Abstract:
:Combining two or more nanoparticles is a promising approach. Previously we have reported synthesis of nanoparticles Dysprosium (Dy) substituted with manganese (Mn) zinc (Zn) by using ultrasonication method. The five different nanoparticles (NPs) Mn0.5Zn0.5DyxFe2-xO4 (x ≤ 0.1) have been structurally and morphologically characterized but there is no report on the biological application of these NPs. In the present study, we have examined the anti-cancer, anti-bacterial, and anti-fungal activities of Mn0.5Zn0.5DyxFe2-xO4 (x ≤ 0.1) NPs. Human colorectal carcinoma cells (HCT-116) were tested with different concentrations of NPs by using MTT [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] assay. In addition, the impact of NPs was also examined on normal cells such as human embryonic kidney cells, HEK-293. After 48 h of treatment, Mn0.5Zn0.5DyxFe2-xO4 NPs (x = 0.02, 0.04 and 0.06) showed no inhibitory action on cancer cell's growth and proliferation, whereas Mn0.5Zn0.5DyxFe2-xO4 NPs (x = 0.08 and 0.1) showed profound inhibitory action on cancer cell's growth and proliferation. However, the treatment of Mn0.5Zn0.5DyxFe2-xO4 NPs on the normal cells (HEK-293) did not show cytotoxic or inhibitory action on HEK-293 cells. The treatment of Mn0.5Zn0.5DyxFe2-xO4 NPs (x ≤ 0.1) also inhibited both the bacteria (Escherichia coli ATCC35218 and Staphylococcus aureus) with lowest MIC and MBC values of 4 and 8 mg/mL and fungus (Candida albicans) with MIC and MFC values of 4 and 8 mg/mL on treatment with x = 0.08 and 0. 1.
journal_name
Artif Cells Nanomed Biotechnoljournal_title
Artificial cells, nanomedicine, and biotechnologyauthors
Al-Jameel SS,Rehman S,Almessiere MA,Khan FA,Slimani Y,Al-Saleh NS,Manikandan A,Al-Suhaimi EA,Baykal Adoi
10.1080/21691401.2021.1938592keywords:
["Nanoparticles","anti-bacterial","anti-cancer","anti-fungal","in vitro assay","spinel ferrites"]subject
Has Abstractpub_date
2021-12-01 00:00:00pages
493-499issue
1eissn
2169-1401issn
2169-141Xjournal_volume
49pub_type
杂志文章相关文献
文献大全abstract::Glucagon-like peptide-1 (GLP-1) as an endogenous glucose-lowering peptide has great potential in diabetes therapy, but its clinical utility is compromised by its limited activity in vivo. Herein to improve the anti-diabetic activity of GLP-1, we constructed a fusion protein (GLP-1-globular adiponectin, GAD) using this...
journal_title:Artificial cells, nanomedicine, and biotechnology
pub_type: 杂志文章
doi:10.3109/10731199.2012.712042
更新日期:2013-06-01 00:00:00
abstract::Paraoxonase (PON) was purified and characterized from the Merino and Kivircik sheep's blood serums by a two-step procedure using ammonium sulphate precipitation and Sepharose-4B-L-tyrosine-1-napthylamine hydrophobic interaction chromatography for the first time. On SDS-polyacyrilamide gel electrophoresis, purified hum...
journal_title:Artificial cells, nanomedicine, and biotechnology
pub_type: 杂志文章
doi:10.3109/10731199.2012.696065
更新日期:2013-04-01 00:00:00
abstract::This paper proposes a nano-antenna system using the optical spins generated by a PANDA ring resonator for radio therapeutic applications. Initially, the magnetic field is induced by the coupling effects between aluminium plate (Al) and TE and TM light modes. The generated electromagnetic wave radiation is controlled b...
journal_title:Artificial cells, nanomedicine, and biotechnology
pub_type: 杂志文章
doi:10.3109/10731199.2012.696068
更新日期:2013-02-01 00:00:00
abstract::Hemoglobin-based oxygen carriers (HBOCs) have been developed as a transfusion alternative and oxygen therapy. The Hb source is usually outdated donated human blood or cow blood obtained from cattle industries because of its abundance. This study examined the feasibility of using swine Hb ((S)Hb) for preparation of cel...
journal_title:Artificial cells, nanomedicine, and biotechnology
pub_type: 杂志文章
doi:10.3109/10731199.2012.716067
更新日期:2013-02-01 00:00:00
abstract::The oxaliplatin nanoparticles were prepared with polylactic acid matrix, orthogonal test was applied to optimize the prescriptions, and the qualities of oxaliplatin nanoparticles were characterized by the shape, particle size, encapsulation efficiency (EE), and drug loading (DL). Oxaliplatin nanoparticle was prepared ...
journal_title:Artificial cells, nanomedicine, and biotechnology
pub_type: 杂志文章
doi:10.3109/21691401.2012.749482
更新日期:2013-08-01 00:00:00
abstract::A novel design of nerve communications and networks using the coupling effects between bio-cells and optical dipoles is proposed. The electrical signals are coupled to the dipoles and cells which propagate within the optical networks for long distance without any electromagnetic interference. Results have shown that t...
journal_title:Artificial cells, nanomedicine, and biotechnology
pub_type: 杂志文章
doi:10.3109/21691401.2012.759124
更新日期:2013-12-01 00:00:00
abstract::The aim of this study is to prepare supermacroporous cryogels embedded with Fe(3+)-attached sporopollenin particles (Fe(3++)-ASPs) having large surface area for high DNA adsorption capacity. Supermacroporous poly(2-hydroxyethyl methacrylate) (PHEMA)-based monolithic cryogel column embedded with Fe3+(+)-ASPs was prepar...
journal_title:Artificial cells, nanomedicine, and biotechnology
pub_type: 杂志文章
doi:10.3109/21691401.2012.759125
更新日期:2013-12-01 00:00:00
abstract::The objective of this study was to develop an oral formulation that would improve the solubility and oral absorption of sirolimus using a TPGS micellar solution. The effect of TPGS on the solubility and stability of sirolimus was evaluated. The sirolimus-loaded TPGS micelles were prepared using the thin-film hydration...
journal_title:Artificial cells, nanomedicine, and biotechnology
pub_type: 杂志文章
doi:10.3109/21691401.2012.742100
更新日期:2013-04-01 00:00:00
abstract::Even though erythrocytes transport both oxygen and carbon dioxide, research on blood substitutes has concentrated on the transport of oxygen and its vasoactivity and oxidative effects. Recent study in a hemorrhagic shock animal model shows that the degree of tissue PCO(2) elevation is directly related to mortality rat...
journal_title:Artificial cells, nanomedicine, and biotechnology
pub_type: 杂志文章
doi:10.3109/10731199.2013.745291
更新日期:2013-02-01 00:00:00
abstract::We present a method for retrieval of cells encapsulated in alginate-polyethersulfone (AP) microcapsules. AP microcapsules consist of alginate hydrogel core and a semi-permeable polymer membrane. Proposed method is based on chemical destruction of microcapsule structure that is, polymer membranes are removed by dissolu...
journal_title:Artificial cells, nanomedicine, and biotechnology
pub_type: 杂志文章
doi:10.3109/21691401.2013.800083
更新日期:2014-06-01 00:00:00
abstract::The present study was aimed at exploring the targeting potential of LTA-anchored chitosan nanoparticles (CH-NP) specifically to M cell following oral immunization. The lectinized CH-NP exhibited 7-29% coupling capacity depending upon the amount of glutaraldehyde added. Induction of the mucosal immunity was assessed by...
journal_title:Artificial cells, nanomedicine, and biotechnology
pub_type: 杂志文章
doi:10.3109/21691401.2013.809726
更新日期:2014-08-01 00:00:00
abstract::The study aims to explore the potential of solid lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs) in improving the topical delivery of capsaicin (CAP) by in vitro and in vivo studies. The lipidic nanoparticles were prepared by solvent diffusion method and were characterized for average particle size...
journal_title:Artificial cells, nanomedicine, and biotechnology
pub_type: 杂志文章
doi:10.3109/21691401.2013.832683
更新日期:2015-02-01 00:00:00
abstract::Encapsulation techniques have the potential to protect hepatocytes from cryoinjury. In this study, we comparatively evaluated the viability and metabolic function of primary rat hepatocytes encapsulated in calcium alginate microbeads, in chitosan tripolyphosphate beads, and in three-layered alginate-chitosan-alginate ...
journal_title:Artificial cells, nanomedicine, and biotechnology
pub_type: 杂志文章
doi:10.3109/21691401.2013.837476
更新日期:2015-02-01 00:00:00
abstract::We report that adenovirus mediated TNF-related apoptosis-inducing ligand (TRAIL) influenced the cell growth and cell cycle in the glioma cells in vitro. After being infected with the Ad-sTRAIL, U251 cell growth was inhibited. The expression of sTRAIL was detected using immunofluorescence. The higher rate of apoptosis ...
journal_title:Artificial cells, nanomedicine, and biotechnology
pub_type: 杂志文章
doi:10.3109/21691401.2013.794350
更新日期:2014-06-01 00:00:00
abstract::We report a easy approach for the immobilization of glucose oxidase enzyme (GOx) on nanoparticles. Nanoparticles-modified polystyrene-ANH2 (PSA) with some salicylaldehyde derivatives were synthesized by means of condensation and investigated the enzymatic properties of GOx immobilized on there. Modified polystyrenes w...
journal_title:Artificial cells, nanomedicine, and biotechnology
pub_type: 杂志文章
doi:10.3109/21691401.2013.856014
更新日期:2015-01-01 00:00:00
abstract::Multiwavelength optical capsules can be generated and controlled by using soliton/Gaussian pulses within a nonlinear device system known as a "PANDA" ring circuit and system. The security of molecule/drug transportation can be formed by the strong coupling of soliton-like pulse, where the high-capacity optical capsule...
journal_title:Artificial cells, nanomedicine, and biotechnology
pub_type: 杂志文章
doi:10.3109/21691401.2013.866575
更新日期:2015-01-01 00:00:00
abstract::Calcium phosphates are one of the biomaterials that are used for bone regeneration. In this study, Hydroxyapatite (HAp) nanoparticles with chitosan gel filled with unrestricted somatic stem cells (USSCs) were used for healing calvarial bone in rat model. The healing effects of these injectable scaffolds with and witho...
journal_title:Artificial cells, nanomedicine, and biotechnology
pub_type: 杂志文章
doi:10.3109/21691401.2013.848874
更新日期:2015-04-01 00:00:00
abstract::Molecularly imprinted PHEMAH cryogels were synthesized and used for purification of carbonic anhydrase from bovine erythrocyte. Cryogels were prepared with free radical cryopolymerization of 2-hydroxyethyl methacrylate and methacryloylamido histidine and characterized by swelling degree, macroporosity, FTIR, SEM, surf...
journal_title:Artificial cells, nanomedicine, and biotechnology
pub_type: 杂志文章
doi:10.3109/21691401.2013.864663
更新日期:2014-04-01 00:00:00
abstract::This study was to investigate whether glutaraldehyde-polymerized human placenta hemoglobin (PolyPHb) could attenuate ischemia/reperfusion (I/R)-induced liver injury. Isovolemic hemodilution of SD rats was performed by exchanging 15% total blood volume with PolyPHb. I/R was induced by left liver lobes pedicle cross-cla...
journal_title:Artificial cells, nanomedicine, and biotechnology
pub_type: 杂志文章
doi:10.3109/21691401.2013.796311
更新日期:2014-04-01 00:00:00
abstract::Ex-vivo expansion technologies were developed for application of hematopoietic stem cells (HSCs) derived from cord blood (CB). The cytokine combination was essential to expand HSCs ex vivo and maintain the function of expanded HSCs. However the optimal cytokine combination was not determined. In this study, two combin...
journal_title:Artificial cells, nanomedicine, and biotechnology
pub_type: 杂志文章
doi:10.3109/21691401.2014.897630
更新日期:2015-01-01 00:00:00
abstract::The exact mechanism of hemoglobin-based oxygen carrier (HBOC)-related vasoactivity is still unclear. This study measured the isometric tension of dog arteries and large conductance Ca(2+)-activated K(+) (BKCa) channel currents in vascular smooth muscle cells after exposure to HBOC with increasing concentrations. Data ...
journal_title:Artificial cells, nanomedicine, and biotechnology
pub_type: 杂志文章
doi:10.3109/21691401.2014.930746
更新日期:2016-01-01 00:00:00
abstract::The effect of different genetically engineered bacteria, Pseudomonas syringae, Pseudomonas savastanoi, and Ralostonia solanacerum and also a natural marine bacterial species, Vibrio fischeri NRRL B-11177, is studied in producing gold nanoparticles. This is the first report about the biosynthesis of gold nanoparticles ...
journal_title:Artificial cells, nanomedicine, and biotechnology
pub_type: 杂志文章
doi:10.3109/21691401.2014.942457
更新日期:2014-08-04 00:00:00
abstract::The objectives of this study were the biosynthesis of silver nanoparticles (NPs) by biotransformations using Saccharomyces cerevisiae and analysis of the sizes and shapes of the NPs produced. Dried and freshly cultured S. cerevisiae were used as the biocatalyst. Dried yeast synthesized few NPs, but freshly cultured ye...
journal_title:Artificial cells, nanomedicine, and biotechnology
pub_type: 杂志文章
doi:10.3109/21691401.2014.937870
更新日期:2016-01-01 00:00:00
abstract::Liposomes provide an established basis for the sustainable development of different commercial products for treatment of medical diseases by the smart delivery of drugs. The industrial applications include the use of liposomes as drug delivery vehicles in medicine, adjuvants in vaccination, signal enhancers/carriers i...
journal_title:Artificial cells, nanomedicine, and biotechnology
pub_type: 杂志文章,评审
doi:10.3109/21691401.2014.953633
更新日期:2016-01-01 00:00:00
abstract::The present review briefly describes the nature, type and pathogenesis of ulcerative colitis, and explores the potential use of peptides and proteins in the treatment of inflammatory bowel disease, especially ulcerative colitis. Intestinal absorption and the barrier mechanism of peptide and protein drugs are also disc...
journal_title:Artificial cells, nanomedicine, and biotechnology
pub_type: 杂志文章,评审
doi:10.3109/21691401.2014.975239
更新日期:2016-01-01 00:00:00
abstract::The purpose of this research was to develop a suitable and alternate adjuvant for the tetanus toxoid (TT) vaccine that induces long term immunity after a single-dose immunization. In our study, the preformulation studies were carried out by using different ratios (7/3, 8/2, and 9/1) of chitosan-hydroxypropyl methylcel...
journal_title:Artificial cells, nanomedicine, and biotechnology
pub_type: 杂志文章
doi:10.3109/21691401.2014.966193
更新日期:2016-01-01 00:00:00
abstract::In this report, the oligosaccharides of hyaluronan (oHA)-histidine-menthone 1,2-glycerol ketal (MGK) (oHM) carried pH-sensitive MGK as hydrophobic moieties and oHA as the target of the CD44 receptor. The oHM could self-assemble, with a diameter of 65 nm. The cellular uptake, indicated by the fluorescent signals, was h...
journal_title:Artificial cells, nanomedicine, and biotechnology
pub_type: 杂志文章
doi:10.3109/21691401.2014.998828
更新日期:2016-05-01 00:00:00
abstract::Polymerized porcine hemoglobin (pPolyHb) exhibits a protective effect on ischemia/reperfusion of organ grafts. A series of experiments were performed to explore the underlying cytoprotective mechanisms of pPolyHb pretreatment on H2O2-induced cell death and apoptosis. The results showed that the pretreatment augmented ...
journal_title:Artificial cells, nanomedicine, and biotechnology
pub_type: 杂志文章
doi:10.3109/21691401.2014.1001494
更新日期:2015-06-01 00:00:00
abstract::In this study, we aimed to produce pH-sensitive microspheres for the controlled release of the nonsteroidal anti-inflammatory drug, ketorolac tromethamine (KT). For this purpose, an interpenetrating polymer network (IPN) of microspheres of poly(vinyl alcohol) (PVA)/sodium carboxymethyl cellulose (NaCMC) were prepared,...
journal_title:Artificial cells, nanomedicine, and biotechnology
pub_type: 杂志文章
doi:10.3109/21691401.2014.982805
更新日期:2016-05-01 00:00:00
abstract::Selenium acts as an important element in the prevention and treatment of cardiovascular diseases but their health-related effects have not been fully explored. As a novel attempt, zebrafish embryos were treated separately with SeNPs (5-25 μg/ml) and sodium selenite (5-25 μg/ml) starting at early blastula stage. Abnorm...
journal_title:Artificial cells, nanomedicine, and biotechnology
pub_type: 杂志文章
doi:10.3109/21691401.2015.1008507
更新日期:2016-05-01 00:00:00