Bone tissue engineering: recent advances and promising therapeutic agents.

abstract：INTRODUCTION:Statins are currently the most commonly used agents for treatment of hypercholesterolemia in patients with atherosclerotic cardiovascular disease. However, some patients on statins do not achieve their treatment goals or are intolerant to statins. Therefore, new therapies for treatment of hypercholesterole...

journal_title：Expert opinion on biological therapy

authors： Valerio MG,Velayati A,Jain D,Aronow WS

更新日期：2016-01-01 00:00:00

abstract：:Gene-based modulation of immune functions is a promising means of eliciting protective immunity and induction of tolerance. Novel viral and non-viral DNA delivery systems are being investigated to achieve efficient gene transfer into mammalian cells. Antigen-presenting cells (APCs), in particular dendritic cells, are ...

journal_title：Expert opinion on biological therapy

authors： Meng WS,Butterfield LH

更新日期：2005-08-01 00:00:00

abstract：INTRODUCTION:The study of the endocrine compartment of the pancreas (the islets of Langerhans) is of great translational interest, as strategies aimed at restoring its mass could become therapies for glycemic dysregulation in type 1 and 2 diabetes mellitus, drug-related diabetes following diabetogenic therapies or hype...

journal_title：Expert opinion on biological therapy

authors： Domínguez-Bendala J,Inverardi L,Ricordi C

更新日期：2012-06-01 00:00:00

abstract：:Recent mechanistic studies on the role of heat-shock proteins (HSPs) to induce innate and adaptive immune responses have resulted in conflicting reports. Whereas some groups reported that HSPs have direct immunological function, others emphasised the endotoxin contamination of HSP preparations and questioned the antig...

journal_title：Expert opinion on biological therapy

authors： Manjili MH,Wang XY,MacDonald IJ,Arnouk H,Yang GY,Pritchard MT,Subjeck JR

更新日期：2004-03-01 00:00:00

abstract：:The lysosomal storage disorders (LSD) are monogenic inborn errors of metabolism with heterogeneous pathophysiology and clinical manifestations. In the last decades, these disorders have been models for the development of molecular and cellular therapies for inherited metabolic diseases. Studies in preclinical in vitro...

journal_title：Expert opinion on biological therapy

authors： Barranger JM,Novelli EA

更新日期：2001-09-01 00:00:00

abstract：:Daclizumab is a humanized monoclonal antibody which binds to the IL-2 receptor on activated lymphocytes and blocks the production of IL-2. Its use is well established in solid organ transplantation as induction therapy, especially in high-risk patients where reduction or delayed dose of standard immunosuppression woul...

journal_title：Expert opinion on biological therapy

authors： Mottershead M,Neuberger J

更新日期：2007-10-01 00:00:00

abstract：INTRODUCTION:Melanocytes produce pigment granules that color both skin and hair. In the hair follicles melanocytes are derived from stem cells (MelSCs) that are present in hair bulges or sub-bulge regions and function as melanocyte reservoirs. Quiescence, maintenance, activation and proliferation of MelSCs are controll...

journal_title：Expert opinion on biological therapy

authors： Lee JH,Fisher DE

更新日期：2014-11-01 00:00:00

abstract：:Psoriasis is an immune-mediated disease in which memory-effector (CD45RO+), skin-homing T cells play a key role in driving the disease process. Available therapies are often poorly tolerated, none are curative and most only suppress disease symptoms without attacking the underlying cause of the illness. Alefacept (Ame...

journal_title：Expert opinion on biological therapy

authors： Krueger GG

更新日期：2002-04-01 00:00:00

abstract：:Tumor necrosis factor (TNF)-alpha has been thoroughly investigated and established as a pivotal component of the inflammatory cascade. This review encompasses the safety and efficacy of TNF antagonists in rheumatoid arthritis, the interplay between rheumatoid arthritis and heart failure, as well as presentation of the...

journal_title：Expert opinion on biological therapy

authors： Mousa SA,Goncharuk O,Miller D

更新日期：2007-05-01 00:00:00

abstract：IMPORTANCE OF THE FIELD:In the USA only 35% of patients with hypertension achieve adequate blood pressure control. Non-compliance is one of the main barriers to treatment. Vaccine against hypertension is an innovative treatment, injected every 4 - 6 months, to combat non-compliance. AREAS COVERED IN THIS REVIEW:Pathog...

journal_title：Expert opinion on biological therapy

authors： Do TH,Chen Y,Nguyen VT,Phisitkul S

更新日期：2010-07-01 00:00:00

abstract：INTRODUCTION:Atopic dermatitis (AD) is a chronic inflammatory skin condition characterized by erythematous lesions, pruritus, and a skin barrier defect. Long-term treatment in children is challenging, as there is only one Food and Drug Administration-approved systemic medication. Current treatments may have limited eff...

journal_title：Expert opinion on biological therapy

authors： Ghamrawi R,Bell KA,Balogh EA,Strowd LC,Feldman SR

更新日期：2020-12-01 00:00:00

abstract：INTRODUCTION:Kidney diseases are a global public health problem whose incidence is rapidly growing due to a global rise in the aged population and the increasing prevalence of cardiovascular disease, hypertension and diabetes. With the emergence of stem cells as potential therapeutic agents, attempts in using them to s...

journal_title：Expert opinion on biological therapy

authors： Lazzeri E,Romagnani P,Lasagni L

更新日期：2015-01-01 00:00:00

abstract：INTRODUCTION:The actin-sequestering thymosin beta4 (Tβ4) is the most abundant member of the β-thymosins, and is widely expressed in the central nervous system (CNS), but its functions in the healthy and diseased brain are poorly understood. The expression of Tβ4 in neurons and microglia, the resident immune cells of th...

journal_title：Expert opinion on biological therapy

authors： Pardon MC

更新日期：2018-07-01 00:00:00

abstract：:Background: Pemphigus vulgaris is an autoimmune blistering disease affecting the skin and mucous membranes. Current treatments for pemphigus vulgaris include anti-inflammatory and immunosuppressive agents. Rituximab, an anti-CD20 monoclonal antibody, has been shown to be effective for the treatment of pemphigus vulgar...

journal_title：Expert opinion on biological therapy

authors： Russo I,Miotto S,Saponeri A,Alaibac M

更新日期：2020-06-01 00:00:00

abstract：BACKGROUND:Neisseria meningitidis is a leading cause of meningitis and sepsis worldwide. Since 1981, a tetravalent meningococcal polysaccharide vaccine has been available in the US but it has been limited to high-risk patients and outbreak settings. In 2005, a tetravalent polysaccharide meningococcal conjugate vaccine ...

journal_title：Expert opinion on biological therapy

authors： Smith MJ

更新日期：2008-12-01 00:00:00

abstract：INTRODUCTION:Fibrin sealants (FS) have been approved for use in the United States since 1998. Since approval, they have been used in a wide variety of clinical settings and new products continue to be introduced. AREAS COVERED:This review covers the literature supporting the USA FDA-approved indications for FS product...

journal_title：Expert opinion on biological therapy

authors： Mandell SP,Gibran NS

更新日期：2014-06-01 00:00:00

abstract：INTRODUCTION:Preclinical models, by definition, are an approximation of reality, and their use in developing anticancer drugs is eagerly explored. Positive clinical correlations have been identified with different test systems, in addition to limitations and a need to improve preclinical model systems. Predicting wheth...

journal_title：Expert opinion on biological therapy

authors： Schüler J,Ewerth D,Waldschmidt J,Wäsch R,Engelhardt M

更新日期：2013-06-01 00:00:00

abstract：INTRODUCTION:Rheumatoid arthritis (RA) demonstrates a high heterogeneity in clinical responses to treatment. Although the efficacy of biological therapy has undoubtedly been established, the response differs considerably between individuals. This variability between individuals has aroused the research for biomarkers p...

journal_title：Expert opinion on biological therapy

authors： Xie X,Zhang D,Chen JW,Tian J,Ling GH,Li F

更新日期：2014-02-01 00:00:00

abstract：:The concept of in utero stem cell transplantation has provided hope that at least some of the genetic disorders which can be diagnosed prenatally can be treated before the pathological sequelae become manifested. Our increasing knowledge of haematopoietic stem cell biology has provided further possibilities for optimi...

journal_title：Expert opinion on biological therapy

authors： Jones DR

更新日期：2001-03-01 00:00:00

abstract：INTRODUCTION:Glycans are increasingly important in the development of new biopharmaceuticals with optimized efficacy, half-life, and antigenicity. Current expression platforms for recombinant glycoprotein therapeutics typically do not produce homogeneous glycans and frequently display non-human glycans which may cause ...

journal_title：Expert opinion on biological therapy

authors： Dicker M,Strasser R

更新日期：2015-01-01 00:00:00

abstract：:The key role and contribution of various pro-inflammatory cytokines in common chronic inflammatory disorders such as inflammatory bowel disease (IBD) has been thoroughly investigated in recent years. Besides IL-1, TNF-alpha has been identified as one of the central immune mediators controlling inflammatory processes. ...

journal_title：Expert opinion on biological therapy

authors： Tilg H,Kaser A

更新日期：2002-10-01 00:00:00

abstract：IMPORTANCE OF THE FIELD:The therapeutic use of platelet-rich plasma (PRP) is an autologous biotechnology that relies on the local delivery of a wide range of growth factors and cytokines with the aim of enhancing tissue healing. Understanding both tendon healing and PRP therapies is an area of research that is critical...

journal_title：Expert opinion on biological therapy

authors： Andia I,Sanchez M,Maffulli N

更新日期：2010-10-01 00:00:00

abstract：IMPORTANCE OF THE FIELD:Viral oncolysis, or virotherapy, is an emerging strategy for the treatment of cancer based on tumor cell killing by virus infection and replication. Oncolytic adenoviruses have shown promise in clinical trials, which demonstrated proof-of-concept for tumor-selective virus replication and a favor...

journal_title：Expert opinion on biological therapy

authors： Pei DS,Zheng JN

更新日期：2010-06-01 00:00:00

abstract：:Advances in immunosuppressive therapies have made tissue and organ transplantation a common procedure in clinical medicine. However, true donor and recipient tolerance is not regularly achieved and almost all transplant recipients continue to require immunosuppressants throughout life, which is associated with side ef...

journal_title：Expert opinion on biological therapy

authors： Albert MH,Anasetti C,Yu XZ

更新日期：2006-04-01 00:00:00

abstract：:Introduction: Although viruses have generally been considered as pathogens ever since their discovery, recent research has revealed that they might assume a more important role in the survival and evolution of their hosts. Besides this, they also hold the potential as therapies for the treatment of infections, cancers...

journal_title：Expert opinion on biological therapy

authors： Zhang Q,Wu W,Zhang J,Xia X

更新日期：2020-12-30 00:00:00

abstract：INTRODUCTION:In hemophilia, advanced therapies are warranted from a conceptual and methodological standpoint. Current advanced therapy strategies are centered on the use of adeno-associated viral vectors, although problems related to immunogenicity and hepatotoxicity still remain. AREAS COVERED:Future clinical trials ...

journal_title：Expert opinion on biological therapy

authors： Liras A

更新日期：2015-05-01 00:00:00

abstract：:The First International Symposium on Melanoma and Other Cutaneous Malignancies, held in New York City on 23-25 April 2004, brought together researchers and clinicians from all over the world to discuss recent advances in the prevention, treatment and diagnosis of melanoma and other cutaneous malignancies. Discussion t...

journal_title：Expert opinion on biological therapy

authors： Tarhini AA,Agarwala SS

更新日期：2004-09-01 00:00:00

abstract：:Neovascularisation is a promising alternative therapeutic approach to re-establish blood flow in ischaemic tissues of patients suffering from coronary artery or peripheral artery disease. Often, these patients are not suitable candidates for current revascularisation procedures such as coronary angioplasty or bypass s...

journal_title：Expert opinion on biological therapy

authors： Ennett AB,Mooney DJ

更新日期：2002-12-01 00:00:00

abstract：INTRODUCTION:Brain-derived neurotrophic factor (BDNF) has been implicated in wide range of neurological diseases and injury. This neurotrophic factor is vital for neuronal health, survival, and synaptic connectivity. Many therapies focus on the restoration or enhancement of BDNF following injury or disease progression....

journal_title：Expert opinion on biological therapy

authors： Deng P,Anderson JD,Yu AS,Annett G,Fink KD,Nolta JA

更新日期：2016-08-01 00:00:00

abstract：:The thymus is an endocrine organ. A unified, physiological concept of humoral regulation of the immune response emerged in the last three decades. The thymus is the primary major site of production of immunocompetent T-lymphocytes from their haematopoietic stem cells. The thymus provides a superior humoral microenviro...

journal_title：Expert opinion on biological therapy

authors： Bodey B

更新日期：2001-01-01 00:00:00