Chronic liver injury promotes hepatocarcinoma cell seeding and growth, associated with infiltration by macrophages.

abstract：:The SFRP1 gene on chromosome 8p11.2 encodes a Wnt signaling antagonist, and was recently demonstrated to be a new tumor suppressor that is inactivated by promoter methylation in human colon cancers. Here, we analyzed promoter methylation of the SFRP1 gene in human ovarian cancers, in which loss of heterozygosity in 8p...

journal_title：Cancer science

authors： Takada T,Yagi Y,Maekita T,Imura M,Nakagawa S,Tsao SW,Miyamoto K,Yoshino O,Yasugi T,Taketani Y,Ushijima T

更新日期：2004-09-01 00:00:00

abstract：:MDR1/ABCB1, a member of the ABC group of proteins, is clinically important because it is not only involved in multidrug resistance in cancer but also affects the pharmacokinetic properties of various drugs. The most puzzling feature of MDR1 is that it recognizes and transports such a wide variety of substrates. In the...

journal_title：Cancer science

authors： Kimura Y,Morita SY,Matsuo M,Ueda K

更新日期：2007-09-01 00:00:00

abstract：:Epstein-Barr virus (EBV) BamHI A rightward transcripts (BART) encoded microRNAs (EBV-miR-BARTs) are abnormally highly expressed in nasopharyngeal carcinoma (NPC). This study aims to investigate the diagnostic and prognostic performance of miR-BART7-3p and miR-BART13-3p. Plasma levels of EBV DNA, miR-BART7-3p, and miR-...

journal_title：Cancer science

authors： Lu T,Guo Q,Lin K,Chen H,Chen Y,Xu Y,Lin C,Su Y,Chen Y,Chen M,Zheng Y,Ye Y,Lin S,Zong J,Pan J

更新日期：2020-05-01 00:00:00

abstract：:Most clinical trials of non-small-cell lung cancer (NSCLC) exclude patients with poor ECOG performance status (PS). Thus, the efficacy of immune checkpoint inhibitors (ICIs) in patients with poor PS remains unclear. Herein, we used data from a retrospective cohort to assess the potential clinical benefits of ICIs in N...

journal_title：Cancer science

authors： Kano H,Ichihara E,Harada D,Inoue K,Kayatani H,Hosokawa S,Kishino D,Watanabe K,Ochi N,Oda N,Hara N,Ninomiya K,Hotta K,Maeda Y,Kiura K

更新日期：2020-10-01 00:00:00

abstract：:JARID1B/KDM5B histone demethylase's mRNA is markedly overexpressed in breast cancer tissues and cell lines and the protein has been shown to have a prominent role in cancer cell proliferation and DNA repair. However, the mechanism of its post-transcriptional regulation in cancer cells remains elusive. We performed a c...

journal_title：Cancer science

authors： Mocavini I,Pippa S,Licursi V,Paci P,Trisciuoglio D,Mannironi C,Presutti C,Negri R

更新日期：2019-04-01 00:00:00

abstract：:TRIM44 has oncogenic roles in various cancers. However, TRIM44 expression and its function in renal cell carcinoma (RCC) are still unknown. Here in this study, we investigated the clinical significance of TRIM44 and its biological function in RCC. TRIM44 overexpression was significantly associated with clinical M stag...

journal_title：Cancer science

authors： Yamada Y,Kimura N,Takayama KI,Sato Y,Suzuki T,Azuma K,Fujimura T,Ikeda K,Kume H,Inoue S

更新日期：2020-03-01 00:00:00

abstract：:Mesothelioma is an aggressive tumor caused by asbestos exposure, the incidence of which is predicted to increase globally. The prognosis of patients with mesothelioma undergoing conventional therapy is poor. Radiation therapy for mesothelioma is of limited use because of the intrinsic radioresistance of tumor cells co...

journal_title：Cancer science

authors： Sudo H,Tsuji AB,Sugyo A,Ogawa Y,Sagara M,Saga T

更新日期：2012-02-01 00:00:00

abstract：:The development of gefitinib ('Iressa', ZD1839) by targeting the EGFR tyrosine kinase is a recent therapeutic highlight. We have reported that gefitinib is antiangiogenic in vitro, as well as in vivo. In this study, we asked if the anti-angiogenic action of gefitinib is due to a direct effect on activation of vascular...

journal_title：Cancer science

authors： Hirata A,Uehara H,Izumi K,Naito S,Kuwano M,Ono M

更新日期：2004-07-01 00:00:00

abstract：:This phase I, dose-escalation study evaluated the safety, preliminary efficacy and pharmacokinetics of nintedanib, a triple angiokinase inhibitor, in Japanese patients with advanced hepatocellular carcinoma and mild/moderate liver impairment. Thirty patients with unresectable hepatocellular carcinoma were enrolled to ...

journal_title：Cancer science

authors： Okusaka T,Otsuka T,Ueno H,Mitsunaga S,Sugimoto R,Muro K,Saito I,Tadayasu Y,Inoue K,Loembé AB,Ikeda M

更新日期：2016-12-01 00:00:00

abstract：:Numerous lines of evidence have shown that angiogenesis plays a pivotal role in the development of tumors. Therefore anti-angiogenesis therapy represents a potentially promising approach to cancer therapy. Recently, a new inhibitor called vasohibin was discovered to operate as an intrinsic and highly specific feedback...

journal_title：Cancer science

authors： Li D,Zhou K,Wang S,Shi Z,Yang Z

更新日期：2010-02-01 00:00:00

abstract：:This study aimed to analyze the association between driver mutations and predictive markers for some anti-tumor agents in non-small cell lung cancer (NSCLC). A cohort of 785 Chinese patients with NSCLC who underwent resection from March 2016 to November 2017 in the First Affiliated Hospital of Guangzhou Medical Univer...

journal_title：Cancer science

authors： Liang W,Guo M,Pan Z,Cai X,Li C,Zhao Y,Liang H,Yang H,Wang Z,Chen W,Xu C,Yang X,Sun J,He P,Gu X,Yin W,He J

更新日期：2019-06-01 00:00:00

abstract：:In February 2013, Japan became the first country in the world to cover Helicobacter pylori eradication for chronic gastritis under its National Health Insurance (NHI) system. Now that eradication therapy is covered by NHI, its usage has increased dramatically, and gastric cancer deaths have begun to decrease. We under...

journal_title：Cancer science

authors： Asaka M,Kobayashi M,Kudo T,Akino K,Asaka Y,Fujimori K,Kikuchi S,Kawai S,Kato M

更新日期：2020-10-01 00:00:00

abstract：:Nucleophosmin (NPM) is a nucleolar phosphoprotein that plays multiple roles in ribosome assembly and transport, cytoplasmic-nuclear trafficking, centrosome duplication and regulation of p53. In hematological malignancies, the NPM1 gene is frequently involved in chromosomal translocation, mutation and deletion. The NPM...

journal_title：Cancer science

authors： Naoe T,Suzuki T,Kiyoi H,Urano T

更新日期：2006-10-01 00:00:00

abstract：:Mucin 1 (MUC1), as an oncogene, is overexpressed in hepatocellular carcinoma (HCC) cells and promotes the progression and tumorigenesis of HCC through JNK/TGF-β signaling pathway. In the present study, RNA interference (RNAi) and JNK inhibitor SP600125, which target MUC1 and/or JNK, were used to treat HCC cells in vit...

journal_title：Cancer science

authors： Wang J,Ni WH,Hu KB,Zhai XY,Xie F,Jie J,Zhang NN,Jiang LN,Yuan HY,Tai GX

更新日期：2017-03-01 00:00:00

abstract：:The clinical significance of pancreatic intraepithelial neoplasia (PanIN) lesions in non-neoplastic pancreata of pancreatic ductal adenocarcinoma (PDAC) patients remains controversial. As chronic inflammation has been recently demonstrated to promote dissemination of in situ precancerous lesions, we investigated the p...

journal_title：Cancer science

authors： Hwang IK,Kim H,Lee YS,Kim J,Cho JY,Yoon YS,Han HS,Hwang JH

更新日期：2015-10-01 00:00:00

abstract：:Uniform antibody microdistribution throughout tumor nodules is crucial for antibody-targeted therapy, because non-uniform microdistribution leads to suboptimal therapeutic effect, a commonly observed limitation of therapeutic antibodies. Herein, we evaluated the microdistribution of different doses of intraperitoneall...

journal_title：Cancer science

authors： Kosaka N,Ogawa M,Paik DS,Paik CH,Choyke PL,Kobayashi H

更新日期：2010-03-01 00:00:00

abstract：:In the present paper, recent advances in the molecular pathology of soft tissue sarcomas (STS) and the implications for their prognostic value are reviewed, and the potential targets of molecular therapy are discussed. According to the molecular genetic aspect, STS are divided into two groups: chromosome translocation...

journal_title：Cancer science

authors： Oda Y,Tsuneyoshi M

更新日期：2009-02-01 00:00:00

abstract：:This study was undertaken to clarify the risk factors, including the mutation status of CTNNB1, for the local recurrence after surgery of the rare disease desmoid-type fibromatosis. It was designed as a multiinstitutional joint research project with 7 major centers in Japan participating. The committee members of 7 ma...

journal_title：Cancer science

authors： Nishida Y,Hamada S,Kawai A,Kunisada T,Ogose A,Matsumoto Y,Ae K,Toguchida J,Ozaki T,Hirakawa A,Motoi T,Sakai T,Kobayashi E,Gokita T,Okamoto T,Matsunobu T,Shimizu K,Koike H

更新日期：2020-08-01 00:00:00

abstract：:Osteosarcoma (OS) is the most common malignant bone tumor and frequently affects adolescents. Norcantharidin (NCTD), a demethylated derivative of cantharidin, has been reported to exhibit anticancer activity against various types of tumors but not human OS. The aim of the present study was to evaluate the effects of N...

journal_title：Cancer science

authors： Mei L,Sang W,Cui K,Zhang Y,Chen F,Li X

更新日期：2019-02-01 00:00:00

abstract：:Recent studies have shown that cyclooxygenase-2 is crucially involved in angiogenesis. In fact, several specific cyclooxygenase-2 inhibitors suppress angiogenesis in vivo, suggesting that cyclooxygenase-2 is a promising target for the treatment of angiogenesis-related diseases. In the present study we investigate the ...

journal_title：Cancer science

authors： Jung HJ,Shim JS,Suh YG,Kim YM,Ono M,Kwon HJ

更新日期：2007-12-01 00:00:00

abstract：:Clinicians frequently require cytopathological assessment of tumor samples for preoperative diagnosis, but in some specimens, diagnosis remains inconclusive after cytological examination. To date, several molecular markers, including human telomerase reverse transcriptase (hTERT), have been assessed for the ability to...

journal_title：Cancer science

authors： Fujita H,Ohuchida K,Mizumoto K,Egami T,Miyasaka Y,Yamaguchi H,Yu J,Cui L,Onimaru M,Takahata S,Tsuneyoshi M,Tanaka M

更新日期：2008-11-01 00:00:00

abstract：:Protein arginine methyltransferases (PRMT) catalyze protein arginine methylation and play an important role in many biological processes. Aberrant PRMT expression in tumor cells has been documented in several common cancer types; however, its precise contribution to hepatocellular carcinoma (HCC) cell invasion and met...

journal_title：Cancer science

authors： Jiang H,Zhou Z,Jin S,Xu K,Zhang H,Xu J,Sun Q,Wang J,Xu J

更新日期：2018-05-01 00:00:00

abstract：:Regulatory T cells play an important role in tumor escape from host antitumor immunity. Increased frequencies of CD4(+)CD25(+) regulatory T cells have been documented in the tumor sites, malignant effusions, and peripheral blood of patients with ovarian carcinoma. However, the mechanism involved remains unclear. In th...

journal_title：Cancer science

authors： Zhao X,Ye F,Chen L,Lu W,Xie X

更新日期：2009-11-01 00:00:00

abstract：:Glypican-3 (GPC3) is a heparan sulfate proteoglycan that is bound to the cell membrane by a glycosylphosphatidylinositol (GPI) anchor, and glypicans can regulate the activity of a wide variety of growth and survival factors. We report here that GPC3 was expressed in clear cell carcinoma of the ovary, and not in other ...

journal_title：Cancer science

authors： Umezu T,Shibata K,Shimaoka M,Kajiyama H,Yamamoto E,Ino K,Nawa A,Senga T,Kikkawa F

更新日期：2010-01-01 00:00:00

abstract：:The steroid and xenobiotic receptor (SXR) regulates cytochrome P450 (CYP) enzymes, which are key inactivators of testosterone in the liver and prostate. In the present study, we investigated SXR expression in human prostate tissues. We determined SXR immunoreactivity using an anti-SXR antibody in benign (n = 78) and c...

journal_title：Cancer science

authors： Fujimura T,Takahashi S,Urano T,Tanaka T,Zhang W,Azuma K,Takayama K,Obinata D,Murata T,Horie-Inoue K,Kodama T,Ouchi Y,Homma Y,Inoue S

更新日期：2012-02-01 00:00:00

abstract：:Ultrasound-mediated gene transfection (sonotransfection) is a promising physical method for gene therapy, especially for cancer gene therapy. To investigate the optimal sonotransfection conditions and to determine whether the optimal transfection rate using sonotransfection is comparable to that of electrotransfection...

journal_title：Cancer science

authors： Feril LB Jr,Ogawa R,Tachibana K,Kondo T

更新日期：2006-10-01 00:00:00

abstract：:Sequential changes in the phenotype of prostatic lesions and the impact of additional carcinogen treatment or castration on development and progression of prostate cancers were examined in probasin/simian virus 40 (SV40) T antigen transgenic (TG) rats. Non-invasive prostate adenocarcinomas were evident in all lobes at...

journal_title：Cancer science

authors： Cho YM,Takahashi S,Asamoto M,Suzuki S,Inaguma S,Hokaiwado N,Shirai T

更新日期：2003-02-01 00:00:00

abstract：:To determine the effect of 2,2'-azobis(2-amidinopropane) dihydrochloride (AAPH) on ultrasound (US)-induced cell killing, human monocytic leukemia cells (U937) were incubated at various temperatures (25.0, 37.0 and 40.0 degrees C) for 1 min in air-saturated phosphate-buffered solution (PBS) containing 50 mM AAPH before...

journal_title：Cancer science

authors： Feril LB Jr,Tsuda Y,Kondo T,Zhao QL,Ogawa R,Cui ZG,Tsukada K,Riesz P

更新日期：2004-02-01 00:00:00

abstract：:TP53 alterations are frequent relapse-acquired mutations in childhood acute lymphoblastic leukemia (ALL). The present study evaluated the clinical significance of relapsed childhood ALL in Taiwan. Diagnostic and/or relapsed bone marrow or peripheral blood was obtained from 111 children with relapsed ALL who were initi...

journal_title：Cancer science

authors： Yu CH,Chang WT,Jou ST,Lin TK,Chang YH,Lin CY,Lin KH,Lu MY,Chen SH,Wu KH,Wang SC,Chang HH,Su YN,Hung CC,Lin DT,Chen HY,Yang YL

更新日期：2020-01-01 00:00:00

abstract：:Hormone therapy has become one of the main strategies for breast cancer, however, many estrogen receptor (ER) positive patients end in tumor collapse due to initial or acquired resistance to hormone treatment, which includes Fulvestrant. Here we report that ErbB receptors and downstream PI3K/AKT and ERK pathway have b...

journal_title：Cancer science

authors： Bai J,Zhou G,Qiu Y,Hu Y,Liu J,Zhao J,Zhang S,Zhang J

更新日期：2017-06-01 00:00:00