Knockdown of circNRIP1 sensitizes colorectal cancer to 5‑FU via sponging miR‑532‑3p.

abstract：:The purpose of this study was to examine the correlations among enhancement of apoptosis, cell proliferation and expression of oncogenes in gastric carcinomas induced by preoperative oral administration of 5-fluorouracil (5-FU). The occurrence of spontaneous apoptotic cell death in 42 patients with gastric carcinoma w...

journal_title：Oncology reports

authors： Kimura H,Konishi K,Kaji M,Maeda K,Yabushita K,Tsuji M,Ogino H,Satomura Y,Unoura M,Miwa A

更新日期：2000-09-01 00:00:00

abstract：:Collagen gel droplet embedded culture drug sensitivity test (CD-DST) was applied to 33 patients with gastric cancer (30 primary tumors, 12 metastatic tumors and 25 biopsy specimens). Evaluable rates by CD-DST were 80% for primary tumors, 75% for metastatic tumors and 72% for biopsy specimens. Chemosensitivities of pri...

journal_title：Oncology reports

authors： Hanatani Y,Kobayashi H,Kodaira S,Takami H,Asagoe T,Kaneshiro E

更新日期：2000-09-01 00:00:00

abstract：:To study the role of telomerase in the pathogenesis of different grades and subtype of gliomas, telomerase activity in 31 gliomas was assessed with the use of non-radioisotopic and semi-quantitative procedures for the terminal repeat amplification protocol in this study. Among the samples were 17 glioblastoma multifor...

journal_title：Oncology reports

authors： Sugita Y,Nakashima A,Kato S,Sakata K,Morimatsu M,Shigemori M

更新日期：2000-09-01 00:00:00

abstract：:We evaluated whether feeding pregnant female rats a diet high in olive-oil, that showed a tumor-preventive effect in adults, has a similar preventive effect on chemically-induced cancer in offspring (i.e. mammary glands and colon cancer in rats). The control group was fed the same 7% corn-oil diet as their mothers. Ex...

journal_title：Oncology reports

authors： Kossoy G,Yarden G,Benhur H,Sandler B,Zusman II,Stark A,Madar Z

更新日期：2000-09-01 00:00:00

abstract：:We developed a rapid, non-invasive, and inexpensive, assay capable of identifying BRCA1 and BRCA2 (BRCA) mutations in buccal cells. To determine the predictive value of this immunoassay, a double blind study of 13 high risk individuals was conducted by two independent teams. As greater than 90% of BRCA mutations resul...

journal_title：Oncology reports

authors： Byrne TJ,Reece MT,Adams LA,Hoffman DE,Lane MA,Cohn GM

更新日期：2000-11-01 00:00:00

abstract：:Fourteen cases with symptomatic ductal carcinoma in situ (DCIS) were treated with breast-conservation treatment intensified with endocrine therapy. Nine of 14 patients with palpable mass had tumor detected on mammography. CT, ultrasonography, and MRI were able to detect linear and/or spotty lesion or enhancement sugge...

journal_title：Oncology reports

authors： Terashima M,Ogawa Y,Kariya S,Inomata T,Nishioka A,Shimizu K,Yamanishi T,Tanaka Y,Tochika N,Yoshida S

更新日期：2000-11-01 00:00:00

abstract：:5-Fluorouracil (5-FU) is the main drug used in the treatment of advanced gastric cancer. Combination chemotherapy is not always superior to 5-FU alone, especially when biomodulators are also administered. In an attempt to exploit all the cytotoxic mechanisms of 5-FU, we carried out a pilot study with a double route of...

journal_title：Oncology reports

authors： Barone C,Cassano A,Landriscina M,Longo R,Astone A,Pozzo C

更新日期：2000-11-01 00:00:00

abstract：:Intussusception in adult is a rare condition. Pathologic process is identifiable in 90% of cases. Emergency clinical diagnosis is generally difficult and CT scan typical features are of use. Surgery is always necessary to treat bowel necrosis and to perform pathologic examination. Diagnosis of cancer must be in mind a...

journal_title：Oncology reports

authors： Sebbag H,Brunaud L,Marchal F,Collinet-Adler S,Grosdidier G

更新日期：2000-11-01 00:00:00

abstract：:We performed a dose-escalation study of carboplatin combined with a fixed dose of intraperitoneal cisplatin and G-CSF in patients with epithelial ovarian cancer, and analyzed the progression-free and overall survival. Six of the patients who entered the study with stage IC and II disease are still alive with no eviden...

journal_title：Oncology reports

authors： Adachi S,Itani Y,Ito K,Noda T,Shintani M,Saito K,Furukawa N,Tomii Y

更新日期：2001-01-01 00:00:00

abstract：:We analyzed the chromosomal gains and losses that occur in 30 non-small cell lung carcinomas by comparative genomic hybridization. Their chromosomal imbalances showed histological type-specific patterns in adenocarcinomas and in squamous cell carcinomas. The genetic changes in non-small cell lung carcinoma were also s...

journal_title：Oncology reports

authors： Ubagai T,Matsuura S,Tauchi H,Itou K,Komatsu K

更新日期：2001-01-01 00:00:00

abstract：:Osteosarcoma is an uncommon tumor. Family occurrence of osteosarcoma is even rarer. Four cases of osteosarcoma in two siblings and in a father and son treated at our Institute with surgery and chemotherapy are reported. These patients had no other tumors in their family history, and had negative p53 mutations in exons...

journal_title：Oncology reports

authors： Longhi A,Benassi MS,Molendini L,Macchiagodena M,Picci P,Bacci G

更新日期：2001-01-01 00:00:00

abstract：:We investigated the use of unencapsulated silicon semiconductor detectors for backscatter radiation detection. The results were compared with Monte Carlo (MC) calculations modelling the experimental set-up. A special diode was manufactured, which was designed so that it allowed the positioning of different materials i...

journal_title：Oncology reports

authors： Lennernäs B,Rosengren B,Rikner G,Nilsson B,Montelius A,Grusell E

更新日期：2001-01-01 00:00:00

abstract：:To investigate the involvement of S. anginosus infection in head and neck cancer in the extra-oropharyngeal cavity, we analyzed 3 DNA samples prepared from squamous cell carcinoma of the external auditory canal and one from squamous cell carcinoma of the skin using polymerase chain reaction (PCR) analysis and Southern...

journal_title：Oncology reports

authors： Shiga K,Tateda M,Saijo S,Hori T,Sato I,Tateno H,Matsuura K,Takasaka T,Miyagi T

更新日期：2001-03-01 00:00:00

abstract：:The purpose of this study was to elucidate microsatellite instability (MSI) and p53 expression for each tumor in cases with sporadic synchronous multiple colorectal cancers. Twenty-nine patients with sporadic synchronous multiple colorectal cancer were examined. There were sixty-five tumors, all of which indicated ade...

journal_title：Oncology reports

authors： Abe Y,Masuda H,Okubo R

更新日期：2001-03-01 00:00:00

abstract：:The squamous cell carcinoma antigen (SCCA) serves as a serological marker for squamous cell carcinomas. Molecular cloning of the SCCA genomic region has revealed the presence of two tandemly arrayed genes, SCCA1 and SCCA2. SCCA1 is a papain-like cysteine proteinase inhibitor, while SCCA2 is a chymotrypsin-like serine ...

journal_title：Oncology reports

authors： Hamada K,Hanakawa Y,Hashimoto K,Iwamoto M,Kihana T,Hirose S,Nakamura M,Ito M

更新日期：2001-03-01 00:00:00

abstract：:Endostatin is a negative regulator of angiogenesis. We examined plasma endostatin levels (PESLs) in cancer patients and healthy controls. PESLs were detected by competitive enzyme immunoassay in 147 patients with primary breast cancer, 44 patients with other histological types of cancer, 26 patients with recurrent bre...

journal_title：Oncology reports

authors： Kuroi K,Tanaka C,Toi M

更新日期：2001-03-01 00:00:00

abstract：:To understand the fundamental determinants of urokinase plasminogen activator (uPA) driven angiogenesis in cancer we studied how inhibition of uPA activity could reduce neovascularization and consequently reduce tumor size in experimental animals. Proteolytic enzymes are required to mediate tumor cell invasion to adja...

journal_title：Oncology reports

authors： Swiercz R,Keck RW,Skrzypczak-Jankun E,Selman SH,Jankun J

更新日期：2001-05-01 00:00:00

abstract：:We developed a method to measure membrane fluidity of living cancer cells in two- and three-dimensional cultures, and found that there was a close relationship between the membrane fluidity of cancer cells and their proliferative and infiltrative ability. Membrane fluidity is thus a promising indicator of the probabil...

journal_title：Oncology reports

authors： Funaki NO,Tanaka J,Kohmoto M,Sugiyama T,Ohshio G,Nonaka A,Yotsumoto F,Takeda Y,Imamura M

更新日期：2001-05-01 00:00:00

abstract：:We analyzed six cystectomized specimens diagnosed as transitional cell carcinoma by immunohistochemical evaluation to determine the presence of c-erbB2, transforming growth factor-alpha (TGF-alpha), c-myc, c-fos, and c-fms. Representative sections of flat lesions with atypia (e.g., reactive atypia, dysplasia, and carc...

journal_title：Oncology reports

authors： Kee KH,Lee MJ,Ro JY

更新日期：2001-05-01 00:00:00

abstract：:We examined the susceptibility of five human bone and soft tissue sarcoma cell lines to transfection with recombinant p53 adenovirus vector (AxCA-p53). Transfection efficiency was more than 90% at 72 h with AxCA-lacZ at a multiplicity of infection (MOI) of 50 in all the cell lines, except for MG-63 (p53 gene mutated) ...

journal_title：Oncology reports

authors： Endo K,Kuratate I,Watanabe M,Yoshida H,Teshima R,Osaki M,Ito H

更新日期：2001-05-01 00:00:00

abstract：:We investigated the presence of free mRNA in the plasma of patients with chronic myeloid leukemia (CML), through RT-PCR analysis of G3PDH, a metabolism gene. We also analysed the presence of mRNA for HLM, a human oxysterol-binding protein homologue recently described as a potential marker for blood dissemination of so...

journal_title：Oncology reports

authors： Silva NH,Pimenta G,Pulcheri WA,Fournier MV,Spector N,da Costa Carvalho MG

更新日期：2001-05-01 00:00:00

abstract：:The effect of extremely large hepatomas on splenic lymphoid elements and apoptosis-related proteins in rats were studied. Hepatoma cells were inoculated subcutaneously into 6-week-old rats, and 4 months later the quantities of T and B cells, macrophages, and cells positive for Fas, Fas ligand (FasL) and interleukin-2 ...

journal_title：Oncology reports

authors： Ben-Hur H,Gurevich P,Calmanovich S,Gurevich E,Zusman I

更新日期：2001-07-01 00:00:00

abstract：:From March 1992 to October 1997, a total of 38 patients with histologically proven esophageal cancer received combination therapy of daily low-dose cisplatin (CDDP) and radiation therapy. The clinical stages (UICC 1997) were I in 3, IIA,B in 13, III in 13, and IVA in 9 patients. CDDP (5 mg/m2) was administered intrave...

journal_title：Oncology reports

authors： Nemoto K,Ogawa Y,Matsushita H,Takeda K,Takahashi C,Saito H,Takai Y,Yamada S,Hosoi Y

更新日期：2001-07-01 00:00:00

abstract：:This retrospective analysis evaluates the treatment results and prognostic factors of 114 patients with ductal carcinoma in situ (DCIS) undergoing breast conserving therapy (BCT) at Keio University Hospital Department of Radiology, between 1988 and 1997. A total of 132 patients with DCIS of the breast came to our hosp...

journal_title：Oncology reports

authors： Takeda A,Shigematsu N,Kondo M,Amemiya A,Kawaguchi O,Kutsuki S,Ishibashi R,Kawata T,Masago K,Fukada J,Kubo A

更新日期：2001-07-01 00:00:00

abstract：:To evaluate the association of mutations in the K-ras gene with the incidence of non-small cell lung cancer (NSCLC) in Japanese patients, 410 patients treated surgically were studied. DNA was extracted from frozen specimens, and polymerase chain reaction-sequence specific oligonucleotide probe (PCR-SSOP) hybridization...

journal_title：Oncology reports

authors： Noda N,Matsuzoe D,Konno T,Kawahara K,Yamashita Y,Shirakusa T

更新日期：2001-07-01 00:00:00

abstract：:Epstein Barr virus (EBV) has been reported to be present in a minority of gastric carcinomas and may be implicated in its pathogenesis. This study was aimed at determining the occurrence of EBV in 43 consecutive gastrectomy specimens with a variety of benign and malignant lesions. In situ hybridisation was used for de...

journal_title：Oncology reports

authors： Luqmani YA,Linjawi SO,Shousha S

更新日期：2001-09-01 00:00:00

abstract：:We studied whether feeding pregnant female rats a 15% olive-oil diet affects the activity of lymph cells in the spleen and tumors in offspring with chemically-induced colon tumors. Rat mothers were fed either a 7% corn-oil or a 15% olive-oil diet. Five-week-old male offspring were divided into 3 groups. A control grou...

journal_title：Oncology reports

authors： Kossoy G,Madar Z,Ben-Hur H,Gal R,Stark A,Cohen O,Zusman I

更新日期：2001-09-01 00:00:00

abstract：:The disadvantage brought by the preoperative therapy with insufficient effectiveness for the patients with esophageal carcinoma has not been previously investigated. The aim of the current study was to show that the prognosis of patients with advanced esophageal carcinoma treated with preoperative therapy with insuffi...

journal_title：Oncology reports

authors： Nozoe T,Saeki H,Ohga T,Sugimachi K

更新日期：2001-09-01 00:00:00

abstract：:Iron complexed by ATP induces lymphomas in mouse organs other than the specific targets of the lympho-adenitis provoked by sodium ATP: lymph nodes, spleen and liver. The reduction of life spans and the production of substantial volumes of ascites, that are lacking in the case of sodium ATP, are an index of the degree ...

journal_title：Oncology reports

authors： Anghileri LJ,Plenat F,Thouvenot P

更新日期：2001-09-01 00:00:00

abstract：:Heregulin (HRG) is one of the groups of polypeptide growth factors that activate the erbB-2 receptor via induction of heterodimerization with erbB-3 and erbB-4 receptors. The biological effects of HRG have been extensively studied. The vast majority of the reports indicate that HRG induces cell growth in breast cancer...

journal_title：Oncology reports

authors： Guerra-Vladusic FK,Vladusic EA,Tsai MS,Lupu R

更新日期：2001-11-01 00:00:00