Abstract:
:We would like to estimate the parameters of a dose-response function with the greatest precision as possible. For a two-parameter model, this is equivalent to minimizing the area of the confidence ellipsoid, i.e., a D-optimal design. Previous work on this particular model has included minimal designs. These designs are unable to determine lack of fit. We introduce a distinct dose level to the design to be able to estimate the lack of fit. The minimal and new designs will be compared, and the sample size needed to achieve adequate power for the lack-of-fit test will be derived.
journal_name
J Biopharm Statjournal_title
Journal of biopharmaceutical statisticsauthors
Lupinacci PJ,Raghavarao Ddoi
10.1081/BIP-100101012keywords:
subject
Has Abstractpub_date
2000-02-01 00:00:00pages
45-53issue
1eissn
1054-3406issn
1520-5711journal_volume
10pub_type
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