Abstract:
:A 3-month-old boy and a 29-year-old woman presented with myelodysplastic syndrome (MDS) following therapy for primary malignant brain tumor. Both received intensive alkylating agent doses for induction and maintenance chemotherapy combined with craniospinal or cranial radiation for medulloblastoma and anaplastic astrocytoma, respectively. They developed refractory anemia and pancytopenia. Approximately 9 years after the completion of induction chemoradiotherapy, chromosomal analysis of bone marrow cells resulted in the diagnosis of MDS. The boy died of leukemic evolution 15 months later, the woman died of hematopoietic failure 3 months later. The most common symptom of MDS is refractory anemia, either alone or as part of bi- or pancytopenia. Clonal proliferation with chromosomal analysis of bone marrow cells establishes the diagnosis of MDS. Patients with malignant brain tumors are at risk of the development of MDS as a late complication of chemotherapy based on high cumulative doses of alkylating agents.
journal_name
Neurol Med Chir (Tokyo)journal_title
Neurologia medico-chirurgicaauthors
Sugiyama K,Kurisu K,Arita K,Taniguchi E,Okamura T,Itoh Y,Yamasaki F,Kajiwara Y,Ueda H,Sakai Adoi
10.2176/nmc.42.170keywords:
subject
Has Abstractpub_date
2002-04-01 00:00:00pages
170-4issue
4eissn
0470-8105issn
1349-8029pii
JST.JSTAGE/nmc/42.170journal_volume
42pub_type
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