Abstract:
:This study aimed to investigate aquaporin 4 expression and the ultrastructure of the blood-brain barrier at 2-72 hours following cerebral contusion injury, and correlate these changes to the formation of brain edema. Results revealed that at 2 hours after cerebral contusion and laceration injury, aquaporin 4 expression significantly increased, brain water content and blood-brain barrier permeability increased, and the number of pinocytotic vesicles in cerebral microvascular endothelial cells increased. In addition, the mitochondrial accumulation was observed. As contusion and laceration injury became aggravated, aquaporin 4 expression continued to increase, brain water content and blood-brain barrier permeability gradually increased, brain capillary endothelial cells and astrocytes swelled, and capillary basement membrane injury gradually increased. The above changes were most apparent at 12 hours after injury, after which they gradually attenuated. Aquaporin 4 expression positively correlated with brain water content and the blood-brain barrier index. Our experimental findings indicate that increasing aquaporin 4 expression and blood-brain barrier permeability after cerebral contusion and laceration injury in humans is involved in the formation of brain edema.
journal_name
Neural Regen Resjournal_title
Neural regeneration researchauthors
Li X,Han Y,Xu H,Sun Z,Zhou Z,Long X,Yang Y,Zou Ldoi
10.3969/j.issn.1673-5374.2013.04.006keywords:
["aquaporin 4","blood-brain barrier","brain edema","brain injury","cerebral contusion and laceration injury","early stage","human","neural regeneration","neuroregeneration","photographs-containing paper","ultrastructure"]subject
Has Abstractpub_date
2013-02-05 00:00:00pages
338-45issue
4eissn
1673-5374issn
1876-7958pii
NRR-8-338journal_volume
8pub_type
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