[Retracted] MicroRNA‑144 acts as a tumor suppressor by targeting Rho‑associated coiled‑coil containing protein kinase 1 in osteosarcoma cells.

abstract：:While saliva is a source of easily accessible bodily fluids, there has been little effort to study its value in cancer diagnosis. We hypothesized that certain proteins would be elevated in the saliva of patients with breast cancer. Our study included 49 healthy individuals and 49 breast cancer patients. The levels of ...

journal_title：Molecular medicine reports

authors： Brooks MN,Wang J,Li Y,Zhang R,Elashoff D,Wong DT

更新日期：2008-05-01 00:00:00

abstract：:Resistance or insensitivity to radiation therapy is one of the hallmarks of hepatocellular carcinoma. Sensitizing radioresistant cancer by combining radiation with other therapeutics to induce apoptosis has been widely investigated. Our previous study showed that chicken anaemia virus-derived apoptin protein induced t...

journal_title：Molecular medicine reports

authors： Han SX,Zhu Q,Ma JL,Lv Y,Zhao J,Huang C,Jia X,Ou W,Guo HT

更新日期：2011-01-01 00:00:00

abstract：:Cervical cancer is a leading cause of mortality in women. Molecular and epidemiological data have unequivocally confirmed that high-risk human papillomaviruses (HPVs) are a major etiological agent of this malignancy, as host epigenetic alterations are induced in response to viral infection. The present study evaluated...

journal_title：Molecular medicine reports

authors： Botezatu A,Goia-Rusanu CD,Iancu IV,Huica I,Plesa A,Socolov D,Ungureanu C,Anton G

更新日期：2011-01-01 00:00:00

abstract：:Hyperthermia is a promising treatment for human cervical cancer. However, little is known about whether and under what conditions heat treatment exerts tumor inhibition effects on cervical cancer, and the molecular mechanisms behind these cellular responses have yet to be elucidated. We employed the human cervical can...

journal_title：Molecular medicine reports

authors： Zhou J,Wang X,Du L,Zhao L,Lei F,Ouyang W,Zhang Y,Liao Y,Tang J

更新日期：2011-01-01 00:00:00

abstract：:Estrogen receptor α (ERα) mediates most of the biological effects of estrogen in mammary epithelial cells and stimulates growth signals involving phosphoinositide-3-OH kinase (PI3K)/Akt in breast cancer cells. Phosphatase and tensin homologue (PTEN) is a critical counter-regulator of PI3K signaling and is thus one of ...

journal_title：Molecular medicine reports

authors： Noh EM,Lee YR,Chay KO,Chung EY,Jung SH,Kim JS,Youn HJ

更新日期：2011-03-01 00:00:00

abstract：:Hemoglobin (Hb) Q-Thailand, also known as G-Taichung, Mahidol, Kurashiki-I and Asabara, is an α-globin chain variant that results from a point mutation (GAC→CAC; Asp→His) at codon 74 of the α1-globin gene on chromosome 16p with a leftward single α-globin gene deletion (-α(4.2)). Co-inheritance of Hb Q-Thailand with α-...

journal_title：Molecular medicine reports

authors： Hu C,Zhang L,Pan J,Zeng Z,Zhen S,Fang J,Zhu Q

更新日期：2011-03-01 00:00:00

abstract：:Esculetin, a potent non-competitive inhibitor of lipoxygenase, has been shown to inhibit vascular smooth muscle cell (VSMC) proliferation. However, the effect of esculetin on the matrix metalloproteinase-9 (MMP-9) regulation responsible for cell migration and invasion has not been previously investigated. The results ...

journal_title：Molecular medicine reports

authors： Lee SJ,Lee US,Kim WJ,Moon SK

更新日期：2011-03-01 00:00:00

abstract：:Gastric cancer cells are usually insensitive to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL). In the present study, in MGC803 cells treated with 100 ng/ml TRAIL for 24 h, the inhibition rate of cell proliferation was 9.76±2.39% and the rate of cell apoptosis was only 4.37 ± 1.45%. Treatment with epi...

journal_title：Molecular medicine reports

authors： Xu L,Qu X,Luo Y,Zhang Y,Liu J,Qu J,Zhang L,Liu Y

更新日期：2011-05-01 00:00:00

abstract：:Prenatal androgens have important organizing effects on the development and future behavior of the brain. The second-to-fourth digit length ratio (2D:4D) has been proposed as a marker of these prenatal androgen effects, with a relatively longer fourth finger indicating higher prenatal androgen exposure. 2D:4D has been...

journal_title：Molecular medicine reports

authors： Coco M,Perciavalle V,Maci T,Nicoletti F,Di Corrado D,Perciavalle V

更新日期：2011-05-01 00:00:00

abstract：:Chronic fatigue syndrome (CFS) is an inflammatory disease of unknown aetiology. Researchers have proposed infectious, neurological and immunological causes of this syndrome. Recently, the xenotropic murine leukemia virus-related virus was detected in 67% of patients with CFS in a US study. This observation is in agree...

journal_title：Molecular medicine reports

authors： Pasi A,Bozzini S,Carlo-Stella N,Martinetti M,Bombardieri S,De Silvestri A,Salvaneschi L,Cuccia M

更新日期：2011-05-01 00:00:00

abstract：:Wound healing is a very complex process of interactions between different cells, growth factors, blood elements and extracellular matrix. Keloids represent one of the possible complications in the fundamental process of cutaneous wound repair. Despite all efforts, keloids remain a therapeutic challenge since no treatm...

journal_title：Molecular medicine reports

authors： Gieringer M,Elliott K,Gosepath J,Naim R

更新日期：2010-01-01 00:00:00

abstract：:The analysis of genes preferentially expressed in the peripheral blood cells of atopic dermatitis patients may provide information on the molecular pathogenesis of the disease. We employed differential display PCR to clone a new gene (AB100163) with 99% homology to coiled-coil domain containing 132, transcript variant...

journal_title：Molecular medicine reports

authors： Matsumoto Y,Imai Y,Sugita Y,Tanaka T,Tsujimoto G,Saito H,Oshida T

更新日期：2010-01-01 00:00:00

abstract：:High frequency of invasion and metastasis is one of the key characteristics of pancreatic cancer. In our recent study, tight junction protein-2 (Tjp-2) was identified as a differentially expressed gene related to invasion-metastasis in highly (PC-1.0) and weakly (PC-1) invasive and metastatic pancreatic cancer cells b...

journal_title：Molecular medicine reports

authors： Zhou L,Tan X,Wang W,Wang B,Dai X,Liu J

更新日期：2010-01-01 00:00:00

abstract：:We examined gene expression profiles in rat adrenal glands using genome-wide microarray technology. Gene expression levels were determined in four rat strains, including one normotensive strain [Wistar-Kyoto (WKY)] and three substrains derived from WKY rats: spontaneously hypertensive rats (SHR), stroke-prone SHR (SHR...

journal_title：Molecular medicine reports

authors： Ashenagar MS,Tabuchi M,Kinoshita K,Ooshima K,Niwa A,Watanabe Y,Yoshida M,Shimada K,Yasunaga T,Yamanishi H,Higashino H

更新日期：2010-03-01 00:00:00

abstract：:The purpose of this study was to determine whether saponified sunflower and safflower oils can potentially be used as whitening agents, and to investigate their underlying mechanisms. Saponified sunflower (sap-SU) and safflower (sap-SA) oils dose-dependently inhibited isobutylmethylxanthine-induced melanogenesis in B1...

journal_title：Molecular medicine reports

authors： Koo JH,Lee I,Yun SK,Kim HU,Park BH,Park JW

更新日期：2010-03-01 00:00:00

abstract：:Studies have shown that the 26S proteasome is involved in cell cycle control, transcription, DNA repair, immune response and protein synthesis. In the present study, we investigated the antiproliferative effects of the proteasome inhibitor bortezomib and heat shock protein (Hsp)70 inhibitors on the B16F10 melanoma cel...

journal_title：Molecular medicine reports

authors： Yerlikaya A,Okur E,Eker S,Erin N

更新日期：2010-03-01 00:00:00

abstract：:The aim of this study was to observe the location of paired immunoglobulin-like receptor B (PirB) in the retina and to evaluate the expressive varieties of PirB in the retina of mice after optic nerve injury. In situ hybridization was used to observe the location of PirB mRNA in the retina of mice. Western blotting wa...

journal_title：Molecular medicine reports

authors： Wang F,Cui H,Su Y,Zhao SG,Teng Y

更新日期：2010-05-01 00:00:00

abstract：:X-linked juvenile retinoschisis (XLRS) is the leading cause of juvenile macular degeneration in males and is rare in females. Previous studies have shown that there is a marked intra- and inter-familial variation in disease severity and progression. This suggests that additional factors, such as genetic modifiers and ...

journal_title：Molecular medicine reports

authors： Shastry BS

更新日期：2010-05-01 00:00:00

abstract：:Previous studies investigating the effects of exogenous growth hormone (GH) on the expression of adiponectin and the adiponectin receptors have generated seemingly conflicting results. Here, to determine the effects of chronic exogenous GH levels, we investigated the expression of adiponectin receptor R1 (adipoR1) in ...

journal_title：Molecular medicine reports

authors： Qin Y,Tian YP

更新日期：2010-05-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is one of the most common types of cancer worldwide. The initial hepatocellular alterations that precede the appearence of HCC include chronic viral hepatitis/cirrhosis, foci of phenotypically altered hepatocytes and, subsequently, dysplastic hepatocytes that form foci and nodules. These...

journal_title：Molecular medicine reports

authors： Chen XL,Zhou L,Yang J,Shen FK,Zhao SP,Wang YL

更新日期：2010-07-01 00:00:00

abstract：:Vasodilator stimulated phosphoprotein (VASP) is known as an actin-binding protein. The phosphorylation of VASP plays an important role in its function. In a previous study, serine 157 phosphorylated VASP (p-VASP S157) was shown to be co-localized with α-tubulin on the spindle of SGC-7901 cells. In the present study, w...

journal_title：Molecular medicine reports

authors： Tao Y,Chen YC,Sang JR,Xu WR

更新日期：2010-07-01 00:00:00

abstract：:Cysteine-rich protein 61 (CYR61) is a member of the CCN (CYR61/CTGF/NOV) family, which is associated with progression in a variety of human cancers. Our previous study confirmed that the expression levels of CYR61 protein were decreased in gastric carcinoma compared to non-tumoral mucosa as determined by proteome anal...

journal_title：Molecular medicine reports

authors： Osaki M,Inaba A,Nishikawa K,Sugimoto Y,Shomori K,Inoue T,Oshimura M,Ito H

更新日期：2010-07-01 00:00:00

abstract：:The aim of this study was to compare the expression of annexin II (ANXA2) in benign prostatic hyperplasia (BPH) with that of prostate cancer (PC), and to correlate the expression levels with pathologic grade and stage. Immunohistochemistry was performed on samples from 85 patients with PC and 40 patients with BPH. The...

journal_title：Molecular medicine reports

authors： Ding T,Yang L,Wang Y,Yuan J,Chen T,Cai X

更新日期：2010-09-01 00:00:00

abstract：:Dissociation of pancreatic cancer cells from primary sites is the critical first step in tumour invasion and metastasis. Changes in the structure and function of tight junctions are reported to be correlated with carcinogenesis and tumour development. Using cDNA microarray analysis, we recently identified claudin-23 a...

journal_title：Molecular medicine reports

authors： Wang W,Tan X,Zhou L,Gao F,Dai X

更新日期：2010-09-01 00:00:00

abstract：:Angiogenesis is a prerequisite for tumor progression and metastasis. Alphastatin, as an endogenous angiogenesis inhibitor, was recently used as an anticancer agent in several tumor models. We constructed recombinant self-inactivating lentivirus vectors expressing alphastatin and evaluated their ability to transfer gen...

journal_title：Molecular medicine reports

authors： Guo SW,Che HM,Li WZ

更新日期：2010-11-01 00:00:00

abstract：:Adipocytes account for more than 90% of human breast volume and secrete adipocytokines, which play a role in breast cancer development. Among the adipocytokines is leptin, which is secreted mainly by adipocytes and plays a key role in breast cancer development. Leptin expression is up-regulated in both obese and breas...

journal_title：Molecular medicine reports

authors： Xu P,Ye W,Zhong S,Li H,Feng E,Lin SH,Kuo CT,Liu JY,Lin YC

更新日期：2010-11-01 00:00:00

abstract：:Macrophage scavenger receptors (SRs), particularly type A SR (SR-A) and CD36, have been implicated in binding and internalizing modified forms of low-density lipoprotein (LDL) through a mechanism not regulated by cellular cholesterol content, resulting in cholesterol accumulation and foam cell formation. To test the i...

journal_title：Molecular medicine reports

authors： Liu H,Liu Q,Lei H,Li X,Chen X

更新日期：2010-11-01 00:00:00

abstract：:To date, no enclosure method for risk grouping patients with poorly-differentiated gastric adenocarcinoma has been identified. We examined the relationship between mutations in toll-like receptor 4 (TLR4) and patients with poorly-differentiated gastric adenocarcinoma. Genomic DNA was extracted from the peripheral bloo...

journal_title：Molecular medicine reports

authors： Ohara T,Kanoh Y,Tani N,Ohdaira H,Suzuki Y,Kameyama J,Yoshino K,Kitajima M

更新日期：2009-01-01 00:00:00

abstract：:In the present study, the influence of the chelating agents of ethylenediaminetetraacetic acid (EDTA), ethylene glycol-bis (β-aminoethyl ether) (EGTA) and 1,10-phenanthroline (PHEN) on growth rate, cytoadherence ability and surface protein expression was examined in a clinical strain of Streptococcus agalactiae isolat...

journal_title：Molecular medicine reports

authors： Dos Santos MH,Da Costa AF,Da Silva Santos G,Dos Santos AL,Nagao PE

更新日期：2009-01-01 00:00:00

abstract：:The intestine is a major target organ in hemorrhagic shock (HS)-induced tissue injury. Hypoxia-inducible factor (HIF)-1α is the primary transcription factor responsible for regulating cellular response to changes in oxygen tension. Since HS is an acute hypoxic insult, the present study examined changes in the gene exp...

journal_title：Molecular medicine reports

authors： Nishie H,Takahashi T,Inoue K,Shimizu H,Morimatsu H,Toda Y,Omori E,Akagi R,Katayama H,Morita K

更新日期：2009-03-01 00:00:00