PseudoBase: a genomic visualization and exploration resource for the Drosophila pseudoobscura subgroup.

abstract：:Mutations in the Drosophila gene drop-dead (drd) result in early adult lethality and neurodegeneration, but the molecular identity of the drd gene and its mechanism of action are not known. This paper describes the characterization of a new X-linked recessive adult-lethal mutation, originally called lot's wife (lwf(1)...

journal_title：Fly

authors： Blumenthal EM

更新日期：2008-07-01 00:00:00

abstract：:Transgenes, especially those driving production of the GAL4 transcription factor in a specific spatial pattern, are a critical and widely used tool in the Drosophila research community. We recently noticed loss of GAL4-driven reporter gene expression in a series of crosses, and traced that loss of reporter gene expres...

journal_title：Fly

authors： Barrett A,Krueger S,Jackson M,Datta S

更新日期：2008-03-01 00:00:00

abstract：:In mammals, the hedonic aspects (good versus bad) and sensory aspects (i.e., the molecular quality) of taste are associated with different brain regions. Anatomical data argue against such a separation in the primary taste center of Drosophila larvae. Is only one aspect of taste represented or do both co-exist at the ...

journal_title：Fly

authors： Colomb J,Stocker RF

更新日期：2007-07-01 00:00:00

abstract：:On August 1, 2006 the Howard Hughes Medical Institute's first stand-alone research campus opened at Janelia Farm, near Washington DC. Our mission at Janelia is to do exceptional fundamental research. Our two scientific foci are to understand the function of neural circuits and to develop synergistic imaging technologi...

journal_title：Fly

authors： Moses K

更新日期：2007-05-01 00:00:00

abstract：:Desiccation resistance and body mass were measured in multiple populations of each of four species of Drosophila: two desert endemic species (D. nigrospiracula and D. mojavensis), and two with more widespread distributions (D. melanogaster and D. pseudoobscura). While flies from the desert species were more desiccatio...

journal_title：Fly

authors： Matzkin LM,Watts TD,Markow TA

更新日期：2007-09-01 00:00:00

abstract：:The function of the conserved Drosophila Hippo signaling pathway has been shown to be required to limit cell proliferation. Several studies have identified different target genes of this pathway that could modulate this function. However, the ectopic expression of these genes cannot account for all of the hyperplasic ...

journal_title：Fly

authors： Rodríguez I,Baena-Lopez LA,Baonza A

更新日期：2008-11-01 00:00:00

abstract：:The 16(th) Biennial Meeting of the EMBO-Sponsored International Workshop on the Molecular and Developmental Biology of Drosophila was held in Kolymbari, Crete from June 23 to June 28, 2008. As in previous years, the weather was hot, the Mediterranean Sea was clear and blue and the presentations were exciting and illum...

journal_title：Fly

authors： Stein D,Lasko P

更新日期：2008-11-01 00:00:00

abstract：:As research in the biological sciences continues to advance at a rapid pace, it is increasingly important that the data be captured, standardized, organized and made accessible to the scientific community. This is the job of a biocurator. Here we describe the process of biocuration from our perspective as FlyBase cura...

journal_title：Fly

authors： St Pierre S,McQuilton P

更新日期：2009-01-01 00:00:00

abstract：:Activation of the immune system is beneficial in defending against pathogens, but may also have costly side effects on an organism's fitness. In this study we examine the fitness consequences of immune challenge in female Drosophila melanogaster by examining both direct (within generation) and indirect (between genera...

journal_title：Fly

authors： Linder JE,Promislow DE

更新日期：2009-04-01 00:00:00

abstract：:Drosophila ananassae and its relatives have many advantages as a model of genetic differentiation and speciation. In this report, we examine evolutionary relationships in the ananassae species subgroup using a multi-locus molecular data set, karyotypes, meiotic chromosome configuration, chromosomal inversions, morphol...

journal_title：Fly

authors： Matsuda M,Ng CS,Doi M,Kopp A,Tobari YN

更新日期：2009-04-01 00:00:00

abstract：:In modern functional genomics registration techniques areused to construct reference gene expression patterns and createa spatiotemporal atlas of the expression of all the genes in anetwork. In this paper we present a software package calledGCPReg, which can be used to register the expression patterns ofsegmentation g...

journal_title：Fly

authors： Kozlov KN,Myasnikova E,Samsonova AA,Surkova S,Reinitz J,Samsonova M

更新日期：2009-04-01 00:00:00

abstract：:Altering the cellular response to internal and external stressors is essential for survival, hence the process of translation is exquisitely regulated to rapidly change the proteomic profile upon physiological challenges. We recently reported that genetic and pharmacological manipulation of translation may be benefici...

journal_title：Fly

authors： Tain LS,Whitworth AJ

更新日期：2009-10-01 00:00:00

abstract：:The Hedgehog (Hh) signaling pathway is an essential regulator of embryonic development and a key factor in carcinogenesis.(1,2) Hh, a secreted morphogen, activates intracellular signaling events via downstream effector proteins, which translate the signal to regulate target gene transcription.(3,4) In a recent publica...

journal_title：Fly

authors： Farzan SF,Ogden SK,Robbins DJ

更新日期：2010-04-01 00:00:00

abstract：:We have generated wing disc compartments that contain marked fast growing M+ clones surrounded by slow dividing M/+ cells. Under these conditions the interactions between fast and slow dividing cells at the clone borders frequently lead to cell competition. However, our assay suppressing apoptosis indicates that cell ...

journal_title：Fly

authors： Morata G,Herrera SC

更新日期：2010-07-01 00:00:00

abstract：:The innate immune response was once considered to be a limited set of responses that aims to contain an infection by primitive "ingest and kill" mechanisms, thus giving the host time to mount a more specific humoral and cellular immune response. It is now known that the innate immune response is a complex integrated r...

journal_title：Fly

authors： Charroux B,Royet J

更新日期：2010-01-01 00:00:00

abstract：:Understanding the causes of aging is a complex problem due to the multiple factors that influence aging, which include genetics, environment, metabolism and reproduction, among others. These multiple factors create logistical difficulties in the evaluation of anti-aging agents. There is a need for good model systems t...

journal_title：Fly

authors： Jafari M

更新日期：2010-07-01 00:00:00

abstract：:The steroid 20-hydroxy-ecdysone (20-HE) and the sesquiterpenoid Juvenile Hormone (JH) coordinate insect life stage transitions. 20-HE exerts these effects by the sequential induction of response genes. In the nematode Caenorhabditis elegans hormones also play a role in such transitions, but notably, microRNA such as l...

journal_title：Fly

authors： Garbuzov A,Tatar M

更新日期：2010-10-01 00:00:00

abstract：:Gamete development requires a coordinated soma-germ line interaction that ensures renewal and differentiation of germline and somatic stem cells. The physical contact between the germline and somatic cell populations is crucial because it allows the exchange of diffusible signals among them. The tumor suppressor gene ...

journal_title：Fly

authors： Papagiannouli F,Mechler BM

更新日期：2010-10-01 00:00:00

abstract：:Drosophila muscleblind (mbl), the ortholog of human Muscleblind-like 1 (MBNL1) gene involved in Myotonic Dystrophy (DM), gives raise to protein isoforms MblA to G. The specific functions and subcellular distribution of isoforms are still largely unknown. To overcome the lack of isoform-specific antibodies we generated...

journal_title：Fly

authors： Pascual M,Monferrer L,Fernandez Costa JM,Bargiela A,Artero R,Llamusi B

更新日期：2010-10-01 00:00:00

abstract：:N-glycans are post-translational modifications in which the sugar chain is covalently linked to protein by a GlcNAcβ1-N-asparagine linkage. Drosophila melanogaster and other invertebrates, but not vertebrates, synthesize large amounts of "paucimannose" N-glycans that contain only three or four mannose residues. The en...

journal_title：Fly

authors： Schachter H,Boulianne G

更新日期：2011-01-01 00:00:00

abstract：:The epithelial follicle cell layer over the egg chamber in Drosophila ovary undergoes patterning and morphogenesis at oogenesis. These developmental processes are essential for constructing the eggshell and establishing the body axes of the egg and resultant embryo, thereby being crucial for the egg development. We ha...

journal_title：Fly

authors： Li Q,Feng S,Yu L,Zhao G,Li M

更新日期：2011-04-01 00:00:00

abstract：:Obesity has reached pandemic proportions globally and is often associated with lipotoxic heart diseases. In the obese state, caloric surplus is accommodated in the adipocytes as triglycerides. As the storage capacity of adipocytes is exceeded or malfunctioning, lipids begin to infiltrate and accumulate in non-adipose ...

journal_title：Fly

authors： Lim HY,Bodmer R

更新日期：2011-07-01 00:00:00

abstract：:Posttranscriptional modifications of proteins by the ubiquitin and SUMO (Small Ubiquitin-related Modifier) pathways regulate the function of protein networks, enable cells to respond to signaling cues during development, and to cope with the changing environment during adult life. Both modifications can impact protein...

journal_title：Fly

authors： Abed M,Bitman-Lotan E,Orian A

更新日期：2011-10-01 00:00:00

abstract：:Central to the study of molecular evolution, and an area of long-standing debate, is the appropriate model for the fitness landscape of proteins. Much of this debate has focused on the strength and frequency of positive and purifying selection, but the form and frequency of selective correlations is also a vital eleme...

journal_title：Fly

authors： Callahan BJ

更新日期：2012-01-01 00:00:00

abstract：:Huntington disease (HD) is a fatal inherited neurodegenerative disorder caused by a polyglutamine expansion in the huntingtin protein (htt). A pathological hallmark of the disease is the loss of a specific population of striatal neurons, and considerable attention has been paid to the role of the kynurenine pathway (K...

journal_title：Fly

authors： Green EW,Campesan S,Breda C,Sathyasaikumar KV,Muchowski PJ,Schwarcz R,Kyriacou CP,Giorgini F

更新日期：2012-04-01 00:00:00

abstract：:Genes occasionally change their location in the genome through inter-chromosomal duplication and loss. These changes happen as mistakes during recombination or through retrotransposition. In Han and Hahn 2011,(1) we surveyed the genomes of ten Drosophila species, to identify and characterize the gene transposition eve...

journal_title：Fly

authors： Han MV

更新日期：2012-04-01 00:00:00

abstract：:The JIL-1 kinase is a multidomain protein that localizes specifically to euchromatin interband regions of polytene chromosomes and is the kinase responsible for histone H3S10 phosphorylation at interphase. Genetic interaction assays have suggested that the function of the epigenetic histone H3S10ph mark is to antagoni...

journal_title：Fly

authors： Wang C,Cai W,Li Y,Girton J,Johansen J,Johansen KM

更新日期：2012-04-01 00:00:00

abstract：:Hematopoiesis is well-conserved between Drosophila and vertebrates. Similar as in vertebrates, the sites of hematopoiesis shift during Drosophila development. Blood cells (hemocytes) originate de novo during hematopoietic waves in the embryo and in the Drosophila lymph gland. In contrast, the hematopoietic wave in the...

journal_title：Fly

authors： Makhijani K,Brückner K

更新日期：2012-10-01 00:00:00

abstract：:During metamorphosis in holometabolous insects, the nervous system undergoes dramatic remodeling as it transitions from its larval to its adult form. Many neurons are generated through post-embryonic neurogenesis to have adult-specific roles, but perhaps more striking is the dramatic remodeling that occurs to transiti...

journal_title：Fly

authors： Veverytsa L,Allan DW

更新日期：2013-04-01 00:00:00

abstract：:Maintenance of genomic stability during eukaryotic cell division relies on the Spindle Assembly Checkpoint (SAC), which has evolved as a surveillance mechanism that monitors kinetochore-microtubule attachment and prevents APC/C-mediated mitotic exit until all chromosomes are properly attached to the mitotic spindle. R...

journal_title：Fly

authors： Conde C,Osswald M,Sunkel CE

更新日期：2013-10-01 00:00:00