Myelodysplastic syndrome following therapy for brain tumor--two case reports.

Abstract:

:A 3-month-old boy and a 29-year-old woman presented with myelodysplastic syndrome (MDS) following therapy for primary malignant brain tumor. Both received intensive alkylating agent doses for induction and maintenance chemotherapy combined with craniospinal or cranial radiation for medulloblastoma and anaplastic astrocytoma, respectively. They developed refractory anemia and pancytopenia. Approximately 9 years after the completion of induction chemoradiotherapy, chromosomal analysis of bone marrow cells resulted in the diagnosis of MDS. The boy died of leukemic evolution 15 months later, the woman died of hematopoietic failure 3 months later. The most common symptom of MDS is refractory anemia, either alone or as part of bi- or pancytopenia. Clonal proliferation with chromosomal analysis of bone marrow cells establishes the diagnosis of MDS. Patients with malignant brain tumors are at risk of the development of MDS as a late complication of chemotherapy based on high cumulative doses of alkylating agents.

authors

Sugiyama K,Kurisu K,Arita K,Taniguchi E,Okamura T,Itoh Y,Yamasaki F,Kajiwara Y,Ueda H,Sakai A

doi

10.2176/nmc.42.170

keywords:

subject

Has Abstract

pub_date

2002-04-01 00:00:00

pages

170-4

issue

4

eissn

0470-8105

issn

1349-8029

pii

JST.JSTAGE/nmc/42.170

journal_volume

42

pub_type

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