Abstract：
:After some preliminary remarks of a biochemical and pharmacological nature, the authors have started a clinical study to test the antiinflammatory activity of the S-adenosyl-methionine (SAMe). An open trial, carried out on 90 patients with severe degenerative arthropathies has shown that 30 mg SAMe intravenously twice a day for 14 days have a marked anti-inflammatory effect a rather term and no side-effects. In a "double-crossover" investigation, SAMe was next compared to indomethacin by i.m. administrations to 15 arthropathic patients. The therapeutic responses of the two drugs proved exactly alike, whereas the side-effects following indomethacin administration were not present after SAMe. In 9 patients affected with rheumatoid arthritis administrations of SAMe have proved less effective, although some clinical parameters showed improvements.
journal_name
Minerva Medjournal_title
Minerva medicaauthors
Polli E,Cortellaro M,Parrini L,Tessari L,Chériè Lignière Gkeywords:
subject
Has Abstractpub_date
1975-12-05 00:00:00pages
4443-59issue
83eissn
0026-4806issn
1827-1669journal_volume
66pub_type
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