Abstract:
:Obesity is a leading risk factor for post-menopausal breast cancer, and this is concerning as 40% of cancer diagnoses in 2014 were associated with overweight/obesity. Despite this epidemiological link, the underlying mechanism responsible is unknown. We recently published that visceral adipose tissue (VAT) releases FGF2 and stimulates the transformation of skin epithelial cells. Furthermore, obesity is differentially associated with many epithelial cancers, and this mechanistic link could be translational. As FGF2 and FGFR1 are implicated in breast cancer progression, we hypothesize that VAT-derived FGF2 plays a translational role in promoting adiposity-associated mammary epithelial cell transformation. In this brief report, data suggest that FGF2/FGFR1 signaling is a potential mechanistic link in VAT-stimulated transformation of breast epithelial cells.
journal_name
Adipocytejournal_title
Adipocyteauthors
Benham V,Chakraborty D,Bullard B,Bernard JJdoi
10.1080/21623945.2018.1445889keywords:
["FGF2","Obesity","adiposity","breast","breast cancer","cancer","visceral fat"]subject
Has Abstractpub_date
2018-01-01 00:00:00pages
113-120issue
2eissn
2162-3945issn
2162-397Xjournal_volume
7pub_type
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