Maculosin, a non-toxic antioxidant compound isolated from Streptomyces sp. KTM18.

abstract：:The Purdue-UAB Botanicals Research Center for Age Related Disease uses multidisciplinary and innovative technologies to investigate the bioavailability of bioactive polyphenolic constituents from botanicals and their relationship to human health. Many age-related diseases are associated with oxidative stress and tissu...

journal_title：Pharmaceutical biology

authors： Weaver CM,Barnes S,Wyss JM,Kim H,Morré DM,Morré DJ,Simon JE,Lila MA,Janle EM,Ferruzzi MG

更新日期：2009-08-01 00:00:00

abstract：:Previous investigations demonstrated that a standardized extract of ginger rhizome inhibited the growth of Helicobacter pylori in vitro with a minimum inhibitory concentration in the range 0.78 to 12.5 mug/mL. In the present work, the extract was tested in a rodent model of H. pylori-induced disease, the Mongolian ger...

journal_title：Pharmaceutical biology

authors： Gaus K,Huang Y,Israel DA,Pendland SL,Adeniyi BA,Mahady GB

更新日期：2009-01-01 00:00:00

abstract：:Paracoccidioidomycosis (PCM) is a systemic granulomatous disease caused by Paracoccidioides brasiliensis Almeida (Onygenales) that requires 1-2 years of treatment. In the absence of drug therapy, the disease is usually fatal, highlighting the need for the identification of safer, novel, and more effective antifungal c...

journal_title：Pharmaceutical biology

authors： Johann S,Cisalpino PS,Watanabe GA,Cota BB,de Siqueira EP,Pizzolatti MG,Zani CL,de Resende MA

更新日期：2010-04-01 00:00:00

abstract：:Cellular damage caused by reactive oxygen species (ROS) has been implicated in several diseases and antioxidants are known to protect the body from this damage. Antioxidants thus, have gained significant importance in human health. The search for effective, non-toxic natural compounds with antioxidant activity has int...

journal_title：Pharmaceutical biology

authors： Nitha B,De S,Adhikari SK,Devasagayam TP,Janardhanan KK

更新日期：2010-04-01 00:00:00

abstract：:Beta-sitosterol is used as a dietary supplement for lowering plasma cholesterol, and has atherosclerosis preventive, anti-inflammatory, antimicrobial, antipyretic, induced apoptosis, and anticancer effects. In order to understand the effect of the molecule we have investigated the molecule theoretically. The structura...

journal_title：Pharmaceutical biology

authors： Kurban S,Erkoç F,Erkoç S

更新日期：2010-06-01 00:00:00

abstract：:Cell suspension cultures of Silybum marianum L. Gaertn (Compositae) produce silymarin, a mixture of flavonolignans. In an attempt to increase cell growth and silymarin production, we exposed cell cultures to various levels of Ag+ (0.2, 0.4, 0.8, 1, and 2 mM) for different exposure times (12, 24, 48, 72, 144, and 216 h...

journal_title：Pharmaceutical biology

authors： Ashtiani SR,Hasanloo T,Bihamta MR

更新日期：2010-06-01 00:00:00

abstract：:Antioxidative, skin protective activities, and cytotoxicity of three extracts (water, methanol, and hexane) from the fruit hull of mangosteen (Garcinia mangostana Linn. (Guttiferae)) and their phenolic constituents such as alpha-mangostin, epicatechin, and tannin, were evaluated. The amounts of alpha-mangostin, total ...

journal_title：Pharmaceutical biology

authors： Ngawhirunpat T,Opanasopi P,Sukma M,Sittisombut C,Kat A,Adachi I

更新日期：2010-01-01 00:00:00

abstract：:The 80% aqueous acetone extract of the whole plant of Rhopalocnemis phalloides Jungh. (Balanophoraceae) showed obvious radical scavenging activity (SC(50) = 32.1 mug/mL) on 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical assay. Further chemical investigation of the extract led to the isolation of 12 phenolic compounds (1...

journal_title：Pharmaceutical biology

authors： She GM,Hu JB,Zhang YJ,Yang CR

更新日期：2010-01-01 00:00:00

abstract：:Conflicting reports are found in the literature about the efficacy of Mirazid (MZ), which is a special formulation of myrrh obtained from the stem of Commiphora molmol (Nees), Engl. tree (Burseraceae), as an antischistosomal drug. This initiated the present study to further assess this drug in experimental schistosomi...

journal_title：Pharmaceutical biology

authors： Ramzy F,Mahmoud S,William S

更新日期：2010-07-01 00:00:00

abstract：:Chemical investigations from a foliar extract of Araucaria excelsa (Lamb.) (Araucariaceae) resulted in the identification of seven phenolic metabolites including one flavananol, one flavananol 3-O-glycoside, four C-glycoside flavonoids, and one phenolic acid. Structures were elucidated by spectral determination includ...

journal_title：Pharmaceutical biology

authors： Michael HN,Awad HM,El-Sayed NH,Paré PW

更新日期：2010-05-01 00:00:00

abstract：:Prosopis africana (Guill. & Perr.) Taub. (Mimosoideae) is a shrub used for menstrual and general body pain in Nupe land in north central Nigeria. In this study, the methanol extract of the stem bark of Prosopis africana (at doses of 62.5, 125, and 250 mg/kg) was evaluated for analgesic and anti-inflammatory activities...

journal_title：Pharmaceutical biology

authors： Ayanwuyi LO,Yaro AH,Abodunde OM

更新日期：2010-03-01 00:00:00

abstract：:The naringinase-treated methanol extract of Sophora japonica L. (Fabaceae) seeds showed potent estrogen agonist activity. Through bioassay-guided isolation of the main active constituents from the naringinase-treated methanol extract of S. japonica, the aglycones genistein and kaempferol were found to be the main phyt...

journal_title：Pharmaceutical biology

authors： El-Halawany AM,Chung MH,Abdallah HM,Nishihara T,Hattori M

更新日期：2010-02-01 00:00:00

abstract：:This study evaluated the in vivo immunomodulatory activities of the aqueous extract of Caesalpinia bonducella Fleming (Caesalpiniaceae) seeds. C. bonducella is a plant widely used in the traditional medicinal systems of India. In the present investigation, the aqueous extract of C. bonducella seeds was tested for its ...

journal_title：Pharmaceutical biology

authors： Shukla S,Mehta A,Mehta P,Vyas SP,Shivaprasad HN

更新日期：2010-02-01 00:00:00

abstract：:Aristolochia elegans Mast. (Aristolochiaceae) has been used to treat scorpion envenoming in Mexican traditional medicine. In vitro studies of the pharmacological activity of raw extracts from A. elegans roots have shown activity against scorpion bite. The aim of the present study was to determine for the first time th...

journal_title：Pharmaceutical biology

authors： Izquierdo AM,Zapata EV,Jiménez-Ferrer JE,Muñoz CB,Aparicio AJ,Torres KB,Torres LO

更新日期：2010-08-01 00:00:00

abstract：CONTEXT:Many plants have been explored scientifically and systematically and claimed to be useful for the treatment of diabetes mellitus by various research groups worldwide. The present study is a further effort in the direction of developing a novel oral antidiabetic agent of high potential with minimal or no side ef...

journal_title：Pharmaceutical biology

authors： Shukla S,Chatterji S,Mehta S,Rai PK,Singh RK,Yadav DK,Watal G

更新日期：2011-01-01 00:00:00

abstract：CONTEXT:The search for innovative therapeutic approaches is gaining more interest in clinical oncology. OBJECTIVE:In the present investigation we reported the chemical profile and the photo-induced cytotoxic activity of two endemic Calabrian Citrus species (Rutaceae): Citrus bergamia Risso & Poit. and Citrus medica L....

journal_title：Pharmaceutical biology

authors： Menichini F,Tundis R,Loizzo MR,Bonesi M,Provenzano E,de Cindio B,Menichini F

更新日期：2010-09-01 00:00:00

abstract：CONTEXT:Blank chitosan nanoparticles are currently used as reference for the calibration curve, which fails to resolve the supernatant of the nanoparticles in the interference of Coomassie Brilliant Blue G-250 reagent; supernatants are generated at different chitosan nanoparticulate prescriptions, which have different ...

journal_title：Pharmaceutical biology

authors： Su ZQ,Wu SH,Zhang HL,Feng YF

更新日期：2010-09-01 00:00:00

abstract：CONTEXT:Thirty-one medicinal plant species from Hawaii, Morocco, and the Sonoran Desert, USA have been shown in past studies to be highly inhibitory to pathogenic bacteria, fungi, and certain cancer cell lines. However, none were tested for antiviral activity. OBJECTIVE:Acetone and methanol extracts from these species...

journal_title：Pharmaceutical biology

authors： Jaeger Greer MR,Cates RG,Johnson FB,Lamnaouer D,Ohai L

更新日期：2010-09-01 00:00:00

abstract：CONTEXT:Tianhua (TH-R) is extracted from Trichosanthes kirilowii Maxim (Cucurbitaceae) containing trichosanthin, a traditional Chinese medicine, which has been locally reported to have good anticancer effects in vivo in both animal and human models. However, there have been several reports that trichosanthin has an ant...

journal_title：Pharmaceutical biology

authors： Li CT,Lin CH,Kao TY,Wu MF,Yeh CS,Yeh KT,Ko JL

更新日期：2010-11-01 00:00:00

abstract：CONTEXT:The whole plant of Sphaeranthus indicus Linn. (Asteraceae) is traditionally used in the treatment of diabetes mellitus. OBJECTIVE:The present study investigated the effect of the methanol extract of Sphaeranthus indicus whole plant in dexamethasone-induced insulin resistance in mice. MATERIALS AND METHODS:The...

journal_title：Pharmaceutical biology

authors： Ghaisas M,Zope V,Takawale A,Navghare V,Tanwar M,Deshpande A

更新日期：2010-12-01 00:00:00

abstract：CONTEXT:Phytochemical investigation of Clerodendrum chinense (Osbeck) Mabberley (Lamiaceae) cultivated in Egypt and evaluation for anti-inflammatory, analgesic, and antipyretic effects of the methanol and chloroform extracts of Clerodendrum chinense, Clerodendrum indicum (L.) Kuntze, Clerodendrum glabrum E. Meyer. OBJ...

journal_title：Pharmaceutical biology

authors： Wahba HM,AbouZid SF,Sleem AA,Apers S,Pieters L,Shahat AA

更新日期：2011-01-01 00:00:00

abstract：CONTEXT:Decoctions of Baliospermum montanum Müll. Arg. (Euphorbiaceae) leaves are reported to be useful in the treatment of asthma and other respiratory complications in the Ayurvedic system. OBJECTIVE:To evaluate the mast cell stabilization and antihistaminic activities of the chloroform (BMLC) and ethanol (BMLE) ext...

journal_title：Pharmaceutical biology

authors： Venkatesh P,Mukherjee PK,Mukherjee D,Bandyopadhyay A,Fukui H,Mizuguchi H

更新日期：2010-11-01 00:00:00

abstract：CONTEXT:Among strategies to combat malaria, the search for newer antimalarial compounds is a priority. Traditionally, Tagetes erecta Linn. (Compositae) has been used for the treatment of various diseases and ailments including malaria. OBJECTIVE:Five successive extracts (petroleum ether, chloroform, ethyl acetate, met...

journal_title：Pharmaceutical biology

authors： Gupta P,Vasudeva N

更新日期：2010-11-01 00:00:00

abstract：CONTEXT: Nauclea latifolia Smith (Rubiaceae) is a small tree found in tropical areas in Africa. It is used in traditional medicine to treat malaria, epilepsy, anxiety, pain, fever, etc. OBJECTIVE: The aim of this study was to investigate the effects of Nauclea latifolia roots decoction on the peripheral and central ne...

journal_title：Pharmaceutical biology

authors： Taïwe GS,Bum EN,Talla E,Dimo T,Weiss N,Sidiki N,Dawe A,Moto FC,Dzeufiet PD,De Waard M

更新日期：2011-01-01 00:00:00

abstract：CONTEXT:The clinical applications of well-known benzodiazepines as anxiolytic agents are limited because of their side effects. Therefore, the development of new pharmacological agents, from medicinal plants, is well justified. OBJECTIVE:Among medicinal plants, Gelsemium sempervirens (L.) Aiton. (Loganiaceae) has been...

journal_title：Pharmaceutical biology

authors： Dutt V,Dhar VJ,Sharma A

更新日期：2010-10-01 00:00:00

abstract：CONTEXT:Many herbal remedies have so far been employed for the treatment and management of various ailments since the beginning of human civilization. Medicago is an extensive genus of the family Leguminosae, comprising about 83 different species. Medicago sativa (Linn.) has long been used as traditional herbal medicin...

journal_title：Pharmaceutical biology

authors： Bora KS,Sharma A

更新日期：2011-02-01 00:00:00

abstract：:A phytochemical preparation known as "Slimax" was administered orally to human volunteers for a six week period, using a double-blind experimental method. This preparation is an aqueous extract of the Chinese medicinal plants Hordeum vulgare , Polygonatum multiflorum , Dimocarpus longan , Ligusticum sinense , Lilium b...

journal_title：Pharmaceutical biology

authors： Ignjatovic V,Ogru E,Heffernan M,Libinaki R,Lim Y,Ng F

更新日期：2000-01-01 00:00:00

abstract：:The adequate management of cryptococcosis is difficult with the available armamentarium of synthetic antifungals. We made an effort to evaluate fresh extracts of garlic ( Allium sativum L.) to assess potential therapeutic use of this herb as an anticryptococcal agent. The in vitro antifungal activity in broth showed g...

journal_title：Pharmaceutical biology

authors： Khan ZK,Katiyar R

更新日期：2000-01-01 00:00:00

abstract：:The leaves and tuber of Curcuma raktakanda were investigated as a mosquito larvicide against the early fourth instar larvae of four mosquito species, viz., Culex quinquefasciatus , Culex sitiens , Aedes aegypti and Anopheles stephensi . The petroleum ether extract of the leaves and tuber exhibited toxicity towards all...

journal_title：Pharmaceutical biology

authors： Latha C,Ammini J

更新日期：2000-01-01 00:00:00

abstract：:Thirteen compounds have been isolated from the methanol extract of Saxifraga cuneifolia L. (Saxifragaceae) whole plant. These were identified as five new compounds, (E)-5-O-ß-D-glucopyranosyl-stilbene-3,3', 4,5'-tetraol, (E)-4-O-ß-D-glucopyranosyl-5-methoxy-stilbene-3,3',5'-triol, 4-[4'-O-(6''-O-galloyl-ß-D-glucopyran...

journal_title：Pharmaceutical biology

authors： Chevalley I,Marston A,Hostettmann K

更新日期：2000-01-01 00:00:00