Abstract:
BACKGROUND:Conflicting data suggest that statins could cause chronic liver disease in certain group of patients, while improving prognosis in those with chronic viral hepatitis (CVH). PURPOSE:To quantify the potential protective role of statins on some main liver-related health outcomes in clinical studies on CVH patients.Data Sources: The search strategy was explored by a medical librarian using bibliographic databases, from January 2015 to April 2020.Data synthesis: The results showed no significant difference in the risk of mortality between statin users and non-users in the overall analysis. However, the risk of mortality significantly reduced by 39% in statin users who were followed for more than three years. Moreover, the risk of HCC, fibrosis, and cirrhosis in those on statins decreased by 53%, 45% and 41%, respectively. Although ALT and AST reduced slightly following statin therapy, this reduction was not statistically significant. LIMITATIONS:A significant heterogeneity among studies was observed, resulting from differences in clinical characteristics between statin users and non-users, study designs, population samples, diseases stage, comorbidities, and confounding covariates. CONCLUSION:Not only long-term treatment with statins seems to be safe in patients affected by hepatitis, but also it significantly improves their prognosis.
journal_name
Ann Medjournal_title
Annals of medicineauthors
Vahedian-Azimi A,Shojaie S,Banach M,Heidari F,Cicero AFG,Khoshfetrat M,Jamialahmadi T,Sahebkar Adoi
10.1080/07853890.2021.1956686keywords:
["Statins","fibrosis","hepatitis","liver","prognosis"]subject
Has Abstractpub_date
2021-12-01 00:00:00pages
1227-1242issue
1eissn
0785-3890issn
1365-2060journal_volume
53pub_type
杂志文章相关文献
文献大全abstract::Traditionally, cancer vaccines have used whole tumour cells administered in adjuvant or infected with viruses to increase the immunogenicity of the cells. With the identification of tumour-associated and tumour-specific antigens (TAA, TSA), antigen and epitope-specific vaccines have been designed. Compared to tumour c...
journal_title:Annals of medicine
pub_type: 杂志文章,评审
doi:10.3109/07853899909019264
更新日期:1999-02-01 00:00:00
abstract::The concern about the current epidemic of obesity is heightened by recent data showing an increase in the prevalence of overweight and obesity in children and adolescents. As obese children are at increased risk of becoming obese adults, early identification of individuals at risk of becoming obese is important for th...
journal_title:Annals of medicine
pub_type: 杂志文章,评审
doi:
更新日期:1999-04-01 00:00:00
abstract::The light-entrainable circadian pacemaker located in the suprachiasmatic nucleus of the hypothalamus regulates the timing and consolidation of sleep by generating a paradoxical rhythm of sleep propensity; the circadian drive for wakefulness peaks at the end of the day spent awake, ie close to the onset of melatonin se...
journal_title:Annals of medicine
pub_type: 杂志文章,评审
doi:10.3109/07853899908998789
更新日期:1999-04-01 00:00:00
abstract::The production of erythroid cells is a dynamic and exquisitely regulated process. The mature red cell is only the final phase of a complex but orderly series of genetic events that are initiated at the time a multipotent stem cell becomes committed to expressing the erythroid programme. Aberrations either in the intri...
journal_title:Annals of medicine
pub_type: 杂志文章,评审
doi:10.3109/07853899909115980
更新日期:1999-06-01 00:00:00
abstract::Despite dramatic declines in human immunodeficiency virus (HIV)-associated morbidity and mortality as a result of highly active antiretroviral combination therapies, including protease inhibitors, treatment failure occurs at such high rates as 20-50%. As drug regimens are very demanding, even short decreases of drug c...
journal_title:Annals of medicine
pub_type: 杂志文章,评审
doi:10.3109/07853899908995888
更新日期:1999-08-01 00:00:00
abstract::Myasthenia gravis (MG) is an autoimmune disorder, in which end-plate membrane damage is induced by antibodies directed toward various epitopes of the main immunogenic region of the nicotinic acetylcholine receptor (AChR). This article reviews the mechanisms responsible for the development of MG. Recent investigations ...
journal_title:Annals of medicine
pub_type: 杂志文章,评审
doi:
更新日期:1999-10-01 00:00:00
abstract::The majority of doctors in North America, Australia and much of Europe now inform patients about a cancer diagnosis. However, many doctors report that they have difficulty disclosing a cancer diagnosis. Poor doctor-patient communication skills may lead to psychological distress including increased anxiety and depressi...
journal_title:Annals of medicine
pub_type: 杂志文章,评审
doi:10.3109/07853899908995900
更新日期:1999-10-01 00:00:00
abstract::Suicide gene therapy represents a new therapeutic approach to the treatment of patients with otherwise incurable malignant brain tumours. This strategy involves the introduction of a gene that renders the tumour cell susceptible to an otherwise nontoxic prodrug. The most often used genetic prodrug activation system is...
journal_title:Annals of medicine
pub_type: 杂志文章,评审
doi:10.3109/07853899908998799
更新日期:1999-12-01 00:00:00
abstract::In the USA radical surgery remains the golden standard for invasive bladder cancer. Yet in most other areas of surgical oncology the trend of the 1990s has been towards organ conservation with chemoradiation with or without limited local surgery. Patients with breast, oesophageal, anal, lung and larynx cancer are rout...
journal_title:Annals of medicine
pub_type: 杂志文章,评审
doi:10.3109/07853890008995908
更新日期:2000-02-01 00:00:00
abstract::The socioeconomic status (SES) of the family influences the cardiovascular risk status of children and adolescents; however, it is not as well known whether parental SES has any effect on the risk factor profile of young adults. The aim of the present study was to investigate the relations of different aspects of pare...
journal_title:Annals of medicine
pub_type: 杂志文章
doi:10.3109/07853890009011764
更新日期:2000-03-01 00:00:00
abstract::Several opposite effects of serotonin (5HT) on tumour growth have been reported. On one hand, 5HT is known as a growth factor for several types of nontumoural cells, and it has been proposed to take part in the autocrine loops of growth factors contributing to cell proliferation in aggressive tumours such as small cel...
journal_title:Annals of medicine
pub_type: 杂志文章,评审
doi:10.3109/07853890008998826
更新日期:2000-04-01 00:00:00
abstract::Oscillations of arterial pressures, heart periods, and muscle sympathetic nerve activity have been studied intensively in recent years to explore otherwise obscure human neurophysiological mechanisms. The best-studied rhythms are those occurring at breathing frequencies. Published evidence indicates that respiratory f...
journal_title:Annals of medicine
pub_type: 杂志文章,评审
doi:10.3109/07853890008995937
更新日期:2000-07-01 00:00:00
abstract::The objective of this article is to review studies that have examined the relation of daycare to asthma and atopy. In order to identify studies for inclusion, abstracts of all studies referenced in Medline from January 1966 to January 2000 and in BIBSYS were searched and extracted if they included 'asthma' or 'atopy' ...
journal_title:Annals of medicine
pub_type: 杂志文章,评审
doi:10.3109/07853890008995945
更新日期:2000-09-01 00:00:00
abstract::The cloning of mammals originated with the production of limited numbers of genetically identical offspring by blastomere separation or embryo splitting. In the past few years, remarkable progress has been reported in cloning by nuclear transfer (NT) with donor nuclei recovered from embryonic, fetal or adult cells. Fa...
journal_title:Annals of medicine
pub_type: 杂志文章
doi:10.3109/07853890009002021
更新日期:2000-10-01 00:00:00
abstract::Hypolipidaemic 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor (statin) treatment reduces cardiovascular risk and is also associated with the reduction of C-reactive protein (CRP) concentrations. However, there is scant data concerning the relationship between CRP and lipid changes during statin tr...
journal_title:Annals of medicine
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.3109/07853890008998838
更新日期:2000-11-01 00:00:00
abstract::Caffeine and nicotine are the most common psychostimulant drugs used worldwide. Structural neuroimaging findings associated with caffeine and nicotine consumption are limited and primarily reflect the putative relationship between smoking and white matter hyperintensities (WMH), a finding that warrants further apprais...
journal_title:Annals of medicine
pub_type: 杂志文章,评审
doi:10.3109/07853890009002029
更新日期:2000-12-01 00:00:00
abstract::Haemostasis is the process that arrests bleeding from wounds, preventing blood from flowing outside of the vascular bed. Thrombosis is an abnormal condition in which the vascular lumen becomes occluded by a mass constituted primarily of aggregated platelets and polymerized fibrin. These thrombi impede the normal flow ...
journal_title:Annals of medicine
pub_type: 杂志文章,评审
doi:
更新日期:2000-12-01 00:00:00
abstract::Thrombomodulin (TM) binds thrombin, changes thrombin conformation and allows thrombin to activate protein C and thrombin-activatable fibrinolysis inhibitor (TAFI). Activated protein C and TAFI inhibit coagulation and fibrinolysis, respectively. TM is, thus, a linker of endogenous control of coagulation and fibrinolysi...
journal_title:Annals of medicine
pub_type: 杂志文章,评审
doi:
更新日期:2000-12-01 00:00:00
abstract::Gene transfer into the central nervous system (CNS) is one of the foremost scientific challenges today. To give a brief survey of possible approaches to gene therapy in diseases affecting the CNS, we have selected the lysosomal storage diseases (LDS), which are an excellent model of both early-onset infantile neurolog...
journal_title:Annals of medicine
pub_type: 杂志文章,评审
doi:10.3109/07853890109002057
更新日期:2001-02-01 00:00:00
abstract::The molecular mechanisms underlying the development and progression of prostate cancer are poorly understood. Epidemiological studies have suggested that 5-10% of all prostate cancers are familial, and numerous chromosomal loci have been associated with prostate cancer in multicentre linkage studies. However, no putat...
journal_title:Annals of medicine
pub_type: 杂志文章,评审
doi:10.3109/07853890109002068
更新日期:2001-03-01 00:00:00
abstract::Genetic factors undoubtedly play an important role in determining vulnerability to bipolar disorder but the task of finding susceptibility genes is not trivial. Candidate gene studies, usually employing the association approach, offer the potential to discover the genes of relatively modest effect size that are expect...
journal_title:Annals of medicine
pub_type: 杂志文章,评审
doi:10.3109/07853890108998753
更新日期:2001-05-01 00:00:00
abstract::The concept of using viruses as oncolytic agents has a long history. However, relatively new developments are the use of these viruses as gene delivery vehicles and the restriction of viral replication and lysis to tumour cells. The latter is attempted by the use of tumour-specific promoters, which transcriptionally t...
journal_title:Annals of medicine
pub_type: 杂志文章,评审
doi:10.3109/07853890109002081
更新日期:2001-07-01 00:00:00
abstract::Cost-utility analysis uses the quality-adjusted life year (QALY) as a measure of the benefit of health interventions. It presupposes the assignment of utility scores to different states of health on a scale from zero (dead) to unity (healthy). A number of so-called multiattribute utility (MAU) instruments are availabl...
journal_title:Annals of medicine
pub_type: 杂志文章,评审
doi:10.3109/07853890109002091
更新日期:2001-07-01 00:00:00
abstract:BACKGROUND:Neurological symptoms of unknown origin are common in coeliac disease (CD). Evidence suggests that CD may also contribute to the development of idiopathic late-onset ataxia. AIM:To evaluate the frequency of CD in patients with cerebellar ataxia of unknown origin. METHODS:The medical files of adult patients...
journal_title:Annals of medicine
pub_type: 杂志文章
doi:10.3109/07853890108995958
更新日期:2001-09-01 00:00:00
abstract::In the last decade, retrospective cohort data has provided evidence of premature atherosclerosis in patients with hypopituitarism which may account for the recently observed increased death rate from vascular events in these patients. The exact mechanism(s) for such propensity to atherosclerotic vascular disease is no...
journal_title:Annals of medicine
pub_type: 杂志文章,评审
doi:10.3109/07853890109002097
更新日期:2001-10-01 00:00:00
abstract::The emergence of antibiotic resistance among pathogenic bacteria is one of the most critical problems of modern medicine, and novel, effective approaches for treating infections caused by multidrug-resistant bacteria are urgently required. In this context, one intriguing approach is to use bacteriophages (viruses that...
journal_title:Annals of medicine
pub_type: 社论,历史文章
doi:10.3109/07853890108995959
更新日期:2001-11-01 00:00:00
abstract::In response to a requirement for increased contractile power in vivo, mammalian cardiac myocytes adapt through a hypertrophic response (cell enlargement in the absence of cell division). This response can be simulated by exposing isolated myocytes in primary culture to alpha-adrenergic agonists or the vasoactive pepti...
journal_title:Annals of medicine
pub_type: 杂志文章,评审
doi:
更新日期:2001-12-01 00:00:00
abstract:BACKGROUND:Highly active antiretroviral therapies (HAART) in HIV-infected patients are often associated with lipodystrophy syndrome and metabolic disorders. Atherogenic lipid profile could expose these patients to atheromatous cardiovascular disease. We describe carotid artery intima-media thickness (IMT), a surrogate ...
journal_title:Annals of medicine
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1080/078538902317338652
更新日期:2002-01-01 00:00:00
abstract:BACKGROUND:Experimental studies have suggested that R-R interval dynamics during ventricular fibrillation (VF) have organized features, but whether dynamic behavior of non-sustained VF differs from sustained VF is unknown. AIM:The purpose of this study was to investigate whether the dynamics of R-R intervals during no...
journal_title:Annals of medicine
pub_type: 杂志文章
doi:10.1080/07853890252953527
更新日期:2002-01-01 00:00:00
abstract:BACKGROUND:There is a clear east-west difference in coronary heart disease (CHD) mortality and incidence in Finland, people living in east Finland having higher CHD rate. A study of Finnish immigrants to Sweden has suggested that a long stay in Sweden would be associated with reduced CHD risk. AIM:To determine whether...
journal_title:Annals of medicine
pub_type: 杂志文章
doi:
更新日期:2002-01-01 00:00:00