Honokiol confers immunogenicity by dictating calreticulin exposure, activating ER stress and inhibiting epithelial-to-mesenchymal transition.

abstract：:Brain metastases are life-threatening complications of triple-negative breast cancer, melanoma, and a few other tumor types. Poor outcome of cerebral secondary tumors largely depends on the microenvironment formed by cells of the neurovascular unit, among which pericytes are the least characterized. By using in vivo a...

journal_title：Molecular oncology

authors： Molnár K,Mészáros Á,Fazakas C,Kozma M,Győri F,Reisz Z,Tiszlavicz L,Farkas AE,Nyúl-Tóth Á,Haskó J,Krizbai IA,Wilhelm I

更新日期：2020-09-01 00:00:00

abstract：:Targeted toxin-based therapeutics are hindered by poor intracellular uptake, limited stability and non-specific immune stimulation. To address these problems, ligand-targeted toxins in combination with low dose saponin mixtures have been adapted and tested in vivo in the past, however, undefined saponin raw mixtures a...

journal_title：Molecular oncology

authors： Thakur M,Mergel K,Weng A,von Mallinckrodt B,Gilabert-Oriol R,Dürkop H,Melzig MF,Fuchs H

更新日期：2013-06-01 00:00:00

abstract：:Aberrant expression of the pluripotency factor OCT4A in embryonal tumors of the central nervous system (CNS) is a key factor that contributes to tumor aggressiveness and correlates with poor patient survival. OCT4A overexpression has been shown to up-regulate miR-367, a microRNA (miRNA) that regulates pluripotency in ...

journal_title：Molecular oncology

authors： Kaid C,Jordan D,Bueno HMS,Araujo BHS,Assoni A,Okamoto OK

更新日期：2019-12-01 00:00:00

abstract：:Circulating tumor cell (CTC) analysis holds great potential to be a noninvasive solution for clinical cancer management. A complete workflow that combined CTC detection and single-cell molecular analysis is required. We developed the ChimeraX® -i120 platform to facilitate negative enrichment, immunofluorescent labelin...

journal_title：Molecular oncology

authors： Wang PX,Sun YF,Jin WX,Cheng JW,Peng HX,Xu Y,Zhou KQ,Chen LM,Huang K,Wu SY,Hu B,Zhang ZF,Guo W,Cao Y,Zhou J,Fan J,Yang XR

更新日期：2020-12-10 00:00:00

abstract：:ATR-CHEK1 signalling is critical for genomic stability. ATR-CHEK1 signalling may be deregulated in breast cancer and have prognostic, predictive and therapeutic significance. We investigated ATR, CHEK1 and phosphorylated CHEK1 (Ser345) protein (pCHEK1) levels in 1712 breast cancers. ATR and CHEK1 mRNA expression was e...

journal_title：Molecular oncology

authors： Abdel-Fatah TM,Middleton FK,Arora A,Agarwal D,Chen T,Moseley PM,Perry C,Doherty R,Chan S,Green AR,Rakha E,Ball G,Ellis IO,Curtin NJ,Madhusudan S

更新日期：2015-03-01 00:00:00

abstract：:The cancer stem cell (CSC) hypothesis postulates that tumors are maintained by a self-renewing CSC population that is also capable of differentiating into non-self-renewing cell populations that constitute the bulk of the tumor. Although, the CSC hypothesis does not directly address the cell of origin of cancer, it is...

journal_title：Molecular oncology

authors： McDermott SP,Wicha MS

更新日期：2010-10-01 00:00:00

abstract：:The absence of biomarkers to accurately predict anticancer therapy response remains a major obstacle in clinical oncology. We applied a genome-wide loss-of-function screening approach in human haploid cells to characterize genetic vulnerabilities to classical microtubule-targeting agents. Using docetaxel and vinorelbi...

journal_title：Molecular oncology

authors： Gerhards NM,Blomen VA,Mutlu M,Nieuwenhuis J,Howald D,Guyader C,Jonkers J,Brummelkamp TR,Rottenberg S

更新日期：2018-06-01 00:00:00

abstract：:Cancer is a noncommunicable disease (NCD) with increasing incidence and therefore constitutes a major public health issue. To reduce the health and economic burden of cancer, policy-makers across the world have implemented a range of preventative interventions targeting risk factors with a known link to the disease. I...

journal_title：Molecular oncology

authors： Cheatley J,Aldea A,Lerouge A,Devaux M,Vuik S,Cecchini M

更新日期：2020-10-05 00:00:00

abstract：:Platinum-based chemotherapy has been the cornerstone treatment for small cell lung cancer (SCLC) for decades, but no major progress has been made in the past 20 years with regard to overcoming chemoresistance. As the cell cycle checkpoint kinase 1 (Chk1) plays a key role in DNA damage response to chemotherapeutic drug...

journal_title：Molecular oncology

authors： Zhao X,Kim IK,Kallakury B,Chahine JJ,Iwama E,Pierobon M,Petricoin E,McCutcheon JN,Zhang YW,Umemura S,Chen V,Wang C,Giaccone G

更新日期：2020-12-15 00:00:00

abstract：:Triple negative breast cancer (TNBC) is a very aggressive subgroup of breast carcinoma, still lacking specific markers for an effective targeted therapy and with a poorer prognosis compared to other breast cancer subtypes. In this study we investigated the possibility that TNBC cells contribute to the establishment of...

journal_title：Molecular oncology

authors： Plantamura I,Casalini P,Dugnani E,Sasso M,D'Ippolito E,Tortoreto M,Cacciatore M,Guarnotta C,Ghirelli C,Barajon I,Bianchi F,Triulzi T,Agresti R,Balsari A,Campiglio M,Tripodo C,Iorio MV,Tagliabue E

更新日期：2014-07-01 00:00:00

abstract：:Deregulation of the insulin-like growth factor (IGF) axis and dysbalance of components of the IGF system as potential therapeutic targets have been described in different tumor types. IGF2 is a major embryonic growth factor and an important activator of IGF signaling. It is regulated by imprinting in a development- an...

journal_title：Molecular oncology

authors： Küffer S,Gutting T,Belharazem D,Sauer C,Michel MS,Marx A,Trojan L,Ströbel P

更新日期：2018-02-01 00:00:00

abstract：:Amplification of 3q26.2, found in many cancer lineages, is a frequent and early event in ovarian cancer. We previously defined the most frequent region of copy number increase at 3q26.2 to EVI1 (ecotropic viral integration site-1) and MDS1 (myelodysplastic syndrome 1) (aka MECOM), an observation recently confirmed by ...

journal_title：Molecular oncology

authors： Dutta P,Bui T,Bauckman KA,Keyomarsi K,Mills GB,Nanjundan M

更新日期：2013-06-01 00:00:00

abstract：:Gain-of-function (GOF) mutants of p53 upregulate genes implicated in cell proliferation and oncogenesis. Here, we report that GOF p53 induces tumorigenicity through simultaneous activation of key oncogenic pathways including those controlling putative tumor-initiating cell functions. We determined that in cells expres...

journal_title：Molecular oncology

authors： Vaughan CA,Singh S,Grossman SR,Windle B,Deb SP,Deb S

更新日期：2017-06-01 00:00:00

abstract：:ERBB2 amplification and overexpression are strongly associated with invasive cancer with high recurrence and poor prognosis. Enhanced ErbB2 signaling induces cysteine cathepsin B and L expression leading to their higher proteolytic activity (zFRase activity), which is crucial for the invasion of ErbB2-positive breast ...

journal_title：Molecular oncology

authors： Brix DM,Rafn B,Bundgaard Clemmensen K,Andersen SH,Ambartsumian N,Jäättelä M,Kallunki T

更新日期：2014-12-01 00:00:00

abstract：:In our previous study, we identified 1241 loci with somatic copy number alterations in human hepatocellular carcinoma (HCC) using Affymetrix SNP 6.0 arrays, and a putative cancer gene SERPINA5 was uncovered in a novel chromosomal region with recurrent copy number loss at 14q31.1-32.13. The SERPINA5 was reported to be ...

journal_title：Molecular oncology

authors： Jing Y,Jia D,Wong CM,Oi-Lin Ng I,Zhang Z,Liu L,Wang Q,Zhao F,Li J,Yao M,Wu X,He X

更新日期：2014-03-01 00:00:00

abstract：:Hypoxia is a feature of the microenvironment of many cancers and can trigger epithelial-mesenchymal transition (EMT), a process by which cells acquire a more invasive phenotype with enriched survival. A remodeling of adenosine 5'-triphosphate (ATP)-induced Ca(2+) signaling via purinergic receptors is associated with e...

journal_title：Molecular oncology

authors： Azimi I,Beilby H,Davis FM,Marcial DL,Kenny PA,Thompson EW,Roberts-Thomson SJ,Monteith GR

更新日期：2016-01-01 00:00:00

abstract：:Platinum-based compounds remain a well-established chemotherapy for cancer treatment despite their adverse effects which substantially restrict the therapeutic windows of the drugs. Both the cell type-specific toxicity and the clinical responsiveness of tumors have been associated with mechanisms that alter drug entry...

journal_title：Molecular oncology

authors： Melnikova M,Wauer US,Mendus D,Hilger RA,Oliver TG,Mercer K,Gohlke BO,Erdmann K,Niederacher D,Neubauer H,Buderath P,Wimberger P,Kuhlmann JD,Thomale J

更新日期：2020-04-01 00:00:00

abstract：:Due to the speed, efficiency, relative risk, and lower costs compared to traditional drug discovery, the prioritization of candidate drugs for repurposing against cancers of interest has attracted the attention of experts in recent years. Herein, we present a powerful computational approach, termed prioritization of c...

journal_title：Molecular oncology

authors： Di J,Zheng B,Kong Q,Jiang Y,Liu S,Yang Y,Han X,Sheng Y,Zhang Y,Cheng L,Han J

更新日期：2019-10-01 00:00:00

abstract：:Targeted therapy for patients with HER2-positive (HER2+) breast cancer has improved overall survival, but many patients still suffer relapse and death from the disease. Intratumor heterogeneity of both estrogen receptor (ER) and HER2 expression has been proposed to play a key role in treatment failure, but little work...

journal_title：Molecular oncology

authors： Rye IH,Trinh A,Saetersdal AB,Nebdal D,Lingjaerde OC,Almendro V,Polyak K,Børresen-Dale AL,Helland Å,Markowetz F,Russnes HG

更新日期：2018-11-01 00:00:00

abstract：:Endoplasmic reticulum (ER) stress is an adaptive response to various stress conditions and plays emerging roles in cancer. Activating transcription factor 6 (ATF6), one of the three major ER stress transducers, has been shown to contribute to chemoresistance by altering cancer cell survival. Cancerous inhibitor of pro...

journal_title：Molecular oncology

authors： Liu CY,Hsu CC,Huang TT,Lee CH,Chen JL,Yang SH,Jiang JK,Chen WS,Lee KD,Teng HW

更新日期：2018-10-01 00:00:00

abstract：:Histone methyltransferases (HMTs) catalyze the methylation of lysine and arginine residues on histone tails and non-histone targets. These important post-translational modifications are exquisitely regulated and affect chromatin compaction and transcriptional programs leading to diverse biological outcomes. There is a...

journal_title：Molecular oncology

authors： Michalak EM,Visvader JE

更新日期：2016-12-01 00:00:00

abstract：:Breast cancer is the most common malignancy among women, with the highest incidence rate worldwide. Dysregulation of long noncoding RNAs during the preliminary stages of breast carcinogenesis is poorly understood. In this study, we performed RNA sequencing to identify long noncoding RNA expression profiles associated ...

journal_title：Molecular oncology

authors： Deva Magendhra Rao AK,Patel K,Korivi Jyothiraj S,Meenakumari B,Sundersingh S,Sridevi V,Rajkumar T,Pandey A,Chatterjee A,Gowda H,Mani S

更新日期：2019-06-01 00:00:00

abstract：:As a critical feature of the tumor microenvironment, hypoxia is known to be a potent inducer of tumor metastasis, and it has been proposed that the initial steps in metastasis involve epithelial-mesenchymal transition (EMT). The strong correlation among hypoxia, EMT, and metastasis suggests that integrative assessment...

journal_title：Molecular oncology

authors： Chen YL,Zhang Y,Wang J,Chen N,Fang W,Zhong J,Liu Y,Qin R,Yu X,Sun Z,Gao F

更新日期：2019-07-01 00:00:00

abstract：:The above article, published online on 28 February 2020 in Wiley Online Library (wileyonlinelibrary.com) as an Accepted Article (https://doi.org/10.1002/1878-0261.12656), has been withdrawn at the authors' request, and in agreement between the authors, the journal Editors in Chief J. E. Celis and K. Ryan, and John Wil...

journal_title：Molecular oncology

authors：

更新日期：2020-12-01 00:00:00

abstract：:Resistance to chemotherapy is a serious problem for the successful treatment of ovarian cancer patients but signalling pathways that contribute to this chemoinsensitivity are largely unknown. We demonstrate that the chemotherapeutic drug doxorubicin induces activation of the HER3-PI3K-AKT signalling cascade in ovarian...

journal_title：Molecular oncology

authors： Bezler M,Hengstler JG,Ullrich A

更新日期：2012-10-01 00:00:00

abstract：:Bone morphogenetic proteins (BMPs) are a group of growth factors with dual functions in cancer development and progression. Recently, certain tumor-promoting roles have been identified for selected antagonists/inhibitors (BMPIs) of this developmental pathway. A recent focus on the implication of BMP in colorectal canc...

journal_title：Molecular oncology

authors： Karagiannis GS,Treacy A,Messenger D,Grin A,Kirsch R,Riddell RH,Diamandis EP

更新日期：2014-10-01 00:00:00

abstract：:Cancer is a multifactorial and heterogeneous disease. The corresponding complexity appears at multiple levels: from the molecular and the cellular constitution to the macroscopic phenotype, and at the diagnostic and therapeutic management stages. The overall complexity can be approximated to a certain extent, e.g. cha...

journal_title：Molecular oncology

authors： Dominietto M,Tsinoremas N,Capobianco E

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:The association between nuclear factor I/B (NFIB) gene and triple negative breast cancer has been previously suggested. METHODS:We investigated the relationship between NFIB mRNA and protein expression and molecular subtypes of breast cancer as well as the effect of NFIB silencing on the proliferation and a...

journal_title：Molecular oncology

authors： Moon HG,Hwang KT,Kim JA,Kim HS,Lee MJ,Jung EM,Ko E,Han W,Noh DY

更新日期：2011-12-01 00:00:00

abstract：:Infiltration of the tumor microenvironment by nerve fibers is an understudied aspect of breast carcinogenesis. In this study, the presence of nerve fibers was investigated in a cohort of 369 primary breast cancers (ductal carcinomas in situ, invasive ductal and lobular carcinomas) by immunohistochemistry for the neuro...

journal_title：Molecular oncology

authors： Pundavela J,Roselli S,Faulkner S,Attia J,Scott RJ,Thorne RF,Forbes JF,Bradshaw RA,Walker MM,Jobling P,Hondermarck H

更新日期：2015-10-01 00:00:00

abstract：:The GILUPI CellCollector (CC) is a novel in vivo circulating tumor cell (CTC) detection device reported to overcome the limitations of small blood sample volumes. The aim of this prospective, blinded study was to evaluate the clinical application of the CC and to compare its performance to the CellSearch (CS) system i...

journal_title：Molecular oncology

authors： Dizdar L,Fluegen G,van Dalum G,Honisch E,Neves RP,Niederacher D,Neubauer H,Fehm T,Rehders A,Krieg A,Knoefel WT,Stoecklein NH

更新日期：2019-07-01 00:00:00