Abstract:
STUDY OBJECTIVE:This study aimed to evaluate the analgesic effects of a 5% lidocaine patch in acute postoperative pain after cesarean section. DESIGN:This is a prospective, randomized, double-blind study. SETTING:After surgery, active and placebo patches were applied in the operating room, and patients were evaluated during their stay at the postoperative recovery room and at the hospital ward. PATIENTS:Seventy-two women (18 years of age or older and American Society of Anesthesiologists status II) scheduled for cesarean section under spinal anesthesia were enrolled in the study. INTERVENTIONS:Patients were randomly assigned to an intervention or placebo group. According to the assigned group, a 5% lidocaine patch or a placebo patch was applied 1 cm above and below the Pfannenstiel incision after the surgery. MEASUREMENTS:The primary outcome was the pain score, evaluated using an 11-point numerical verbal scale in the first 36 h postoperatively. Secondary outcomes were the quality of recovery 24 h after surgery, consumption of rescue opioids, and the presence of adverse effects. MAIN RESULTS:Sixty-five women completed the study. The pain score was lower in the lidocaine group at 6 h (lidocaine group: 2.16 ± 1.71, placebo group: 3.21 ± 2.25; p = 0.031), 12 h (lidocaine: 1.58 ± 0.81, placebo: 2.24 ± 0.74; p = 0.001), 24 h (lidocaine: 0.74 ± 0.89, placebo: 1.94 ± 1.39; p < 0.0001), and 36 h (lidocaine: 0.48 ± 1.03, placebo: 1.68 ± 0.94; p = 0.001) after surgery. There were no differences in secondary outcomes during the follow-up period. CONCLUSION:The lidocaine patch reduced pain scores compared to placebo in the first 36 h after the surgery, despite no influence over opioid consumption, quality of recovery, or incidence of side effects.
journal_name
J Clin Anesthjournal_title
Journal of clinical anesthesiaauthors
de Queiroz VKP,da Nóbrega Marinho AM,de Barros GAMdoi
10.1016/j.jclinane.2021.110328keywords:
["Acute pain","Cesarean section","Enhanced postsurgical recovery","Lidocaine","Transdermal patch"]subject
Has Abstractpub_date
2021-10-01 00:00:00pages
110328eissn
0952-8180issn
1873-4529pii
S0952-8180(21)00167-7journal_volume
73pub_type
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