Metformin suppresses phenylephrine-induced hypertrophic responses by inhibiting p300-HAT activity in cardiomyocytes.

abstract：:Although tremendous effort has been put towards identifying the surface molecules of nontypeable Haemophilus influenzae (NTHi) for vaccine development over the past decades, it is only recently that we have begun to appreciate the intricate host epithelial signaling networks activated by NTHi, an important human patho...

journal_title：Journal of pharmacological sciences

authors： Li JD

更新日期：2003-01-01 00:00:00

abstract：:The role of ET(A) endothelin receptor (ET(A)R) in the regulation of the delayed rectifier potassium current (I(K)) was examined in guinea pig atrial myocytes. Application of ET-1 (10 nM) together with an ET(B)-receptor-selective antagonist, BQ-788 (300 nM), significantly increased the voltage-dependent activation of I...

journal_title：Journal of pharmacological sciences

authors： Ono K

更新日期：2003-01-01 00:00:00

abstract：:The effects of pimobendan, a Ca(2+) sensitizer with inhibitory action against cyclic-GMP-inhibited phosphodiesterase (PDE-III), on catecholamine (CA) secretion were studied in bovine adrenal chromaffin cells. In intact cells, pimobendan (10 - 100 microM) inhibited CA secretion stimulated by acetylcholine (10 and 30 mi...

journal_title：Journal of pharmacological sciences

authors： Kuwashima H,Matsumura C,Kimura T

更新日期：2003-03-01 00:00:00

abstract：:Donepezil, an acetylcholinesterase (AChE) inhibitor, has not been evaluated for its binding characteristics using a radioactive tracer, although its inhibitory action on AChE has been studied. The aim of this research is to examine whether AChE can be visualized in vivo and in vitro with [(11)C]donepezil. [5-(11)C-met...

journal_title：Journal of pharmacological sciences

authors： Funaki Y,Kato M,Iwata R,Sakurai E,Sakurai E,Tashiro M,Ido T,Yanai K

更新日期：2003-02-01 00:00:00

abstract：:Activity-dependent changes in synaptic strength are considered mechanisms underlying learning and memory. Brain-derived neurotrophic factor (BDNF) plays an important role in activity-dependent synaptic plasticity such as long-term potentiation. Recent experimental evidence supports the role of BDNF in memory processes...

journal_title：Journal of pharmacological sciences

authors： Yamada K,Nabeshima T

更新日期：2003-04-01 00:00:00

abstract：:Calcium entry into nerve termini via voltage gated calcium channels is an essential step in neurotransmission. Consequently, second messenger regulation of calcium channel activity modulates synaptic activity. It has been suggested that calcium channels must physically couple to the release machinery, and a physical i...

journal_title：Journal of pharmacological sciences

authors： Zamponi GW

更新日期：2003-06-01 00:00:00

abstract：:The present study examines the effect of the cognition enhancer (1R)-1-benzo[b]thiophen-5-yl-2-[2-(diethylamino)ethoxy]ethan-1-ol hydrochloride (T-588) on neuronal injury induced by serum deprivation or amyloid-beta protein (A beta). T-588 protected partially against neuronal injury induced by serum deprivation or A b...

journal_title：Journal of pharmacological sciences

authors： Yamamuro A,Ago Y,Maeda S,Sakai Y,Baba A,Matsuda T

更新日期：2003-06-01 00:00:00

abstract：:The effects of cimetidine on rat adjuvant arthritis (AA) and rat osteoclast differentiation were studied. For the in vivo experiments, AA was induced by injections of Mycobacterium tuberculosis H37RA either subcutaneously into the base of the tail or into the right hind paw. The osteoclast differentiation was assessed...

journal_title：Journal of pharmacological sciences

authors： Yamaura K,Yonekawa T,Nakamura T,Yano S,Ueno K

更新日期：2003-05-01 00:00:00

abstract：:The intracellular signalling pathway for alpha-adrenoceptor-mediated negative inotropy was studied pharmacologically in isolated adult mouse ventricle. The negative inotropy was inhibited by GF-109203X, a nonselective protein kinase C inhibitor. Phorbol 12-myristate 13-acetate also produced sustained negative inotropy...

journal_title：Journal of pharmacological sciences

authors： Nishimaru K,Tanaka Y,Tanaka H,Shigenobu K

更新日期：2003-07-01 00:00:00

abstract：:As described previously (H. Togashi et al. Biochem Pharmacol. 1998;56:583-590), the irradiated products of provitamin D(2) (ergosterol) inhibit the activities of eukaryotic DNA polymerases. In this report, therefore, we investigated whether vitamin D and its related compounds inhibited the activities of DNA polymerase...

journal_title：Journal of pharmacological sciences

authors： Mizushina Y,Xu X,Murakami C,Okano T,Takemura M,Yoshida H,Sakaguchi K

更新日期：2003-07-01 00:00:00

abstract：:Airway mucus hypersecretion is one of the major clinical manifestations of patients suffering from various pulmonary diseases. However, no drugs are yet available to control airway mucus hypersecretion. For the past 15 years, a plethora of information has amassed with regard to the pharmacology of airway goblet cell m...

journal_title：Journal of pharmacological sciences

authors： Kim KC,Hisatsune A,Kim DJ,Miyata T

更新日期：2003-08-01 00:00:00

abstract：:trans-1,2-Cyclohexanediol, the major metabolite of the cilexetil moiety of candesartan cilexetil (CC), has been reported to have potent pro-arrhythmic effects in dogs with congestive heart failure (CHF), especially when co-administered with digoxin. To verify this and to clarify the clinical relevance and the underlyi...

journal_title：Journal of pharmacological sciences

authors： Yamamoto K,Kitayoshi T,Nishimura S,Chatani F,Watanabe T

更新日期：2003-08-01 00:00:00

abstract：:Lagerstroemin, an ellagitannin isolated from the leaves of Lagerstroemia speciosa (L.) Pers. (Lythraceae), was examined for its biological activities. In rat adipocytes, the compound increased the rate of glucose uptake and decreased the isoproterenol-induced glycerol release. In Chinese hamster ovary cells expressing...

journal_title：Journal of pharmacological sciences

authors： Hattori K,Sukenobu N,Sasaki T,Takasuga S,Hayashi T,Kasai R,Yamasaki K,Hazeki O

更新日期：2003-09-01 00:00:00

abstract：:We investigated the effect of benidipine, a calcium antagonist, against sodium azide (NaN(3))-induced cell death in cultured neonatal rat cardiac myocytes with increase of LDH release, depletion of cellular ATP contents, and collapse of mitochondrial membrane potential (DeltaPsi) as indicators. Cells were treated with...

journal_title：Journal of pharmacological sciences

authors： Inomata K,Tanaka H

更新日期：2003-10-01 00:00:00

abstract：:To explore cellular signaling molecules that respond to amyloid beta protein (A beta), we investigated the effect of A beta on tyrosine phosphorylation of cellular proteins in cultured rat cortical astrocytes. Western blotting with the phosphotyrosine-specific monoclonal antibody 4G10 demonstrated that exposure of cul...

journal_title：Journal of pharmacological sciences

authors： Abe K,Hisatomi R,Misawa M

更新日期：2003-11-01 00:00:00

abstract：:Adenosine receptors are expressed in various mammalian tissues where they mediate the effects of adenosine on cellular functions through a number of signalling mechanisms. 18F-NECA is the positron-emitting derivative of the A(2)-receptor agonist NECA (5'-n-ethyl-carboxamidoadenosine) and is a radioligand for PET imagi...

journal_title：Journal of pharmacological sciences

authors： Rubovszky B,Szentmiklósi AJ,Márián T,Cseppento A,Gesztelyi R,Székely A,Fórizs F,Gáspár R,Trón L,Krasznai Z

更新日期：2003-11-01 00:00:00

abstract：:Whether a state of nasal hyperresponsiveness influences antigen-induced biphasic nasal blockage and sneezing were examined using a guinea pig model of allergic rhinitis. Sensitized animals were challenged with an antigen, Japanese cedar pollen, once every week. Before the 13th challenge, the animals were randomly divi...

journal_title：Journal of pharmacological sciences

authors： Mizutani N,Nabe T,Takenaka H,Kohno S

更新日期：2003-12-01 00:00:00

abstract：:In the present study, the hepatoprotective effect of metformin (Met), a dimethylbiguanide anti-hyperglycemic, was examined in a mouse model of liver damage induced by chronic repeated administration of carbon tetrachloride (CCl(4)) (5 microl/kg, twice a week for 12 weeks). Met, when given orally in drinking water at a...

journal_title：Journal of pharmacological sciences

authors： Poon MK,Chiu PY,Mak DH,Ko KM

更新日期：2003-12-01 00:00:00

abstract：:To study calcium imaging data of cell populations that have various response patterns in peak amplitude and frequency of calcium oscillation in response to stimulation, comprehensive characterization based on statistical analysis of each response is important. In cultures of cells that are flat and in contact with eac...

journal_title：Journal of pharmacological sciences

authors： Morita M,Susuki J,Moto T,Higuchi C,Kudo Y

更新日期：2004-01-01 00:00:00

abstract：:Adenosine enhanced intracellular Ca(2+) concentrations in astrocytes via A(2a) adenosine receptors involving protein kinase A (PKA) activation. The Ca(2+) rise is inhibited by brefeldin A, an inhibitor of vesicular transport; but not by neomycin and U73122, phospholipase C inhibitors; xestospongin, an IP(3)-receptor i...

journal_title：Journal of pharmacological sciences

authors： Nishizaki T

更新日期：2004-02-01 00:00:00

abstract：:Antidepressant drugs, especially tricyclics have been widely used in the treatment of chronic pain, but not in acute pain. Because of numerous undesirable side effects, the selective serotonin reuptake inhibitors (SSRIs), with their favorable side effect profile, are preferred nowadays. An activation of the endogenous...

journal_title：Journal of pharmacological sciences

authors： Duman EN,Kesim M,Kadioglu M,Yaris E,Kalyoncu NI,Erciyes N

更新日期：2004-02-01 00:00:00

abstract：:The present study was conducted to evaluate the contribution of endothelin (ET) to the pharmacodynamic response to chronic cigarette smoke in spontaneously hypertensive rats (SHR). The contribution of ET was studied consequent to the hemodynamic response following 8 weeks of cigarette smoke by determining the changes ...

journal_title：Journal of pharmacological sciences

authors： Ohno N,Tanaka T,Kita T,Kubo K,Shimada K,Yonetani Y,Konishi N,Nakashima T

更新日期：2004-03-01 00:00:00

abstract：:Increasing use of tobacco and its related health problems are a great concern in the world. Recent epidemiological findings have demonstrated the positive association between cigarette smoking and several gastrointestinal (GI) diseases, including peptic ulcer and cancers. Interestingly, smoking also modifies the disea...

journal_title：Journal of pharmacological sciences

authors： Wu WK,Cho CH

更新日期：2004-04-01 00:00:00

abstract：:The aim of this study was to investigate the effect of different novel extracts and fractions obtained from Allium sativum (garlic) on in vitro vessel contraction in order to deepen our knowledge of their mechanism of action on vascular reactivity. The contraction induced by noradrenaline (NE, 10(-6) or 10(-5) M) or K...

journal_title：Journal of pharmacological sciences

authors： Ganado P,Sanz M,Padilla E,Tejerina T

更新日期：2004-04-01 00:00:00

abstract：:Recent progress in molecular and cellular biology has developed numerous effective cardiovascular drugs. However, there are still a number of diseases for which no known effective therapy exists, such as peripheral arterial disease, ischemic heart disease, restenosis after angioplasty, vascular bypass graft occlusion,...

journal_title：Journal of pharmacological sciences

authors： Morishita R

更新日期：2004-05-01 00:00:00

abstract：:G protein-coupled receptors (GPCRs) are distributed widely throughout the human body, and nearly 50% of current medicines act on a GPCR. GPCRs are considered to consist of seven transmembrane alpha-helices that form an alpha-helical bundle in which agonists and antagonists bind. A 3D structure of the target GPCR is in...

journal_title：Journal of pharmacological sciences

authors： Hiramoto T,Nonaka Y,Inoue K,Yamamoto T,Omatsu-Kanbe M,Matsuura H,Gohda K,Fujita N

更新日期：2004-05-01 00:00:00

abstract：:In this study, we investigated whether the Na(+)/Ca(2+) exchanger (NCX) inhibitor SEA0400 (2-[4-[(2,5-difluorophenyl)methoxy]phenoxy-5-ethoxyaniline) might have a protective effect against myocardial ischemia-reperfusion injury in rats. In particular, we focused on cardiac function using Doppler echocardiography and c...

journal_title：Journal of pharmacological sciences

authors： Yoshiyama M,Nakamura Y,Omura T,Hayashi T,Takagi Y,Hasegawa T,Nishioka H,Takeuchi K,Iwao H,Yoshikawa J

更新日期：2004-06-01 00:00:00

abstract：:We previously reported that sphingosine 1-phosphate (S1P) induces inhibition of adenylyl cyclase and activation of phospholipase C via independent G protein-coupled receptors in adult rat hepatocytes. Although S1P activation of phospholipase C and subsequent increase of intracellular Ca(2+) concentration were enhanced...

journal_title：Journal of pharmacological sciences

authors： Im DS,Tomura H,Tobo M,Sato K,Okajima F

更新日期：2004-06-01 00:00:00

abstract：:The Ca(2+) sensitizer levosimendan (LEV) improves myocardial contractility by enhancing the sensitivity of the contractile apparatus to Ca(2+). In addition, LEV promotes Ca(2+) entry through L-type channels in human cardiac myocytes. In this study, which was performed using microdialysis, infusion of LEV at 0.25 micro...

journal_title：Journal of pharmacological sciences

authors： Rocchitta G,Delogu RM,Migheli R,Solinas L,Susini G,Desole MS,Miele E,Miele M,Serra PA

更新日期：2004-07-01 00:00:00

abstract：:In the present study, we investigated the antidepressant- and anxiolytic-like effects of (+)-4-[(aR)-a-((2S,5R)-4-allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl]-N,N-diethylbenzamide (SNC80), a non-peptidic selective delta-opioid receptor agonist, in various animal models in rodents. SNC80 significantly reduced the...

journal_title：Journal of pharmacological sciences

authors： Saitoh A,Kimura Y,Suzuki T,Kawai K,Nagase H,Kamei J

更新日期：2004-07-01 00:00:00