Changes in peripheral HCN2 channels during persistent inflammation.

abstract：:Potassium channel activation regulates cellular excitability, such as in neuronal and cardiac cells. Regulation of ion channel activity relies on a switching mechanism between two major conformations, the open and closed states, known as gating. It has been suggested that potassium channels are generally gated via a p...

journal_title：Channels (Austin, Tex.)

authors： Rosenhouse-Dantsker A,Logothetis DE

更新日期：2007-05-01 00:00:00

abstract：:Inhibition by intracellular H(+) (pH gating) and activation by phosphoinositides such as PIP(2) (PIP(2)-gating) are key regulatory mechanisms in the physiology of inwardly-rectifying potassium (Kir) channels. Our recent findings suggest that PIP(2) gating and pH gating are controlled by an intra-subunit H-bond at the ...

journal_title：Channels (Austin, Tex.)

authors： Rapedius M,Paynter JJ,Fowler PW,Shang L,Sansom MS,Tucker SJ,Baukrowitz T

更新日期：2007-09-01 00:00:00

abstract：:HERG (KCNH2) and ether-à-go-go (eag) (KCNH1) are members of the same subfamily of voltage-gated K+ channels. In eag, voltage-dependent activation is significantly slowed by extracellular divalent cations. To exert this effect, ions bind to a site located between transmembrane segments S2 and S3 in the voltage sensor d...

journal_title：Channels (Austin, Tex.)

authors： Lin MC,Papazian DM

更新日期：2007-11-01 00:00:00

abstract：:Sulfonylurea receptors (SURs) associate with Kir6.x subunits to form tetradimeric K(ATP) channel complexes. SUR1 and SUR2 confer differential channel sensitivities to nucleotides and pharmacological agents, and are expressed in specific, but overlapping, tissues. This raises the question of whether these different SUR...

journal_title：Channels (Austin, Tex.)

authors： Cheng WW,Tong A,Flagg TP,Nichols CG

更新日期：2008-01-01 00:00:00

abstract：:The endogenous polyamines spermine, spermidine and putrescine are present at high concentrations inside neurons and can be released into the extracellular space where they have been shown to modulate ion channels. Here, we have examined polyamine modulation of voltage-activated Ca(2+) channels (VACCs) and voltage-acti...

journal_title：Channels (Austin, Tex.)

authors： Chen W,Harnett MT,Smith SM

更新日期：2007-07-01 00:00:00

abstract：:It is known that extracellular Mg(2+) and Ca(2+) can permeate TRPM7 and at the same time block the permeation by monovalent cations. In the present study, we examined the molecular basis for the conductivity and sensitivity of human TRPM7 to these divalent cations. Extracellular acidification to pH 4.0 markedly reduce...

journal_title：Channels (Austin, Tex.)

authors： Numata T,Okada Y

更新日期：2008-07-01 00:00:00

abstract：:Nonselective and lipid-regulated cation channels formed by TRPC3, TRPC6 and TRPC7 have recently obtained attention in view their potential pathophysiological impact. It appears as a particular challenge to understand the molecular basis of TRPC3/6/7-related diseases in order to further delineate their value as therape...

journal_title：Channels (Austin, Tex.)

authors： Eder P,Groschner K

更新日期：2008-03-01 00:00:00

abstract：:Hemichannels are large pore ion channels that in the traditional view are formed when half a gap connexin junction opens to the extracellular space. It is now evident that other ion channel families, including the newly discovered pannexin family can form channels with all the nascent properties of hemichannels. This ...

journal_title：Channels (Austin, Tex.)

authors： Thompson RJ,Macvicar BA

更新日期：2008-03-01 00:00:00

abstract：:Voltage-dependent inactivation is an important property of voltage-gated calcium channels. Recently, we have reported that 14-3-3 proteins profoundly reduce inactivation of the Ca(V)2.2 channel at both open- and closed-states. Using a combination of molecular, biochemical and electrophysiological approaches, we have s...

journal_title：Channels (Austin, Tex.)

authors： Li Y,Wu Y,Li R,Zhou Y

更新日期：2007-01-01 00:00:00

abstract：:Aquaporins facilitate osmotically driven water movement across cell membranes. Aquaporin 4 (AQP4) is a major water channel in the central nervous system where it participates in cerebral water balance. AQP4 is also present in basolateral membranes of lower respiratory tract airway and renal collecting duct epithelial ...

journal_title：Channels (Austin, Tex.)

authors： Mobasheri A,Marples D,Young IS,Floyd RV,Moskaluk CA,Frigeri A

更新日期：2007-01-01 00:00:00

abstract：:Mitsugumin 53 (MG53) is a muscle-specific RBCC/TRIM family member predominantly localized on small vesicles underneath the plasma membrane. Upon cell-surface lesion MG53 recruits the vesicles to the repair site in an oxidation-dependent manner and MG53-knockout mice develop progressive myopathy associated with defecti...

journal_title：Channels (Austin, Tex.)

authors： Masumiya H,Asaumi Y,Nishi M,Minamisawa S,Adachi-Akahane S,Yoshida M,Kangawa K,Ito K,Kagaya Y,Yanagisawa T,Yamazaki T,Ma J,Takeshima H

更新日期：2009-01-01 00:00:00

abstract：:In response to depolarizations that open voltage dependent Ca2+ channels single porcine beta-cells display heterogeneous time courses of exocytosis. Some cells display phasic exocytosis that is triggered by individual or short burst of action potentials typically characteristic of glucose-induced electrical activity o...

journal_title：Channels (Austin, Tex.)

authors： Misler S,Silva AM,Barnett D,Dickey AS

更新日期：2009-03-01 00:00:00

abstract：:G-protein-coupled inwardly rectifying potassium channels (GIRK/Kir3.x) are involved in neurotransmission-mediated reduction of excitability. The gating mechanism following G protein activation of these channels likely proceeds from movement of inner transmembrane helices to allow K(+) ions movement through the pore of...

journal_title：Channels (Austin, Tex.)

authors： Sadja R,Reuveny E

更新日期：2009-05-01 00:00:00

abstract：:Drug induced Long QT syndrome results primarily from block of the cardiac potassium channel HERG (human-ether-a-go-go related gene). In some cases prolongation of the QT interval can result in the lethal arrhythmia torsade de pointes, an arrhythmia characterized by a rapid heart rate and severely compromised cardiac o...

journal_title：Channels (Austin, Tex.)

authors： Barrows B,Cheung K,Bialobrzeski T,Foster J,Schulze J,Miller A

更新日期：2009-07-01 00:00:00

abstract：:Activation of gene expression by FOXO transcription factors can promote neuronal death in response to loss of trophic support, or oxidative stress. The predominant neuronal FOXOs, FOXO1 and FOXO3, promote the expression of pro-death genes, such as Fas Ligand, Bim and Txnip. Neuroprotective signals initiated by neurotr...

journal_title：Channels (Austin, Tex.)

authors： Al-Mubarak B,Soriano FX,Hardingham GE

更新日期：2009-07-01 00:00:00

abstract：:Cardiac hypertrophy is associated with profound remodeling of Ca(2+) signaling pathways. During the early, compensated stages of hypertrophy, Ca(2+) fluxes may be enhanced to facilitate greater contraction, whereas as the hypertrophic heart decompensates, Ca(2+) homeostatic mechanisms are dysregulated leading to decre...

journal_title：Channels (Austin, Tex.)

authors： Harzheim D,Talasila A,Movassagh M,Foo RS,Figg N,Bootman MD,Roderick HL

更新日期：2010-01-01 00:00:00

abstract：:Channelrhodopsin-2 (ChR2) is a light-gated ion channel that is successfully used in neurosciences to depolarize cells with blue light. In this regard control of membrane voltage with light opens new perspectives for the characterization of ion channels and the search for inhibitors or modulators. Here, we report a con...

journal_title：Channels (Austin, Tex.)

authors： Prigge M,Rösler A,Hegemann P

更新日期：2010-05-01 00:00:00

abstract：:Electrophysiological and biophysical analyses were used to compare the partial and complete transport cycles of the intestinal oligopeptide transporter PepT1 among three species (seabass, zebrafish and rabbit). On the whole, the presteady-state currents of the fish transporters were similar to each other. Rabbit PepT1...

journal_title：Channels (Austin, Tex.)

authors： Renna MD,Sangaletti R,Bossi E,Cherubino F,Kottra G,Peres A

更新日期：2011-01-01 00:00:00

abstract：:The electrical excitability of neurons is mediated primarily by voltage-gated ion channels, particularly voltage-gated Na(+) (Na(v)), K(+) (K(v)) and Cl(-) (ClC) channels. Cells regulate their electrical excitability by controlling not only the activity, but also the number of individual ion channels in the plasma mem...

journal_title：Channels (Austin, Tex.)

authors： Bongiorno D,Schuetz F,Poronnik P,Adams DJ

更新日期：2011-01-01 00:00:00

abstract：:Celecoxib is a drug designed to selectively inhibit COX-2, an inflammation-inducible cyclooxygenase isoform, over the constitutively expressed COX-1 isoform. In addition to this selective inhibition it is now known that celecoxib exerts a variety of effects on several types of ion channels, thus producing secondary ph...

journal_title：Channels (Austin, Tex.)

authors： Arias-Olguin II,Carrillo E,Meza-Torres B,Barriga-Montoya C,Balleza D,Gomez-Lagunas F

更新日期：2011-01-01 00:00:00

abstract：:Ryanodine receptors (RyRs) are calcium release channels found in the membrane of the endoplasmic reticulum (ER). We recently described the crystal structure of the RyR1 N-terminal disease hot spot. It is built up by three domains that show clear structural homology with the inositol-1,4,5-triphosphate (IP3) binding co...

journal_title：Channels (Austin, Tex.)

authors： Yuchi Z,Van Petegem F

更新日期：2011-03-01 00:00:00

abstract：:Gabapentin and pregabalin are anticonvulsant drugs that are extensively used for the treatment of several neurological and psychiatric disorders. Gabapentinoids (GBPs) are known to have a high affinity binding to α2δ-1 and α2δ-2 auxiliary subunit of specific voltage-gated calcium channels. Despite the confusing effect...

journal_title：Channels (Austin, Tex.)

authors： Uchitel OD,Di Guilmi MN,Urbano FJ,Gonzalez-Inchauspe C

更新日期：2010-11-01 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease characterized by selective loss of motoneurons. Recently we studied glycine receptors (GlyRs) in motoneurons in an ALS mouse model expressing a mutant form of human superoxide dismutase-1 with a Gly93→Ala substitution (G93A-SOD1). Living mo...

journal_title：Channels (Austin, Tex.)

authors： Chang Q,Martin LJ

更新日期：2011-07-01 00:00:00

abstract：:Our bodies are constantly bombarded by a diversity of environmental stimuli, such as touch, taste, sound, smell, light, etc. To detect and process this broad array of signals, nature has evolved a variety of cellular sensory mechanisms and pathways that interface with the environment and transmit neural signals back t...

journal_title：Channels (Austin, Tex.)

authors： Braun AP

更新日期：2012-01-01 00:00:00

abstract：:The lipid-protein interface is an important domain of the nicotinic acetylcholine receptor (nAChR) that has recently garnered increased relevance. Several studies have made significant advances toward determining the structure and dynamics of the lipid-exposed domains of the nAChR. However, there is still a need to ga...

journal_title：Channels (Austin, Tex.)

authors： Caballero-Rivera D,Cruz-Nieves OA,Oyola-Cintrón J,Torres-Nunez DA,Otero-Cruz JD,Lasalde-Dominicci JA

更新日期：2012-03-01 00:00:00

abstract：:The ability of cells to reliably fire action potentials is critically dependent upon the maintenance of a hyperpolarized resting potential, which allows voltage-gated Na(+) and Ca(2+) channels to recover from inactivation and open in response to a subsequent stimulus. Hodgkin and Huxley first recognized the functional...

journal_title：Channels (Austin, Tex.)

authors： Braun AP

更新日期：2012-05-01 00:00:00

abstract：:A C-terminal modulatory domain (CTM) tightly regulates the biophysical properties of Ca(v)1.3 L-type Ca(2+) channels, in particular the voltage dependence of activation (V(0.5)) and Ca(2+) dependent inactivation (CDI). A functional CTM is present in the long C-terminus of human and mouse Ca(v)1.3 (Ca(v)1.3(L)), but no...

journal_title：Channels (Austin, Tex.)

authors： Lieb A,Scharinger A,Sartori S,Sinnegger-Brauns MJ,Striessnig J

更新日期：2012-05-01 00:00:00

abstract：:The bacterial mechanosensitive channel of large conductance, MscL, is one of the best characterized mechanosensitive channels serving as a paradigm for how proteins can sense and transduce mechanical forces. The physiological role of MscL is that of an emergency release valve that opens a large pore upon a sudden drop...

journal_title：Channels (Austin, Tex.)

authors： Iscla I,Wray R,Blount P

更新日期：2012-07-01 00:00:00

abstract：:In our recent publication, we describe the local anesthetic (LA) inhibition of the prokaryotic voltage gated sodium channel NaChBac. Despite the numerous functional and putative structural differences with the mammalian sodium channels, the data show that LA compounds effectively and reversibly inhibit NaChBac channel...

journal_title：Channels (Austin, Tex.)

authors： Lee S,Goodchild SJ,Ahern CA

更新日期：2012-09-01 00:00:00

abstract：:Ryanodine receptors (RyRs), located in the sarcoplasmic/endoplasmic reticulum (SR/ER) membrane, are required for intracellular Ca2+ release that is involved in a wide range of cellular functions. In addition to Ca2+-induced Ca2+ release in cardiac cells and voltage-induced Ca2+ release in skeletal muscle cells, we rec...

journal_title：Channels (Austin, Tex.)

authors： Kakizawa S,Yamazawa T,Iino M

更新日期：2013-01-01 00:00:00