Cafeteria diet induces global and Slc27a3-specific hypomethylation in male Wistar rats.

abstract：:In recent years white adipose tissue inflammation has been recognized to be associated with obesity. Adipocytes and adipose tissue associated macrophages (ATMs) secrete bioactive molecules, including adipokines, chemokines/cytokines and free fatty acids that modulate the development of low-grade inflammation and insul...

journal_title：Adipocyte

authors： Jacobi D,Stanya KJ,Lee CH

更新日期：2012-01-01 00:00:00

abstract：:Adipose cells are unique in the dynamism of their sizes, a requisite for their main function of storing and releasing lipid. Lipid metabolism is crucial for energy homeostasis. However, the regulation of lipid storage capacity in conditions of energy excess and scarcity is still not clear. It is not technically feasib...

journal_title：Adipocyte

authors： Jo J,Shreif Z,Periwal V

更新日期：2012-04-01 00:00:00

abstract：:A constitutively downregulated cytoprotective mechanism in response to oxidative stress and its constant companion, inflammation, may exist in clinical and experimental diabetes. The Nrf2 signaling pathway promotes the expression of a plethora of genes that regulate processes involved in protein stability, proteosome ...

journal_title：Adipocyte

authors： Bitar MS

更新日期：2012-07-01 00:00:00

abstract：:We have reported the production of white adipocytes in adipose tissue from hematopoietic progenitors arising from bone marrow. However, technical challenges have hindered detection of this adipocyte population by certain other laboratories. These disparate results highlight the need for sensitive and definitive techni...

journal_title：Adipocyte

authors： Majka SM,Miller HL,Sullivan T,Erickson PF,Kong R,Weiser-Evans M,Nemenoff R,Moldovan R,Morandi SA,Davis JA,Klemm DJ

更新日期：2012-10-01 00:00:00

abstract：:Members of the acyl-CoA thioesterase (Acot) gene family catalyze the hydrolysis of fatty acyl-CoA thioesters. Thioesterase superfamily member (Them) 1 (synonym: Acot11) is enriched in brown adipose tissue and is markedly upregulated when mice are exposed to cold ambient temperatures. In a recent study, we demonstrated...

journal_title：Adipocyte

authors： Cohen DE

更新日期：2013-01-01 00:00:00

abstract：:Adipose tissue macrophage (ATM) accumulation through C-C motif chemokine receptor 2 (CCR2) and its ligand monocyte chemoattractant protein-1 (MCP-1) is considered pivotal in the development of insulin resistance. However, our new study has demonstrated that CCR5, a different CC chemokine receptor, plays an important r...

journal_title：Adipocyte

authors： Ota T

更新日期：2013-04-01 00:00:00

abstract：:The vitamin A metabolite retinoic acid (RA) regulates gene transcription by activating the nuclear receptors RAR and PPARβ/δ and their cognate lipid binding proteins CRABP-II, which delivers RA to RAR, and FABP5, which shuttles the hormone to PPARβ/δ. In preadipocytes, RA signals predominantly through CRABP-II and the...

journal_title：Adipocyte

authors： Noy N

更新日期：2013-07-01 00:00:00

abstract：:Oxidative stress is caused by an increase in reactive oxygen species (ROS) relative to the antioxidant defense system. An increase in ROS is known to decrease vascular function, increase inflammatory cytokines, and promote adipocyte hypertrophy. A known regulator of the oxidative stress response is the heat shock prot...

journal_title：Adipocyte

authors： Angevine K,Wuescher L,Mensah-Osman E

更新日期：2013-10-01 00:00:00

abstract：:Synucleins are a family of homologous, predominantly neuronal proteins known for their involvement in synaptic transmission and neurodegeneration. γ-synuclein is predominantly localized in axons and presynaptic terminals of selected populations of peripheral and central neurons but is also highly expressed in human wh...

journal_title：Adipocyte

authors： Millership S,Ninkina N,Rochford JJ,Buchman VL

更新日期：2013-10-01 00:00:00

abstract：:G6PDH is the rate-limiting enzyme of the pentose phosphate pathway and one of the principal source of NADPH, a major cellular reductant. Importantly, in ruminant's metabolism the aforementioned NADPH provided, is utilized for de novo fatty acid synthesis. Previous work of cloning the ovine (Ovis aries) og6pdh gene has...

journal_title：Adipocyte

authors： Triantaphyllopoulos KA,Laliotis GP,Bizelis IA

更新日期：2014-01-01 00:00:00

abstract：:Matricellular proteins are extracellular macromolecules that do not serve a structural role, but when incorporated into the matrix, modulate cell:cell and cell:matrix interactions. The matricellular protein thrombospondin (TSP)-1, a potent angiostatic mediator and activator of transforming growth factor (TGF)-β, is up...

journal_title：Adipocyte

authors： Kong P,Cavalera M,Frangogiannis NG

更新日期：2014-01-01 00:00:00

abstract：:Since adipose tissue is composed of adipocytes as well as other cell types including endothelial cells, this study sought to determine how mediators from adipocytes and from endothelial cells impact on immune cell production of cytokines. A minimalistic design was used in which media conditioned by adipocytes or by en...

journal_title：Adipocyte

authors： Vielma SA,Klein RL,Levingston CA,Young MR

更新日期：2014-04-01 00:00:00

abstract：:Subcutaneous adipose tissue expansion through adipogenesis is increasingly recognized as a major determinant of body fat distribution and obesity-related cardiometabolic alterations. Our objective was to assess whether adipogenic rates of cultured human primary preadipocytes from the visceral and subcutaneous compartm...

journal_title：Adipocyte

authors： Lessard J,Laforest S,Pelletier M,Leboeuf M,Blackburn L,Tchernof A

更新日期：2014-07-01 00:00:00

abstract：:Obesity is often associated with systemic insulin resistance, and the decline of insulin sensitivity marks the progression of obesity into a disease state. We recently generated a mouse with adipose-specific ablation of the p110α phosphoinositide 3-kinase (PI3K) catalytic subunit to model insulin resistance in this or...

journal_title：Adipocyte

authors： Nelson VL,Ballou LM,Lin RZ

更新日期：2014-11-14 00:00:00

abstract：:A diet enriched with citrulline (CIT) reduces white adipose tissue (WAT) mass. We recently showed that CIT stimulated β-oxidation in rat WAT explants from young (2-4 months) but not old (25 months) rats. Here we show that both in old rats and high-fat-diet-fed young rats, uncoupling protein one (UCP1) mRNA and protein...

journal_title：Adipocyte

authors： Joffin N,Jaubert AM,Bamba J,Barouki R,Noirez P,Forest C

更新日期：2015-01-07 00:00:00

abstract：:Early studies reported that the size of adipose cells positively correlates with insulin resistance, but recent evidence suggests that the relationship between adipose cell size and insulin resistance is more complex. We previously reported that among BMI-matched moderately obese subjects who were either insulin sensi...

journal_title：Adipocyte

authors： Eliasson B,Smith U,Mullen S,Cushman SW,Sherman AS,Yang J

更新日期：2014-12-10 00:00:00

abstract：:Differentiated 3T3-L1 adipocytes are a widely used in vitro model of white adipocytes. In addition to classical white and brown adipocytes that are derived from different cell lineages, beige adipocytes have also been identified, which have characteristics of both white and brown adipocytes. Here we show that 3T3-L1 a...

journal_title：Adipocyte

authors： Morrison S,McGee SL

更新日期：2015-04-18 00:00:00

abstract：:The role of the angiotensin type-2 receptor in adipose physiology remains controversial. The aim of the present study was to demonstrate whether genetic angiotensin type-2 receptor-deficiency prevents or worsens metabolic and adipose tissue morphometric changes observed following a 6-week high-fat/high-fructose diet w...

journal_title：Adipocyte

authors： Noll C,Labbé SM,Pinard S,Shum M,Bilodeau L,Chouinard L,Phoenix S,Lecomte R,Carpentier AC,Gallo-Payet N

更新日期：2015-12-08 00:00:00

abstract：:The discovery of brown adipose tissue in adult humans along with the recognition of adipocyte heterogeneity and plasticity of white fat depots has renewed the interest in targeting adipose tissue for therapeutic benefit. Adrenergic activation is a well-established means of recruiting catabolic adipocyte phenotypes in ...

journal_title：Adipocyte

authors： Ramseyer VD,Granneman JG

更新日期：2016-02-18 00:00:00

abstract：:Obesity is characterized by an excessive fat accumulation in adipose tissues leading to weight gain and is increasing in prevalence and is strongly associated with metabolic and cardiovascular disorders. The renin-angiotensin system (RAS) has emerged as a key pathogenic mechanism for these disorders; activated RAS and...

journal_title：Adipocyte

authors： Patel VB,Basu R,Oudit GY

更新日期：2016-01-06 00:00:00

abstract：:The physiologic function of adipose tissue is altered by the host's inflammatory response; the implications for maintaining human health and regulating inflammation-associated disease progression are ill defined. However, this cannot be investigated in humans, therefore the use of animal models is required. With the a...

journal_title：Adipocyte

authors： Sime K,Choy EH,Williams AS

更新日期：2017-04-03 00:00:00

abstract：:Some bona fide adult adipocytes arise de novo from a bone marrow-derived myeloid lineage. These studies further demonstrate that adipose tissue stroma contains a resident population of myeloid cells capable of adipocyte and multilineage mesenchymal differentiation. These resident myeloid cells lack hematopoietic marke...

journal_title：Adipocyte

authors： Gavin KM,Majka SM,Kohrt WM,Miller HL,Sullivan TM,Klemm DJ

更新日期：2017-07-03 00:00:00

abstract：:Reactive oxygen species (ROS) production and oxidative stress (OS) in adipose tissue are associated with obesity and insulin resistance (IR). The nature of this relationship i.e., cause and effect or consequence has not been clearly determined. We provide evidence that elevated mitochondrial ROS generated by adipocyte...

journal_title：Adipocyte

authors： Ortega SP,Chouchani ET,Boudina S

更新日期：2017-01-02 00:00:00

abstract：:The human body is an integrated circuit between microbial symbionts and our Homo sapien genome, which communicate bi-directionally to maintain homeostasis within the human meta-organism. There is now strong evidence that microbes resident in the human intestine can directly contribute to the pathogenesis of obesity an...

journal_title：Adipocyte

authors： Schugar RC,Willard B,Wang Z,Brown JM

更新日期：2018-01-02 00:00:00

abstract：:Loss of ovarian hormones is associated with increased adiposity, white adipose tissue (WAT) inflammation, and insulin resistance (IR). Previous work demonstrated ovariectomized (OVX) rats bred for high aerobic fitness (HCR) are protected against weight gain and IR compared to rats bred for low aerobic fitness (LCR) ye...

journal_title：Adipocyte

authors： Zidon TM,Park YM,Welly RJ,Woodford ML,Scroggins RJ,Britton SL,Koch LG,Booth FW,Padilla J,Kanaley JA,Vieira-Potter VJ

更新日期：2018-01-02 00:00:00

abstract：:The intestinal microbiota may contribute to the development of obesity by affecting host lipid metabolism and insulin sensitivity. To investigate the effects of microbiota manipulation on ex vivo basal and β-adrenergically-stimulated lipolysis in human adipocytes, 36 obese men were randomized to amoxicillin (broad-spe...

journal_title：Adipocyte

authors： Jocken JWE,Reijnders D,Canfora EE,Boekschoten MV,Plat J,Goossens GH,Blaak EE

更新日期：2018-01-01 00:00:00

abstract：:Obesity is a low-grade sustained inflammatory state that causes oxidative stress in different metabolic tissues, which leads to insulin resistance and nonalcoholic fatty liver disease (NAFLD). Particularly, obesity-induced metabolic endotoxemia plays an important role in the pathogenesis of insulin resistance and infl...

journal_title：Adipocyte

authors： Xu L,Nagata N,Ota T

更新日期：2018-01-01 00:00:00

abstract：:The circadian clock is an intricate molecular network that paces a variety of physiological process to ~ 24 hour day/night cycles. Whereas the central circadian clock in the brain is primarily entrained by light signals, peripheral circadian clocks, which are in most cells in the body, receive cues not only from the c...

journal_title：Adipocyte

authors： Jung Y,Feldman BJ

更新日期：2018-01-01 00:00:00

abstract：:The protective effects of lower body subcutaneous adiposity are linked to the depot functioning as a "metabolic sink" receiving and sequestering excess lipid. This postulate, however, is based on indirect evidence. Mechanisms that mediate this protection are unknown. Here we directly examined this with progressive sub...

journal_title：Adipocyte

authors： Booth AD,Magnuson AM,Fouts J,Wei Y,Wang D,Pagliassotti MJ,Foster MT

更新日期：2018-01-01 00:00:00

abstract：:Individual cell types vary enormously in the amount of different organelles they contain. One such organelle is the mitochondrion. Understanding how mitochondrial levels are controlled is essential since so many disease states seem to involve mitochondrial function. The beige adipocyte is an inducible form of adipocyt...

journal_title：Adipocyte

authors： Lu X

更新日期：2019-12-01 00:00:00