Effect of inhaled anesthetic gases on immune status alterations in health care workers.

abstract：:The purpose of immunotoxicity testing is to obtain data that is meaningful for safety assessment. Host resistance assays are the best measure of a toxicant's effect on the overall ability to mount an effective immune response and protect the host from infectious disease. An outline is presented for immunotoxicological...

journal_title：Journal of immunotoxicology

authors： Burleson GR,Burleson FG

更新日期：2008-01-01 00:00:00

abstract：:Both immune and non-immune cells express an extensive array of scavenger receptors that bind a variety of ligands including bacterial cell-wall components and lipoproteins. Over the past several years, significant advances have been made in elucidating the role of scavenger receptors, predominantly Class A scavenger r...

journal_title：Journal of immunotoxicology

authors： Thakur SA,Hamilton RF Jr,Holian A

更新日期：2008-04-01 00:00:00

abstract：:T-Cell leukemias and lymphomas represent a less common and heterogeneous group of lymphoid neoplasms. Overall, they respond less well to chemotherapy and have a poorer prognosis than their B-cell counterparts. T-Cell tumors express a number of potential targets for receptor-directed antibody therapy; however, there is...

journal_title：Journal of immunotoxicology

authors： Morris JC,Waldmann TA,Janik JE

更新日期：2008-04-01 00:00:00

abstract：:Hypersensitivity reactions to systemically administered drugs cannot be predicted using available preclinical models. This research is a collaborative project to evaluate the ability of the Lymph Node Proliferation Assay (LNPA) to predict systemic hypersensitivity caused by pharmaceuticals. The assay design is a modif...

journal_title：Journal of immunotoxicology

authors： Weaver JL,Chapdelaine JM,Descotes J,Germolec D,Holsapple M,House R,Lebrec H,Meade J,Pieters R,Hastings KL,Dean JH

更新日期：2005-01-01 00:00:00

abstract：:Methanol (MeOH) toxicity, a potential problem from accidental, intentional, as well as occupational and daily ingestion of the agent, receives attention only after severe signs of intoxication have set in or death is imminent. While accidental and intentional exposures involve high doses, the occupational and ingestio...

journal_title：Journal of immunotoxicology

authors： Parthasarathy NJ,Kumar RS,Devi RS

更新日期：2005-04-01 00:00:00

abstract：:The assessment of the immunogenicity of recombinant therapeutic proteins (RTPs) has received more attention in the past 4 years than in the previous 20 years. The induction of clinically adverse events in RTP-treated patients and the subsequent measurement of antibodies to those RTPs has challenged the scientific comm...

journal_title：Journal of immunotoxicology

authors： Smith HW,Wierda D

更新日期：2005-10-01 00:00:00

abstract：:Fluoride pollution in drinking water is an international problem as the fluoride present is often at levels above acceptable limits. In the studies reported here, sodium fluoride (NaF) treatment of rats by gavage for 28 days resulted in the induction of oxidative stress and immunotoxicity. It was shown here that NaF t...

journal_title：Journal of immunotoxicology

authors： Das SS,Maiti R,Ghosh D

更新日期：2006-07-01 00:00:00

abstract：:With the recent increase in the approval and use of biotherapeutics in clinical practice, management of the development of anti-drug antibodies (ADA) has become a key issue for effective long-term use of these drugs. In most instances, the clinical benefit derived from the use of the therapeutics outweighs the risk of...

journal_title：Journal of immunotoxicology

authors： Subramanyam M

更新日期：2006-09-01 00:00:00

abstract：:Organotins are used commercially as pesticides, antifouling agents, and stabilizers for polyvinyl chloride (PVC) pipe. Mono-and di-substituted butyltins, used in PVC pipe production, are of concern to the United States EPA, they leach from supply pipes into drinking water and are reported multisystem toxicants. We ass...

journal_title：Journal of immunotoxicology

authors： DeWitt JC,Copeland CB,Luebke RW

更新日期：2006-12-01 00:00:00

abstract：:An enzyme-linked immunosorbent assay (ELISA) using whole sheep red blood cells (SRBC) has been reported as one of the methods for detecting a T-lymphocyte-dependent antibody response. However, it has not been widely used because of SRBC problems such as the weak attachment to ELISA plates, specificity and short-term s...

journal_title：Journal of immunotoxicology

authors： Koganei A,Tsuchiya T,Samura K,Nishikibe M

更新日期：2007-01-01 00:00:00

abstract：:The primary T-cell-dependent antibody response (TDAR) to antigens is widely used as a functional test in immunotoxicology. TDAR assays can be performed using different antigens, e.g., sheep red blood cells (SRBC) and keyhole limpet hemocyanin (KLH) are presently utilized by different laboratories. The purpose of this ...

journal_title：Journal of immunotoxicology

authors： Bugelski PJ,Kim C

更新日期：2007-04-01 00:00:00

abstract：:The primary objective of this study was to investigate the effects of cobalt (Co(2 +)), palladium (Pd(2 +)), platinum (Pt(4 +)) and vanadium (V(2 +), V(3 +), V(4 +) and V(5 +)) on the ability of the neutrophil chemoattractants C5a and IL-8, as well as the pneumococcal toxin, pneumolysin, to activate human neutrophils ...

journal_title：Journal of immunotoxicology

authors： Fickl H,Theron AJ,Anderson R,Mitchell TJ,Feldman C

更新日期：2007-07-01 00:00:00

abstract：:Modulation of the developing immune system can occur following perinatal exposure to a number of immunotoxic compounds, including polyhalogenated hydrocarbons like 2,3,7,8-tetra-chlorodibenzo-p-dioxin (TCDD; dioxin), the most toxic of the congeners. Studies in rodents have shown immunologic effects from perinatal TCDD...

journal_title：Journal of immunotoxicology

authors： Gogal RM Jr,Holladay SD

更新日期：2008-10-01 00:00:00

abstract：:There is extensive evidence that pro-inflammatory cytokines produced by macrophages are involved in toxicity induced by drugs such as acetaminophen (APAP). We investigated the effect of subtoxic concentrations of acetaminophen in conjunction with bacterial lipopolysaccharide (LPS) on the expression of the pro-inflamma...

journal_title：Journal of immunotoxicology

authors： Lacour S,Antonios D,Gautier JC,Pallardy M

更新日期：2009-06-01 00:00:00

abstract：:Owing to increased obesity, non-alcoholic fatty liver disease (NAFLD) is now the most prevalent liver disease in the United States. NAFLD is considered a component of metabolic syndrome, a cluster of disorders that also includes diabetes mellitus, dyslipidemia, arteriosclerosis, and hypertension. Exposure to ambient a...

journal_title：Journal of immunotoxicology

authors： Tan HH,Fiel MI,Sun Q,Guo J,Gordon RE,Chen LC,Friedman SL,Odin JA,Allina J

更新日期：2009-12-01 00:00:00

abstract：:Several types of pesticides, such as organophosphates and organochlorines, can induce thymocyte apoptosis, resulting in thymic atrophy and predisposing the highly sensitive fetal immune system to loss of tolerance to self-antigens and subsequent increased risk for autoimmune disease and allergies. In the studies here,...

journal_title：Journal of immunotoxicology

authors： Fukuyama T,Tajima Y,Ueda H,Hayashi K,Shutoh Y,Harada T,Kosaka T

更新日期：2010-03-01 00:00:00

abstract：:Non-human primates have assumed an important role in preclinical safety assessment studies, particularly in the evaluation of biopharmaceutical and immunomodulatory therapies. Naturally occurring simian retrovirus infections may adversely affect the suitability of primates for use in such studies. Various species of n...

journal_title：Journal of immunotoxicology

authors： Lerche NW

更新日期：2010-04-01 00:00:00

abstract：:Ultrafine nanoparticles of zinc oxide (ZnO) recently became available as a substitute for larger-size fine ZnO particles. However, the biological activity of ultrafine ZnO currently remains undefined. In the present study, we investigated the effect of ultrafine ZnO on oral tolerance that plays an important role in th...

journal_title：Journal of immunotoxicology

authors： Matsumura M,Takasu N,Nagata M,Nakamura K,Kawai M,Yoshino S

更新日期：2010-07-01 00:00:00

abstract：:Saquinavir (SQV) is a protease inhibitor that binds to the protease active site of the human immunodeficiency virus and prevents the cleavage of viral polyproteins resulting in the formation of non-infectious virus particles. The purpose of these studies was to determine the potential effects of SQV on the immune syst...

journal_title：Journal of immunotoxicology

authors： Guo TL,Germolec DR,Roesh DM,White KL Jr

更新日期：2010-10-01 00:00:00

abstract：:Here, we investigated whether titanium dioxide (TiO₂) nanoparticles affect in vivo tumor growth through the modulation of mononuclear leukocytes. In vitro lymphocyte proliferation by lipopolysaccharide (LPS) or concanavalin A (ConA) was reduced by < 25 nm TiO₂ with a dose-dependent manner. Similarly, TiO₂ nanoparticle...

journal_title：Journal of immunotoxicology

authors： Moon EY,Yi GH,Kang JS,Lim JS,Kim HM,Pyo S

更新日期：2011-01-01 00:00:00

abstract：:Autism, a member of the pervasive developmental disorders (PDDs), has been increasing dramatically since its description by Leo Kanner in 1943. First estimated to occur in 4 to 5 per 10,000 children, the incidence of autism is now 1 per 110 in the United States, and 1 per 64 in the United Kingdom, with similar inciden...

journal_title：Journal of immunotoxicology

authors： Ratajczak HV

更新日期：2011-01-01 00:00:00

abstract：:Lipopolysaccharide (LPS) is a known inducer of acute respiratory distress syndrome (ARDS) in humans and animals. In this study, ARDS was developed in rats by intratracheal instillation of LPS and the effect of two types of surfactant (natural vs. synthetic) was examined to determine their potential corrective roles in...

journal_title：Journal of immunotoxicology

authors： Mittal N,Sanyal SN

更新日期：2011-10-01 00:00:00

abstract：:In addition to the effector T-cells subsets, T-cells can also differentiate into cells that play a suppressive or regulatory role in adaptive immune responses. The cell types currently identified as regulatory T-cells (T(regs)) include natural or thymic-derived T(regs), T-cells which express Foxp3(+)CD25(+)CD4(+) and ...

journal_title：Journal of immunotoxicology

authors： Corsini E,Oukka M,Pieters R,Kerkvliet NI,Ponce R,Germolec DR

更新日期：2011-10-01 00:00:00

abstract：:Sudanonautes africanus is a freshwater crab local to Nigeria and West Africa that has no documentation of its innate immunity reactions. The objective of this study was to assess the effect of endotoxin (lipopolysaccharide [LPS]) on coagulation and on phenoloxidase (PO) activity in the hemolymph fractions of S. africa...

journal_title：Journal of immunotoxicology

authors： Salawu MO,Oloyede OB

更新日期：2011-10-01 00:00:00

abstract：:Cell-mediated immunity offers protection against virus-infected cells and tumor cells, involves activation of natural killer (NK) cells, production of antigen-specific cytotoxic T-lymphocytes, and release of various cytokines in response to an antigen. Administration of an ethanolic extract of Aerva lanata was found t...

journal_title：Journal of immunotoxicology

authors： Siveen KS,Kuttan G

更新日期：2012-01-01 00:00:00

abstract：:Polybrominated diphenyl ethers (PBDEs) are an important class of flame-retardants that are environmentally persistent and bioaccumulative. Toxicity of these compounds has become a concern because detectable levels of PBDEs are present in humans and wildlife and they are structurally similar to polychlorinated biphenyl...

journal_title：Journal of immunotoxicology

authors： Fair PA,Stavros HC,Mollenhauer MA,DeWitt JC,Henry N,Kannan K,Yun SH,Bossart GD,Keil DE,Peden-Adams MM

更新日期：2012-01-01 00:00:00

abstract：:The present study was performed to assess the immune response in women with human papilloma virus (HPV) DNA⁺ and DNA⁻ cervical lesions. Eighty women with cervical lesions (age range = 25-70 years) and 20 healthy individuals (control group) were enrolled in the study. Lesions were cytologically classified into four gro...

journal_title：Journal of immunotoxicology

authors： Ali KS,Ali HY,Jubrael JM

更新日期：2012-04-01 00:00:00

abstract：:Histamine, involved in many inflammatory reactions and immune responses, is reported to suppress--via H4R stimulation--injury concomitant with the late phase of warm hepatic ischemia/re-perfusion (I/R). The current study investigated the possible effects of histamine on the acute phase of hepatic I/R injury, and the p...

journal_title：Journal of immunotoxicology

authors： El-Mahdy NA,El-Sisi AE,Dewidar BI,El-Desouky KI

更新日期：2013-01-01 00:00:00

abstract：:Chemotherapeutic agents (CT) and ionizing radiation (X-ray) induce DNA damage and primarily aim to stop the proliferation of tumor cells. However, multimodal anti-cancer therapies should finally result in tumor cell death and, best, in the induction of systemic anti-tumor immunity. Since distinct therapy-induced tumor...

journal_title：Journal of immunotoxicology

authors： Frey B,Stache C,Rubner Y,Werthmöller N,Schulz K,Sieber R,Semrau S,Rödel F,Fietkau R,Gaipl US

更新日期：2012-07-01 00:00:00

abstract：:Contact dermatitis is the second most reported occupational injury associated with workers compensation. Inflammatory cytokines are closely involved with the development of dermatitis, and their modulation could exacerbate skin damage, thus contributing to increased irritancy. IL-6 is a pro-inflammatory cytokine parad...

journal_title：Journal of immunotoxicology

authors： Lee EG,Mickle-Kawar BM,Gallucci RM

更新日期：2013-04-01 00:00:00