Abstract:
Introduction:Evaluation of thyroid function is often requested and therefore defining paediatric reference intervals (RIs) is of vital importance. Currently, there is a distinct lack of paediatric RIs for thyroid function tests in Croatia. Thus, we established RIs for thyroid stimulating hormone (TSH), total triiodothyronine (TT3), total thyroxine (TT4), free triiodothyronine (FT3) and free thyroxine (FT4) in the Croatian paediatric population. Materials and methods:Reference intervals were calculated from 397 apparently healthy children, aged from 2 days to < 19 years. Serum samples were analysed for thyroid function tests on the Abbott Architect i2000. Age- and sex-specific 95% RIs with 90% confidence intervals were established according to Clinical and Laboratory Standards Institute guidelines. To express the magnitude of sex and age variation, standard deviation ratio (SDR) was calculated using two-level nested ANOVA. The criterion for considering partitioning reference values was set to SDR > 0.3. Results:All thyroid function tests required age partitioning, confirmed by SDR above 0.3. There was no need for sex partitioning, confirmed by SDR below 0.3. Still, FT3 was partitioned due to visually noticeable sex related difference for the oldest group (12 years to < 19 years). Conclusion:This is the first study to establish RIs for thyroid function tests in the Croatian paediatric population. We propose RIs for widely used Abbott platform, thus giving laboratories method- and population-specific paediatric RIs for thyroid function tests that should improve clinical test interpretation.
journal_name
Biochem Med (Zagreb)journal_title
Biochemia medicaauthors
Bokulić A,Zec I,Marijančević D,Goreta S,Požgaj Šepec M,La Grasta Sabolić Ldoi
10.11613/BM.2021.030702keywords:
["immunoassay","paediatric","reference values","standard deviation ratio","thyroid function tests"]subject
Has Abstractpub_date
2021-10-15 00:00:00pages
030702issue
3eissn
1330-0962issn
1846-7482pii
bm-31-3-030702journal_volume
31pub_type
杂志文章相关文献
Biochemia Medica文献大全abstract:INTRODUCTION:Tourniquet due venous stasis can alter both concentration and/or activity of several blood analytes, but is rarely regarded as an issue of laboratory variability. To overcome the problem transillumination devices (TD) have been proposed for a stasis-free phlebotomy. In this paper the use of a TD in place o...
journal_title:Biochemia medica
pub_type: 杂志文章
doi:10.11613/bm.2011.024
更新日期:2011-01-01 00:00:00
abstract::In Lithuania there are two types of specialists working in medical laboratories and having a university degree: laboratory medicine physicians and medical biologists. Both types of specialists are officially being recognized and regulated by the Ministry of Health of Lithuania. Laboratory medicine physicians become sp...
journal_title:Biochemia medica
pub_type: 杂志文章
doi:10.11613/bm.2011.009
更新日期:2011-01-01 00:00:00
abstract::After being indexed in 2006 in EMBASE/Excerpta Medica and Scopus, and later in Science Citation Index Expanded and Journal Citation Reports/ Science Edition citation databases, Biochemia Medica launched a new web page and online manuscript submission system in 2010, and celebrated its first Impact Factor in the same y...
journal_title:Biochemia medica
pub_type: 社论
doi:
更新日期:2012-01-01 00:00:00
abstract:INTRODUCTION:The aim of this study was to investigate whether serum levels of interleukin-1beta (IL-1beta) has any possible correlation on inflammatory parameters such as C-reactive protein (CRP), erythrocyte sedimentation rate (ESR) and fibrinogen concentration in patients with familial Mediterranean fever (FMF) patie...
journal_title:Biochemia medica
pub_type: 杂志文章
doi:10.11613/bm.2012.012
更新日期:2012-01-01 00:00:00
abstract::Anti-Müllerian hormone (AMH) is a glycoprotein belonging to the transforming growth factors (TGF-P). AMH plays a fundamental role in the regression of Müllerian ducts in male embryo. In its absence, Müllerian ducts develop into female inner reproductive organs. In boys, it is significantly produced in Sertoli cells of...
journal_title:Biochemia medica
pub_type: 杂志文章,评审
doi:10.11613/bm.2011.031
更新日期:2011-01-01 00:00:00
abstract:INTRODUCTION:Measurement and monitoring of blood glucose levels in hospitalized patients with portable glucose meters (PGMs) is performed widely and is an essential part of diabetes monitoring, despite the increasing evidence of several interferences which can negatively bias the accuracy of measurements. The purpose o...
journal_title:Biochemia medica
pub_type: 杂志文章
doi:10.11613/bm.2011.041
更新日期:2011-01-01 00:00:00
abstract:INTRODUCTION:We evaluated the effect of different syringe volume, needle size and sample volume on blood gas analysis in syringes washed with heparin. MATERIALS AND METHODS:In this multi-step experimental study, percent dilution ratios (PDRs) and final heparin concentrations (FHCs) were calculated by gravimetric metho...
journal_title:Biochemia medica
pub_type: 杂志文章
doi:
更新日期:2012-01-01 00:00:00
abstract:INTRODUCTION:The activities involving phlebotomy, a critical task for obtaining diagnostic blood samples, are poorly studied as regards the major sources of errors and the procedures related to laboratory quality control. The aim of this study was to verify the compliance with CLSI documents of clinical laboratories fr...
journal_title:Biochemia medica
pub_type: 杂志文章
doi:10.11613/bm.2012.036
更新日期:2012-01-01 00:00:00
abstract::Bone and immune system are functionally interconnected. Immune and bone cells derive from same progenitors in the bone marrow, they share a common microenvironment and are being influenced by similar mediators. The evidence on increased bone resorption associated with inappropriate activation of T cells such as during...
journal_title:Biochemia medica
pub_type: 杂志文章,评审
doi:10.11613/bm.2013.007
更新日期:2013-01-01 00:00:00
abstract:BACKGROUND:It is still uncertain whether or not avoidance to let disinfectant alcohol dry at the site of venipuncture is a source of spurious hemolysis when drawing venous blood. METHODS:In a consecutive series of 52 outpatients referred for routine laboratory testing, venous blood was drawn by direct venipuncture wit...
journal_title:Biochemia medica
pub_type: 杂志文章,随机对照试验
doi:10.11613/bm.2013.023
更新日期:2013-01-01 00:00:00
abstract::Polycyclic aromatic hydrocarbons (PAHs) are among the most prevalent environmental pollutants and result from the incomplete combustion of hydrocarbons (coal and gasoline, fossil fuel combustion, byproducts of industrial processing, natural emission, cigarette smoking, etc.). The first phase of xenobiotic biotransform...
journal_title:Biochemia medica
pub_type: 杂志文章,评审
doi:10.11613/bm.2013.032
更新日期:2013-01-01 00:00:00
abstract:INTRODUCTION:The aim of the study was to identify biomarkers of alteration in bone mineral density (BMD) in patients on haemodialysis (HD) and peritoneal dialysis (PD). MATERIALS AND METHODS:In a cross-sectional, longitudinal study dual-energy X-ray absorptiometry scans were performed in 146 HD-patients and 28 PD-pati...
journal_title:Biochemia medica
pub_type: 杂志文章
doi:10.11613/bm.2013.042
更新日期:2013-01-01 00:00:00
abstract::In the clinical laboratory setting, interferences can be a significant source of laboratory errors with potential to cause serious harm for the patient. After hemolysis, lipemia is the most frequent endogenous interference that can influence results of various laboratory methods by several mechanisms. The most common ...
journal_title:Biochemia medica
pub_type: 杂志文章,评审
doi:10.11613/BM.2014.008
更新日期:2014-02-15 00:00:00
abstract:INTRODUCTION:Additional nucleotide substitutions in the 3'-untranslated region of prothrombin gene could explain some thrombotic events and also adverse pregnancy outcomes. We describe the first case of a homozygous 20209C>T mutation as the cause of deep vein thrombosis in a Spanish patient. CASE AND METHODS:The 56-ye...
journal_title:Biochemia medica
pub_type: 杂志文章
doi:10.11613/BM.2014.018
更新日期:2014-02-15 00:00:00
abstract::This evidence-based opinion piece gives a short overview of the increase in retractions of publications in scientific journals and discusses various reasons for that increase. Also discussed are some of the recent prominent cases of scientific misconduct, the number of authors with multiple retractions, and problems w...
journal_title:Biochemia medica
pub_type: 杂志文章
doi:10.11613/BM.2014.024
更新日期:2014-01-01 00:00:00
abstract:INTRODUCTION:Preanalytical variables account for most of laboratory errors. There is a wide range of factors that affect the reliability of laboratory report. Most convenient sample type for routine laboratory analysis is serum. BD Vacutainer(®) Rapid Serum Tube (RST) (Becton, Dickinson and Company, Franklin Lakes, NJ,...
journal_title:Biochemia medica
pub_type: 杂志文章
doi:10.11613/BM.2014.039
更新日期:2014-10-15 00:00:00
abstract::Interleukin 10 (IL-10) is important pleiotropic immunoregulatory cytokine which gene is located on chromosome 1 at 1q31-32. There are many genetic variants of IL-10 gene. However, the most studied are two dinucleotide repeats (microsatellites), IL10.G and IL10.R, located 1.2 kb and 4 kb upstream of the transcription s...
journal_title:Biochemia medica
pub_type: 杂志文章,评审
doi:10.11613/BM.2015.004
更新日期:2015-01-01 00:00:00
abstract:INTRODUCTION:Gentamicin due to its low level of resistance and rapid bactericidal activity is commonly used to treat gram-negative bacteria. However, due to its toxic effects it needs to be monitored. To date, no interference has been reported with gentamicin assays. MATERIALS AND METHODS:A patient with leg cellulitis...
journal_title:Biochemia medica
pub_type: 杂志文章
doi:10.11613/BM.2015.014
更新日期:2015-01-01 00:00:00
abstract:INTRODUCTION:Preanalytical errors still constitute the largest source of errors in laboratory work. Proper patient preparation and patient's knowledge about a particular procedure affects its accuracy and reliability. We hypothesized that most of pregnant women are not well enough informed about the proper procedure fo...
journal_title:Biochemia medica
pub_type: 杂志文章,多中心研究
doi:10.11613/BM.2015.023
更新日期:2015-06-05 00:00:00
abstract::Capillary blood sampling is a medical procedure aimed at assisting in patient diagnosis, management and treatment, and is increasingly used worldwide, in part because of the increasing availability of point-of-care testing. It is also frequently used to obtain small blood volumes for laboratory testing because it mini...
journal_title:Biochemia medica
pub_type: 杂志文章,实务指引,评审
doi:10.11613/BM.2015.034
更新日期:2015-10-15 00:00:00
abstract:INTRODUCTION:There is increasing awareness of the importance of transforming organisational culture in order to raise safety standards. This paper describes the results obtained from an evaluation of patient safety culture in a sample of clinical laboratories in public hospitals in the Spanish National Health System. ...
journal_title:Biochemia medica
pub_type: 杂志文章,多中心研究
doi:10.11613/BM.2015.036
更新日期:2015-10-15 00:00:00
abstract:INTRODUCTION:Diagnosis and monitoring of diabetes mellitus in sub-Saharan Africa, based on blood analyses, are hampered by infrastructural and cultural reasons. The first aim of this study was to evaluate the diagnostic accuracy of glycated nail proteins for diabetes mellitus. The second aim was to compare the course o...
journal_title:Biochemia medica
pub_type: 杂志文章
doi:10.11613/BM.2015.048
更新日期:2015-10-15 00:00:00
abstract:INTRODUCTION:The aim of this study was to identify clinical variables which may be independently associated with positivity of a cardiac troponin I (cTnI) assay in a large population of patients admitted to the emergency department (ED). MATERIALS AND METHODS:3166 subjects, with at least two troponin I tests ordered w...
journal_title:Biochemia medica
pub_type: 杂志文章
doi:10.11613/BM.2015.043
更新日期:2015-10-15 00:00:00
abstract::Reliable and accurate reference intervals (RIs) for laboratory analyses are an integral part of the process of correct interpretation of clinical laboratory test results. RIs given in laboratory reports have an important role in aiding the clinician in interpreting test results in reference to values for healthy popul...
journal_title:Biochemia medica
pub_type: 杂志文章,评审
doi:10.11613/BM.2016.001
更新日期:2016-01-01 00:00:00
abstract:INTRODUCTION:Screening programs for colorectal cancer (CRC) are mainly based on a first-line fecal immunochemical test for hemoglobin (FIT). Fecal M2-type pyruvate kinase (M2-PK) has been evaluated in clinical settings showing promising results for early CRC detection. However, the impact of fecal M2-PK assessment on t...
journal_title:Biochemia medica
pub_type: 杂志文章
doi:10.11613/BM.2016.012
更新日期:2016-01-01 00:00:00
abstract:INTRODUCTION:The aim of this study is to present a model for assuring the quality of a large number of glucometers being used in a high-volume hospital clinical setting. MATERIALS AND METHODS:Internal quality-control samples and blood samples from two patients were used to determine the accuracy of 83 glucometers used...
journal_title:Biochemia medica
pub_type: 杂志文章
doi:10.11613/BM.2016.022
更新日期:2016-01-01 00:00:00
abstract::Anti-phospholipid syndrome (APS) is one of the main causes for recurrent miscarriages. The diagnosis of APS is based on the occurrence of clinical symptoms such as thrombotic events or obstetric complications as well as the detection of antiphospholipid antibodies directed against β2-glycoprotein I and cardiolipin, or...
journal_title:Biochemia medica
pub_type: 杂志文章
doi:10.11613/BM.2016.032
更新日期:2016-01-01 00:00:00
abstract:INTRODUCTION:Urine screening is achieved by either automated or manual microscopic analysis. The aim of the study was to compare Cobas 6500 and Iris IQ200 urine analyzers, and manual urine microscopic analysis. MATERIALS AND METHODS:A total of 540 urine samples sent to the laboratory for chemical and sediment analysis...
journal_title:Biochemia medica
pub_type: 杂志文章
doi:10.11613/BM.2016.040
更新日期:2016-10-15 00:00:00
abstract::Reports act as an important feedback tool in External Quality Assessment (EQA). Their main role is to score laboratories for their performance in an EQA round. The most common scores that apply to quantitative data are Q- and Z-scores. To calculate these scores, EQA providers need to have an assigned value and standar...
journal_title:Biochemia medica
pub_type: 杂志文章,评审
doi:10.11613/BM.2017.006
更新日期:2017-02-15 00:00:00
abstract:INTRODUCTION:Sweat test has a diagnostic role in evaluation of cystic fibrosis. Its performance includes sweat stimulation, collection and analysis. All listed may be sources of inconsistencies in everyday practice. The aim of this study was an evaluation of external quality assessment (EQA) of sweat chloride measureme...
journal_title:Biochemia medica
pub_type: 杂志文章
doi:10.11613/BM.2017.016
更新日期:2017-02-15 00:00:00