Non-invasive detection of genomic imbalances in Hodgkin/Reed-Sternberg cells in early and advanced stage Hodgkin's lymphoma by sequencing of circulating cell-free DNA: a technical proof-of-principle study.

abstract：BACKGROUND:Substantial evidence links exposure to moderate or high doses of ionising radiation, particularly in childhood, with increased risk of leukaemia. The association of leukaemia with exposure to low-dose (<100 mSv) radiation is less certain, although this is the dose range most relevant to the general populatio...

journal_title：The Lancet. Haematology

authors： Little MP,Wakeford R,Borrego D,French B,Zablotska LB,Adams MJ,Allodji R,de Vathaire F,Lee C,Brenner AV,Miller JS,Campbell D,Pearce MS,Doody MM,Holmberg E,Lundell M,Sadetzki S,Linet MS,Berrington de González A

更新日期：2018-08-01 00:00:00

abstract：BACKGROUND:High-dose melphalan is of little benefit as a regimen for patients with relapsed or refractory myeloma undergoing an autologous stem-cell transplant (ASCT). The poor performance of single-agent melphalan in this setting prompted us to study a new high-dose combination of infused gemcitabine, busulfan, and me...

journal_title：The Lancet. Haematology

authors： Nieto Y,Valdez BC,Pingali SR,Bassett R,Delgado R,Nguyen J,Shah N,Popat U,Jones RB,Andersson BS,Gulbis A,Ahmed S,Bashir Q,Parmar S,Patel K,Myers A,Rondon G,Orlowski RZ,Champlin R,Qazilbash M

更新日期：2017-06-01 00:00:00

abstract：BACKGROUND:High-dose methotrexate-based chemotherapy is standard for primary CNS lymphoma, but most patients relapse. High-dose chemotherapy with autologous stem cell transplantation (HCT-ASCT) is supposed to overcome the blood-brain barrier and eliminate residual disease in the CNS. We aimed to investigate the safety ...

journal_title：The Lancet. Haematology

authors： Illerhaus G,Kasenda B,Ihorst G,Egerer G,Lamprecht M,Keller U,Wolf HH,Hirt C,Stilgenbauer S,Binder M,Hau P,Edinger M,Frickhofen N,Bentz M,Möhle R,Röth A,Pfreundschuh M,von Baumgarten L,Deckert M,Hader C,Fricker H,

更新日期：2016-08-01 00:00:00

abstract：BACKGROUND:Anaemia and iron deficiency are common after post-bariatric abdominoplasty, which can involve removal of large areas of skin with associated blood loss. Because the oral absorbability of iron is reduced after bariatric surgery (through reduced intake, reduction of gastric acid secretion for conjugation of ir...

journal_title：The Lancet. Haematology

authors： Montano-Pedroso JC,Bueno Garcia E,Alcântara Rodrigues de Moraes M,Francescato Veiga D,Masako Ferreira L

更新日期：2018-07-01 00:00:00

abstract：BACKGROUND:The optimum preparative regimen for unrelated donor marrow transplantation in patients with severe aplastic anaemia remains to be established. We investigated whether the combination of fludarabine, anti-thymocyte globulin, and total body irradiation (TBI) would enable reduction of the cyclophosphamide dose ...

journal_title：The Lancet. Haematology

authors： Anderlini P,Wu J,Gersten I,Ewell M,Tolar J,Antin JH,Adams R,Arai S,Eames G,Horwitz ME,McCarty J,Nakamura R,Pulsipher MA,Rowley S,Leifer E,Carter SL,DiFronzo NL,Horowitz MM,Confer D,Deeg HJ,Eapen M

更新日期：2015-09-01 00:00:00

abstract：BACKGROUND:Ponatinib has shown efficacy in patients with refractory chronic myeloid leukaemia (CML) and in those with CML with a Thr315Ile mutation. We aimed to investigate the activity and safety of ponatinib as first-line treatment for patients with chronic-phase CML. METHODS:We did a single-arm, phase 2 trial at MD...

journal_title：The Lancet. Haematology

authors： Jain P,Kantarjian H,Jabbour E,Gonzalez GN,Borthakur G,Pemmaraju N,Daver N,Gachimova E,Ferrajoli A,Kornblau S,Ravandi F,O'Brien S,Cortes J

更新日期：2015-09-01 00:00:00

abstract：BACKGROUND:Treatment of venous thromboembolism in children is based on data obtained in adults with little direct documentation of its efficacy and safety in children. The aim of our study was to compare the efficacy and safety of rivaroxaban versus standard anticoagulants in children with venous thromboembolism. METH...

journal_title：The Lancet. Haematology

authors： Male C,Lensing AWA,Palumbo JS,Kumar R,Nurmeev I,Hege K,Bonnet D,Connor P,Hooimeijer HL,Torres M,Chan AKC,Kenet G,Holzhauer S,Santamaría A,Amedro P,Chalmers E,Simioni P,Bhat RV,Yee DL,Lvova O,Beyer-Westendorf J,B

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:Among the syndromes characterised by thrombotic microangiopathy, thrombotic thrombocytopenic purpura is distinguished by a severe deficiency in the ADAMTS13 enzyme. Patients with this disorder need urgent treatment with plasma exchange. Because ADAMTS13 activity testing typically requires prolonged turnaroun...

journal_title：The Lancet. Haematology

authors： Bendapudi PK,Hurwitz S,Fry A,Marques MB,Waldo SW,Li A,Sun L,Upadhyay V,Hamdan A,Brunner AM,Gansner JM,Viswanathan S,Kaufman RM,Uhl L,Stowell CP,Dzik WH,Makar RS

更新日期：2017-04-01 00:00:00

abstract：BACKGROUND:The ability of the pulmonary embolism rule-out criteria (PERC) to exclude pulmonary embolism without further testing remains debated outside the USA, especially in the population with suspected pulmonary embolism who have a high prevalence of the condition. Our main objective was to prospectively assess the ...

journal_title：The Lancet. Haematology

authors： Penaloza A,Soulié C,Moumneh T,Delmez Q,Ghuysen A,El Kouri D,Brice C,Marjanovic NS,Bouget J,Moustafa F,Trinh-Duc A,Le Gall C,Imsaad L,Chrétien JM,Gable B,Girard P,Sanchez O,Schmidt J,Le Gal G,Meyer G,Delvau N,Roy

更新日期：2017-12-01 00:00:00

abstract：BACKGROUND:Panobinostat (a pan histone deacetylase inhibitor) is approved in combination with bortezomib and dexamethasone for patients with relapsed multiple myeloma who have received two or more previous lines of therapy. We aimed to improve the safety of this combination and investigate efficacy by incorporating low...

journal_title：The Lancet. Haematology

authors： Popat R,Brown SR,Flanagan L,Hall A,Gregory W,Kishore B,Streetly M,Oakervee H,Yong K,Cook G,Low E,Cavenagh J,Myeloma UK Early Phase Clinical Trial Network.

更新日期：2016-12-01 00:00:00

abstract：BACKGROUND:Although cytomegalovirus viral load is commonly used to guide pre-emptive therapy in the post-transplantation setting, few data are available correlating viraemia with clinical endpoints. We therefore investigated the association between cytomegalovirus viral load and mortality in the first year after haemop...

journal_title：The Lancet. Haematology

authors： Green ML,Leisenring W,Xie H,Mast TC,Cui Y,Sandmaier BM,Sorror ML,Goyal S,Özkök S,Yi J,Sahoo F,Kimball LE,Jerome KR,Marks MA,Boeckh M

更新日期：2016-03-01 00:00:00

abstract：BACKGROUND:Sintilimab (Innovent Biologics, Suzhou, China), a highly selective, fully humanised, monoclonal antibody, blocks the interaction between PD-1 and its ligands. We aimed to assess the activity and safety profile of sintilimab in Chinese patients with relapsed or refractory classical Hodgkin lymphoma. METHODS:...

journal_title：The Lancet. Haematology

authors： Shi Y,Su H,Song Y,Jiang W,Sun X,Qian W,Zhang W,Gao Y,Jin Z,Zhou J,Jin C,Zou L,Qiu L,Li W,Yang J,Hou M,Zeng S,Zhang Q,Hu J,Zhou H,Xiong Y,Liu P

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:Fit patients with mantle cell lymphoma aged 18-65 years are usually given cytarabine and rituximab-based induction regimens followed by autologous haematopoetic stem-cell transplantation (HSCT). We investigated whether post-autologous HSCT maintenance with lenalidomide improves progression-free survival in t...

journal_title：The Lancet. Haematology

authors： Ladetto M,Cortelazzo S,Ferrero S,Evangelista A,Mian M,Tavarozzi R,Zanni M,Cavallo F,Di Rocco A,Stefoni V,Pagani C,Re A,Chiappella A,Balzarotti M,Zilioli VR,Gomes da Silva M,Arcaini L,Molinari AL,Ballerini F,Ferreri

更新日期：2021-01-01 00:00:00

abstract：BACKGROUND:Gilbert's syndrome is a common inherited disorder of bilirubin metabolism, characterised by mild, unconjugated hyperbilirubinaemia. However, the effect of Gilbert's syndrome on the disposition of some drugs can lead to unexpected toxicity. We tested the hypothesis that patients undergoing myeloablative condi...

journal_title：The Lancet. Haematology

authors： McDonald GB,Evans AT,McCune JS,Schoch G,Ostrow JD,Gooley TA

更新日期：2016-11-01 00:00:00

abstract：BACKGROUND:The INO-VATE study demonstrated efficacy and safety of inotuzumab ozogamicin versus standard care in adults with relapsed or refractory B-cell acute lymphoblastic leukaemia. Here, we report the frequency of, and potential risk factors for, hepatotoxicity in patients in this trial and after treatment and subs...

journal_title：The Lancet. Haematology

authors： Kantarjian HM,DeAngelo DJ,Advani AS,Stelljes M,Kebriaei P,Cassaday RD,Merchant AA,Fujishima N,Uchida T,Calbacho M,Ejduk AA,O'Brien SM,Jabbour EJ,Zhang H,Sleight BJ,Vandendries ER,Marks DI

更新日期：2017-08-01 00:00:00

abstract：BACKGROUND:In patients with pulmonary embolism, right ventricular dysfunction is associated with early mortality. The Hokusai-VTE study used N-terminal pro-brain natriuretic peptide (NT-proBNP) and right to left ventricular diameter ratio on CT as indicators of right ventricular dysfunction and reported that recurrent ...

journal_title：The Lancet. Haematology

authors： Brekelmans MP,Ageno W,Beenen LF,Brenner B,Buller HR,Chen CZ,Cohen AT,Grosso MA,Meyer G,Raskob G,Segers A,Vanassche T,Verhamme P,Wells PS,Zhang G,Weitz JI

更新日期：2016-09-01 00:00:00

abstract：BACKGROUND:Venous thromboembolism is a common complication of cancer, but the risk of developing venous thromboembolism varies greatly among individuals and depends on numerous factors, including type of cancer. We aimed to develop and externally validate a clinical prediction model for cancer-associated venous thrombo...

journal_title：The Lancet. Haematology

authors： Pabinger I,van Es N,Heinze G,Posch F,Riedl J,Reitter EM,Di Nisio M,Cesarman-Maus G,Kraaijpoel N,Zielinski CC,Büller HR,Ay C

更新日期：2018-07-01 00:00:00

abstract：BACKGROUND:Intravenous rituximab is the standard of care in B-cell non-Hodgkin lymphoma, and is administered over 1·5-6 h. A subcutaneous formulation could reduce patients' treatment burden and improve resource utilisation in health care. We aimed to show the pharmacokinetic non-inferiority of subcutaneous rituximab to...

journal_title：The Lancet. Haematology

authors： Davies A,Merli F,Mihaljević B,Mercadal S,Siritanaratkul N,Solal-Céligny P,Boehnke A,Berge C,Genevray M,Zharkov A,Dixon M,Brewster M,Barrett M,MacDonald D

更新日期：2017-06-01 00:00:00

abstract：BACKGROUND:Effective treatment of trauma-induced coagulopathy is important; however, the optimal therapy is still not known. We aimed to compare the efficacy of first-line therapy using fresh frozen plasma (FFP) or coagulation factor concentrates (CFC) for the reversal of trauma-induced coagulopathy, the arising transf...

journal_title：The Lancet. Haematology

authors： Innerhofer P,Fries D,Mittermayr M,Innerhofer N,von Langen D,Hell T,Gruber G,Schmid S,Friesenecker B,Lorenz IH,Ströhle M,Rastner V,Trübsbach S,Raab H,Treml B,Wally D,Treichl B,Mayr A,Kranewitter C,Oswald E

更新日期：2017-06-01 00:00:00

abstract：BACKGROUND:Bortezomib with lenalidomide and dexamethasone (VRd) is a standard regimen for the front-line treatment of multiple myeloma. Panobinostat is approved in combination with bortezomib and dexamethasone in patients with myeloma who 'have been given at least two previous regimens including bortezomib and an immun...

journal_title：The Lancet. Haematology

authors： Manasanch EE,Shah JJ,Lee HC,Weber DM,Thomas SK,Amini B,Feng L,Berkova Z,Hildebrandt M,Orlowski RZ

更新日期：2018-12-01 00:00:00

abstract：:Evaluation of tolerability is increasingly relevant for patients with haematological malignancies treated with chronically administered therapies. Adverse events from these agents might affect the ability of patients to tolerate treatment over time. Conventional toxicity tables that include the incidence of high-grade...

journal_title：The Lancet. Haematology

authors： Thanarajasingam G,Leonard JP,Witzig TE,Habermann TM,Blum KA,Bartlett NL,Flowers CR,Pitcher BN,Jung SH,Atherton PJ,Tan A,Novotny PJ,Dueck AC

更新日期：2020-06-01 00:00:00

abstract：BACKGROUND:The introduction of donors other than HLA-matched siblings has been a pivotal change in stem cell transplantation. We aimed to assess the evolution of outcomes within donor groups over time and explore whether donor-recipient HLA disparity might be advantageous in patients with aggressive disease. METHODS:I...

journal_title：The Lancet. Haematology

authors： Shouval R,Fein JA,Labopin M,Kröger N,Duarte RF,Bader P,Chabannon C,Kuball J,Basak GW,Dufour C,Galimard JE,Polge E,Lankester A,Montoto S,Snowden JA,Styczynski J,Yakoub-Agha I,Mohty M,Nagler A

更新日期：2019-11-01 00:00:00

abstract：BACKGROUND:Prevention of graft-versus-host disease (GvHD) without malignant relapse is the overall goal of allogeneic haemopoietic cell transplantation (HCT). We aimed to evaluate regimens using either maraviroc, bortezomib, or post-transplantation cyclophosphamide for GvHD prophylaxis compared with controls receiving ...

journal_title：The Lancet. Haematology

authors： Bolaños-Meade J,Reshef R,Fraser R,Fei M,Abhyankar S,Al-Kadhimi Z,Alousi AM,Antin JH,Arai S,Bickett K,Chen YB,Damon LE,Efebera YA,Geller NL,Giralt SA,Hari P,Holtan SG,Horowitz MM,Jacobsohn DA,Jones RJ,Liesveld JL,

更新日期：2019-03-01 00:00:00

abstract：BACKGROUND:In patients with chronic lymphocytic leukaemia, achievement of a complete response with minimal residual disease of less than 0·01% (ie, <1 chronic lymphocytic leukaemia cell per 10 000 leukocytes) in bone marrow has been associated with improved progression-free survival. We aimed to explore the activity of...

journal_title：The Lancet. Haematology

authors： Michallet AS,Dilhuydy MS,Subtil F,Rouille V,Mahe B,Laribi K,Villemagne B,Salles G,Tournilhac O,Delmer A,Portois C,Pegourie B,Leblond V,Tomowiak C,de Guibert S,Orsini F,Banos A,Carassou P,Cartron G,Fornecker LM,Yse

更新日期：2019-09-01 00:00:00

abstract：BACKGROUND:Leukoencephalopathy is observed in some children undergoing chemotherapy for acute lymphoblastic leukaemia, although its effects on long-term outcomes is unknown. This study examines the associations between acute leukoencephalopathy and neurobehavioural, neurocognitive, and brain white matter imaging outcom...

journal_title：The Lancet. Haematology

authors： Cheung YT,Sabin ND,Reddick WE,Bhojwani D,Liu W,Brinkman TM,Glass JO,Hwang SN,Srivastava D,Pui CH,Robison LL,Hudson MM,Krull KR

更新日期：2016-10-01 00:00:00

abstract：BACKGROUND:Data to inform surveillance and treatment for leukaemia predisposition syndromes are scarce and recommendations are largely based on expert opinion. This study aimed to investigate the clinical features and outcomes of patients with myelodysplastic syndrome or acute myeloid leukaemia and Shwachman-Diamond sy...

journal_title：The Lancet. Haematology

authors： Myers KC,Furutani E,Weller E,Siegele B,Galvin A,Arsenault V,Alter BP,Boulad F,Bueso-Ramos C,Burroughs L,Castillo P,Connelly J,Davies SM,DiNardo CD,Hanif I,Ho RH,Karras N,Manalang M,McReynolds LJ,Nakano TA,Nalepa G

更新日期：2020-03-01 00:00:00

abstract：BACKGROUND:Deep vein thrombosis (DVT) and pulmonary embolism are collectively known as venous thromboembolism (VTE), which is a common vascular disease and a major cause of morbidity and mortality worldwide. We compare effectiveness and safety of rivaroxaban versus warfarin in a prospective cohort of routine care patie...

journal_title：The Lancet. Haematology

authors： Larsen TB,Skjøth F,Kjældgaard JN,Lip GYH,Nielsen PB,Søgaard M

更新日期：2017-05-01 00:00:00

abstract：BACKGROUND:Studies in patients with rheumatoid arthritis have shown that the rituximab biosimilar CT-P10 (Celltrion, Incheon, South Korea) has equivalent efficacy and pharmacokinetics to rituximab. In this phase 3 study, we aimed to assess the non-inferior efficacy and pharmacokinetic equivalence of CT-P10 compared wit...

journal_title：The Lancet. Haematology

authors： Kim WS,Buske C,Ogura M,Jurczak W,Sancho JM,Zhavrid E,Kim JS,Hernández-Rivas JÁ,Prokharau A,Vasilica M,Nagarkar R,Osmanov D,Kwak LW,Lee SJ,Lee SY,Bae YJ,Coiffier B

更新日期：2017-08-01 00:00:00

abstract：:Machine learning is a branch of computer science and statistics that generates predictive or descriptive models by learning from training data rather than by being rigidly programmed. It has attracted substantial attention for its many applications in medicine, both as a catalyst for research and as a means of improvi...

journal_title：The Lancet. Haematology

authors： Radakovich N,Nagy M,Nazha A

更新日期：2020-07-01 00:00:00

abstract：BACKGROUND:Pegylated interferon alfa-2a is an immunomodulatory agent used to treat polycythemia vera. The durability of responses and long-term safety of this drug in patients with polycythaemia vera and essential thrombocythaemia have not been reported. Here, we present long-term efficacy and safety data from a single...

journal_title：The Lancet. Haematology

authors： Masarova L,Patel KP,Newberry KJ,Cortes J,Borthakur G,Konopleva M,Estrov Z,Kantarjian H,Verstovsek S

更新日期：2017-04-01 00:00:00