Abstract:
:The number of studies published in the biomedical literature has dramatically increased over the last few decades. This massive proliferation of literature makes clinical medicine increasingly complex, and information from multiple studies is often needed to inform a particular clinical decision. However, available studies often vary in their design, methodological quality, and population studied, and may define the research question of interest quite differently. This can make it challenging to synthesize the conclusions of multiple studies. In addition, since even highly cited trials may be challenged over time, clinical decision-making requires ongoing reconciliation of studies which provide different answers to the same question. Because it is often impractical for readers to track down and review all the primary studies, systematic reviews and meta-analyses are an important source of evidence on the diagnosis, prognosis and treatment of any given disease. This chapter summarizes methods for conducting and reading systematic reviews and meta-analyses, as well as describes potential advantages and disadvantages of these publications.
journal_name
Methods Mol Bioljournal_title
Methods in molecular biology (Clifton, N.J.)authors
Bello A,Vandermeer B,Wiebe N,Garg AX,Tonelli Mdoi
10.1007/978-1-0716-1138-8_22keywords:
["Forest plot","Literature synthesis","Meta-analysis","Random effects","Systematic review"]subject
Has Abstractpub_date
2021-01-01 00:00:00pages
405-428eissn
1064-3745issn
1940-6029journal_volume
2249pub_type
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