Virus-inspired surface-nanoengineered antimicrobial liposome: A potential system to simultaneously achieve high activity and selectivity.

abstract：:Gelatin based adhesives have been used in the last decades in different biomedical applications due to the excellent biocompatibility, easy processability, transparency, non-toxicity, and reasonable mechanical properties to mimic the extracellular matrix (ECM). Gelatin adhesives can be easily tuned to gain different v...

journal_title：Bioactive materials

authors： Sharifi S,Islam MM,Sharifi H,Islam R,Koza D,Reyes-Ortega F,Alba-Molina D,Nilsson PH,Dohlman CH,Mollnes TE,Chodosh J,Gonzalez-Andrades M

更新日期：2021-04-17 00:00:00

abstract：:Extracellular vesicles (EV) are lipid-bilayer enclosed vesicles in submicron size that are released from cells. A variety of molecules, including proteins, DNA fragments, RNAs, lipids, and metabolites can be selectively encapsulated into EVs and delivered to nearby and distant recipient cells. In tumors, through such ...

journal_title：Bioactive materials

authors： Abhange K,Makler A,Wen Y,Ramnauth N,Mao W,Asghar W,Wan Y

更新日期：2021-04-07 00:00:00

abstract：:Traditional Chinese medicine and Chinese herbs have a demonstrated value for disease therapy and sub-health improvement. Attempts in this area tend to develop new forms to make their applications more convenient and wider. Here, we propose a novel Chinese herb microneedle (CHMN) patch by integrating the herbal extract...

journal_title：Bioactive materials

authors： Chi J,Sun L,Cai L,Fan L,Shao C,Shang L,Zhao Y

更新日期：2021-03-21 00:00:00

abstract：:The periodontium is an integrated, functional unit of multiple tissues surrounding and supporting the tooth, including but not limited to cementum (CM), periodontal ligament (PDL) and alveolar bone (AB). Periodontal tissues can be destructed by chronic periodontal disease, which can lead to tooth loss. In support of t...

journal_title：Bioactive materials

authors： Woo HN,Cho YJ,Tarafder S,Lee CH

更新日期：2021-03-18 00:00:00

abstract：:The management of aggressive breast cancer, particularly, triple negative breast cancer (TNBC) remains a formidable challenge, despite treatment advancement. Although newer therapies such as atezolizumab, olaparib, and sacituzumab can tackle the breast cancer prognosis and/or progression, but achieved limited survival...

journal_title：Bioactive materials

authors： Chowdhury P,Ghosh U,Samanta K,Jaggi M,Chauhan SC,Yallapu MM

更新日期：2021-03-13 00:00:00

abstract：:As an implantable biomaterial, polyetherketoneketone (PEKK) exhibits good mechanical strength but it is biologically inert while tantalum (Ta) possesses outstanding osteogenic bioactivity but has a high density and elastic modulus. Also, silicon nitride (SN) has osteogenic and antibacterial activity. In this study, a ...

journal_title：Bioactive materials

authors： Hu X,Mei S,Wang F,Tang S,Xie D,Ding C,Du W,Zhao J,Yang L,Wu Z,Wei J

更新日期：2021-03-09 00:00:00

abstract：:Sterilization is the process of killing all microorganisms, while disinfection is the process of killing or removing all kinds of pathogenic microorganisms except bacterial spores. Biomaterials involved in cell experiments, animal experiments, and clinical applications need to be in the aseptic state, but their physic...

journal_title：Bioactive materials

authors： Tao M,Ao T,Mao X,Yan X,Javed R,Hou W,Wang Y,Sun C,Lin S,Yu T,Ao Q

更新日期：2021-02-27 00:00:00

abstract：:Natural polymer (NP) hydrogels are an irreplaceable class of biomaterials owing to their identified biosafety; however, the intrinsic poor mechanical strengths severely limit their applications as structural tissue engineering scaffolds. Inspired by the stiffening albumen gel of tea eggs, a traditional Chinese snack, ...

journal_title：Bioactive materials

authors： Wu T,Cui C,Fan C,Xu Z,Liu Y,Liu W

更新日期：2021-02-18 00:00:00

abstract：:Titanium (Ti) has been the most widely used orthopedic implant in the past decades. However, their inert surface often leads to insufficient osteointegration of Ti implant. To solve this issue, two bioactive Mg(OH)2 films were developed on Ti surfaces using hydrothermal treatment (Ti-M1# and Ti-M2#). The Mg(OH)2 films...

journal_title：Bioactive materials

authors： Yao M,Cheng S,Zhong G,Zhou J,Shao H,Ma L,Du C,Peng F,Zhang Y

更新日期：2021-02-13 00:00:00

abstract：Introduction:Magnesium (Mg) has a prophylactic potential against the onset of hyperlipidemia. Similar to statin, Mg is recommended as lipid-lowering medication for hypercholesterolemia and concomitantly exhibits an association with increased bone mass. The combination of statin with Mg ions (Mg2+) may be able to allevi...

journal_title：Bioactive materials

authors： Dai B,Li X,Xu J,Zhu Y,Huang L,Tong W,Yao H,Chow DH,Qin L

更新日期：2021-02-03 00:00:00

abstract：:Limited surface lubrication and bacterial biofilm formation pose great challenges to biomedical implants. Although hydrophilic lubricated coatings and bacterial resistance coatings have been reported, the harsh and tedious synthesis greatly compromises their application, and more importantly, the bacterial resistance ...

journal_title：Bioactive materials

authors： Han Y,Zhao W,Zheng Y,Wang H,Sun Y,Zhang Y,Luo J,Zhang H

更新日期：2021-02-04 00:00:00

abstract：:Hypertrophic scar (HS) is an undesirable skin abnormality following deep burns or operations. Although intralesional multi-injection with the suspension of triamcinolone acetonide (TA) and 5-fluorouracil (5-Fu) has exhibited great promise to HS treatment in clinical, the difference of metabolic behavior between TA and...

journal_title：Bioactive materials

authors： Yang B,Dong Y,Shen Y,Hou A,Quan G,Pan X,Wu C

更新日期：2021-01-27 00:00:00

abstract：:Cardiovascular diseases (CVDs) are the leading cause of death worldwide. Heart attack and stroke cause irreversible tissue damage. The currently available treatment options are limited to "damage-control" rather than tissue repair. The recent advances in nanomaterials have offered novel approaches to restore tissue fu...

journal_title：Bioactive materials

authors： Alagarsamy KN,Mathan S,Yan W,Rafieerad A,Sekaran S,Manego H,Dhingra S

更新日期：2021-01-22 00:00:00

abstract：:Tumor vasculature constitutes a formidable hurdle for the efficient delivery of cancer nanomedicine into tumors. The leverage of passive pathway through inter-endothelial gaps in tumor blood vessels might account for limited extravasation of nanomedicine into tumor microenvironment (TME). Herein, Annexin A1 antibody-i...

journal_title：Bioactive materials

authors： Huang T,Li S,Fang J,Li F,Tu S

更新日期：2021-01-14 00:00:00

abstract：:Macrophage-mediated inflammation compromises bone repair in diabetic patients. Electrical signaling cues are known to regulate macrophage functions. However, the biological effects of electrical microenvironment from charged biomaterials on the immune response for regulating osteogenesis under diabetic conditions rema...

journal_title：Bioactive materials

authors： Dai X,Heng BC,Bai Y,You F,Sun X,Li Y,Tang Z,Xu M,Zhang X,Deng X

更新日期：2020-12-31 00:00:00

abstract：:Currently the standard surgical treatment for bladder defects is augmentation cystoplasty with autologous tissues, which has many side effects. Biomaterials such as small intestine submucosa (SIS) can provide an alternative scaffold for the repair as bladder patches. Previous studies have shown that SIS could enhance ...

journal_title：Bioactive materials

authors： Zhang XZ,Jiang YL,Hu JG,Zhao LM,Chen QZ,Liang Y,Zhang Y,Lei XX,Wang R,Lei Y,Zhang QY,Li-Ling J,Xie HQ

更新日期：2020-12-06 00:00:00

abstract：:In the field of bone defect repair, 3D printed scaffolds have the characteristics of personalized customization and accurate internal structure. However, how to construct a well-structured vascular network quickly and effectively inside the scaffold is essential for bone repair after transplantation. Herein, inspired ...

journal_title：Bioactive materials

authors： Han X,Sun M,Chen B,Saiding Q,Zhang J,Song H,Deng L,Wang P,Gong W,Cui W

更新日期：2020-11-27 00:00:00

abstract：:Magnesium alloys are promising biomaterials for orthopedic implants because of their degradability, osteogenic effects, and biocompatibility. Magnesium has been proven to promote distraction osteogenesis. However, its mechanism of promoting distraction osteogenesis is not thoroughly studied. In this work, a high-purit...

journal_title：Bioactive materials

authors： Hamushan M,Cai W,Zhang Y,Ren Z,Du J,Zhang S,Zhao C,Cheng P,Zhang X,Shen H,Han P

更新日期：2020-11-20 00:00:00

abstract：:Stainless steel implants are suitable candidates for bone replacement due to their cytocompatibility and mechanical resistance, but they suffer from lack of bioactivity and are prone to bacterial infections. Accordingly, to overcome those limitations, in this study we developed by electrophoretic deposition (EPD), an ...

journal_title：Bioactive materials

authors： Rivera LR,Cochis A,Biser S,Canciani E,Ferraris S,Rimondini L,Boccaccini AR

更新日期：2020-11-13 00:00:00

abstract：:Hepatic cancer is a serious disease with high morbidity and mortality. Theranostic agents with effective diagnostic and therapeutic capability are highly needed for the treatment of hepatic cancer. Herein, we aimed to develop a novel mesoporous polydopamine (MPDA)-based theranostic agent for T1/T2 dual magnetic resona...

journal_title：Bioactive materials

authors： Shu G,Chen M,Song J,Xu X,Lu C,Du Y,Xu M,Zhao Z,Zhu M,Fan K,Fan X,Fang S,Tang B,Dai Y,Du Y,Ji J

更新日期：2020-11-10 00:00:00

abstract：:Investigation of thermostability will lead the groundbreaking of unraveling the mechanism of influence of ion-doping on the properties of calcium phosphates. In this work, octacalcium phosphate (OCP), a metastable precursor of biological apatite, was used as a stability model for doping ions (Fe3+ and Sr2+) with diffe...

journal_title：Bioactive materials

authors： Shi H,Ye X,Zhang J,Wu T,Yu T,Zhou C,Ye J

更新日期：2020-11-08 00:00:00

abstract：:Detection of in vivo biodegradation is critical for development of next-generation medical devices such as bioresorbable stents or scaffolds (BRSs). In particular, it is urgent to establish a nondestructive approach to examine in vivo degradation of a new-generation coronary stent for interventional treatment based on...

journal_title：Bioactive materials

authors： Lin W,Zhang H,Zhang W,Qi H,Zhang G,Qian J,Li X,Qin L,Li H,Wang X,Qiu H,Shi X,Zheng W,Zhang D,Gao R,Ding J

更新日期：2020-10-12 00:00:00

abstract：:Compared with paclitaxel, sirolimus has been more used in the treatment of vascular restenosis gradually as an anti-proliferative drug, but few basic studies have elucidated its mechanism. The anti-proliferative effects of sirolimus or paclitaxel have been demonstrated by numerous studies under normoxia, but few studi...

journal_title：Bioactive materials

authors： Chen Y,Zeng Y,Zhu X,Miao L,Liang X,Duan J,Li H,Tian X,Pang L,Wei Y,Yang J

更新日期：2020-10-01 00:00:00

abstract：:Development of innovative nanomedicine enabling enhanced theranostics of multidrug-resistant (MDR) tumors remains to be challenging. Herein, we report the development of a newly designed multifunctional yellow-fluorescent carbon dot (y-CD)/dendrimer nanohybrids as a platform for ultrasound (US)-enhanced fluorescence i...

journal_title：Bioactive materials

authors： Li D,Lin L,Fan Y,Liu L,Shen M,Wu R,Du L,Shi X

更新日期：2020-09-24 00:00:00

abstract：:The efficient cutaneous wound healing accompanied with the enhanced skin appendage regeneration is still a challenge. The bacterial infection and excessive/prolonged inflammation inhibit wound healing process and result in the scar formation. Herein, we reported an anti-inflammatory polycitrate-polyethyleneimine-Ibupr...

journal_title：Bioactive materials

authors： Liu W,Wang M,Cheng W,Niu W,Chen M,Luo M,Xie C,Leng T,Zhang L,Lei B

更新日期：2020-09-23 00:00:00

abstract：:Silk fibroin (SF) is considered biocompatible and biodegradable for osteochondral repair. However, it lacks a bioactive domain for cell adhesion, proliferation and differentiation, limiting its therapeutic efficacy. To revamp SF as a biomimicking and bioactive microenvironment to regulate cell behaviours, we engineere...

journal_title：Bioactive materials

authors： Chen Z,Zhang Q,Li H,Wei Q,Zhao X,Chen F

更新日期：2020-09-18 00:00:00

abstract：:Photo-immunotherapy is a novel therapeutic approach against malignant tumors with minimal invasiveness. Herein, a targeting multifunctional black phosphorus (BP) nanoparticle, modified by PEGylated hyaluronic acid (HA), was designed for photothermal/photodynamic/photo-immunotherapy. In vitro and in vivo assays indicat...

journal_title：Bioactive materials

authors： Zhang X,Tang J,Li C,Lu Y,Cheng L,Liu J

更新日期：2020-09-09 00:00:00

abstract：:Conditioned medium (CM) contains variety of factors secreted by cells, which directly regulate cellular processes, showing tremendous potential in regenerative medicine. Here, for the first time, we proposed a novel regenerative therapy mediated by biodegradable micro-nano electrospun fibers loaded with highly active ...

journal_title：Bioactive materials

authors： Chen L,Cheng L,Wang Z,Zhang J,Mao X,Liu Z,Zhang Y,Cui W,Sun X

更新日期：2020-09-02 00:00:00

abstract：:Chemotherapy is one of the major approaches for the treatment of metastatic lung cancer. However, systemic chemotherapy is limited by poor therapeutic efficiency and severe toxic side effects, due to the extremely low delivery efficacy and non-specificity of anticancer drugs. Herein, we report a sericin microparticles...

journal_title：Bioactive materials

authors： Liu J,Deng Y,Fu D,Yuan Y,Li Q,Shi L,Wang G,Wang Z,Wang L

更新日期：2020-08-22 00:00:00

abstract：:Soft tissue sealing around implants acts as a barrier between the alveolar bone and oral environment, protecting implants from the invasion of bacteria or external stimuli. In this work, magnesium (Mg) and zinc (Zn) are introduced into titanium by plasma immersed ion implantation technology, and their effects on the b...

journal_title：Bioactive materials

authors： Wang L,Luo Q,Zhang X,Qiu J,Qian S,Liu X

更新日期：2020-08-10 00:00:00