action. Among gene therapy vectors, vaccinia virus has emerged as an attractive agent especially when used as an oncolytic virus. AREAS COVERED:This review describes the use of vaccinia virus in cancer ther...

    journal_title:Expert opinion on biological therapy

    pub_type: 杂志文章,评审


    authors: Guse K,Cerullo V,Hemminki A

    更新日期:2011-05-01 00:00:00

  • γδ cell-based immunotherapy for cancer.

    abstract::Introduction: Cancer immunotherapy relies on the development of an efficient and long-lasting anti-tumor response, generally mediated by cytotoxic T cells. γδ T cells possess distinctive features that justify their use in cancer immunotherapy. Areas covered: Here we will review our current knowledge on the functions o...

    journal_title:Expert opinion on biological therapy

    pub_type: 杂志文章,评审


    authors: Lo Presti E,Corsale AM,Dieli F,Meraviglia S

    更新日期:2019-09-01 00:00:00

  • The role of adjuvants in the development of mucosal vaccines.

    abstract::It is well-established that most pathogens that cause infectious diseases enter the host via mucosal membranes of the respiratory, digestive and genital tracts. Some parenterally administered vaccines induce protection against mucosal pathogens. However, there is increasing evidence that mucosal protection is better a...

    journal_title:Expert opinion on biological therapy

    pub_type: 杂志文章,评审


    authors: Vajdy M,Singh M

    更新日期:2005-07-01 00:00:00

  • Oncolytic virotherapy for multiple myeloma.

    abstract:BACKGROUND:Current therapies for multiple myeloma (MM) are not curative, thus novel targeted therapeutics are being developed. One such targeted therapy is oncolytic virotherapy, wherein viruses specifically infect and kill the malignant plasma cells, leaving normal cells intact. OBJECTIVE:This review provides an over...

    journal_title:Expert opinion on biological therapy

    pub_type: 杂志文章,评审


    authors: Stief AE,McCart JA

    更新日期:2008-04-01 00:00:00

  • Current concepts in stem cell therapy for articular cartilage repair.

    abstract:INTRODUCTION:Hyaline articular cartilage is the connective tissue responsible for frictionless joint movement. Its degeneration ultimately results in complete loss of joint function in the late stages of osteoarthritis. Intrinsic repair is compromised, and cartilage tissue regeneration is difficult. However, new option...

    journal_title:Expert opinion on biological therapy

    pub_type: 杂志文章,评审


    authors: Muhammad H,Schminke B,Miosge N

    更新日期:2013-04-01 00:00:00

  • Bevacizumab in the treatment of colorectal cancer.

    abstract::Colorectal cancer is a common disease with therapy that has a proven effectiveness in the adjuvant and metastatic setting. Bevacizumab, a vascular endothelial growth factor inhibitor, is an antiangiogenesis monoclonal antibody that has benefit in response rate and overall survival when used in combination with existin...

    journal_title:Expert opinion on biological therapy

    pub_type: 杂志文章,评审


    authors: Cilley JC,Barfi K,Benson AB 3rd,Mulcahy MF

    更新日期:2007-05-01 00:00:00

  • T regulatory cells as an immunotherapy for transplantation.

    abstract::Advances in immunosuppressive therapies have made tissue and organ transplantation a common procedure in clinical medicine. However, true donor and recipient tolerance is not regularly achieved and almost all transplant recipients continue to require immunosuppressants throughout life, which is associated with side ef...

    journal_title:Expert opinion on biological therapy

    pub_type: 杂志文章,评审


    authors: Albert MH,Anasetti C,Yu XZ

    更新日期:2006-04-01 00:00:00

  • Role of neuropeptides in skin inflammation and its involvement in diabetic wound healing.

    abstract:IMPORTANCE OF THE FIELD:In 2010, the world prevalence of diabetes is 6.4%, affecting 285 million adults. Diabetic patients are at risk of developing neuropathy and delayed wound healing that can culminate in incurable diabetic foot ulcerations (DFUs) or even foot amputation. AREAS COVERED IN THIS REVIEW:The contrast b...

    journal_title:Expert opinion on biological therapy

    pub_type: 杂志文章,评审


    authors: da Silva L,Carvalho E,Cruz MT

    更新日期:2010-10-01 00:00:00