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A MoS2 platform and thionine-carbon nanodots for sensitive and selective detection of pathogens.

Abstract：

:This work focuses on the combination of molybdenum disulfide (MoS2) and à la carte functionalized carbon nanodots (CNDs) for the development of DNA biosensors for selective and sensitive detection of pathogens. MoS2 flakes prepared through liquid-phase exfoliation, serves as platform for thiolated DNA probe immobilization, while thionine functionalized carbon nanodots (Thi-CNDs) are used as electrochemical indicator of the hybridization event. Spectroscopic and electrochemical studies confirmed the interaction of Thi-CNDs with DNA. As an illustration of the pathogen biosensor functioning, DNA sequences from InIA gen of Listeria monocytogenes bacteria and open reading frame sequence (ORF1ab) of SARS-CoV-2 virus were detected and quantified with a detection limit of 67.0 fM and 1.01 pM, respectively. Given the paradigmatic selectivity of the DNA hybridization, this approach allows pathogen detection in the presence of other pathogens, demonstrated by the detection of Listeria monocytogenes in presence of Escherichia coli. We note that this design is in principle amenable to any pathogen for which the DNA has been sequenced, including other viruses and bacteria. As example of the application of the method in real samples it has been used to directly detect Listeria monocytogenes in cultures without any DNA Polymerase Chain Reaction (PCR) amplification process.

journal_name

Biosens Bioelectron

journal_title

Biosensors & bioelectronics

authors

Martínez-Periñán E,García-Mendiola T,Enebral-Romero E,Del Caño R,Vera-Hidalgo M,Vázquez Sulleiro M,Navío C,Pariente F,Pérez EM,Lorenzo E

doi

10.1016/j.bios.2021.113375

keywords:

["Biosensor","CNDs","COVID-19","Listeria","MoS(2)"]

subject

Has Abstract

pub_date

2021-10-01 00:00:00

pages

113375

eissn

0956-5663

issn

1873-4235

pii

S0956-5663(21)00412-7

journal_volume

189

pub_type

杂志文章

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