Abstract:
:Acute myeloid leukemia (AML) is a common acute leukemia in both adults and children, with poor early detection and diagnosis. Therefore, identifying new indicators for AML detection is significant for effective treatment. Here, we developed a supramolecular probe that exhibits high specificity and sensitivity to G-quadruplex structures in physiological buffer solution, chromosomes, and cells. Using this probe, we tested the DNA extracted from different types of cells and found that the DNA extracted from human acute myeloid leukemia cells HL-60 and KG-1 enhanced the probe fluorescence more significantly than the DNA extracted from other cells. This phenomenon may be related to a large number of G-quadruplexes in acute myeloid leukemia cells, implicating that G-quadruplex levels may be a potential indicator for the detection of acute myeloid leukemia.
journal_name
Spectrochim Acta A Mol Biomol Spectroscauthors
Chen H,Guo X,Li X,Tang Y,Sun Hdoi
10.1016/j.saa.2021.119968keywords:
["Acute myeloid leukemia","G-quadruplex","Supramolecular probe"]subject
Has Abstractpub_date
2021-11-05 00:00:00pages
119968eissn
1386-1425issn
1873-3557pii
S1386-1425(21)00545-Xjournal_volume
260pub_type
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