The antihypertensive effect of irbesartan in spontaneously hypertensive rats is associated with improvement of the leptin-adiponectin imbalance.

abstract：:Non-shivering thermogenesis in brown adipose tissue (BAT) plays an important role in thermoregulatory cold-defense and, through its metabolic consumption of energy reserves to produce heat, can affect the long-term regulation of adiposity. An orexinergic pathway from the perifornical lateral hypothalamus (PeF/LH) to t...

journal_title：Adipocyte

authors： Morrison SF,Madden CJ,Tupone D

更新日期：2012-04-01 00:00:00

abstract：:Fat depots of different localization vary in their biological/metabolic function. We recently provided evidence for different regulation of lipolysis between perigonadal and mesenteric adipocytes; in particular insulin-induced suppression of lipolysis was significantly higher in perigonadal compared with mesenteric ad...

journal_title：Adipocyte

authors： Wueest S,Schoenle EJ,Konrad D

更新日期：2012-07-01 00:00:00

abstract：:The integrated control of animal physiology requires intimate tissue crosstalk, a vital task mediated by circulating humoral factors. As one type of these factors, adipose tissue-derived adipokines have recently garnered attention as important regulators of systemic insulin sensitivity and metabolic homeostasis. Howev...

journal_title：Adipocyte

authors： Seldin MM,Wong GW

更新日期：2012-10-01 00:00:00

abstract：:A population of brown adipocytes emerges in white fat depots at weaning. The function of these adipocytes is not known, but at this late stage of development it is unlikely they are essential for body temperature regulation experienced during the cold stress at birth. A dietary protocol of under-nutrition during the p...

journal_title：Adipocyte

authors： Kozak LP

更新日期：2012-10-01 00:00:00

abstract：:A contribution of structural genomic variation to the heritability of complex metabolic phenotypes was illuminated by the recent characterization of chromosome-engineered mouse models for genomic disorders associated with metabolic dysfunction. Herein we discuss our study, "A duplication CNV that conveys traits recipr...

journal_title：Adipocyte

authors： Lacaria M,Gu W,Lupski JR

更新日期：2013-01-01 00:00:00

abstract：:Adipose-derived stem cells (ASCs) show great promise for tissue engineering applications and cell-based therapies because of their multipotency, relative abundance and immunosuppressive properties. However, ASCs must be isolated from heterogeneous cell populations present in adipose tissue. In this brief report, we pr...

journal_title：Adipocyte

authors： González-Cruz RD,Darling EM

更新日期：2013-04-01 00:00:00

abstract：:Obesity has reached epidemic proportions in most of the western world. With obesity comes a variety of adverse health effects such as insulin resistance, dyslipidemia, hypertension, glucose intolerance, and hepatic steatosis. It has become clear that a state of low grade chronic inflammation, typically associated with...

journal_title：Adipocyte

authors： Eguchi A,Feldstein AE

更新日期：2013-07-01 00:00:00

abstract：:The capacity for increased thermogenesis through brown adipose tissue (BAT) activation is important for body weight homeostasis. Differences in BAT thermogenesis can underlie significant differences in body weight and body composition, as we demonstrate in a rat model of obesity. This mini-review focuses on our curren...

journal_title：Adipocyte

authors： Lockie SH,Stefanidis A,Oldfield BJ,Perez-Tilve D

更新日期：2013-10-01 00:00:00

abstract：:The cells of the innate and adaptive immune systems have been implicated in the development of obesity-induced metaflammation and metabolic disorders including type 2 diabetes. Galectin-3, a β-galactoside-binding lectin, modulates immune/inflammatory responses and specifically binds to advanced glycation end products ...

journal_title：Adipocyte

authors： Pejnovic NN,Pantic JM,Jovanovic IP,Radosavljevic GD,Djukic ALj,Arsenijevic NN,Lukic ML

更新日期：2013-10-01 00:00:00

abstract：:Objective To study whether there is an association between adiponectin and endoplasmic reticulum/sarcoplasmic reticulum (ERSR) stress. Research design Eleven-month-old male wild-type (WT) and adiponectin knockout (ADKO) mice were placed on chow or high fat diet for 12 weeks. The changes in ER stress and inflammatory g...

journal_title：Adipocyte

authors： Boddu NJ,Theus S,Luo S,Wei JY,Ranganathan G

更新日期：2014-01-01 00:00:00

abstract：:Profilin-1 (pfn) is a small ubiquitous protein that can bind to: (1) G-actin, (2) phosphatidylinositol 4,5-bisphosphate, and (3) a heterogeneous group of proteins harboring poly-l-proline stretches. Through these interactions, pfn integrates signaling from a diverse array of extracellular cues with actin cytoskeleton ...

journal_title：Adipocyte

authors： Pae M,Romeo GR

更新日期：2014-01-01 00:00:00

abstract：:A short bout of high fat diet (HFD) impairs glucose tolerance and hepatic insulin sensitivity. We recently identified adipose tissue inflammation and resulting dysfunctional adipose tissue-liver cross-talk as an early event in the development of HFD-induced hepatic insulin resistance. In particular, reducing white adi...

journal_title：Adipocyte

authors： Wiedemann MS,Wueest S,Grob A,Item F,Schoenle EJ,Konrad D

更新日期：2014-04-01 00:00:00

abstract：:Tumor necrosis factor α (TNFα) is a well-known mediator of inflammation in the context of obesity in adipose tissue. Its action appears to be directly linked to perturbations of the insulin pathway, leading to the development of insulin resistance. Visfatin has been suspected to be linked to insulin sensitivity, but t...

journal_title：Adipocyte

authors： Gouranton E,Romier B,Marcotorchino J,Tourniaire F,Astier J,Peiretti F,Landrier JF

更新日期：2014-07-01 00:00:00

abstract：:Adipose tissue and the extracellular matrix were once considered passive players in regulating physiological processes. Now, both entities are acknowledged for their capacity to engage signal transduction pathways, and for their involvement in maintaining normal tissue homeostasis. We recently published a series of st...

journal_title：Adipocyte

authors： Craft CS

更新日期：2014-10-30 00:00:00

abstract：:Visceral adiposity is associated with type-2-diabetes, inflammation, dyslipidemia and non-alcoholic fatty liver disease (NAFLD), whereas subcutaneous adiposity is not. We hypothesized that the link between visceral adiposity and liver pathophysiology involves inherent or diet-derived differences between visceral and s...

journal_title：Adipocyte

authors： Gentile CL,Weir TL,Cox-York KA,Wei Y,Wang D,Reese L,Moran G,Estrada A,Mulligan C,Pagliassotti MJ,Foster MT

更新日期：2015-01-14 00:00:00

abstract：:One major gap in adipocyte biology has been a lack of understanding of the developmental origins of the different visceral white adipose tissue (WAT) depots and subcutaneous WAT. In a recent study we showed that most visceral WAT but no subcutaneous WAT arises from cells expressing the Wilms' tumor 1 (Wt1) gene late i...

journal_title：Adipocyte

authors： Chau YY,Hastie N

更新日期：2015-01-29 00:00:00

abstract：:In this study, total RNA was collected from abdominal adipose tissue samples obtained from ten broiler chickens at 3, 4, 5, and 6 weeks of age and prepared for gene microarray analysis with Affymetrix GeneChip Chicken Genome Arrays (Affymetrix) and quantitative real-time PCR analysis. Studies of global gene expression...

journal_title：Adipocyte

authors： Hausman GJ,Barb CR,Fairchild BD,Gamble J,Lee-Rutherford L

更新日期：2014-12-10 00:00:00

abstract：:Human brown adipose tissue (BAT) has during the last 5 year been subjected to an increasing research interest, due to its putative function as a target for future obesity treatments. The most commonly used method for molecular studies of human BAT is the quantitative polymerase chain reaction (qPCR). This method requi...

journal_title：Adipocyte

authors： Taube M,Andersson-Assarsson JC,Lindberg K,Pereira MJ,Gäbel M,Svensson MK,Eriksson JW,Svensson PA

更新日期：2015-05-28 00:00:00

abstract：:Gene expression (qPCR) was compared in round ligament (RL), omental (OME) and mesenteric (MES) ATs from 48 severely obese women (BMI, 54±11 kg/m(2); 38±9 yrs). The mRNA levels of enzymes of lipid metabolism (LPL, HSL, and PDE-3B), cortisol production (11βHSD-1), adipogenesis (PPAR-γ1/2), thrombosis and inflammation (P...

journal_title：Adipocyte

authors： Mauriège P,Joanisse DR,Cartier A,Lemieux I,Bergeron J,Biron S,Marceau P,Richard D

更新日期：2015-12-08 00:00:00

abstract：:Human brown adipocytes are able to burn fat and glucose and are now considered as a potential strategy to treat obesity, type 2 diabetes and metabolic disorders. Besides their thermogenic function, brown adipocytes are able to secrete adipokines. One of these is visfatin, a nicotinamide phosphoribosyltransferase invol...

journal_title：Adipocyte

authors： Pisani DF,Dumortier O,Beranger GE,Casamento V,Ghandour RA,Giroud M,Gautier N,Balaguer T,Chambard JC,Virtanen KA,Nuutila P,Niemi T,Taittonen M,Van Obberghen E,Hinault C,Amri EZ

更新日期：2015-12-09 00:00:00

abstract：:MicroRNAs (miRNAs) are non-coding RNAs that regulate target gene expression at the post-transcriptional level and are supposed to be implicated in the control of adipogenesis. We aimed to identify miRNAs which are involved in the regulation of human adipogenesis and searched for their molecular targets. Applying micro...

journal_title：Adipocyte

authors： Rockstroh D,Löffler D,Kiess W,Landgraf K,Körner A

更新日期：2016-06-01 00:00:00

abstract：:Adipose tissue contains various types of immunocompetent cells, and these cells of innate and adaptive immunity control adipose tissue inflammation that blunts insulin sensitivity. Recent studies have shown that adipocytes express CD1d and present lipid antigen(s) to activate natural killer T (NKT) cells. The function...

journal_title：Adipocyte

authors： Satoh M,Iwabuchi K

更新日期：2016-09-29 00:00:00

abstract：:Obesity is closely associated with metabolic diseases including type 2 diabetes. One hallmark characteristics of obesity is chronic inflammation that is coordinately controlled by complex signaling networks in adipose tissues. Compelling evidence indicates that reactive oxygen species (ROS) and its related signaling p...

journal_title：Adipocyte

authors： Park YJ,Choe SS,Sohn JH,Kim JB

更新日期：2017-04-03 00:00:00

abstract：:Brown adipose tissue (BAT) mitochondria are distinct from their counterparts in other tissues in that ATP production is not their primary physiologic role. BAT mitochondria are equipped with a specialized protein known as uncoupling protein 1 (UCP1). UCP1 short-circuits the electron transport chain, allowing mitochond...

journal_title：Adipocyte

authors： Porter C

更新日期：2017-04-03 00:00:00

abstract：:The chaperone GRP78 (glucose related protein 78), also called BiP (binding immunoglobulin protein) is a key regulator of endoplasmic reticulum (ER) stress. We recently described that over-expression of GRP78 specifically in the ventromedial nucleus of the hypothalamus (VMH) releases hypothalamic ER stress in rodent ob...

journal_title：Adipocyte

authors： Contreras C,Fondevila MF,López M

更新日期：2018-01-02 00:00:00

abstract：:In rodents, experimentally-induced ovarian hormone deficiency increases adiposity and adipose tissue (AT) inflammation, which is thought to contribute to insulin resistance and increased cardiovascular disease risk. However, whether this occurs in a translationally-relevant large animal model remains unknown. Herein, ...

journal_title：Adipocyte

authors： Jurrissen TJ,Olver TD,Winn NC,Grunewald ZI,Lin GS,Hiemstra JA,Edwards JC,Gastecki ML,Welly RJ,Emter CA,Vieira-Potter VJ,Padilla J

更新日期：2018-01-02 00:00:00

abstract：:Polyunsaturated Fatty acids have multiple effects in peripheral tissues and pancreatic beta cell function. The n-3 Polyunsaturated Fatty acids prevent and reverse high-fat-diet induced adipose tissue inflammation and insulin resistance. Insulin secretion is stimulated by glucose, amino acids, and glucagon- like peptid...

journal_title：Adipocyte

authors： Baynes HW,Mideksa S,Ambachew S

更新日期：2018-01-01 00:00:00

abstract：:Although much is known about that corticosteroids affect the functions of adipose tissues, little genetic information is available for perirenal adipose tissue (peri-N) from patients with cortisol-producing adenoma (CPA). We conducted microarray analysis of peri-N from patients with CPA by using an Affymetrix human U1...

journal_title：Adipocyte

authors： Wu C,Zhang H,Zhang J,Zhang H,Zeng Y,Fang S,Li P,Zhang Y,Lin X,Wang L,Xue Y,Guan M

更新日期：2019-12-01 00:00:00

abstract：AIMS:We investigated whether a lifestyle intervention could influence expression and DNA methylation of diabetes-related genes in patients with impaired glucose regulation (IGR), the results were compared to bariatric surgery, considering it an intensive change. METHODS:Twenty participants with IGR had adipose tissue ...

journal_title：Adipocyte

authors： Fachim HA,Siddals K,Malipatil N,Donn RP,Moreno GY,Dalton CF,Adam S,Soran H,Gibson JM,Heald AH

更新日期：2020-12-01 00:00:00

abstract：:Few human cell strains are suitable and readily available as in vitro adipocyte models. We used resected lipoma tissue from a patient with germline phosphatase and tensin homolog (PTEN) haploinsufficiency to establish a preadipocyte cell strain termed LipPD1 and aimed to characterize cellular functions and signalling ...

journal_title：Adipocyte

authors： Kässner F,Kirstein A,Händel N,Schmid GL,Landgraf K,Berthold A,Tannert A,Schaefer M,Wabitsch M,Kiess W,Körner A,Garten A

更新日期：2020-12-01 00:00:00