Abstract:
:The combination of immunization strategies with gene therapy methods constitutes a powerful tool for the purpose of genetic immunization. The cutaneous microenvironment, rich in professional antigen-presenting cells and accessory cells capable of initiating and controlling the intensity of specific immune responses, makes the skin a unique target for the expression of transgenic antigens. The fact that epidermal and dermal dendritic cells can be directly transfected using genetically engineered vectors allows in vivo manipulation of immune responses by modifying the function of these distinctive antigen-presenting cell populations. Importantly, coexpression of antigenic proteins together with immunostimulatory molecules, and/or adjuvant or leader sequences, makes possible the engineering of antigen-specific immune responses. Even though most of the mechanisms related to DNA immunization remain to be explored, the skin has emerged as an ideal target for evolving genetic vaccination techniques.
journal_name
Hum Gene Therjournal_title
Human gene therapyauthors
Larregina AT,Falo LD Jrdoi
10.1089/104303400750035852keywords:
subject
Has Abstractpub_date
2000-11-01 00:00:00pages
2301-5issue
16eissn
1043-0342issn
1557-7422journal_volume
11pub_type
杂志文章,评审abstract::NKG2D ligands (NKG2DLs) are widely expressed on ovarian cancers to various degrees, making them attractive targets for immunotherapy. Here, we applied a chimeric antigen receptor (CAR) approach for the targeting of NKG2DLs expressed on human ovarian cancer cells and evaluated the impact of pharmacological upregulation...
journal_title:Human gene therapy
pub_type: 杂志文章
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journal_title:Human gene therapy
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doi:10.1089/104303404323142060
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pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:Human gene therapy
pub_type: 杂志文章
doi:10.1089/hum.2018.027
更新日期:2018-10-01 00:00:00
abstract::Abstract Our studies have shown that coinjection of conventional single-stranded adeno-associated virus 2 (ssAAV2) vectors carrying the enhanced green fluorescent protein (EGFP) gene with self-complementary (sc) AAV2-T cell protein tyrosine phosphatase (TC-PTP) and scAAV2-protein phosphatase-5 (PP5) vectors resulted i...
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pub_type: 杂志文章
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更新日期:2010-03-01 00:00:00
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journal_title:Human gene therapy
pub_type: 杂志文章
doi:10.1089/hum.1996.7.1-71
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abstract::DNA vaccination is an attractive approach for tumor immunotherapy because of its stability and simplicity of delivery. Advances demonstrate that helper T cell responses play a critical role in initiating immune responses. The aim of the current study is to test whether targeting HPV-16 E7 to the endosomal/lysosomal co...
journal_title:Human gene therapy
pub_type: 杂志文章
doi:10.1089/10430349950016474
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abstract::Malignant pleural mesothelioma (MPM) is a fatal disease with a median survival of less than 14 months. For the first time, a genetically engineered vaccinia virus is shown to produce efficient infection, replication, and oncolytic effect against MPM. GLV-1h68 is a replication-competent engineered vaccinia virus carryi...
journal_title:Human gene therapy
pub_type: 杂志文章
doi:10.1089/hum.2008.036
更新日期:2008-08-01 00:00:00
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journal_title:Human gene therapy
pub_type: 杂志文章
doi:10.1089/hum.2014.070
更新日期:2015-01-01 00:00:00
abstract::Immunotherapy with whole cell cancer vaccines has been tested in various tumor types. This study investigated the safety profile and antitumor activity of an allogeneic prostate carcinoma cell line, LNCaP, expressing recombinant human interleukin-2 and human interferon-gamma. Thirty HLA-A*0201-matched patients with pr...
journal_title:Human gene therapy
pub_type: 杂志文章
doi:10.1089/hum.2009.101
更新日期:2009-12-01 00:00:00
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journal_title:Human gene therapy
pub_type: 杂志文章,评审
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更新日期:2016-10-01 00:00:00
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journal_title:Human gene therapy
pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:2018-10-01 00:00:00
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journal_title:Human gene therapy
pub_type: 杂志文章
doi:10.1089/10430349950017059
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journal_title:Human gene therapy
pub_type: 杂志文章
doi:10.1089/hum.1998.9.7-1093
更新日期:1998-05-01 00:00:00
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pub_type: 杂志文章
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更新日期:2019-02-01 00:00:00
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journal_title:Human gene therapy
pub_type: 杂志文章
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更新日期:1998-06-10 00:00:00
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pub_type: 杂志文章
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更新日期:2011-06-01 00:00:00
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pub_type: 杂志文章
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journal_title:Human gene therapy
pub_type: 杂志文章
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