CD4+ T cells in the lungs of acute sarcoidosis patients recognize an Aspergillus nidulans epitope.

abstract：:Human iron-saturated Lf (FeLf), which was labeled with 125I or 50Fe, was found to combine with the membrane of mouse peritoneal cells (MPC) which consisted of 70% macrophages. The following experimental data suggested the involvement of a specific receptor. (a) The binding of FeLf to MPC reached a saturation point. (b...

journal_title：The Journal of experimental medicine

authors： Van Snick JL,Masson PL

更新日期：1976-12-01 00:00:00

abstract：:It is widely accepted that cellular immune responses are induced by CD4(+) T helper 1 (Th1) cells secreting interleukin (IL)-2 and interferon (IFN)-gamma. Tumor immunity is often mediated by cytotoxic T lymphocytes (CTLs) whose activation is supported by Th1 cytokines. Since IL-4 directs Th2 development and has been s...

journal_title：The Journal of experimental medicine

authors： Schüler T,Qin Z,Ibe S,Noben-Trauth N,Blankenstein T

更新日期：1999-03-01 00:00:00

abstract：:Somatic cell hybrid clones were isolated from the fusion of RPC 5,4 mouse myeloma cells and B lymphocytes from three patients with agammaglobulinemia. One patient had X-linked agammaglobulinemia; the remaining two patients had common varied agammaglobulinemia. All three patients had B lymphocytes which fail to secrete...

journal_title：The Journal of experimental medicine

authors： Schwaber JF,Rosen FS

更新日期：1978-10-01 00:00:00

abstract：:Staphylococcus epidermidis releases factors that activate the HIV-1 long terminal repeat, induce cytokine release, and activate nuclear factor B in cells of macrophage lineage. The active material had a mass of 34,500 daltons, was inactivated by proteases and partitioned into the phenol layer on hot aqueous phenol ext...

journal_title：The Journal of experimental medicine

authors： Mehlin C,Headley CM,Klebanoff SJ

更新日期：1999-03-15 00:00:00

abstract：:The effectiveness of interleukin 10 (IL-10) in the treatment of autoimmune-mediated central nervous system inflammation is controversial. Studies of the model system, experimental autoimmune encephalomyelitis (EAE), using various routes, regimens, and delivery methods of IL-10 suggest that these variables may affect i...

journal_title：The Journal of experimental medicine

authors： Cua DJ,Groux H,Hinton DR,Stohlman SA,Coffman RL

更新日期：1999-03-15 00:00:00

abstract：:Experimental autoimmune encephalomyelitis (EAE) is a widely used animal model for multiple sclerosis (MS). EAE is typically initiated by CD4(+) T helper cell type 1 (Th1) autoreactivity directed against a single priming immunodominant myelin peptide determinant. Recent studies have shown that clinical progression of E...

journal_title：The Journal of experimental medicine

authors： Tuohy VK,Yu M,Yin L,Kawczak JA,Kinkel RP

更新日期：1999-04-05 00:00:00

abstract：:Interleukin (IL)-18 is functionally similar to IL-12 in mediating T helper cell type 1 (Th1) response and natural killer (NK) cell activity but is related to IL-1 in protein structure and signaling, including recruitment of IL-1 receptor-associated kinase (IRAK) to the receptor and activation of c-Jun NH2-terminal kin...

journal_title：The Journal of experimental medicine

authors： Kanakaraj P,Ngo K,Wu Y,Angulo A,Ghazal P,Harris CA,Siekierka JJ,Peterson PA,Fung-Leung WP

更新日期：1999-04-05 00:00:00

abstract：:Molecular mimicry refers to structural homologies between a self-protein and a microbial protein. A major epitope of myelin basic protein (MBP), p87-99 (VHFFKNIVTPRTP), induces experimental autoimmune encephalomyelitis (EAE). VHFFK contains the major residues for binding of this self-molecule to T cell receptor (TCR) ...

journal_title：The Journal of experimental medicine

authors： Ruiz PJ,Garren H,Hirschberg DL,Langer-Gould AM,Levite M,Karpuj MV,Southwood S,Sette A,Conlon P,Steinman L

更新日期：1999-04-19 00:00:00

abstract：:We have shown previously that a mutation of the KI-KII site immediately 5' to J(kappa)1 on the mouse immunoglobulin light chain kappa locus reduces the rearrangement level in cis, although it does not affect transcription. Here we deleted by homologous recombination in mouse embryonic stem cells a 4-kb DNA fragment, l...

journal_title：The Journal of experimental medicine

authors： Cocea L,De Smet A,Saghatchian M,Fillatreau S,Ferradini L,Schurmans S,Weill JC,Reynaud CA

更新日期：1999-05-03 00:00:00

abstract：:Rhesus monkeys were immunized with a preparation of Plasmodium knowlesi parasites containing principally microgametes with lesser numbers of macrogametes and asexual trophozoites. The antigen mixture was emulsified in Freund's complete adjuvant (FCA) and administered intramuscularly. After one or two inoculations of f...

journal_title：The Journal of experimental medicine

authors： Gwadz RW,Green I

更新日期：1978-11-01 00:00:00

abstract：:We have previously shown that interferon and tumor necrosis factor noncytopathically abolish hepatitis B virus (HBV) replication from the hepatocyte and kidney tubular epithelial cells in vivo. Here we show that a persistent lymphocytic choriomeningitis virus (LCMV) infection is cleared from the hepatocyte noncytopath...

journal_title：The Journal of experimental medicine

authors： Guidotti LG,Borrow P,Brown A,McClary H,Koch R,Chisari FV

更新日期：1999-05-17 00:00:00

abstract：:Synaptotagmins (Syts) I and II are believed to act as Ca2+ sensors in the control of neurotransmission. Here we demonstrate that mast cells express Syt II in their lysosomal fraction. We further show that activation of mast cells by either aggregation of FcepsilonRI or by Ca2+ ionophores results in exocytosis of lysos...

journal_title：The Journal of experimental medicine

authors： Baram D,Adachi R,Medalia O,Tuvim M,Dickey BF,Mekori YA,Sagi-Eisenberg R

更新日期：1999-05-17 00:00:00

abstract：:Tumor necrosis factor alpha (TNF-alpha) is a proinflammatory cytokine. Its pleiotropic biological properties are signaled through two distinct cell surface receptors: the TNF receptor type I (TNFR-I) and the TNF receptor type II. Neither of the two receptors possesses tyrosine kinase activity. A large majority of TNF-...

journal_title：The Journal of experimental medicine

authors： Hildt E,Oess S

更新日期：1999-06-07 00:00:00

abstract：:A hallmark of systemic lupus erythematosus and the MRL murine model for lupus is the presence of anti-double-stranded (ds)DNA antibodies (Abs). To identify the steps leading to the production of these Abs in autoimmune mice, we have compared the phenotype and localization of anti-dsDNA B cells in autoimmune (MRL+/+ an...

journal_title：The Journal of experimental medicine

authors： Mandik-Nayak L,Seo SJ,Sokol C,Potts KM,Bui A,Erikson J

更新日期：1999-06-07 00:00:00

abstract：:Intradermal administration of short overlapping peptides derived from chain 1 of the cat allergen Fel d 1 (FC1P) that did not cross-link IgE, elicited isolated late asthmatic reactions with no visible early or late cutaneous response in 9/40 cat-allergic asthmatics. Four of the nine were human histocompatibility leuko...

journal_title：The Journal of experimental medicine

authors： Haselden BM,Kay AB,Larché M

更新日期：1999-06-21 00:00:00

abstract：:We investigated the role of antigen-presenting cells in early interferon (IFN)-gamma production in normal and recombinase activating gene 2-deficient (Rag-2(-/-)) mice in response to Listeria monocytogenes (LM) infection and interleukin (IL)-12 administration. Levels of serum IFN-gamma in Rag-2(-/-) mice were comparab...

journal_title：The Journal of experimental medicine

authors： Ohteki T,Fukao T,Suzue K,Maki C,Ito M,Nakamura M,Koyasu S

更新日期：1999-06-21 00:00:00

abstract：:Trichosanthin (TCS), an active protein component isolated from a traditional Chinese medicinal herb Trichosanthes kirilowii, has been shown to inhibit HIV infection and has been applied in clinical treatment of AIDS. The recent development that chemokines and chemokine receptors play important roles in HIV infection l...

journal_title：The Journal of experimental medicine

authors： Zhao J,Ben LH,Wu YL,Hu W,Ling K,Xin SM,Nie HL,Ma L,Pei G

更新日期：1999-07-05 00:00:00

abstract：:We examined the effectiveness of cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) blockade, alone or in combination with a granulocyte/macrophage colony-stimulating factor (GM-CSF)-expressing tumor cell vaccine, on rejection of the highly tumorigenic, poorly immunogenic murine melanoma B16-BL6. Recently establishe...

journal_title：The Journal of experimental medicine

authors： van Elsas A,Hurwitz AA,Allison JP

更新日期：1999-08-02 00:00:00

abstract：:Histocompatibility leukocyte antigen (HLA)-A2 is used as a restricting element to present several melanoma-associated antigen (MAA)-derived peptides to cytotoxic T lymphocytes (CTLs). HLA-A2 antigen is selectively lost in primary melanoma lesions and more frequently in metastases. Only scanty information is available ...

journal_title：The Journal of experimental medicine

authors： Wang Z,Marincola FM,Rivoltini L,Parmiani G,Ferrone S

更新日期：1999-07-19 00:00:00

abstract：:Disruption of the balance between proteases and protease inhibitors is often associated with pathologic tissue destruction. To explore the therapeutic potential of secretory leukocyte protease inhibitor (SLPI) in erosive joint diseases, we cloned, sequenced, and expressed active rat SLPI, which shares the protease-rea...

journal_title：The Journal of experimental medicine

authors： Song Xy,Zeng L,Jin W,Thompson J,Mizel DE,Lei K,Billinghurst RC,Poole AR,Wahl SM

更新日期：1999-08-16 00:00:00

abstract：:Using fluorescent HLA-A*0201 tetramers containing the immunodominant Melan-A/MART-1 (Melan-A) tumor-associated antigen (Ag), we previously observed that metastatic lymph nodes of melanoma patients contain high numbers of Ag-experienced Melan-A-specific cytolytic T lymphocytes (CTLs). In this paper, we enumerated and c...

journal_title：The Journal of experimental medicine

authors： Pittet MJ,Valmori D,Dunbar PR,Speiser DE,Liénard D,Lejeune F,Fleischhauer K,Cerundolo V,Cerottini JC,Romero P

更新日期：1999-09-06 00:00:00

abstract：:The majority ( approximately 70%) of postselection CD4(+) single-positive (SP) thymocytes are CD8(lo)CD4(hi). These cells express very low levels of CD8, undetectable by flow cytofluorimetric (FCM) analysis, but sufficiently high to allow purification by panning. Unlike the fully mature CD8(-)CD4(hi) thymocytes, which...

journal_title：The Journal of experimental medicine

authors： Dyall R,Nikolic-Zugić J

更新日期：1999-09-20 00:00:00

abstract：:Noninflammatory monocyte macrophages use alphavbeta3 integrin to selectively bind apoptotic cells, initiating their phagocytic removal. In a related process, the retinal pigment epithelium (RPE) employs alphavbeta5 integrin to recognize spent photoreceptor outer segment particles (OS). Here, we show that apoptotic cel...

journal_title：The Journal of experimental medicine

authors： Finnemann SC,Rodriguez-Boulan E

更新日期：1999-09-20 00:00:00

abstract：:We have previously demonstrated that invasion of erythrocytes (RBCs) by malaria merozoites follows a sequence: recognition and attachment in an apical orientation associated with widespread deformation of the RBC, junction formation, movement of the junction around the merozoite that brings the merozoite into the inva...

journal_title：The Journal of experimental medicine

authors： Miller LH,Aikawa M,Johnson JG,Shiroishi T

更新日期：1979-01-01 00:00:00

abstract：:Thymocyte maturation is governed by antigen-T cell receptor (TCR) affinity and the extent of TCR aggregation. Signals provided by coactivating molecules such as CD4 and CD28 also influence the fate of immature thymocytes. The mechanism by which differences in antigen-TCR avidity encode unique maturational responses of...

journal_title：The Journal of experimental medicine

authors： Freedman BD,Liu QH,Somersan S,Kotlikoff MI,Punt JA

更新日期：1999-10-04 00:00:00

abstract：:The majority of lymphomas induced in Rag-deficient mice by Moloney murine leukemia virus (MoMuLV) infection express the CD4 and/or CD8 markers, indicating that proviral insertions cause activation of genes affecting the development from CD4(-)8(-) pro-T cells into CD4(+)8(+) pre-T cells. Similar to MoMuLV wild-type tu...

journal_title：The Journal of experimental medicine

authors： Jacobs H,Krimpenfort P,Haks M,Allen J,Blom B,Démollière C,Kruisbeek A,Spits H,Berns A

更新日期：1999-10-18 00:00:00

abstract：:Complement is part of the innate immune system and one of the first lines of host defense against infections. Its importance was evaluated in this study in virus infections in mice deficient either in soluble complement factors (C3(-/-), C4(-/-)) or in the complement signaling complex (complement receptor [CR]2(-/-), ...

journal_title：The Journal of experimental medicine

authors： Ochsenbein AF,Pinschewer DD,Odermatt B,Carroll MC,Hengartner H,Zinkernagel RM

更新日期：1999-10-18 00:00:00

abstract：:Systemic tolerance can be elicited by introducing antigen into an immune-privileged site, such as the eye, or directly into the blood. Both routes of immunization result in a selective deficiency of systemic delayed type hypersensitivity. Although the experimental animal model of anterior chamber-associated immune dev...

journal_title：The Journal of experimental medicine

authors： Sonoda KH,Exley M,Snapper S,Balk SP,Stein-Streilein J

更新日期：1999-11-01 00:00:00

abstract：:The Wiskott-Aldrich syndrome protein (WASp) has been implicated in modulation of lymphocyte activation and cytoskeletal reorganization. To address the mechanisms whereby WASp subserves such functions, we have examined WASp roles in lymphocyte development and activation using mice carrying a WAS null allele (WAS(-)(/)(...

journal_title：The Journal of experimental medicine

authors： Zhang J,Shehabeldin A,da Cruz LA,Butler J,Somani AK,McGavin M,Kozieradzki I,dos Santos AO,Nagy A,Grinstein S,Penninger JM,Siminovitch KA

更新日期：1999-11-01 00:00:00

abstract：:It has been proposed that CD2, which is highly expressed on T cells, serves to enhance T cell-antigen presenting cell (APC) adhesion and costimulate T cell activation. Here we analyzed the role of CD2 using CD2-deficient mice crossed with transgenic mice expressing a T cell receptor specific for lymphocytic choriomeni...

journal_title：The Journal of experimental medicine

authors： Bachmann MF,Barner M,Kopf M

更新日期：1999-11-15 00:00:00