A comparison of the available phosphodiesterase-5 inhibitors in the treatment of erectile dysfunction: a focus on avanafil.


BACKGROUND:Numerous pathways can lead to erectile dysfunction (ED) in patients, with some patients having multiple causes. Regardless of the etiology, ED has been successfully treated in many patients with the advent of oral phosphodiesterase-5 inhibitors (PDE5Is). With the release of avanafil, there are currently four PDE5I options available, and choosing between them should be based on patient-specific considerations and preferences. OBJECTIVE:To review the treatment of ED with PDE5Is, taking into account the effectiveness, safety, and patient satisfaction of these agents, as well as avanafil's place in therapy. METHODS:A PubMed search was completed to find articles published in English studying patient satisfaction and adherence to ED medication. Additional searches looked specifically for any data regarding the use of avanafil. RESULTS:ED is effectively treated in most patients with PDE5Is, with the most common side effects from the medications being headache, flushing, and visual disturbances. Patients have identified many different factors, such as efficacy, side effects, duration of action, and daily use, in determining overall satisfaction and the right medication for them. While avanafil does not have any patient satisfaction trials to date, it has been proven to be a safe and effective treatment for ED with possibly the fastest onset of action and fewer visual disturbances than its competitors. CONCLUSION:Avanafil along with the other PDE5Is has shown to be a safe and effective oral treatment for ED, with avanafil's possible place in therapy for patients who want an on-demand option or as an alternative in patients who experience visual disturbances with the other agents.


Evans JD,Hill SR




Has Abstract


2015-08-12 00:00:00










  • Drug holidays: the most frequent type of noncompliance with calcium plus vitamin D supplementation in persistent patients with osteoporosis.

    abstract:PURPOSE:All current recommendations include calcium and vitamin D (Ca-D) as an integrated part of osteoporosis treatment. The purpose of this pilot study was to analyze compliance with a fixed combination of Ca-D in women persistent with the treatment. PATIENTS AND METHODS:An observational study was carried out in thr...

    journal_title:Patient preference and adherence

    pub_type: 杂志文章


    authors: Touskova T,Vytrisalova M,Palicka V,Hendrychova T,Fuksa L,Holcova R,Konopacova J,Kubena AA

    更新日期:2015-12-16 00:00:00

  • Access to credible information on schizophrenia patients' medication adherence by prescribers can change their treatment strategies: evidence from an online survey of providers.

    abstract:OBJECTIVE:Overestimating patients' medication adherence diminishes the ability of psychiatric care providers to prescribe the most effective treatment and to identify the root causes of treatment resistance in schizophrenia. This study was conducted to determine how credible patient drug adherence information (PDAI) mi...

    journal_title:Patient preference and adherence

    pub_type: 杂志文章


    authors: Shafrin J,May SG,Shrestha A,Ruetsch C,Gerlanc N,Forma F,Hatch A,Lakdawalla DN,Lindenmayer JP

    更新日期:2017-06-27 00:00:00

  • Factors influencing the use of biologic therapy and adoption of treat-to-target recommendations in current European rheumatology practice.

    abstract:Objective:The aim of this study was to identify factors that influence treatment adjustments and adoption of a treat-to-target (T2T) strategy in patients with rheumatoid arthritis (RA) in European practices. Methods:Cross-sectional data were drawn from the Adelphi 2014 RA Disease Specific Programme. Treatment patterns...

    journal_title:Patient preference and adherence

    pub_type: 杂志文章


    authors: Taylor PC,Alten R,Reino JJG,Caporali R,Bertin P,Sullivan E,Wood R,Piercy J,Vasilescu R,Spurden D,Alvir J,Tarallo M

    更新日期:2018-10-04 00:00:00

  • Text messaging to decrease tuberculosis treatment attrition in TB-HIV coinfection in Uganda.

    abstract:BACKGROUND:Low tuberculosis (TB) treatment completion rates in sub-Saharan Africa are an important driver of multidrug resistance. Mobile technology-based interventions have been shown to improve adherence to antiretroviral therapy in sub-Saharan Africa. We aimed to test the effect of a short-message service (SMS) inte...

    journal_title:Patient preference and adherence

    pub_type: 杂志文章


    authors: Hermans SM,Elbireer S,Tibakabikoba H,Hoefman BJ,Manabe YC

    更新日期:2017-08-31 00:00:00

  • Impact of late-to-refill reminder calls on medication adherence in the Medicare Part D population: evaluation of a randomized controlled study.

    abstract:OBJECTIVES:This study evaluates a nationwide pharmacy chain's late-to-refill (LTR) reminder program that entails local pharmacists placing reminder calls to Medicare Part D patients. METHODS:We conducted a randomized controlled study among 735,218 patients who exhibited nonadherent behavior by not refilling a maintena...

    journal_title:Patient preference and adherence

    pub_type: 杂志文章


    authors: Taitel MS,Mu Y,Gooptu A,Lou Y

    更新日期:2017-02-28 00:00:00

  • Preference for a prefilled syringe or an auto-injection device for delivering golimumab in patients with moderate-to-severe ulcerative colitis: a randomized crossover study.

    abstract:Purpose:Simponi® (golimumab, MSD) is a fully human monoclonal antibody against tumor necrosis factor alpha administered subcutaneously using an autoinjector or a prefilled syringe. This study examined preference for administration of golimumab by autoinjector or prefilled syringe in patients with moderate-to-severe ulc...

    journal_title:Patient preference and adherence

    pub_type: 杂志文章


    authors: Vermeire S,D'heygere F,Nakad A,Franchimont D,Fontaine F,Louis E,Van Hootegem P,Dewit O,Lambrecht G,Strubbe B,Baert F

    更新日期:2018-07-06 00:00:00

  • Complex sleep apnea syndrome.

    abstract::Complex sleep apnea syndrome (CompSAS) is a distinct form of sleep-disordered breathing characterized as central sleep apnea (CSA), and presents in obstructive sleep apnea (OSA) patients during initial treatment with a continuous positive airway pressure (CPAP) device. The mechanisms of why CompSAS occurs are not well...

    journal_title:Patient preference and adherence

    pub_type: 杂志文章


    authors: Wang J,Wang Y,Feng J,Chen BY,Cao J

    更新日期:2013-07-03 00:00:00

  • A Comparison of the Effects of Teach-Back and Motivational Interviewing on the Adherence to Medical Regimen in Patients with Hypertension.

    abstract:Background and Objective:Arterial hypertension is considered a chronic medical problem and also a challenging condition. The present study aimed to compare the effects of motivational interviewing and teach-back on people with hypertension. Materials and Methods:In this clinical trial conducted in Yasuj in 2018 a tota...

    journal_title:Patient preference and adherence



    authors: Zabolypour S,Alishapour M,Behnammoghadam M,Abbasi Larki R,Zoladl M

    更新日期:2020-02-26 00:00:00

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    abstract:Purpose:The unanticipated admission of a patient to the intensive care unit (ICU) can be particularly frightening and stressful for their family members. The objective of this study was to identify the most important needs of family members of patients admitted in the ICU and determine their relationship with their soc...

    journal_title:Patient preference and adherence

    pub_type: 杂志文章


    authors: Alsharari AF

    更新日期:2019-04-02 00:00:00

  • How do patients with a Turkish background evaluate their medical care in Germany? An observational study in primary care.

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    journal_title:Patient preference and adherence

    pub_type: 杂志文章


    authors: Goetz K,Bungartz J,Szecsenyi J,Steinhaeuser J

    更新日期:2015-11-03 00:00:00

  • Satisfaction of Pregnant Women with Antenatal Care Services at Women and Children Hospital in South Okkalapa, Myanmar: A Facility-Based Cross-Sectional Study Triangulated with Qualitative Study.

    abstract:Background:While patients' satisfaction is a barometer for healthcare quality, Myanmar did not do enough to assess the antenatal care (ANC) satisfaction. Objective:In this study, we aim to assess the satisfaction level of pregnant women with ANC services provided by a public hospital in Myanmar. Methods:A cross-secti...

    journal_title:Patient preference and adherence

    pub_type: 杂志文章


    authors: Hsai NM,Matsui M,Ng CFS,Khaing CT,Imoto A,Sayed AM,Huy NT,Kamiya Y,Moji K

    更新日期:2020-12-18 00:00:00

  • Adherence to Subcutaneous Anti-TNF Treatment in Chronic Inflammatory Rheumatism and Therapeutic Patient Education.

    abstract:Objective:Poor patient adherence to anti-TNF treatment has proven to be a major roadblock to effective management. Therapeutic patient education (TPE) is now recognized as a crucial tool in managing conditions like chronic inflammatory rheumatism and in improving treatment adherence. This study aimed to assess whether ...

    journal_title:Patient preference and adherence

    pub_type: 杂志文章


    authors: Fayet F,Fan A,Rodere M,Savel C,Pereira B,Soubrier M

    更新日期:2020-02-24 00:00:00

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    abstract:PURPOSE:We aimed to conduct a validation in Spanish of the Validated Hemophilia Regimen Treatment Adherence Scale - Prophylaxis (VERITAS-Pro) questionnaire for use in patients with hemophilia under prophylactic treatment. PATIENTS AND METHODS:The VERITAS-Pro scale was adapted through a process of back translation from...

    journal_title:Patient preference and adherence

    pub_type: 杂志文章


    authors: Cuesta-Barriuso R,Torres-Ortuño A,Galindo-Piñana P,Nieto-Munuera J,Duncan N,López-Pina JA

    更新日期:2017-03-27 00:00:00

  • Superselective arterial embolization of the superior mesenteric artery for the treatment of gastrointestinal hemorrhage following allogeneic hematopoietic stem cell transplantation.

    abstract::Superselective arterial embolization is a common therapeutic procedure for cases of visceral hemorrhage. However, until now, it has not been applied in the treatment of gastrointestinal (GI) hemorrhage caused by acute graft-versus-host disease (GVHD) after allogeneic hematopoietic stem cell transplantation. We describ...

    journal_title:Patient preference and adherence



    authors: Chen RZ,Zhao G,Jin N,Chen BA,Ding JH

    更新日期:2014-11-13 00:00:00

  • Investigating the feasibility of text message reminders to improve adherence to nebulized medication in children and adolescents with cystic fibrosis.

    abstract:BACKGROUND:Children with cystic fibrosis (CF) often have suboptimal adherence rates to nebulized medication. Adherence barriers cited include forgetting to take the nebulizers, due to busy home and social lives. Text message reminders have been shown to be effective at improving adherence rates in other chronic disease...

    journal_title:Patient preference and adherence

    pub_type: 杂志文章


    authors: Morton RW,Elphick HE,Edwards E,Daw WJ,West NS

    更新日期:2017-05-08 00:00:00

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    abstract:OBJECTIVE:A disposable autoinjector was developed for subcutaneous (SC) self-injection by patients with chronic diseases. To verify its performance and evaluate its acceptance, a clinical study was conducted in healthy volunteers, comparing SC injections performed by subjects using the autoinjector with SC injections p...

    journal_title:Patient preference and adherence

    pub_type: 杂志文章


    authors: Berteau C,Schwarzenbach F,Donazzolo Y,Latreille M,Berube J,Abry H,Cotten J,Feger C,Laurent PE

    更新日期:2010-10-05 00:00:00

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    journal_title:Patient preference and adherence

    pub_type: 杂志文章


    authors: Mekonen KK,Yismaw MB,Abiye AA,Tadesse TA

    更新日期:2020-02-19 00:00:00

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    journal_title:Patient preference and adherence

    pub_type: 杂志文章


    authors: Hazelton G,Al-Khatib SM,Fonarow GC,Thomas KL,Hayes D,Sanders GD,Campbell SM,Yancy C,Peterson ED,Sears S

    更新日期:2013-04-26 00:00:00

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    pub_type: 杂志文章,评审


    authors: Van den Bosch J,Warren DS,Rutherford PA

    更新日期:2015-09-09 00:00:00

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    journal_title:Patient preference and adherence

    pub_type: 杂志文章


    authors: Ndiaye M,Nyasulu P,Nguyen H,Lowenthal ED,Gross R,Mills EJ,Nachega JB

    更新日期:2013-09-11 00:00:00

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    journal_title:Patient preference and adherence

    pub_type: 杂志文章


    authors: Chapman RH,Pelletier EM,Smith PJ,Roberts CS

    更新日期:2009-11-03 00:00:00

  • A PDA-based dietary self-monitoring intervention to reduce sodium intake in an in-center hemodialysis patient.

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    journal_title:Patient preference and adherence



    authors: Sevick MA,Stone RA,Novak M,Piraino B,Snetselaar L,Marsh RM,Hall B,Lash H,Bernardini J,Burke LE

    更新日期:2008-02-02 00:00:00

  • Spotlight on empagliflozin/metformin fixed-dose combination for the treatment of type 2 diabetes: a systematic review.

    abstract::The dramatic rise in the prevalence of obesity and diabetes is associated with increased morbidity, mortality, and public health care costs worldwide. The need for new, effective, and long-lasting drugs is urgent. Recent research has focused on the role of the inhibitors of sodium- glucose co-transporter 2 (SGLT-2). C...

    journal_title:Patient preference and adherence

    pub_type: 杂志文章,评审


    authors: Kedia R,Kulkarni S,Ross M,Shivaswamy V

    更新日期:2016-09-30 00:00:00

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    journal_title:Patient preference and adherence

    pub_type: 杂志文章


    authors: Hsieh CI,Chung KP,Yang MC,Li TC

    更新日期:2013-07-11 00:00:00

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    journal_title:Patient preference and adherence

    pub_type: 杂志文章


    authors: Pointreau Y,Bensadoun RJ,Bera G,Sire C,Ruffier A,Janoray G,Calais G,Bollet M,Pinel B,Braniste V,Amores X

    更新日期:2020-05-21 00:00:00

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    journal_title:Patient preference and adherence

    pub_type: 杂志文章


    authors: Ah YM,Shin J,Lee JY

    更新日期:2019-01-31 00:00:00

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    journal_title:Patient preference and adherence

    pub_type: 杂志文章,评审


    authors: Yimer YS,Mohammed SA,Hailu AD

    更新日期:2020-07-28 00:00:00

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    journal_title:Patient preference and adherence

    pub_type: 杂志文章


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    更新日期:2018-06-22 00:00:00

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    journal_title:Patient preference and adherence

    pub_type: 社论


    authors: Whalley Buono E,Vrijens B,Bosworth HB,Liu LZ,Zullig LL,Granger BB

    更新日期:2017-06-02 00:00:00

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    pub_type: 杂志文章


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    更新日期:2015-02-09 00:00:00