Abstract：
:Hepatitis B virus (HBV) infection is one of the major infectious hazards for health-care workers (HCWs) because of the frequency of percutaneous exposures to blood or body fluids. For this reason, all HCWs should be vaccinated, including students in medicine and health professional degree programs. The aim of this study was to assess the immune coverage to anti-HBV vaccine and long-lasting protective titres of anti-HBs antibodies in female and male students to evaluate gender-related differences in response to HBV vaccination. Data relative to anti-HBs antibody titre, sex, age, and age at vaccination were collected and analyzed from 5291 Italian students (1812 males and 3479 females) of the graduate courses at the School of Medicine, who underwent the mandatory health surveillance of workers exposed to biological risk. The results indicated that gender affects the immune response to HBV vaccine, particularly evident in the case of females vaccinated after one year of age who exhibited a statistically significant (p = 0.0023) 1.21-fold increase in median antibody titre with respect to males. Our findings could contribute to the optimization of HBV vaccination schedules in health surveillance of HCWs.
journal_name
Int J Environ Res Public Healthauthors
Trevisan A,Giuliani A,Scapellato ML,Anticoli S,Carsetti R,Zaffina S,Brugaletta R,Vonesch N,Tomao P,Ruggieri Adoi
10.3390/ijerph17010327subject
Has Abstractpub_date
2020-01-02 00:00:00issue
1eissn
1661-7827issn
1660-4601pii
ijerph17010327journal_volume
17pub_type
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