当前位置： SCI文献检索 > BRAIN & DEVELOPMENT期刊下所有文献 > Gene expression related to cholesterol metabolism in mouse brain during development.

Gene expression related to cholesterol metabolism in mouse brain during development.

Abstract：

:Although a large amount of cholesterol is known to be needed for brain maturation and differentiation, cholesterol metabolism during these periods remains unclear. To elucidate the developmental regulation of cholesterol metabolism in the brain, we investigated the expression of 3-hydroxy-3-methyglutaryl-coenzyme A (HMG-CoA) reductase (EC 1.1.1.34), low-density-lipoprotein (LDL) receptor and very-low-density-lipoprotein (VLDL)/apolipoprotein E (apo E) receptor (VLDL receptor) using RNase protection assay (RPA) to quantitate mRNA levels in mouse brain, liver and kidney during development. Messenger RNA levels of HMG-CoA reductase in the brain decreased with age, and those levels at -5 (5 days before birth) and 5 days after birth were significantly higher than the control level of adult mice. The period from -5 to 5 days might correspond to stages of active biogenesis of the membranes of brain cells. The mRNA level of HMG-CoA reductase in the liver was also high at -5 days; a finding that correlated with cell proliferation. On the other hand, mRNA levels of the LDL and VLDL receptors in the brain did not change markedly during development. These results suggest that de novo cholesterol biosynthesis in brain cells plays a major role in the supply of cholesterol to the developing brain, rather than the uptake of cholesterol from serum lipoproteins through lipoprotein receptors.

journal_name

Brain Dev

journal_title

Brain & development

authors

Hanaka S,Abe T,Itakura H,Matsumoto A

doi

10.1016/s0387-7604(00)00129-7

keywords:

subject

Has Abstract

pub_date

2000-08-01 00:00:00

pages

321-6

issue

5

eissn

0387-7604

issn

1872-7131

pii

S0387-7604(00)00129-7

journal_volume

22

pub_type

杂志文章

相关文献

BRAIN & DEVELOPMENT文献大全
  • Clinical onset and prognosis of Asian children with organic acidemias, as detected by analysis of urinary organic acids using GC/MS, instead of mass screening.

    abstract：:Organic acidemias (OAs) have been detected worldwide in symptomatic patients using gas chromatography mass spectrometry. We diagnosed 188 Asian cases of OAs by analysis of urinary organic acids and investigated their clinical onset and outcome. Methylmalonic acidemia (MMA) was most common (74 cases), followed by propi...

    journal_title：Brain & development

    pub_type： 杂志文章

    doi：10.1016/j.braindev.2004.04.004

    authors： Hori D,Hasegawa Y,Kimura M,Yang Y,Verma IC,Yamaguchi S

    更新日期：2005-01-01 00:00:00

  • An extra-axial hemangioma mimicking a large prenatal brain tumor.

    abstract：:A rare case of a congenital brain tumor was diagnosed by sonography in a fetus at 37weeks' gestation. The ultrasound examination showed a large area of both increased echogenicity and echolucency in one hemisphere suggestive of brain tumor or hemorrhage. Extensive surgical removal of the tumor was performed and reveal...

    journal_title：Brain & development

    pub_type： 杂志文章

    doi：10.1016/j.braindev.2010.02.006

    authors： Yang CY,Hsu JF,Lin KL,Jung SM,Lien R,Chang YL

    更新日期：2010-11-01 00:00:00

  • Dravet syndrome: early clinical manifestations and cognitive outcome in 37 Italian patients.

    abstract：:Aims of our study were to describe the early clinical features of Dravet syndrome (SMEI) and the neurological, cognitive and behavioral outcome. The clinical history of 37 patients with clinical diagnosis of SMEI, associated with a point mutation of SCN1A gene in 84% of cases, were reviewed with particular attention t...

    journal_title：Brain & development

    pub_type： 杂志文章

    doi：10.1016/j.braindev.2009.09.014

    authors： Ragona F,Brazzo D,De Giorgi I,Morbi M,Freri E,Teutonico F,Gennaro E,Zara F,Binelli S,Veggiotti P,Granata T

    更新日期：2010-01-01 00:00:00

  • Acute autonomic sensory and motor neuropathy associated with parvovirus B19 infection.

    abstract：:We report a 9-year-old girl with acute autonomic sensory and motor neuropathy (AASM) associated with human parvovirus B19 (HPV-B19) infection. The patient presented with fever, erythema of the entire body, and abdominal pain with vomiting. The titer of HPV-B19 IgM antibody was significantly elevated. Symptoms such as ...

    journal_title：Brain & development

    pub_type： 杂志文章

    doi：10.1016/j.braindev.2010.03.003

    authors： Hanai S,Komaki H,Sakuma H,Nakagawa E,Sugai K,Sasaki M,Oya Y,Higurashi N,Hamano S

    更新日期：2011-02-01 00:00:00

  • A novel PLP1 frameshift mutation causing a milder form of Pelizaeus-Merzbacher disease.

    abstract：BACKGROUND:Pelizaeus-Merzbacher disease (PMD), a hypomyelinating leukodystrophy, and the related but less severe allelic spastic paraplegia 2 (SPG2) are caused by mutations in the proteolipid protein 1 (PLP1) gene. Magnetic resonance imaging (MRI) is pivotal for diagnosing these disorders. The severity of PMD/SPG2 vari...

    journal_title：Brain & development

    pub_type： 杂志文章

    doi：10.1016/j.braindev.2014.06.011

    authors： Shiihara T,Watanabe M,Moriyama K,Uematsu M,Sameshima K

    更新日期：2015-04-01 00:00:00

  • Monitoring of concentrations of clobazam and norclobazam in serum and saliva of children with epilepsy.

    abstract：:Clobazam was added to the previous antiepileptic drug therapy of 90 children suffering from drug resistant epilepsy. Ten patients became seizure free, although four of these later developed tolerance. Thirty-three patients experienced a decrease in seizure frequency, and 24 of these, too, developed tolerance. Forty-fo...

    journal_title：Brain & development

    pub_type： 杂志文章

    doi：10.1016/s0387-7604(12)80025-8

    authors： Bardy AH,Seppälä T,Salokorpi T,Granström ML,Santavuori P

    更新日期：1991-05-01 00:00:00

  • MR spectroscopy and diffusion tensor imaging of the brain in congenital muscular dystrophy with merosin deficiency: metabolite level decreases, fractional anisotropy decreases, and apparent diffusion coefficient increases in the white matter.

    abstract：:Brain magnetic resonance spectroscopy (MRS) and diffusion tensor imaging (DTI) in one patient with merosin-deficient congenital muscular dystrophy (MDCMD) revealed significant metabolite (choline, creatine, N-acetyl aspartate) level reductions, fractional anisotropy (FA) reduction and increased apparent diffusion coef...

    journal_title：Brain & development

    pub_type： 杂志文章

    doi：10.1016/j.braindev.2006.10.004

    authors： Sijens PE,Fock JM,Meiners LC,Potze JH,Irwan R,Oudkerk M

    更新日期：2007-06-01 00:00:00

  • White matter abnormalities in an adult patient with l-2-hydroxyglutaric aciduria.

    abstract：:l-2-Hydroxyglutaric aciduria (l-2-HGA) is a rare inborn error of metabolism. Mainly, patients with this disorder exhibit neurological symptoms and characteristic neuroradiological findings, such as subcortical white matter abnormalities, which are believed to be caused by the toxicity of the accumulation of l-2-hydrox...

    journal_title：Brain & development

    pub_type： 杂志文章

    doi：10.1016/j.braindev.2015.04.012

    authors： Yamamoto T,Yoshioka S,Tsurusaki Y,Shino S,Shimojima K,Shigematsu Y,Takeuchi Y,Matsumoto N

    更新日期：2016-01-01 00:00:00

  • Spinal cord demyelination in children: A diagnostic challenge in neuropaediatrics for a good outcome.

    abstract：BACKGROUND:Biotinidase deficiency (BTD) is an autosomal recessive inborn error of metabolism provoking progressive biotin depletion, which causes, in turn, multiple carboxylase deficiency. Its infantile onset is characterized by intractable seizures associated with lethargy, psychomotor regression, hypotonia, feeding a...

    journal_title：Brain & development

    pub_type：

    doi：10.1016/j.braindev.2020.03.001

    authors： Battini R,Olivieri G,Milone R,Mazio F,Scalise R,Verdolotti T,Primiano G,Genovese O,Mercuri E,Servidei S

    更新日期：2020-06-01 00:00:00

  • Epileptic seizures and structural abnormalities in a patient with holoprosencephaly.

    abstract：:In a patient with holoprosencephaly, partial seizures had various initial ictal symptoms, and ictal EEGs showed epileptogenic foci in the right and left brain. Partial seizures did not culminate in secondary generalized tonic-clonic convulsions. Characteristic malformed structures contribute to the absence of secondar...

    journal_title：Brain & development

    pub_type： 杂志文章

    doi：10.1016/s0387-7604(01)00217-0

    authors： Takahashi S,Takahashi Y,Kondo N,Orii T

    更新日期：2001-07-01 00:00:00

  • Familial lissencephaly with extreme neopallial hypoplasia.

    abstract：:Two siblings, male and female, with identical lethal brain malformation are described. Their anomaly is characterized by very low brain weight, lissencephaly, wide ventricles and thin neopallium (colpocephaly) varying in thickness between 0.2 and 3 mm. The neocortex is four layered as in classic lissencephaly. Brainst...

    journal_title：Brain & development

    pub_type： 杂志文章

    doi：10.1016/s0387-7604(82)80008-9

    authors： Barth PG,Mullaart R,Stam FC,Slooff JL

    更新日期：1982-01-01 00:00:00

  • Quantitative assessment of fine motor skills in children using magnetic sensors.

    abstract：AIM:We aimed to establish objective and quantitative data on fine motor development in typically developing children using magnetic sensors. METHODS:The study included 110 Japanese elementary school children volunteers (57 boys, 53 girls). The participants were instructed to tap their thumbs and index fingers together...

    journal_title：Brain & development

    pub_type： 杂志文章

    doi：10.1016/j.braindev.2020.03.004

    authors： Enokizono T,Ohto T,Tanaka M,Maruo K,Sano Y,Kandori A,Takada H

    更新日期：2020-06-01 00:00:00

  • Long-term effectiveness of ethosuximide, valproic acid, and lamotrigine in childhood absence epilepsy.

    abstract：PURPOSE:We performed this study to evaluate the long-term efficacy and tolerability of ethosuximide (ESX), valproic acid (VPA), and lamotrigine (LTG) as initial monotherapies for patients with newly diagnosed childhood absence epilepsy. METHODS:We retrospectively reviewed the medical records of 128 patients (45 boys a...

    journal_title：Brain & development

    pub_type： 杂志文章

    doi：10.1016/j.braindev.2011.08.007

    authors： Hwang H,Kim H,Kim SH,Kim SH,Lim BC,Chae JH,Choi JE,Kim KJ,Hwang YS

    更新日期：2012-05-01 00:00:00

  • Altered brain function in new onset childhood acute lymphoblastic leukemia before chemotherapy: A resting-state fMRI study.

    abstract：OBJECTIVE:Cognitive impairments had been reported in childhood acute lymphoblastic leukemia, what caused the impairments needed to be demonstrated, chemotherapy-related or the disease itself. The primary aim of this exploratory investigation was to determine if there were changes in brain function of children with acut...

    journal_title：Brain & development

    pub_type： 杂志文章

    doi：10.1016/j.braindev.2017.04.014

    authors： Hu Z,Zou D,Mai H,Yuan X,Wang L,Li Y,Liao J,Liu L,Liu G,Zeng H,Wen F

    更新日期：2017-10-01 00:00:00

  • Peripheral nerve involvement in Werdnig-Hoffmann disease.

    abstract：:The number of large myelinated axons was markedly decreased in almost all the intramuscular nerve bundles included in 32 muscle biopsies from patients with Werdnig-Hoffmann disease compared to that in normals. The morphometric analysis of peripheral nerves in 5 epon-embedded sections also showed a selective loss of la...

    journal_title：Brain & development

    pub_type： 杂志文章

    doi：10.1016/s0387-7604(89)80040-3

    authors： Chien YY,Nonaka I

    更新日期：1989-01-01 00:00:00

  • Neuropsychological status of children with newly diagnosed idiopathic childhood epilepsy.

    abstract：:We characterized the neuropsychological status of children with newly diagnosed idiopathic childhood epilepsy and measured differences in IQ between children with different types of epilepsy. The Korean Education Development Institute-Wechsler Intelligence Scale for Children (KEDI-WISC) was administered to 72 patients...

    journal_title：Brain & development

    pub_type： 杂志文章

    doi：10.1016/j.braindev.2010.11.003

    authors： Jeong MH,Yum MS,Ko TS,You SJ,Lee EH,Yoo HK

    更新日期：2011-09-01 00:00:00

  • Cerebellar primary germ-cell tumor in a young boy.

    abstract：:Germ cell tumors originating in the posterior fossa are very rare. Described herein is a case of primary germ cell tumor (yolk sac tumor) found in the cerebellar vermis. A 5-year-old boy who complained of headache was admitted. CT and MRI revealed a tumor with diffuse enhancement by contrast medium in the right cerebe...

    journal_title：Brain & development

    pub_type： 杂志文章

    doi：10.1016/0387-7604(94)90128-7

    authors： Nakase H,Ohnishi H,Touho H,Karasawa J,Tsunoda S

    更新日期：1994-09-01 00:00:00

  • Clinical and MRI findings in a case of D-2-hydroxyglutaric aciduria.

    abstract：:We report the 3rd case in the literature of a 3-year-old boy with D-2-hydroxyglutaric (D-2-HG) aciduria, who presented primarily generalized hypotonia and feeding difficulty during the neonatal period, with eventual development of generalized myoclonic seizures. Gas chromatographic analysis of urinary organic acids sh...

    journal_title：Brain & development

    pub_type： 杂志文章,评审

    doi：10.1016/0387-7604(94)00123-f

    authors： Sugita K,Kakinuma H,Okajima Y,Ogawa A,Watanabe H,Niimi H

    更新日期：1995-03-01 00:00:00

  • Genetically engineered human neural stem cells for brain repair in neurological diseases.

    abstract：:Neural stem cells (NSCs)of the central nervous system (CNS) have recently received a great deal of attention and interest for their therapeutic potential for neurological disorders. NSCs are defined as CNS progenitor cells that have the capacity for self-renewal and multipotent potential to become neurons or glial cel...

    journal_title：Brain & development

    pub_type： 杂志文章,评审

    doi：10.1016/j.braindev.2006.07.012

    authors： Kim SU

    更新日期：2007-05-01 00:00:00

  • Vitamin B6 in acute encephalopathy with biphasic seizures and late reduced diffusion.

    abstract：BACKGROUND:The initial presentation of acute encephalopathy with biphasic seizures and late reduced diffusion (AESD) is indistinguishable from that of complex febrile seizures (FS), which poses a great diagnostic challenge for clinicians. Excitotoxicity is speculated to be the pathogenesis of AESD. Vitamin B6 (VB6) is ...

    journal_title：Brain & development

    pub_type： 杂志文章

    doi：10.1016/j.braindev.2020.02.002

    authors： Akiyama T,Toda S,Kimura N,Mogami Y,Hanaoka Y,Tokorodani C,Ito T,Miyahara H,Hyodo Y,Kobayashi K

    更新日期：2020-05-01 00:00:00

  • High postnatal oxidative stress in neonatal cystic periventricular leukomalacia.

    abstract：:Oxidative stress plays an important role in cystic periventricular leukomalacia (PVL). We performed a case-control study of preterm infants delivered at <35 weeks of gestation between January 2003 and December 2006. Patients were stratified into three groups, according to age at which cysts were initially identified: ...

    journal_title：Brain & development

    pub_type： 杂志文章

    doi：10.1016/j.braindev.2008.10.008

    authors： Kakita H,Hussein MH,Yamada Y,Henmi H,Kato S,Kobayashi S,Ito T,Kato I,Fukuda S,Suzuki S,Togari H

    更新日期：2009-10-01 00:00:00

  • Thiamine-deficient encephalopathy due to excessive intake of isotonic drink or overstrict diet therapy in Japanese children.

    abstract：AIM:To report on two children with encephalopathy caused by dietary thiamine deficiency due to newly developing nutritional problems in contemporary Japan. SUBJECTS:A 1-year-old boy who had consumed 1l of isotonic drinks per day for 4 months after an episode of diarrhea, and presented with ocular movement disorder, dy...

    journal_title：Brain & development

    pub_type： 杂志文章

    doi：10.1016/j.braindev.2009.08.004

    authors： Saeki K,Saito Y,Komaki H,Sakakibra T,Nakagawa E,Sugai K,Sakuma H,Sasaki M,Honda T,Hayashi H,Katori N,Miyahara Y

    更新日期：2010-08-01 00:00:00

  • Clinical manifestations and epilepsy treatment in Japanese patients with pathogenic CDKL5 variants.

    abstract：OBJECTIVE:Patients with pathogenic cyclin-dependent kinase-like-5 gene (CDKL5) variants are designated CDKL5 deficiency disorder (CDD). This study aimed to delineate the clinical characteristics of Japanese patients with CDD and elucidate possible appropriate treatments. METHODS:We recruited patients with pathogenic o...

    journal_title：Brain & development

    pub_type： 杂志文章

    doi：10.1016/j.braindev.2020.12.006

    authors： Kobayashi Y,Tohyama J,Takahashi Y,Goto T,Haginoya K,Inoue T,Kubota M,Fujita H,Honda R,Ito M,Kishimoto K,Nakamura K,Sakai Y,Takanashi JI,Tanaka M,Tanda K,Tominaga K,Yoshioka S,Kato M,Nakashima M,Saitsu H,Matsumot

    更新日期：2021-01-09 00:00:00

  • ARX-associated infantile epileptic-dyskinetic encephalopathy with responsiveness to valproate for controlling seizures and reduced activity of muscle mitochondrial complex IV.

    abstract：BACKGROUND:ARX genetic defect is associated with a spectrum of neurodevelopmental disorders that exhibit a high degree of phenotypic heterogeneity. METHODS:We studied a family with a 13-year old Chinese boy and his two elder brothers presented with infantile epileptic-dyskinetic encephalopathy and clarified the unknow...

    journal_title：Brain & development

    pub_type： 杂志文章

    doi：10.1016/j.braindev.2019.07.003

    authors： Kwong AK,Chu VL,Rodenburg RJT,Smeitink J,Fung CW

    更新日期：2019-11-01 00:00:00

  • A novel mutation of WDR62 gene associated with severe phenotype including infantile spasm, microcephaly, and intellectual disability.

    abstract：:The autosomal recessive form of primary microcephaly (MCPH) is a rare disorder characterized by head circumference of at least 3 standard deviation below the mean. The MCPH exhibits genetic heterogeneity with thirteen loci (MCPH1-MCPH13) identified, and associated with variable degree of intellectual disability. It ha...

    journal_title：Brain & development

    pub_type： 杂志文章

    doi：10.1016/j.braindev.2017.07.003

    authors： Nardello R,Fontana A,Antona V,Beninati A,Mangano GD,Stallone MC,Mangano S

    更新日期：2018-01-01 00:00:00

  • Electroencephalographic features of epileptic drop attacks and absence seizures: a case study.

    abstract：:A study of epileptic drop attacks (EDA) by simultaneous video-polygraphic recordings was carried out in one epileptic patient with myoclonic astatic seizures (Doose syndrome). EDA was shown to correspond to a burst of generalized bilaterally synchronous spike and wave complexes (GBSSW) at 3 Hz. Absence seizures were a...

    journal_title：Brain & development

    pub_type： 杂志文章

    doi：10.1016/0387-7604(93)90070-o

    authors： Oguni H,Imaizumi Y,Uehara T,Oguni M,Fukuyama Y

    更新日期：1993-05-01 00:00:00

  • Neopterin and biopterin concentrations in cerebrospinal fluid in controls less than 1 year old.

    abstract：:Neopterin and biopterin concentrations were measured in cerebrospinal fluid (CSF) and urine samples from controls less than 1 year old. This is the first time for CSF reference data for controls less than 1 year old to be reported. The ratio of neopterin to biopterin in CSF 0-30 days (n = 48) of age in control samples...

    journal_title：Brain & development

    pub_type： 杂志文章

    doi：10.1016/s0387-7604(99)00021-2

    authors： Sawada Y,Shintaku H,Isshiki G

    更新日期：1999-06-01 00:00:00

  • Correlation between the serum level of endotoxin and periventricular leukomalacia in preterm infants.

    abstract：:The objective of our study was to determine the relation between the serum level of endotoxin at birth and the development of periventricular leukomalacia (PVL) in preterm infants. We studied 68 preterm infants whose gestational ages ranged between 27 and 33 weeks, and birthweights between 1000 and 2000 g. The serum e...

    journal_title：Brain & development

    pub_type： 临床试验,杂志文章

    doi：10.1016/s0387-7604(99)00036-4

    authors： Okumura A,Hayakawa F,Kato T,Kuno K,Watanabe K

    更新日期：1999-09-01 00:00:00

  • Rapid-onset dystonia-parkinsonism with ATP1A3 mutation and left lower limb paroxysmal dystonia.

    abstract：BACKGROUND:Rapid-onset dystonia-parkinsonism (RDP) is a disease characterized by an abrupt onset of dystonia accompanied by signs of parkinsonism and prominent bulbar symptoms. CASE REPORT:We describe a case of a female patient, born after normal delivery, but diagnosed with mild intellectual disability at age 7. She ...

    journal_title：Brain & development

    pub_type：

    doi：10.1016/j.braindev.2020.12.009

    authors： Nomura S,Kashiwagi M,Tanabe T,Oba C,Yanagi K,Kaname T,Okamoto N,Ashida A

    更新日期：2021-01-12 00:00:00

  • Familial pachygyria in both genders related to a DCX mutation.

    abstract：:Doublecortin (DCX) and tubulin play critical roles in neuronal migration. DCX mutations usually cause anterior dominant lissencephaly in males and subcortical band heterotopia (SBH) in females. We used whole-exome sequencing to investigate causative gene variants in a large family with late-childhood-onset focal epile...

    journal_title：Brain & development

    pub_type： 杂志文章

    doi：10.1016/j.braindev.2015.12.005

    authors： Kim YO,Nam TS,Park C,Kim SK,Yoon W,Choi SY,Kim MK,Woo YJ

    更新日期：2016-06-01 00:00:00