DNA priming immunization is more effective than recombinant protein vaccine in eliciting antigen-specific B cell responses.

abstract：:The recent outbreak of severe respiratory infections associated with a novel group C betacoronavirus (HCoV-EMC) from Saudi Arabia has drawn global attention to another highly probable "SARS-like" animal-to-human interspecies jumping event in coronavirus (CoV). The genome of HCoV-EMC is most closely related to Tylonyct...

journal_title：Emerging microbes & infections

authors： Woo PC,Lau SK,Li KS,Tsang AK,Yuen KY

更新日期：2012-11-01 00:00:00

abstract：:Recently, we and others reported the discovery of Lichtheimia ramosa (syn. Lichtheimia hongkongensis). We also hypothesized that a proportion of 'Absidia corymbifera (Lichtheimia corymbifera)' reported in the literature could be L. ramosa. In this study, we characterized 13 strains that had been reported as 'A. corymb...

journal_title：Emerging microbes & infections

authors： Woo PC,Leung SY,Ngan AH,Lau SK,Yuen KY

更新日期：2012-08-01 00:00:00

abstract：:Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease that was discovered in China in 2010. The causative agent has been identified as a new member of the Phlebovirus genus in the family Bunyaviridae and has been designated severe fever with thrombocytopenia virus (SFTSV). SFTSV infectio...

journal_title：Emerging microbes & infections

authors： Li D

更新日期：2013-01-01 00:00:00

abstract：:New drugs to treat hepatitis C are expected to be approved over the next few years which promise to cure nearly all patients. However, due to issues of expected drug resistance, suboptimal activity against diverse hepatitis C virus (HCV) genotypes and especially because of their extremely high cost, it is unlikely tha...

journal_title：Emerging microbes & infections

authors： Man John Law L,Landi A,Magee WC,Lorne Tyrrell D,Houghton M

更新日期：2013-11-01 00:00:00

abstract：:Analysis of microbial epidemics has been revolutionized by whole-genome sequencing. We recently sequenced the genomes of 601 type emm59 Group A Streptococcus (GAS) organisms responsible for an ongoing epidemic of invasive infections in Canada and some of the United States. The epidemic has been caused by the emergence...

journal_title：Emerging microbes & infections

authors： Fittipaldi N,Tyrrell GJ,Low DE,Martin I,Lin D,Hari KL,Musser JM

更新日期：2013-03-01 00:00:00

abstract：:Foamy viruses are complex retroviruses that have been shown to be transmitted from nonhuman primates to humans. In Bangladesh, infection with simian foamy virus (SFV) is ubiquitous among rhesus macaques, which come into contact with humans in diverse locations and contexts throughout the country. We analyzed microsate...

journal_title：Emerging microbes & infections

authors： Feeroz MM,Soliven K,Small CT,Engel GA,Andreina Pacheco M,Yee JL,Wang X,Kamrul Hasan M,Oh G,Levine KL,Rabiul Alam SM,Craig KL,Jackson DL,Lee EG,Barry PA,Lerche NW,Escalante AA,Matsen Iv FA,Linial ML,Jones-Engel L

更新日期：2013-05-01 00:00:00

abstract：:A new avian-origin influenza virus A (H7N9) recently crossed the species barrier and infected humans; therefore, there is an urgent need to establish mammalian animal models for studying the pathogenic mechanism of this strain and the immunological response. In this study, we attempted to develop mouse models of H7N9 ...

journal_title：Emerging microbes & infections

authors： Zhu Z,Yang Y,Feng Y,Shi B,Chen L,Zheng Y,Tian D,Song Z,Xu C,Qin B,Zhang X,Guan W,Liu F,Yang T,Yang H,Zeng D,Zhou W,Hu Y,Zhou X

更新日期：2013-08-01 00:00:00

abstract：:Of the seven known species of human retroviruses only one, human T-cell lymphotropic virus type 4 (HTLV-4), lacks a known animal reservoir. We report the largest screening for simian T-cell lymphotropic virus (STLV-4) to date in a wide range of captive and wild non-human primate (NHP) species from Cameroon. Among the ...

journal_title：Emerging microbes & infections

authors： LeBreton M,Switzer WM,Djoko CF,Gillis A,Jia H,Sturgeon MM,Shankar A,Zheng H,Nkeunen G,Tamoufe U,Nana A,Le Doux Diffo J,Tafon B,Kiyang J,Schneider BS,Burke DS,Wolfe ND

更新日期：2014-01-01 00:00:00

abstract：:In light of the current outbreak of Ebola virus disease, there is an urgent need to develop effective therapeutics to treat Ebola infection, and drug repurposing screening is a potentially rapid approach for identifying such therapeutics. We developed a biosafety level 2 (BSL-2) 1536-well plate assay to screen for ent...

journal_title：Emerging microbes & infections

authors： Kouznetsova J,Sun W,Martínez-Romero C,Tawa G,Shinn P,Chen CZ,Schimmer A,Sanderson P,McKew JC,Zheng W,García-Sastre A

更新日期：2014-12-01 00:00:00

abstract：:Pathogenic bacteria display various levels of host specificity or tropism. While many bacteria can infect a wide range of hosts, certain bacteria have strict host selectivity for humans as obligate human pathogens. Understanding the genetic and molecular basis of host specificity in pathogenic bacteria is important fo...

journal_title：Emerging microbes & infections

authors： Pan X,Yang Y,Zhang JR

更新日期：2014-03-01 00:00:00

abstract：:Streptococcus suis is an important pathogen causing economic problems in the pig industry. Moreover, it is a zoonotic agent causing severe infections to people in close contact with infected pigs or pork-derived products. Although considered sporadic in the past, human S. suis infections have been reported during the ...

journal_title：Emerging microbes & infections

authors： Goyette-Desjardins G,Auger JP,Xu J,Segura M,Gottschalk M

更新日期：2014-06-01 00:00:00

abstract：:Enterovirus 71 (EV71) causes severe central nervous system infections, leading to cardiopulmonary complications and death in young children. There is an urgent unmet medical need for new pharmaceutical agents to control EV71 infections. Using a multidisciplinary approach, we found that the approved pediatric antiparas...

journal_title：Emerging microbes & infections

authors： Ren P,Zou G,Bailly B,Xu S,Zeng M,Chen X,Shen L,Zhang Y,Guillon P,Arenzana-Seisdedos F,Buchy P,Li J,von Itzstein M,Li Q,Altmeyer R

更新日期：2014-09-01 00:00:00

abstract：:Moxifloxacin (MOX) and gatifloxacin (GAT) have exhibited promising mycobactericidal activity, and a number of clinical trials have been conducted in recent decades to compare the treatment efficacy of MOX-containing and/or GAT-containing regimens with the standard regimen. The aim of this meta-analysis for clinical tr...

journal_title：Emerging microbes & infections

authors： Ruan Q,Liu Q,Sun F,Shao L,Jin J,Yu S,Ai J,Zhang B,Zhang W

更新日期：2016-02-24 00:00:00

abstract：:In 2014, a serious dengue outbreak in Guangzhou occurred, consisting of 37 354 laboratory confirmed cases of infection. In this study, the clinical picture of dengue fever due to dengue virus (DENV) type 1 in Guangzhou was described. Clinical and laboratory data collected by studying 726 sera of suspected clinical cas...

journal_title：Emerging microbes & infections

authors： Yang L,Chen Y,Yan H,Zhang P,Xu X,Tang B,Zhao P,Ren R

更新日期：2015-09-23 00:00:00

abstract：:Middle East respiratory syndrome coronavirus (MERS-CoV) infection has claimed hundreds of lives and has become a global threat since its emergence in Saudi Arabia in 2012. The ability of MERS-CoV to evade the host innate antiviral response may contribute to its severe pathogenesis. Many MERS-CoV-encoded proteins were ...

journal_title：Emerging microbes & infections

authors： Lui PY,Wong LY,Fung CL,Siu KL,Yeung ML,Yuen KS,Chan CP,Woo PC,Yuen KY,Jin DY

更新日期：2016-04-20 00:00:00

abstract：:Bovine leukemia virus (BLV) is highly endemic in many countries, including Iraq, and it impacts the beef and dairy industries. The current study sought to determine the percentage of BLV infection and persistent lymphocytosis (PL) in cattle in central Iraq. Hematological, serological, and molecular observations in cro...

journal_title：Emerging microbes & infections

authors： Khudhair YI,Hasso SA,Yaseen NY,Al-Shammari AM

更新日期：2016-06-08 00:00:00

abstract：:Dengue is currently the most significant arboviral disease afflicting tropical and sub-tropical countries worldwide. Dengue vaccines, such as the multivalent attenuated, chimeric, DNA and inactivated vaccines, have been developed to prevent dengue infection in humans, and they function predominantly by stimulating imm...

journal_title：Emerging microbes & infections

authors： Liu Y,Liu J,Cheng G

更新日期：2016-07-20 00:00:00

abstract：:Sporadic human infections with the highly pathogenic avian influenza (HPAI) A (H5N6) virus have been reported in different provinces in China since April 2014. From June 2015 to January 2016, routine live poultry market (LPM) surveillance was conducted in Shenzhen, Guangdong Province. H5N6 viruses were not detected un...

journal_title：Emerging microbes & infections

authors： Fang S,Bai T,Yang L,Wang X,Peng B,Liu H,Geng Y,Zhang R,Ma H,Zhu W,Wang D,Cheng J,Shu Y

更新日期：2016-08-03 00:00:00

abstract：:Highly pathogenic avian influenza (HPAI) H5N1 and low pathogenic avian influenza (LPAI) H9N2 viruses have been recognized as threats to public health in Bangladesh since 2007. Although live bird markets (LBMs) have been implicated in the transmission, dissemination, and circulation of these viruses, an in-depth analys...

journal_title：Emerging microbes & infections

authors： Turner JC,Feeroz MM,Hasan MK,Akhtar S,Walker D,Seiler P,Barman S,Franks J,Jones-Engel L,McKenzie P,Krauss S,Webby RJ,Kayali G,Webster RG

更新日期：2017-03-08 00:00:00

abstract：:Many emerging infectious diseases are caused by generalist pathogens that infect and transmit via multiple host species with multiple dissemination routes, thus confounding the understanding of pathogen transmission pathways from wildlife reservoirs to humans. The emergence of these pathogens in human populations has ...

journal_title：Emerging microbes & infections

authors： Combe M,Velvin CJ,Morris A,Garchitorena A,Carolan K,Sanhueza D,Roche B,Couppié P,Guégan JF,Gozlan RE

更新日期：2017-04-26 00:00:00

abstract：:Listeria is ubiquitous in a variety of environments and can be isolated from a wide range of animal hosts. Rodents are capable of carrying pathogenic bacteria in their intestines, such as Listeria, and can disseminate those pathogens into the natural environment and to where human activity occurs. In this study, we in...

journal_title：Emerging microbes & infections

authors： Wang Y,Lu L,Lan R,Salazar JK,Liu J,Xu J,Ye C

更新日期：2017-06-07 00:00:00

abstract：:Two herds of dromedary camels were longitudinally sampled with nasal and rectal swabs and serum, between September 2014 and May 2015, and the samples were tested for Middle East Respiratory Syndrome (MERS) coronavirus RNA and antibodies. Evidence of MERS-CoV infection was confirmed in one herd on the basis of detectio...

journal_title：Emerging microbes & infections

authors： Hemida MG,Alnaeem A,Chu DK,Perera RA,Chan SM,Almathen F,Yau E,Ng BC,Webby RJ,Poon LL,Peiris M

更新日期：2017-06-21 00:00:00

abstract：:This study aimed to identify novel immunogenic epitopes from Mycobacterium tuberculosis (MTB) that could be used in tuberculosis (TB) diagnostics. To determine the diagnostic potential of mycobacterial antigens in serodiagnosis of TB, 256 patients were enrolled in a study and divided into two groups: 126 smear-positiv...

journal_title：Emerging microbes & infections

authors： Luo L,Zhu L,Yue J,Liu J,Liu G,Zhang X,Wang H,Xu Y

更新日期：2017-07-12 00:00:00

abstract：:Transmissible gastroenteritis virus (TGEV) is an infective coronavirus (CoV) that causes diarrhea-related morbidity and mortality in piglets. For the first time, a natural recombination strain of a TGEV Anhui Hefei (AHHF) virus between the Purdue and the Miller clusters was isolated from the small intestine content of...

journal_title：Emerging microbes & infections

authors： Zhang X,Zhu Y,Zhu X,Shi H,Chen J,Shi D,Yuan J,Cao L,Liu J,Dong H,Jing Z,Zhang J,Wang X,Feng L

更新日期：2017-08-23 00:00:00

abstract：:The tick-borne bacterium Anaplasma ovis is a widely distributed pathogen affecting sheep, goats and wild ruminants. Here, the HL-60 human promyelocytic leukemia cell line was used to isolate A. ovis from PCR-positive sheep and goats in Heilongjiang Province, China. Two weeks after inoculation, morulae were observed in...

journal_title：Emerging microbes & infections

authors： Wei R,Liu HB,Jongejan F,Jiang BG,Chang QC,Fu X,Jiang JF,Jia N,Cao WC

更新日期：2017-09-20 00:00:00

abstract：:Fowl adenovirus (FAdV) has caused significant losses in chicken flocks throughout China in recent years. However, the current understanding of the genetic and pathogenic characteristics of the FAdV epidemic in southwestern China remains poorly understood. In this study, a total of 22 strains were isolated from liver s...

journal_title：Emerging microbes & infections

authors： Xia J,Yao KC,Liu YY,You GJ,Li SY,Liu P,Zhao Q,Wen Rui Wu YP,Huang XB,Cao SJ,Han XF,Huang Y

更新日期：2017-11-29 00:00:00

abstract：:Hepatitis E virus (HEV) is the most common cause of acute viral hepatitis in China. Recently, a shift in molecular epidemiology from hepatitis E genotype 1 (HEV-1) to hepatitis E genotype 4 (HEV-4) has been observed in Northern China, marking a switch from human-to-human transmission to zoonosis. However, similar data...

journal_title：Emerging microbes & infections

authors： Sridhar S,Lo SK,Xing F,Yang J,Ye H,Chan JF,Teng JL,Huang C,Yip CC,Lau SK,Woo PC

更新日期：2017-12-20 00:00:00

abstract：:Enterovirus D68 (EV-D68) has been increasingly associated with severe respiratory illness and neurological complications in children worldwide. However, no vaccine is currently available to prevent EV-D68 infection. In the present study, we investigated the possibility of developing a virus-like particle (VLP)-based E...

journal_title：Emerging microbes & infections

authors： Zhang C,Zhang X,Zhang W,Dai W,Xie J,Ye L,Wang H,Chen H,Liu Q,Gong S,Geng L,Huang Z

更新日期：2018-01-10 00:00:00

abstract：:Since 2016, the highly pathogenic avian influenza H5N8 virus has emerged in the Central Asian flyway and Europe, causing massive deaths in poultry and wild birds. In this study, we isolated and identified three H5N8 viruses from swan goose and black swans in Hubei province during the 2016/2017 winter season. Whole-gen...

journal_title：Emerging microbes & infections

authors： Ma L,Jin T,Wang H,Liu H,Wang R,Li Y,Yang G,Xiong Y,Chen J,Zhang J,Chen G,Li W,Liu D,Lin P,Huang Y,Gao GF,Chen Q

更新日期：2018-02-07 00:00:00

abstract：:The 2017 Hong Kong influenza A(H3N2) summer season was unexpectedly severe. However, antigenic characterization of the 2017 circulating A(H3N2) viruses using ferret antisera did not show significant antigenic drift. We analyzed the hemagglutinin amino acid sequences of A(H3N2) virus circulating in Hong Kong in 2017, a...

journal_title：Emerging microbes & infections

authors： Zhu H,Lee ACY,Li C,Mak WWN,Chen YY,Chan KH,Zhang AJX,Fung WF,Zhang RQ,Fung YF,Poon RWS,Lam JY,Tam S,Hung IFN,Chen H,Yuen KY,To KKW

更新日期：2018-03-06 00:00:00