Abstract:
:Changes in neurotransmitter levels in the brain play an important role in epilepsy-like attacks after pregnancy-induced preeclampsia-eclampsia. Metabotropic glutamate receptor 1 participates in the onset of lipid metabolism disorder-induced preeclampsia. Pregnant rats were fed with a high-fat diet for 20 days. Thus, these pregnant rats experienced preeclampsia-like syndromes such as tension and proteinuria. Simultaneously, metabotropic glutamate receptor 1 mRNA and protein expressions were upregulated in the rat hippocampus. These findings indicate that increased sion of metabotropic glutamate receptor 1 promotes the occurrence of high-fat diet-induced preeclampsia in pregnant rats.
journal_name
Neural Regen Resjournal_title
Neural regeneration researchauthors
Ge J,Wang J,Xue D,Zhu Z,Chen Z,Li X,Su D,Du Jdoi
10.3969/j.issn.1673-5374.2013.20.006keywords:
["eclampsia","excitatory neurotransmitter","grants-supported paper","hyperlipidemia","hypertension","lipoprotein-associated phospholipase A2","metabotropic mate receptor 1","neural regeneration","neuroregeneration","neurotoxicity","preeclampsia","pregnancy"]subject
Has Abstractpub_date
2013-07-15 00:00:00pages
1872-80issue
20eissn
1673-5374issn
1876-7958pii
NRR-8-1872journal_volume
8pub_type
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