MAGI1 localizes to mature focal adhesion and modulates endothelial cell adhesion, migration and angiogenesis.

abstract：:Interactions linking the Eph receptor tyrosine kinase and ephrin ligands transduce short-range repulsive signals regulating several motile biological processes including axon path-finding, angiogenesis and tumor growth. These ephrin-induced effects are believed to be mediated by alterations in actin dynamics and cytos...

journal_title：Cell adhesion & migration

authors： Buricchi F,Giannoni E,Grimaldi G,Parri M,Raugei G,Ramponi G,Chiarugi P

更新日期：2007-01-01 00:00:00

abstract：:The treatment of high-grade gliomas remains difficult despite recent advances in surgery, radiotherapy and chemotherapy. True advances may emerge from the increasing understanding in molecular biology and discovery of novel mechanisms for the delivery of tumoricidal agents. In an attempt to overcome this formidable ne...

journal_title：Cell adhesion & migration

authors： Natsume A,Yoshida J

更新日期：2008-07-01 00:00:00

abstract：:The proteolytic processing of amyloid beta precursor protein (APP) has long been studied because of its association with the pathology of Alzheimer's disease (AD). The ectodomain of APP is shed by alpha- or beta-secretase cleavage. The remaining membrane bound stub can then undergo regulated intramembrane proteolysis ...

journal_title：Cell adhesion & migration

authors： Ma QH,Bagnard D,Xiao ZC,Dawe GS

更新日期：2008-01-01 00:00:00

abstract：:The protein phosphatase 2A (PP2A) family of heterotrimeric serine-threonine phosphatases participates in human cell transformation. Each functional PP2A complex contains one structural A subunit (A alpha or A beta), and mutations of both are found to occur at low frequency in human tumors. We have shown that A alpha f...

journal_title：Cell adhesion & migration

authors： Sablina AA,Hahn WC

更新日期：2007-07-01 00:00:00

abstract：:Chemotaxis is the directed movement of a cell towards a gradient of chemicals such as chemokines or growth factors. This phenomenon can be studied in organisms ranging from bacteria to mammalian cells, and here we will focus on eukaryotic amoeboid chemotaxis. Chemotactic responses are mediated by two major classes of ...

journal_title：Cell adhesion & migration

authors： Smirnova T,Segall JE

更新日期：2007-10-01 00:00:00

abstract：:Contactins are a subgroup of molecules belonging to the immunoglobulin superfamily that are expressed exclusively in the nervous system. The subgroup consists of six members: contactin, TAG-1, BIG-1, BIG-2, NB-2 and NB-3. Since their identification in the late 1980s, contactin and TAG-1 have been studied extensively. ...

journal_title：Cell adhesion & migration

authors： Shimoda Y,Watanabe K

更新日期：2009-01-01 00:00:00

abstract：:With over 60 members, the Sterile 20 family of kinases has been implicated in numerous biological processes, including growth, survival, apoptosis and cell migration. Recently, we have shown that, in addition to cell death, the Ste20-like kinase SLK is required for efficient cell migration in fibroblasts. We have obse...

journal_title：Cell adhesion & migration

authors： Wagner SM,Sabourin LA

更新日期：2009-04-01 00:00:00

abstract：:NO is an important regulator of cardiovascular remodelling and function. ADMA, an endogenous L-arginine analogue, reduces NO production by inhibiting the activity of NOS. ADMA levels in turn, are regulated by DDAH, which metabolises ADMA. High levels of ADMA and dysregulated DDAH activity are risk factors for cardiova...

journal_title：Cell adhesion & migration

authors： Fiedler L

更新日期：2008-07-01 00:00:00

abstract：:Cell migration is essential in many physiological and pathological processes. To understand this complex behavior, researchers have turned to quantitative, in vitro, image-based measurements to dissect the steps of cellular motility. With the rise of automated microscopy, the bottleneck in these approaches is no longe...

journal_title：Cell adhesion & migration

authors： Harris MP,Kim E,Weidow B,Wikswo JP,Quaranta V

更新日期：2008-04-01 00:00:00

abstract：:In order to metastasize, cancer cells must first detach from the primary tumor, migrate, invade through tissues and attach to a second site. The transcription factor snail is an important mediator of epithelial-mesenchymal transitions and is involved in tumor progression. Recent data have provided evidence for a requi...

journal_title：Cell adhesion & migration

authors： Haraguchi M

更新日期：2009-07-01 00:00:00

abstract：:When cells are stimulated to move, for instance during development, wound healing or angiogenesis, they undergo changes in the turnover of their cell-matrix adhesions. This is often accompanied by alterations in the expression profile of integrins-the extracellular matrix receptors that mediate anchorage within these ...

journal_title：Cell adhesion & migration

authors： Truong H,Danen EH

更新日期：2009-04-01 00:00:00

abstract：:Caldesmon (CaD) is a major actin-binding protein distributed in a variety of cell types. No functional differences among the isoforms in in vitro studies were found so far. In a previous study we found that the low molecular caldesmon isoform (Hela l-CaD) is expressed in endothelial cells (ECs)/endothelial progenitor ...

journal_title：Cell adhesion & migration

authors： Zheng PP,van der Weiden M,Kros JM

更新日期：2007-04-01 00:00:00

abstract：:Neurovascular development in the central nervous system has a rich history and compelling significance. The developing central nervous system (CNS) does not produce vascular progenitor cells, and so ingression of blood vessels is required for continued CNS development and function. Classic studies provide elegant desc...

journal_title：Cell adhesion & migration

authors： Bautch VL,James JM

更新日期：2009-04-01 00:00:00

abstract：:It has been controversial for many years of whether mtDNA mutations are involved in phenotypes related to cancer due to the difficulty in excluding possible involvement of nuclear DNA mutations in these phenotypes. We addressed this issue by complete trading of mtDNAs between tumor cells expressing different metastati...

journal_title：Cell adhesion & migration

authors： Ishikawa K,Hayashi J

更新日期：2009-01-01 00:00:00

abstract：:Aberrant and/or cumulative amyloid-beta (Abeta) production, resulting from proteolytic processing of the amyloid precursor protein (APP) by beta and gamma-secretases, have been postulated to be a main etiological basis of Alzheimer disease (AD). A number of proteins influence the subcellular trafficking itinerary of A...

journal_title：Cell adhesion & migration

authors： Tang BL

更新日期：2009-01-01 00:00:00

abstract：:Alzheimer disease (AD) is a progressive dementia affecting a large proportion of the aging population. The histopathological changes in AD include neuronal cell death, formation of amyloid plaques and neurofibrillary tangles. There is also evidence that brain tissue in patients with AD is exposed to oxidative stress (...

journal_title：Cell adhesion & migration

authors： Gella A,Durany N

更新日期：2009-01-01 00:00:00

abstract：:The central nervous system (CNS) is a large network of interconnecting and intercommunicating cells that form functional circuits. Disease and injury of the CNS are prominent features of the healthcare landscape. There is an urgent unmet need to generate therapeutic solutions for CNS disease/injury. To increase our un...

journal_title：Cell adhesion & migration

authors： Ahmed S,Gan HT,Lam CS,Poonepalli A,Ramasamy S,Tay Y,Tham M,Yu YH

更新日期：2009-10-01 00:00:00

abstract：:Mesenchymal cell motility is characterized by a polarized distribution of actin filaments, with a network of short branched actin filaments at the leading edge, and polymers of actin filaments arranged into distinct classes of actin stress fibers behind the leading edge. Importantly, the distinct actin filaments are c...

journal_title：Cell adhesion & migration

authors： O'Neill GM

更新日期：2009-10-01 00:00:00

abstract：UNLABELLED:Endothelial dysfunction is a common feature in type-2 diabetic patients and is associated with inflammation, increased levels of circulating soluble adhesion molecules and atherosclerosis. The aim of this study was to evaluate the relationship between the levels of circulating soluble adhesion molecules and ...

journal_title：Cell adhesion & migration

authors： Rubio-Guerra AF,Vargas-Robles H,Serrano AM,Lozano-Nuevo JJ,Escalante-Acosta BA

更新日期：2009-10-01 00:00:00

abstract：:The transmission of mechanical forces to cells is followed among all by biological signals related to changes in the assembly or disassembly of integrins associated linker proteins, such as vinculin. We applied for 3 hours 2% cyclic mechanical strain at the frequency of 1 Hz to human fibroblasts cultured on a deformab...

journal_title：Cell adhesion & migration

authors： Boccafoschi F,Bosetti M,Sandra PM,Leigheb M,Cannas M

更新日期：2010-01-01 00:00:00

abstract：:The developmental morphogen Sonic hedgehog (Shh) is well known for its role in modulating the proliferation and survival of neural progenitor cells in the developing mouse brain. A recent report now showed that Shh could regulate the migration of neuroblast in the adult subventricular zone (SVZ) along the rostral migr...

journal_title：Cell adhesion & migration

authors： Hor CH,Tang BL

更新日期：2010-01-01 00:00:00

abstract：:Lung cancer is the leading cause of cancer-related death worldwide. At the time of initial presentation, most patients are at an advance stage of disease and have a poor associated prognosis. Those diagnosed and treated at earlier stages have a significantly better outcome with 5-year survival for stage I disease appr...

journal_title：Cell adhesion & migration

authors： Tanner NT,Silvestri GA

更新日期：2010-01-01 00:00:00

abstract：:Filopodia are key structures within many cells that serve as sensors constantly probing the local environment. Although filopodia are involved in a number of different cellular processes, their function in migration is often analyzed with special focus on early processes of filopodia formation and the elucidation of f...

journal_title：Cell adhesion & migration

authors： Hoffmann B,Schäfer C

更新日期：2010-04-01 00:00:00

abstract：:The dioxin receptor (AhR) is possibly the best characterized xenobiotic receptor because of its essential role in mediating the harmful effects of highly toxic environmental pollutants. Despite the fact that AhR-dependent toxicity is a major environmental concern, compelling evidence has recently been produced unveili...

journal_title：Cell adhesion & migration

authors： Fernandez-Salguero PM

更新日期：2010-04-01 00:00:00

abstract：:Longitudinal axons grow long distances along precise pathways to connect major CNS regions. However, during embryonic development, it remains largely undefined how the first longitudinal axons choose specific positions and grow along them. Here, we review recent evidence identifying a critical role for Slit/Robo signa...

journal_title：Cell adhesion & migration

authors： Mastick GS,Farmer WT,Altick AL,Nural HF,Dugan JP,Kidd T,Charron F

更新日期：2010-07-01 00:00:00

abstract：:The Cut homeobox gene 1 (CUX1) codes for several homeodomain proteins that display distinct DNA binding and transcriptional properties. Some CUX1 isoforms were previously shown to stimulate entry into S phase. More recently, siRNA-mediated knockdown of CUX1 was shown to cause a decrease in cell migration and invasion....

journal_title：Cell adhesion & migration

authors： Kedinger V,Nepveu A

更新日期：2010-07-01 00:00:00

abstract：:A better knowledge of the molecular mechanisms that govern leukocyte trafficking is of major relevance for the clinics. Both normal and pathologic extravasation of lymphocytes are a fine-tuned spatio-temporal event of migratory path-finding likely regulated by molecular guidance cues underlying cell movements in other...

journal_title：Cell adhesion & migration

authors： Trinidad EM,Zapata AG,Alonso-Colmenar LM

更新日期：2010-07-01 00:00:00

abstract：:Adiponectin is an adipocytokine involved in the pathogenesis of various obesity-related disorders. Also, it has been shown that adiponectin has therapeutic potential for metabolic syndrome, systemic insulin resistance, cardiovascular disease and more recently carcinogenesis. Adiponectin can modulate breast cancer cell...

journal_title：Cell adhesion & migration

authors： Saxena NK,Sharma D

更新日期：2010-07-01 00:00:00

abstract：UNLABELLED:The vitamin A derivative all-trans retinoic acid (ATRA) is considered as a potent chemotherapeutic drug for its capability of regulating cell growth and differentiation. We aimed to study the effect of ATRA on MMP-9 in MDA-MB-231, human breast cancer cells and the probable molecular mechanisms through which ...

journal_title：Cell adhesion & migration

authors： Dutta A,Sen T,Chatterjee A

更新日期：2010-07-01 00:00:00

abstract：:Myofibers with an abnormal branching cytoarchitecture are commonly found in various neuromuscular diseases as well as after severe muscle injury. These aberrant myofibers are fragile and muscles containing a high percentage of these myofibers are weaker and more prone to injury. To date the mechanisms and molecules re...

journal_title：Cell adhesion & migration

authors： Pavlath GK

更新日期：2010-10-01 00:00:00