Oral microbiome shifts during pregnancy and adverse pregnancy outcomes: Hormonal and Immunologic changes at play.

Abstract:

:Because of hormonal and immunologic changes, there are significant changes in the oral microbiome that emerge during pregnancy. Recent evidence further suggests that there is an association between the presence of periodontal disease and a pregnancy-associated oral dysbiosis. Although this oral dysbiosis and pathogenic periodontal bacteria are considered to be associated with adverse pregnancy outcomes, it is still not clear how an oral dysbiosis during pregnancy can modulate oral diseases and birth outcomes. To develop preventive or therapeutic interventions, it is critical to understand the oral microbiome changes that emerge during pregnancy and their association with adverse pregnancy outcomes. In the present review, we summarize the current literature on normal changes in the oral microbiome that occur during pregnancy; the pathogenic changes in the oral microbiome believed to occur in association with adverse pregnancy outcomes; and the association between the placental microbiome and the oral microbiome.

journal_name

Periodontol 2000

journal_title

Periodontology 2000

authors

Ye C,Kapila Y

doi

10.1111/prd.12386

keywords:

["adverse pregnancy outcomes","oral microbiome","periodontal pathogens","placental microbiome"]

subject

Has Abstract

pub_date

2021-10-01 00:00:00

pages

276-281

issue

1

eissn

0906-6713

issn

1600-0757

journal_volume

87

pub_type

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